Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	57571
Gene name	Carnosine synthase 1
Gene symbol	CARNS1
Synonyms (NCBI Gene)	ATPGD1
Chromosome	11
Chromosome location	11q13.2
Summary	CARNS1 (EC 6.3.2.11), a member of the ATP-grasp family of ATPases, catalyzes the formation of carnosine (beta-alanyl-L-histidine) and homocarnosine (gamma-aminobutyryl-L-histidine), which are found mainly in skeletal muscle and the central nervous system,

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019127	hsa-miR-335-5p	Microarray	18185580
MIRT620437	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT664174	hsa-miR-616-3p	HITS-CLIP	23824327
MIRT608016	hsa-miR-663b	HITS-CLIP	23824327
MIRT608017	hsa-miR-3911	HITS-CLIP	23824327
MIRT608015	hsa-miR-644a	HITS-CLIP	23824327
MIRT608014	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620435	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT608013	hsa-miR-7108-5p	HITS-CLIP	23824327
MIRT608011	hsa-miR-147a	HITS-CLIP	23824327
MIRT608012	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT620437	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT608016	hsa-miR-663b	HITS-CLIP	23824327
MIRT608017	hsa-miR-3911	HITS-CLIP	23824327
MIRT608015	hsa-miR-644a	HITS-CLIP	23824327
MIRT608014	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620435	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT608013	hsa-miR-7108-5p	HITS-CLIP	23824327
MIRT608011	hsa-miR-147a	HITS-CLIP	23824327
MIRT608012	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT620437	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT608016	hsa-miR-663b	HITS-CLIP	23824327
MIRT608017	hsa-miR-3911	HITS-CLIP	23824327
MIRT608015	hsa-miR-644a	HITS-CLIP	23824327
MIRT608014	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620435	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT608013	hsa-miR-7108-5p	HITS-CLIP	23824327
MIRT608011	hsa-miR-147a	HITS-CLIP	23824327
MIRT608012	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT608020	hsa-miR-6847-5p	HITS-CLIP	24906430
MIRT608019	hsa-miR-4257	HITS-CLIP	24906430
MIRT608018	hsa-miR-3650	HITS-CLIP	24906430
MIRT608016	hsa-miR-663b	HITS-CLIP	24906430
MIRT608017	hsa-miR-3911	HITS-CLIP	24906430
MIRT608015	hsa-miR-644a	HITS-CLIP	24906430
MIRT608014	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT608013	hsa-miR-7108-5p	HITS-CLIP	24906430
MIRT608011	hsa-miR-147a	HITS-CLIP	24906430
MIRT608012	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT620437	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT664174	hsa-miR-616-3p	HITS-CLIP	23824327
MIRT608016	hsa-miR-663b	HITS-CLIP	23824327
MIRT608017	hsa-miR-3911	HITS-CLIP	23824327
MIRT608015	hsa-miR-644a	HITS-CLIP	23824327
MIRT608014	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620435	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT608013	hsa-miR-7108-5p	HITS-CLIP	23824327
MIRT608011	hsa-miR-147a	HITS-CLIP	23824327
MIRT608012	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT620437	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT608016	hsa-miR-663b	HITS-CLIP	23824327
MIRT608017	hsa-miR-3911	HITS-CLIP	23824327
MIRT608015	hsa-miR-644a	HITS-CLIP	23824327
MIRT608014	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620435	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT608013	hsa-miR-7108-5p	HITS-CLIP	23824327
MIRT608011	hsa-miR-147a	HITS-CLIP	23824327
MIRT608012	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT620437	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT608016	hsa-miR-663b	HITS-CLIP	23824327
MIRT608017	hsa-miR-3911	HITS-CLIP	23824327
MIRT608015	hsa-miR-644a	HITS-CLIP	23824327
MIRT608014	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620435	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT608013	hsa-miR-7108-5p	HITS-CLIP	23824327
MIRT608011	hsa-miR-147a	HITS-CLIP	23824327
MIRT608012	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT863076	hsa-miR-1266	CLIP-seq
MIRT863077	hsa-miR-1915	CLIP-seq
MIRT863078	hsa-miR-3664-3p	CLIP-seq
MIRT863079	hsa-miR-4446-5p	CLIP-seq
MIRT863080	hsa-miR-4474-5p	CLIP-seq
MIRT863081	hsa-miR-4518	CLIP-seq
MIRT863082	hsa-miR-4726-3p	CLIP-seq
MIRT863083	hsa-miR-554	CLIP-seq
MIRT863084	hsa-miR-1207-5p	CLIP-seq
MIRT863085	hsa-miR-1227	CLIP-seq
MIRT863086	hsa-miR-125a-5p	CLIP-seq
MIRT863087	hsa-miR-125b	CLIP-seq
MIRT863088	hsa-miR-3140-5p	CLIP-seq
MIRT863089	hsa-miR-330-3p	CLIP-seq
MIRT863090	hsa-miR-3661	CLIP-seq
MIRT863091	hsa-miR-3926	CLIP-seq
MIRT863092	hsa-miR-4254	CLIP-seq
MIRT863093	hsa-miR-4270	CLIP-seq
MIRT863094	hsa-miR-4319	CLIP-seq
MIRT863095	hsa-miR-4422	CLIP-seq
MIRT863096	hsa-miR-4441	CLIP-seq
MIRT863097	hsa-miR-4685-5p	CLIP-seq
MIRT863098	hsa-miR-4693-3p	CLIP-seq
MIRT863099	hsa-miR-4732-3p	CLIP-seq
MIRT863100	hsa-miR-4736	CLIP-seq
MIRT863101	hsa-miR-4763-3p	CLIP-seq
MIRT863102	hsa-miR-4786-5p	CLIP-seq
MIRT863103	hsa-miR-619	CLIP-seq
MIRT863104	hsa-miR-631	CLIP-seq
MIRT863105	hsa-miR-670	CLIP-seq
MIRT863106	hsa-miR-769-5p	CLIP-seq
MIRT2193555	hsa-miR-3616-3p	CLIP-seq
MIRT2193556	hsa-miR-4468	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006548	Process	L-histidine catabolic process	TAS
GO:0016874	Function	Ligase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0016887	Function	ATP hydrolysis activity	IDA	20097752
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0035499	Process	Carnosine biosynthetic process	IBA
GO:0035499	Process	Carnosine biosynthetic process	IDA	20097752, 24891507
GO:0035499	Process	Carnosine biosynthetic process	IDA	20097752
GO:0035499	Process	Carnosine biosynthetic process	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0047730	Function	Carnosine synthase activity	IBA
GO:0047730	Function	Carnosine synthase activity	IDA	20097752, 24891507
GO:0047730	Function	Carnosine synthase activity	IEA
GO:0047730	Function	Carnosine synthase activity	TAS
GO:0102102	Function	Homocarnosine synthase activity	IBA
GO:0102102	Function	Homocarnosine synthase activity	IDA	20097752
GO:0102102	Function	Homocarnosine synthase activity	IEA

MIM	HGNC	e!Ensembl
613368	29268	ENSG00000172508

A5YM72

Protein name

Carnosine synthase 1 (EC 6.3.2.11) (ATP-grasp domain-containing protein 1)

Protein function

Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15632	ATPgrasp_Ter	596 → 736		Domain
PF18130	ATPgrasp_N	410 → 492	ATP-grasp N-terminal domain	Domain

Sequence

MLLCLSPAWLMKVPAPGQPGEAALLVSKAVSFHPGGLTFLDDFVPPRRATYFLAGLGLGP
GRGREAAELARDLTCPTGASAELARLLEDRLLTRQLLAQQGGVAVPATLAFTYKPPGLLR
GGDASLGLRLVELSGKEGQETLVKEEVEAFLRSEALGDILQVAVKLSGWRWRGRQAWRLH
PRAELGAVVDTVLALLEKLEEEESVLVEAVYPPAQLPCSDGPSPGPGLAVRICAVVCRTQ
GDRPLLSKVVCGVGRGDRPLRHHNSLPRTLEVALAQCGLGEEAQVAAVRQRVKAAAEAAL
AAVLALEAGLSAEQRGGRRAHTDFLGVDFALTAAGGVLTPVALELNGGLCLEACGALEGL
WAAPRLGPAADEAVAAPLVETMLRRSARCLMEGKQLLVVGAGGVSKKFVWEAARDYGLQL
HLVESDPNHFASQLVQTFIHFDMTEHRRDEENARLLAELVRARGLKLDGCFSYWDDCLVL
TALLCQELGLPCSSPAAMRLAKQKSLTQLHLLHHHGPPWPAPSLHAVPCCPLESEADVER
AVHQVPLPGVMKLEFGAGAVGVRLVEDAPQCHEHFSRITRDLQGEADHPGIGLGWGNAML
LMEFVEGTEHDVDLVLFGGRLLAAFVSDNGPTRLPGFTETAACMPTGLAPEQEAQMVQAA
FRCCLGCGLLDGVFNVELKLTGAGPRLIEINPRMGGFYLRDWILELYGVDLLLAAVMVAC
GLRPALPTRPRARGHLVGVMCLVSQHLQALSSTASRETLQALHDRGLLRLNLLEEALVPG
EYEEPYCSVACAGPSPTEARLRLLGLCQGLGIDGPSYPVAHFLSHFK

Sequence length

827

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Arginine and proline metabolism	Histidine catabolism
Histidine metabolism
beta-Alanine metabolism
Metabolic pathways

CARNS1 (carnosine synthase 1)

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