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Gene Gene information from NCBI Gene database.
Entrez ID 57018
Gene name Cyclin L1
Gene symbol CCNL1
Synonyms (NCBI Gene)
ANIA6ABM-001PRO1073ania-6a
Chromosome 3
Chromosome location 3q25.31
miRNA miRNA information provided by mirtarbase database.
347 Show/Hide all (347)
miRTarBase ID miRNA Experiments Reference
MIRT004383 hsa-miR-18a-5p MicroarrayNorthern blot 16331254
MIRT003963 hsa-miR-199a-5p MicroarrayNorthern blot 16331254
MIRT006586 hsa-miR-199a-3p MicroarrayNorthern blot 16331254
MIRT003963 hsa-miR-199a-5p Microarray 17875710
MIRT025231 hsa-miR-34a-5p Proteomics 21566225
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17 Show/Hide all (17)
GO ID Ontology Definition Evidence Reference
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex IEA
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex IPI 18216018
GO:0000307 Component Cyclin-dependent protein kinase holoenzyme complex ISS
GO:0005515 Function Protein binding IPI 23455924, 25416956, 26496610, 32296183, 32814053, 33961781
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613384 20569 ENSG00000163660
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UK58
Protein name Cyclin-L1 (Cyclin-L)
Protein function Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018). Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906). May play a role in the regulation of RNA polymerase II (pol II)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00134 Cyclin_N 56 → 197 Cyclin, N-terminal domain Domain
PF02984 Cyclin_C 200 → 312 Cyclin, C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC). {ECO:0000269|PubMed:11980906, ECO:0000269|PubMed:12414649, ECO:0000269|PubMed:15700036, ECO:0000269|PubMed:18216018}.
Sequence
MASGPHSTATAAAAASSAAPSAGGSSSGTTTTTTTTTGGILIGDRLYSEVSLTIDHSLIP
EERLSPTPSMQDGLDLPSETDLRILGCELIQAAGILLRLPQVAMATGQVLFHRFFYSKSF
VKHSFEIVAMACINLASKIEEAPRRIRDVINVFHHLRQLRGKRTPSPLILDQNYINTKNQ
VIKAERRVLKELGFCVH
VKHPHKIIVMYLQVLECERNQTLVQTAWNYMNDSLRTNVFVRF
QPETIACACIYLAARALQIPLPTRPHWFLLFGTTEEEIQEICIETLRLYTRKKPNYELLE
KEVEKRKVALQE
AKLKAKGLNPDGTPALSTLGGFSPASKPSSPREVKAEEKSPISINVKT
VKKEPEDRQQASKSPYNGVRKDSKRSRNSRSASRSRSRTRSRSRSHTPRRHYNNRRSRSG
TYSSRSRSRSRSHSESPRRHHNHGSPHLKAKHTRDDLKSSNRHGHKRKKSRSRSQSKSRD
HSDAAKKHRHERGHHRDRRERSRSFERSHKSKHHGGSRSGHGRHRR
Sequence length 526
Interactions View interactions