CCNDBP1 (cyclin D1 binding protein 1)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 23582
• Gene name: Cyclin D1 binding protein 1
• Gene symbol: CCNDBP1
• Synonyms (NCBI Gene): DIP1, GCIP, HHM
• Chromosome: 15
• Chromosome location: 15q15.2
• Summary: This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells

miRNA Show/Hide all (59)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021474	hsa-miR-9-5p	Microarray	17612493
MIRT030350	hsa-miR-26b-5p	Microarray	19088304
MIRT052851	hsa-miR-3615	CLASH	23622248
MIRT871778	hsa-miR-1289	CLIP-seq
MIRT871779	hsa-miR-3198	CLIP-seq
MIRT871780	hsa-miR-4294	CLIP-seq
MIRT871781	hsa-miR-4309	CLIP-seq
MIRT871782	hsa-miR-4426	CLIP-seq
MIRT871783	hsa-miR-4647	CLIP-seq
MIRT871784	hsa-miR-4662b	CLIP-seq
MIRT871785	hsa-miR-1179	CLIP-seq
MIRT871778	hsa-miR-1289	CLIP-seq
MIRT871786	hsa-miR-31	CLIP-seq
MIRT871787	hsa-miR-3128	CLIP-seq
MIRT871779	hsa-miR-3198	CLIP-seq
MIRT871788	hsa-miR-34b	CLIP-seq
MIRT871789	hsa-miR-3672	CLIP-seq
MIRT871780	hsa-miR-4294	CLIP-seq
MIRT871781	hsa-miR-4309	CLIP-seq
MIRT871782	hsa-miR-4426	CLIP-seq
MIRT871790	hsa-miR-4461	CLIP-seq
MIRT871783	hsa-miR-4647	CLIP-seq
MIRT871784	hsa-miR-4662b	CLIP-seq
MIRT871791	hsa-miR-4729	CLIP-seq
MIRT871792	hsa-miR-4786-5p	CLIP-seq
MIRT871793	hsa-miR-570	CLIP-seq
MIRT871794	hsa-miR-769-5p	CLIP-seq
MIRT1958730	hsa-miR-124	CLIP-seq
MIRT1958731	hsa-miR-3622a-5p	CLIP-seq
MIRT1958732	hsa-miR-3714	CLIP-seq
MIRT1958733	hsa-miR-3910	CLIP-seq
MIRT1958734	hsa-miR-4423-3p	CLIP-seq
MIRT1958735	hsa-miR-506	CLIP-seq
MIRT2498907	hsa-miR-299-5p	CLIP-seq
MIRT2498908	hsa-miR-3121-3p	CLIP-seq
MIRT2498909	hsa-miR-340	CLIP-seq
MIRT2498910	hsa-miR-3664-3p	CLIP-seq
MIRT2498911	hsa-miR-510	CLIP-seq
MIRT2498912	hsa-miR-539	CLIP-seq
MIRT2498913	hsa-miR-584	CLIP-seq
MIRT2498914	hsa-miR-873	CLIP-seq
MIRT2498915	hsa-miR-944	CLIP-seq
MIRT1958730	hsa-miR-124	CLIP-seq
MIRT2677540	hsa-miR-217	CLIP-seq
MIRT2677541	hsa-miR-3123	CLIP-seq
MIRT2498910	hsa-miR-3664-3p	CLIP-seq
MIRT1958732	hsa-miR-3714	CLIP-seq
MIRT1958733	hsa-miR-3910	CLIP-seq
MIRT2677542	hsa-miR-4311	CLIP-seq
MIRT2677543	hsa-miR-4418	CLIP-seq
MIRT871792	hsa-miR-4786-5p	CLIP-seq
MIRT1958735	hsa-miR-506	CLIP-seq
MIRT2677544	hsa-miR-509-3-5p	CLIP-seq
MIRT2677545	hsa-miR-509-5p	CLIP-seq
MIRT2498911	hsa-miR-510	CLIP-seq
MIRT2498912	hsa-miR-539	CLIP-seq
MIRT871793	hsa-miR-570	CLIP-seq
MIRT871794	hsa-miR-769-5p	CLIP-seq
MIRT2498914	hsa-miR-873	CLIP-seq

Gene ontology (GO) Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	10915743, 15887118, 16189514, 19060904, 20460530, 21516116, 22453338, 25416956, 25910212, 26871637, 27107012, 28514442, 31515488, 32296183, 33961781, 36217029
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	12437976
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0016604	Component	Nuclear body	IDA

Other IDs

• MIM: 607089
• HGNC: 1587
• e!Ensembl: ENSG00000166946

Protein

• UniProt ID: O95273
• Protein name: Cyclin-D1-binding protein 1 (Grap2 and cyclin-D-interacting protein) (Human homolog of Maid)
• Protein function: May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.
• PDB: 3AY5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13324	GCIP	55 → 320		Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas. {ECO:0000269|PubMed:10801854, ECO:0000269|PubMed:1
• Sequence:

  MASATAPAAAVPTLASPLEQLRHLAEELRLLLPRVRVGEAQETTEEFNREMFWRRLNEAA
  VTVSREATTLTIVFSQLPLPSPQETQKFCEQVHAAIKAFIAVYYLLPKDQGITLRKLVRG
  ATLDIVDGMAQLMEVLSVTPTQSPENNDLISYNSVWVACQQMPQIPRDNKAAALLMLTKN
  VDFVKDAHEEMEQAVEECDPYSGLLNDTEENNSDNHNHEDDVLGFPSNQDLYWSEDDQEL
  IIPCLALVRASKACLKKIRMLVAENGKKDQVAQLDDIVDISDEISPSVDDLALSIYPPMC
  HLTVRINSAKLVSVLKKALEITKASHVTPQPEDSWIPLLINAIDHCMNRIKELTQSELEL
  

• Sequence length: 360

Related Genes

No strongly related genes found yet for CCNDBP1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CCNDBP1.