CAPS (calcyphosine)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Diseases linked via similar genes

Gene

• Entrez ID: 828
• Gene name: Calcyphosine
• Gene symbol: CAPS
• Synonyms (NCBI Gene): CAPS1
• Chromosome: 19
• Chromosome location: 19p13.3
• Summary: This gene encodes a calcium-binding protein, which may play a role in the regulation of ion transport. A similar protein was first described as a potentially important regulatory protein in the dog thyroid and was termed as R2D5 antigen in rabbit. Alterna

miRNA Show/Hide all (25)

miRTarBase ID	miRNA	Experiments	Reference
MIRT862478	hsa-miR-1258	CLIP-seq
MIRT862479	hsa-miR-1265	CLIP-seq
MIRT862480	hsa-miR-1307	CLIP-seq
MIRT862481	hsa-miR-1908	CLIP-seq
MIRT862482	hsa-miR-1914	CLIP-seq
MIRT862483	hsa-miR-2392	CLIP-seq
MIRT862484	hsa-miR-4303	CLIP-seq
MIRT862485	hsa-miR-4328	CLIP-seq
MIRT862486	hsa-miR-4649-3p	CLIP-seq
MIRT862487	hsa-miR-4749-3p	CLIP-seq
MIRT862488	hsa-miR-4762-3p	CLIP-seq
MIRT862489	hsa-miR-651	CLIP-seq
MIRT862490	hsa-miR-663	CLIP-seq
MIRT862491	hsa-miR-1184	CLIP-seq
MIRT862492	hsa-miR-1910	CLIP-seq
MIRT862493	hsa-miR-2052	CLIP-seq
MIRT862494	hsa-miR-3663-5p	CLIP-seq
MIRT862495	hsa-miR-3924	CLIP-seq
MIRT862496	hsa-miR-4676-5p	CLIP-seq
MIRT862497	hsa-miR-4729	CLIP-seq
MIRT862498	hsa-miR-575	CLIP-seq
MIRT862499	hsa-miR-601	CLIP-seq
MIRT1955846	hsa-miR-146b-3p	CLIP-seq
MIRT2496544	hsa-miR-1305	CLIP-seq
MIRT2496545	hsa-miR-607	CLIP-seq

Gene ontology (GO) Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005509	Function	Calcium ion binding	TAS	2540953
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0031982	Component	Vesicle	HDA	19190083
GO:0035556	Process	Intracellular signal transduction	TAS	2540953
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 114212
• HGNC: 1487
• e!Ensembl: ENSG00000105519

Protein

• UniProt ID: Q13938
• Protein name: Calcyphosin (Calcyphosine)
• Protein function: Calcium-binding protein. May play a role in cellular signaling events (Potential).
• PDB: 3E3R
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13202	EF-hand_5	153 → 172	EF hand	Domain
  PF13499	EF-hand_7	181 → 253	EF-hand domain pair	Domain

• Sequence:

  MQCHRDLALSQALWGWQLSKQSGWAHPSLPHSPLPSTVHSCSWAPPHLQRHLPLATVSPG
  TTQLTQGPAGRTLGQTQASCPEPRPSMDAVDATMEKLRAQCLSRGASGIQGLARFFRQLD
  RDGSRSLDADEFRQGLAKLGLVLDQAEAEGVCRKWDRNGSGTLDLEEFLRALRPPMSQAR
  EAVIAAAFAKLDRSGDGVVTVDDLRGVYSGRAHPKVRSGEWTEDEVLRRFLDNFDSSEKD
  GQVTLAEFQDYYSGVSASMNTDEEFVAMMTSAWQL

• Sequence length: 275

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
CAPS-related disorder	Likely benign; Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

No strongly related genes found yet for CAPS.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CAPS.