CBLL1 (Cbl proto-oncogene like 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 79872 |
| Gene name | Cbl proto-oncogene like 1 |
| Gene symbol | CBLL1 |
| Synonyms (NCBI Gene) |
HAKAIRNF188
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| Chromosome | 7 |
| Chromosome location | 7q22.3 |
| Summary | This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell pro |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q75N03 | ||||||||||
| Protein name | E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai) | ||||||||||
| Protein function | E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the | ||||||||||
| Family and domains |
Pfam
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| Sequence |
MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDE |
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| Sequence length | 491 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Related Genes
Genes most often co-reported with CBLL1 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to CBLL1 (see Related Genes above), that are NOT already directly curated for CBLL1 itself -- a lead worth checking, not a confirmed association.
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