CCDC28A (coiled-coil domain containing 28A)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 25901
• Gene name: Coiled-coil domain containing 28A
• Gene symbol: CCDC28A
• Synonyms (NCBI Gene): C6orf80, CCRL1AP, LTAP2A
• Chromosome: 6
• Chromosome location: 6q24.1
• Summary: This gene encodes a coiled-coil domain containing protein. Although the specific function of this gene has not yet been determined, this gene is a known translocation partner of nucleoporin 98 in acute leukemias. The resulting fusion gene produces a nucle

miRNA Show/Hide all (52)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016608	hsa-miR-193b-3p	Microarray	20304954
MIRT022982	hsa-miR-124-3p	Microarray	18668037
MIRT030003	hsa-miR-26b-5p	Microarray	19088304
MIRT868775	hsa-miR-1236	CLIP-seq
MIRT868776	hsa-miR-15a	CLIP-seq
MIRT868777	hsa-miR-15b	CLIP-seq
MIRT868778	hsa-miR-16	CLIP-seq
MIRT868779	hsa-miR-195	CLIP-seq
MIRT868780	hsa-miR-216b	CLIP-seq
MIRT868781	hsa-miR-3671	CLIP-seq
MIRT868782	hsa-miR-424	CLIP-seq
MIRT868783	hsa-miR-4520a-5p	CLIP-seq
MIRT868784	hsa-miR-4520b-5p	CLIP-seq
MIRT868785	hsa-miR-4753-3p	CLIP-seq
MIRT868786	hsa-miR-4762-5p	CLIP-seq
MIRT868787	hsa-miR-497	CLIP-seq
MIRT868788	hsa-miR-548u	CLIP-seq
MIRT868789	hsa-miR-607	CLIP-seq
MIRT868790	hsa-miR-942	CLIP-seq
MIRT1957782	hsa-miR-3065-3p	CLIP-seq
MIRT1957783	hsa-miR-338-5p	CLIP-seq
MIRT1957784	hsa-miR-4517	CLIP-seq
MIRT2194824	hsa-miR-1200	CLIP-seq
MIRT868775	hsa-miR-1236	CLIP-seq
MIRT2194825	hsa-miR-1245b-5p	CLIP-seq
MIRT2194826	hsa-miR-145	CLIP-seq
MIRT2194827	hsa-miR-23a	CLIP-seq
MIRT2194828	hsa-miR-23b	CLIP-seq
MIRT2194829	hsa-miR-23c	CLIP-seq
MIRT2194830	hsa-miR-3074-5p	CLIP-seq
MIRT2194831	hsa-miR-3135	CLIP-seq
MIRT2194832	hsa-miR-3142	CLIP-seq
MIRT2194833	hsa-miR-3614-3p	CLIP-seq
MIRT868781	hsa-miR-3671	CLIP-seq
MIRT2194834	hsa-miR-3922-5p	CLIP-seq
MIRT2194835	hsa-miR-3925-3p	CLIP-seq
MIRT2194836	hsa-miR-4502	CLIP-seq
MIRT2194837	hsa-miR-4699-3p	CLIP-seq
MIRT868785	hsa-miR-4753-3p	CLIP-seq
MIRT868786	hsa-miR-4762-5p	CLIP-seq
MIRT2194838	hsa-miR-4786-3p	CLIP-seq
MIRT2194839	hsa-miR-584	CLIP-seq
MIRT868789	hsa-miR-607	CLIP-seq
MIRT868790	hsa-miR-942	CLIP-seq
MIRT2498147	hsa-miR-3190	CLIP-seq
MIRT2498148	hsa-miR-4325	CLIP-seq
MIRT2498149	hsa-miR-4752	CLIP-seq
MIRT2498150	hsa-miR-502-5p	CLIP-seq
MIRT2498151	hsa-miR-7	CLIP-seq
MIRT2498148	hsa-miR-4325	CLIP-seq
MIRT2498149	hsa-miR-4752	CLIP-seq
MIRT2498150	hsa-miR-502-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 31515488

Other IDs

• MIM: 615353
• HGNC: 21098
• e!Ensembl: ENSG00000024862

Protein

• UniProt ID: Q8IWP9
• Protein name: Coiled-coil domain-containing protein 28A (CCRL1AP)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13270	DUF4061	173 → 258	Domain of unknown function (DUF4061)	Family

• Sequence:

  MPRAEPRATLGEQEKAGLPLGAWRLYLLRHFRKQTELRRSGSRDVTGALLVAAAVASEAV
  GSLRVAEGGPNTLLLQVLRSWPWCNKELKTMEERKVKRRSPKSFSAHCTQVVNAKKNAIP
  VSKSTGFSNPASQSTSQRPKLKRVMKEKTKPQGGEGKGAQSTPIQHSFLTDVSDVQEMER
  GLLSLLNDFHSGKLQAFGNECSIEQMEHVRGMQEKLARLNLELYGELEELPEDKRKTASD
  SNLDRLLSDLEELNSSIQKLHLADAQDVPNTSAS

• Sequence length: 274

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Myoepithelial tumor	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (9)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute leukemia	Leukemia	BEFREE	22058212		★☆☆☆☆ Found in Text Mining only
Acute Megakaryocytic Leukemias	Megakaryocytic Leukemia	BEFREE	16028218		★☆☆☆☆ Found in Text Mining only
Childhood Acute Myeloid Leukemia	Acute Myeloid Leukemia	BEFREE	16028218		★☆☆☆☆ Found in Text Mining only
Chronic myeloproliferative disorder	Myeloproliferative disorder	BEFREE	22058212		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	35352485	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	31648321, 34343258	Associate	★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia	Myeloid Leukemia	BEFREE	16028218		★☆☆☆☆ Found in Text Mining only
Myeloproliferative disease	Myeloproliferative disorder	BEFREE	22058212		★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	BEFREE	16467868		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for CCDC28A.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CCDC28A.