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Gene Gene information from NCBI Gene database.
Entrez ID 23473
Gene name Calpain 7
Gene symbol CAPN7
Synonyms (NCBI Gene)
CALPAIN7PALBH
Chromosome 3
Chromosome location 3p25.1
Summary Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, an
miRNA miRNA information provided by mirtarbase database.
415 Show/Hide all (415)
miRTarBase ID miRNA Experiments Reference
MIRT036820 hsa-miR-877-3p CLASH 23622248
MIRT673868 hsa-miR-383-3p HITS-CLIP 23824327
MIRT673867 hsa-miR-4456 HITS-CLIP 23824327
MIRT673866 hsa-miR-214-5p HITS-CLIP 23824327
MIRT673865 hsa-miR-6811-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16 Show/Hide all (16)
GO ID Ontology Definition Evidence Reference
GO:0004175 Function Endopeptidase activity IDA 20849418
GO:0004197 Function Cysteine-type endopeptidase activity IBA
GO:0004198 Function Calcium-dependent cysteine-type endopeptidase activity IEA
GO:0005515 Function Protein binding IPI 20849418, 24953135, 32296183
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606400 1484 ENSG00000131375
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y6W3
Protein name Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH)
Protein function Calcium-regulated non-lysosomal thiol-protease.
PDB 2QFE , 8UC6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00648 Peptidase_C2 241 → 537 Calpain family cysteine protease Family
PF01067 Calpain_III 694 → 801 Calpain large subunit, domain III Domain
PF04212 MIT 87 → 152 MIT (microtubule interacting and transport) domain Domain
PF04212 MIT 8 → 69 MIT (microtubule interacting and transport) domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
Sequence length 813
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Degradation of the extracellular matrix
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Gastric cancer Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Carcinoma Embryonal Embryonal carcinoma Pubtator 36713456 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Endometriosis Endometriosis BEFREE 23855590, 29459744
★★★★★
★☆☆☆☆
Found in Text Mining only
Endometriosis Endometriosis Pubtator 23855590 Stimulate
★★★★★
★☆☆☆☆
Found in Text Mining only