CCNB1IP1 (cyclin B1 interacting protein 1)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 57820
• Gene name: Cyclin B1 interacting protein 1
• Gene symbol: CCNB1IP1
• Synonyms (NCBI Gene): C14orf18, HEI10
• Chromosome: 14
• Chromosome location: 14q11.2
• Summary: HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM, Apr 2004]

miRNA Show/Hide all (154)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029964	hsa-miR-26b-5p	Microarray	19088304
MIRT508717	hsa-miR-411-5p	PAR-CLIP	21572407
MIRT508716	hsa-miR-6871-5p	PAR-CLIP	21572407
MIRT508715	hsa-miR-187-3p	PAR-CLIP	21572407
MIRT508714	hsa-miR-6878-5p	PAR-CLIP	21572407
MIRT508713	hsa-miR-6731-5p	PAR-CLIP	21572407
MIRT508712	hsa-miR-8085	PAR-CLIP	21572407
MIRT508711	hsa-miR-30c-1-3p	PAR-CLIP	21572407
MIRT508710	hsa-miR-30c-2-3p	PAR-CLIP	21572407
MIRT508709	hsa-miR-6788-5p	PAR-CLIP	21572407
MIRT515312	hsa-miR-5003-3p	PAR-CLIP	23446348
MIRT508717	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT508716	hsa-miR-6871-5p	PAR-CLIP	23446348
MIRT508715	hsa-miR-187-3p	PAR-CLIP	23446348
MIRT508714	hsa-miR-6878-5p	PAR-CLIP	23446348
MIRT508713	hsa-miR-6731-5p	PAR-CLIP	23446348
MIRT508712	hsa-miR-8085	PAR-CLIP	23446348
MIRT508711	hsa-miR-30c-1-3p	PAR-CLIP	23446348
MIRT508710	hsa-miR-30c-2-3p	PAR-CLIP	23446348
MIRT508709	hsa-miR-6788-5p	PAR-CLIP	23446348
MIRT508717	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT508716	hsa-miR-6871-5p	PAR-CLIP	23446348
MIRT508715	hsa-miR-187-3p	PAR-CLIP	23446348
MIRT508714	hsa-miR-6878-5p	PAR-CLIP	23446348
MIRT508713	hsa-miR-6731-5p	PAR-CLIP	23446348
MIRT508712	hsa-miR-8085	PAR-CLIP	23446348
MIRT508711	hsa-miR-30c-1-3p	PAR-CLIP	23446348
MIRT508710	hsa-miR-30c-2-3p	PAR-CLIP	23446348
MIRT508709	hsa-miR-6788-5p	PAR-CLIP	23446348
MIRT441646	hsa-miR-6510-3p	PAR-CLIP	22291592
MIRT441645	hsa-miR-3613-3p	PAR-CLIP	22291592
MIRT441644	hsa-miR-3607-3p	PAR-CLIP	22291592
MIRT441643	hsa-miR-3663-3p	PAR-CLIP	22291592
MIRT441646	hsa-miR-6510-3p	PAR-CLIP	23708386
MIRT441645	hsa-miR-3613-3p	PAR-CLIP	23708386
MIRT441644	hsa-miR-3607-3p	PAR-CLIP	23708386
MIRT441643	hsa-miR-3663-3p	PAR-CLIP	23708386
MIRT441646	hsa-miR-6510-3p	PAR-CLIP	22100165
MIRT441645	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT441644	hsa-miR-3607-3p	PAR-CLIP	22100165
MIRT441643	hsa-miR-3663-3p	PAR-CLIP	22100165
MIRT441646	hsa-miR-6510-3p	PAR-CLIP	22100165
MIRT441645	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT441644	hsa-miR-3607-3p	PAR-CLIP	22100165
MIRT441643	hsa-miR-3663-3p	PAR-CLIP	22100165
MIRT508717	hsa-miR-411-5p	PAR-CLIP	21572407
MIRT508716	hsa-miR-6871-5p	PAR-CLIP	21572407
MIRT508715	hsa-miR-187-3p	PAR-CLIP	21572407
MIRT508714	hsa-miR-6878-5p	PAR-CLIP	21572407
MIRT508713	hsa-miR-6731-5p	PAR-CLIP	21572407
MIRT508712	hsa-miR-8085	PAR-CLIP	21572407
MIRT508711	hsa-miR-30c-1-3p	PAR-CLIP	21572407
MIRT508710	hsa-miR-30c-2-3p	PAR-CLIP	21572407
MIRT508709	hsa-miR-6788-5p	PAR-CLIP	21572407
MIRT515312	hsa-miR-5003-3p	PAR-CLIP	23446348
MIRT508717	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT508716	hsa-miR-6871-5p	PAR-CLIP	23446348
MIRT508715	hsa-miR-187-3p	PAR-CLIP	23446348
MIRT508714	hsa-miR-6878-5p	PAR-CLIP	23446348
MIRT508713	hsa-miR-6731-5p	PAR-CLIP	23446348
MIRT508712	hsa-miR-8085	PAR-CLIP	23446348
MIRT508711	hsa-miR-30c-1-3p	PAR-CLIP	23446348
MIRT508710	hsa-miR-30c-2-3p	PAR-CLIP	23446348
MIRT508709	hsa-miR-6788-5p	PAR-CLIP	23446348
MIRT508717	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT508716	hsa-miR-6871-5p	PAR-CLIP	23446348
MIRT508715	hsa-miR-187-3p	PAR-CLIP	23446348
MIRT508714	hsa-miR-6878-5p	PAR-CLIP	23446348
MIRT508713	hsa-miR-6731-5p	PAR-CLIP	23446348
MIRT508712	hsa-miR-8085	PAR-CLIP	23446348
MIRT508711	hsa-miR-30c-1-3p	PAR-CLIP	23446348
MIRT508710	hsa-miR-30c-2-3p	PAR-CLIP	23446348
MIRT508709	hsa-miR-6788-5p	PAR-CLIP	23446348
MIRT441646	hsa-miR-6510-3p	PAR-CLIP	22291592
MIRT441645	hsa-miR-3613-3p	PAR-CLIP	22291592
MIRT441644	hsa-miR-3607-3p	PAR-CLIP	22291592
MIRT441643	hsa-miR-3663-3p	PAR-CLIP	22291592
MIRT441646	hsa-miR-6510-3p	PAR-CLIP	23708386
MIRT441645	hsa-miR-3613-3p	PAR-CLIP	23708386
MIRT441644	hsa-miR-3607-3p	PAR-CLIP	23708386
MIRT441643	hsa-miR-3663-3p	PAR-CLIP	23708386
MIRT441646	hsa-miR-6510-3p	PAR-CLIP	22100165
MIRT441645	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT441644	hsa-miR-3607-3p	PAR-CLIP	22100165
MIRT441643	hsa-miR-3663-3p	PAR-CLIP	22100165
MIRT441646	hsa-miR-6510-3p	PAR-CLIP	22100165
MIRT441645	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT441644	hsa-miR-3607-3p	PAR-CLIP	22100165
MIRT441643	hsa-miR-3663-3p	PAR-CLIP	22100165
MIRT871235	hsa-miR-1182	CLIP-seq
MIRT871236	hsa-miR-1267	CLIP-seq
MIRT871237	hsa-miR-3664-5p	CLIP-seq
MIRT871238	hsa-miR-4423-5p	CLIP-seq
MIRT871239	hsa-miR-450b-3p	CLIP-seq
MIRT871240	hsa-miR-4639-3p	CLIP-seq
MIRT871241	hsa-miR-4713-3p	CLIP-seq
MIRT871242	hsa-miR-4714-3p	CLIP-seq
MIRT871243	hsa-miR-513a-5p	CLIP-seq
MIRT871244	hsa-miR-562	CLIP-seq
MIRT871245	hsa-miR-638	CLIP-seq
MIRT871246	hsa-miR-769-3p	CLIP-seq
MIRT871235	hsa-miR-1182	CLIP-seq
MIRT1546246	hsa-miR-122	CLIP-seq
MIRT871236	hsa-miR-1267	CLIP-seq
MIRT1546247	hsa-miR-3135b	CLIP-seq
MIRT1546248	hsa-miR-3622b-5p	CLIP-seq
MIRT1546249	hsa-miR-3652	CLIP-seq
MIRT871237	hsa-miR-3664-5p	CLIP-seq
MIRT871238	hsa-miR-4423-5p	CLIP-seq
MIRT1546250	hsa-miR-4430	CLIP-seq
MIRT871240	hsa-miR-4639-3p	CLIP-seq
MIRT1546246	hsa-miR-122	CLIP-seq
MIRT1546247	hsa-miR-3135b	CLIP-seq
MIRT1546248	hsa-miR-3622b-5p	CLIP-seq
MIRT1546249	hsa-miR-3652	CLIP-seq
MIRT871238	hsa-miR-4423-5p	CLIP-seq
MIRT1546250	hsa-miR-4430	CLIP-seq
MIRT871235	hsa-miR-1182	CLIP-seq
MIRT1546246	hsa-miR-122	CLIP-seq
MIRT871236	hsa-miR-1267	CLIP-seq
MIRT1546247	hsa-miR-3135b	CLIP-seq
MIRT1546248	hsa-miR-3622b-5p	CLIP-seq
MIRT1546249	hsa-miR-3652	CLIP-seq
MIRT871237	hsa-miR-3664-5p	CLIP-seq
MIRT871238	hsa-miR-4423-5p	CLIP-seq
MIRT1546250	hsa-miR-4430	CLIP-seq
MIRT871240	hsa-miR-4639-3p	CLIP-seq
MIRT871235	hsa-miR-1182	CLIP-seq
MIRT1546246	hsa-miR-122	CLIP-seq
MIRT871236	hsa-miR-1267	CLIP-seq
MIRT1546247	hsa-miR-3135b	CLIP-seq
MIRT1546249	hsa-miR-3652	CLIP-seq
MIRT871237	hsa-miR-3664-5p	CLIP-seq
MIRT871238	hsa-miR-4423-5p	CLIP-seq
MIRT1546250	hsa-miR-4430	CLIP-seq
MIRT871240	hsa-miR-4639-3p	CLIP-seq
MIRT871235	hsa-miR-1182	CLIP-seq
MIRT1546246	hsa-miR-122	CLIP-seq
MIRT871236	hsa-miR-1267	CLIP-seq
MIRT1546247	hsa-miR-3135b	CLIP-seq
MIRT1546249	hsa-miR-3652	CLIP-seq
MIRT871237	hsa-miR-3664-5p	CLIP-seq
MIRT871238	hsa-miR-4423-5p	CLIP-seq
MIRT1546250	hsa-miR-4430	CLIP-seq
MIRT871240	hsa-miR-4639-3p	CLIP-seq
MIRT871235	hsa-miR-1182	CLIP-seq
MIRT1546246	hsa-miR-122	CLIP-seq
MIRT871236	hsa-miR-1267	CLIP-seq
MIRT1546247	hsa-miR-3135b	CLIP-seq
MIRT1546249	hsa-miR-3652	CLIP-seq
MIRT871237	hsa-miR-3664-5p	CLIP-seq
MIRT871238	hsa-miR-4423-5p	CLIP-seq
MIRT1546250	hsa-miR-4430	CLIP-seq
MIRT871240	hsa-miR-4639-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000794	Component	Condensed nuclear chromosome	IEA
GO:0000795	Component	Synaptonemal complex	IEA
GO:0000795	Component	Synaptonemal complex	IEA
GO:0000795	Component	Synaptonemal complex	ISS
GO:0001825	Process	Blastocyst formation	IEA
GO:0005515	Function	Protein binding	IPI	12612082, 25416956, 28514442, 31515488, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IEA
GO:0007131	Process	Reciprocal meiotic recombination	IBA
GO:0007131	Process	Reciprocal meiotic recombination	IEA
GO:0007131	Process	Reciprocal meiotic recombination	ISS
GO:0007286	Process	Spermatid development	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0042802	Function	Identical protein binding	IPI	16189514, 25416956, 31515488
GO:0046872	Function	Metal ion binding	IEA
GO:0051026	Process	Chiasma assembly	IEA
GO:0051026	Process	Chiasma assembly	ISS
GO:0051321	Process	Meiotic cell cycle	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

Other IDs

• MIM: 608249
• HGNC: 19437
• e!Ensembl: ENSG00000100814

Protein

• UniProt ID: Q9NPC3
• Protein name: E3 ubiquitin-protein ligase CCNB1IP1 (EC 2.3.2.27) (Cyclin-B1-interacting protein 1) (Human enhancer of invasion 10) (RING-type E3 ubiquitin transferase CCNB1IP1)
• Protein function: Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of cro
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14634	zf-RING_5	9 → 53	zinc-RING finger domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung. {ECO:0000269|PubMed:12612082}.
• Sequence:

  MSLCEDMLLCNYRKCRIKLSGYAWVTACSHIFCDQHGSGEFSRSPAICPACNSTLSGKLD
  IVRTELSPSEEYKAMVLAGLRPEIVLDISSRALAFWTYQVHQERLYQEYNFSKAEGHLKQ
  MEKIYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDS
  LRLRNITIANHEGTLEPSMIAQSGVLGFPLGNNSKFPLDNTPVRNRGDGDGDFQFRPFFA
  GSPTAPEPSNSFFSFVSPSRELEQQQVSSRAFKVKRI

• Sequence length: 277

Related Genes

No strongly related genes found yet for CCNB1IP1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CCNB1IP1.