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Gene Gene information from NCBI Gene database.
Entrez ID 79872
Gene name Cbl proto-oncogene like 1
Gene symbol CBLL1
Synonyms (NCBI Gene)
HAKAIRNF188
Chromosome 7
Chromosome location 7q22.3
Summary This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell pro
miRNA miRNA information provided by mirtarbase database.
465 Show/Hide all (465)
miRTarBase ID miRNA Experiments Reference
MIRT007353 hsa-miR-203a-3p qRT-PCRWestern blot 23285092
MIRT007353 hsa-miR-203a-3p qRT-PCRWestern blot 23285092
MIRT007353 hsa-miR-203a-3p qRT-PCRWestern blot 23285092
MIRT029151 hsa-miR-26b-5p Microarray 19088304
MIRT716372 hsa-miR-1199-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
33 Show/Hide all (33)
GO ID Ontology Definition Evidence Reference
GO:0000151 Component Ubiquitin ligase complex IC 14996930
GO:0004842 Function Ubiquitin-protein transferase activity ISS
GO:0004842 Function Ubiquitin-protein transferase activity TAS 14996930
GO:0005515 Function Protein binding IPI 11836526, 26871637
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606872 21225 ENSG00000105879
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q75N03
Protein name E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai)
Protein function E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18408 zf_Hakai 161 → 192 C2H2 Hakai zinc finger domain Domain
Sequence
MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDE
EGFDYNEEERYDCKGGELFANQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYG
RMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQR
DLQAHINHRHMR
AGKPVTRASLENVHPPIAPPPTEIPERFIMPPDKHHMSHIPPKQHIMM
PPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDD
SNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQ
AAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPP
PHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRLQGPPSQTPLPGPHH
PDQTRYRPYYQ
Sequence length 491
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
InlA-mediated entry of Listeria monocytogenes into host cells