CCDC186 (coiled-coil domain containing 186)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55088
• Gene name: Coiled-coil domain containing 186
• Gene symbol: CCDC186
• Synonyms (NCBI Gene): C10orf118, CCCP-1, CCCP1, golgin104
• Chromosome: 10
• Chromosome location: 10q25.3

miRNA Show/Hide all (45)

miRTarBase ID	miRNA	Experiments	Reference
MIRT728170	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT728169	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT728168	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT740657	hsa-miR-8485	HITS-CLIP	21572407
MIRT740658	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT740659	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT740660	hsa-miR-603	HITS-CLIP	21572407
MIRT740661	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT740662	hsa-miR-6834-3p	HITS-CLIP	21572407
MIRT740663	hsa-miR-3941	HITS-CLIP	21572407
MIRT740664	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT740665	hsa-let-7c-3p	HITS-CLIP	21572407
MIRT742190	hsa-miR-338-5p	HITS-CLIP	23824327
MIRT740657	hsa-miR-8485	HITS-CLIP	23824327
MIRT740658	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT740659	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT740660	hsa-miR-603	HITS-CLIP	23824327
MIRT740661	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT742191	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT740663	hsa-miR-3941	HITS-CLIP	23824327
MIRT740664	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT742190	hsa-miR-338-5p	HITS-CLIP	23824327
MIRT740657	hsa-miR-8485	HITS-CLIP	23824327
MIRT740658	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT740659	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT740660	hsa-miR-603	HITS-CLIP	23824327
MIRT740661	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT742191	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT740662	hsa-miR-6834-3p	HITS-CLIP	23824327
MIRT742373	hsa-miR-3909	HITS-CLIP	23824327
MIRT742374	hsa-miR-6852-3p	HITS-CLIP	23824327
MIRT740663	hsa-miR-3941	HITS-CLIP	23824327
MIRT740664	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT742375	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT740665	hsa-let-7c-3p	HITS-CLIP	23824327
MIRT742190	hsa-miR-338-5p	PAR-CLIP	21572407
MIRT740657	hsa-miR-8485	PAR-CLIP	21572407
MIRT740658	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT740659	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT740660	hsa-miR-603	PAR-CLIP	21572407
MIRT740661	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT742191	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT740663	hsa-miR-3941	PAR-CLIP	21572407
MIRT740664	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT740665	hsa-let-7c-3p	PAR-CLIP	21572407

Gene ontology (GO) Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005794	Component	Golgi apparatus	IEA
GO:0005802	Component	Trans-Golgi network	IBA
GO:0009617	Process	Response to bacterium	IEA
GO:0031267	Function	Small GTPase binding	IBA
GO:0035773	Process	Insulin secretion involved in cellular response to glucose stimulus	IEA
GO:0042593	Process	Glucose homeostasis	IEA
GO:0099518	Process	Vesicle cytoskeletal trafficking	IBA
GO:0099518	Process	Vesicle cytoskeletal trafficking	IEA

Other IDs

• MIM: 619249
• HGNC: 24349
• e!Ensembl: ENSG00000165813

Protein

• UniProt ID: Q7Z3E2
• Protein name: Coiled-coil domain-containing protein 186 (CTCL tumor antigen HD-CL-01/L14-2)
• Sequence:

  MSETDHIASTSSDKNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHN
  NRIEAQENYIPDHGGGEDSCAKTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILV
  ELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRV
  PNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKR
  TETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKK
  CEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRL
  HQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKL
  TQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAK
  IKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKV
  KTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNA
  QLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELA
  CRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSM
  GSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIE
  FMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPA
  DNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKKT

• Sequence length: 898

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
HYPOTHYROIDISM	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	34343768	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (10)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Atrophy	Atrophy	Pubtator	37569695	Associate	★☆☆☆☆ Found in Text Mining only
Brain Diseases	Brain disease	Pubtator	33259146	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	35508649	Associate	★☆☆☆☆ Found in Text Mining only
Central Nervous System Diseases	Central nervous system disease	Pubtator	37569695	Associate	★☆☆☆☆ Found in Text Mining only
Demyelinating Diseases	Demyelinating diseases	Pubtator	37569695	Associate	★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	33259146, 37569695	Associate	★☆☆☆☆ Found in Text Mining only
Endocrine System Diseases	Endocrine system disease	Pubtator	37569695	Associate	★☆☆☆☆ Found in Text Mining only
Hypoglycemia	Hypoglycemia	Pubtator	37569695	Associate	★☆☆☆☆ Found in Text Mining only
Malpuech facial clefting syndrome	Malpuech facial clefting syndrome	Pubtator	37569695	Associate	★☆☆☆☆ Found in Text Mining only
Seizures	Seizures	Pubtator	37569695	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for CCDC186.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CCDC186.