CAPN6 (calpain 6)

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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 827
• Gene name: Calpain 6
• Gene symbol: CAPN6
• Synonyms (NCBI Gene): CANPX, CAPNX, CalpM, DJ914P14.1
• Chromosome: X
• Chromosome location: Xq23
• Summary: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, an

miRNA Show/Hide all (100)

miRTarBase ID	miRNA	Experiments	Reference
MIRT725610	hsa-miR-670-3p	HITS-CLIP	19536157
MIRT725609	hsa-miR-4687-5p	HITS-CLIP	19536157
MIRT725608	hsa-miR-4690-3p	HITS-CLIP	19536157
MIRT725607	hsa-miR-5685	HITS-CLIP	19536157
MIRT725606	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT725605	hsa-miR-5193	HITS-CLIP	19536157
MIRT725604	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT725603	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT725602	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT725601	hsa-miR-383-5p	HITS-CLIP	19536157
MIRT725600	hsa-miR-4772-5p	HITS-CLIP	19536157
MIRT725599	hsa-miR-4290	HITS-CLIP	19536157
MIRT659896	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT659895	hsa-miR-6870-3p	HITS-CLIP	23824327
MIRT659894	hsa-miR-6744-5p	HITS-CLIP	23824327
MIRT659893	hsa-miR-1255a	HITS-CLIP	23824327
MIRT659892	hsa-miR-1255b-5p	HITS-CLIP	23824327
MIRT659891	hsa-miR-6800-5p	HITS-CLIP	23824327
MIRT659890	hsa-miR-6802-5p	HITS-CLIP	23824327
MIRT659889	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT659887	hsa-miR-4452	HITS-CLIP	23824327
MIRT659888	hsa-miR-6509-5p	HITS-CLIP	23824327
MIRT659886	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT659885	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT659896	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT659895	hsa-miR-6870-3p	HITS-CLIP	23824327
MIRT659894	hsa-miR-6744-5p	HITS-CLIP	23824327
MIRT659893	hsa-miR-1255a	HITS-CLIP	23824327
MIRT659892	hsa-miR-1255b-5p	HITS-CLIP	23824327
MIRT659891	hsa-miR-6800-5p	HITS-CLIP	23824327
MIRT659890	hsa-miR-6802-5p	HITS-CLIP	23824327
MIRT659889	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT659887	hsa-miR-4452	HITS-CLIP	23824327
MIRT659888	hsa-miR-6509-5p	HITS-CLIP	23824327
MIRT659886	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT659885	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT862001	hsa-miR-1184	CLIP-seq
MIRT862002	hsa-miR-124	CLIP-seq
MIRT862003	hsa-miR-1301	CLIP-seq
MIRT862004	hsa-miR-299-5p	CLIP-seq
MIRT862005	hsa-miR-3160-5p	CLIP-seq
MIRT862006	hsa-miR-324-5p	CLIP-seq
MIRT862007	hsa-miR-361-3p	CLIP-seq
MIRT862008	hsa-miR-3714	CLIP-seq
MIRT862009	hsa-miR-380	CLIP-seq
MIRT862010	hsa-miR-3910	CLIP-seq
MIRT862011	hsa-miR-3924	CLIP-seq
MIRT862012	hsa-miR-4282	CLIP-seq
MIRT862013	hsa-miR-4418	CLIP-seq
MIRT862014	hsa-miR-4436b-5p	CLIP-seq
MIRT862015	hsa-miR-4495	CLIP-seq
MIRT862016	hsa-miR-4660	CLIP-seq
MIRT862017	hsa-miR-4733-5p	CLIP-seq
MIRT862018	hsa-miR-4778-3p	CLIP-seq
MIRT862019	hsa-miR-493	CLIP-seq
MIRT862020	hsa-miR-5047	CLIP-seq
MIRT862021	hsa-miR-506	CLIP-seq
MIRT862022	hsa-miR-509-3-5p	CLIP-seq
MIRT862023	hsa-miR-509-5p	CLIP-seq
MIRT862024	hsa-miR-513c	CLIP-seq
MIRT862025	hsa-miR-514b-5p	CLIP-seq
MIRT862026	hsa-miR-548ag	CLIP-seq
MIRT862027	hsa-miR-548ai	CLIP-seq
MIRT862028	hsa-miR-659	CLIP-seq
MIRT1955750	hsa-miR-1287	CLIP-seq
MIRT1955751	hsa-miR-198	CLIP-seq
MIRT1955752	hsa-miR-203	CLIP-seq
MIRT1955753	hsa-miR-3074-3p	CLIP-seq
MIRT1955754	hsa-miR-3135b	CLIP-seq
MIRT1955755	hsa-miR-3650	CLIP-seq
MIRT1955756	hsa-miR-3689d	CLIP-seq
MIRT1955757	hsa-miR-4267	CLIP-seq
MIRT2193394	hsa-miR-1285	CLIP-seq
MIRT2193395	hsa-miR-1587	CLIP-seq
MIRT2193396	hsa-miR-3187-5p	CLIP-seq
MIRT2193397	hsa-miR-3649	CLIP-seq
MIRT2193398	hsa-miR-378g	CLIP-seq
MIRT2193399	hsa-miR-4294	CLIP-seq
MIRT2193400	hsa-miR-4486	CLIP-seq
MIRT2193401	hsa-miR-4492	CLIP-seq
MIRT2193402	hsa-miR-4498	CLIP-seq
MIRT2193403	hsa-miR-4505	CLIP-seq
MIRT2193404	hsa-miR-4656	CLIP-seq
MIRT2193405	hsa-miR-4675	CLIP-seq
MIRT2193406	hsa-miR-4741	CLIP-seq
MIRT2193407	hsa-miR-612	CLIP-seq
MIRT2193408	hsa-miR-762	CLIP-seq
MIRT2385530	hsa-miR-1273g	CLIP-seq
MIRT2385531	hsa-miR-323-5p	CLIP-seq
MIRT1955755	hsa-miR-3650	CLIP-seq
MIRT2385532	hsa-miR-503	CLIP-seq
MIRT2385533	hsa-miR-876-3p	CLIP-seq
MIRT2496474	hsa-miR-1231	CLIP-seq
MIRT2496475	hsa-miR-1255b	CLIP-seq
MIRT2496476	hsa-miR-4782-5p	CLIP-seq
MIRT2496477	hsa-miR-654-3p	CLIP-seq
MIRT2496474	hsa-miR-1231	CLIP-seq
MIRT2496475	hsa-miR-1255b	CLIP-seq
MIRT2496476	hsa-miR-4782-5p	CLIP-seq
MIRT2496477	hsa-miR-654-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
FOXD3	Unknown	21255642
POU2F1	Unknown	21255642

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001578	Process	Microtubule bundle formation	IEA
GO:0001578	Process	Microtubule bundle formation	ISS
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IBA
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	TAS	9503024
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005876	Component	Spindle microtubule	IDA	17210638
GO:0006508	Process	Proteolysis	IBA
GO:0008017	Function	Microtubule binding	IEA
GO:0008017	Function	Microtubule binding	ISS
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	17210638
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051493	Process	Regulation of cytoskeleton organization	IEA
GO:0051493	Process	Regulation of cytoskeleton organization	ISS

Other IDs

• MIM: 300146
• HGNC: 1483
• e!Ensembl: ENSG00000077274

Protein

• UniProt ID: Q9Y6Q1
• Protein name: Calpain-6 (Calpain-like protease X-linked) (Calpamodulin) (CalpM)
• Protein function: Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mo
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00168	C2	516 → 614	C2 domain	Domain
  PF00648	Peptidase_C2	27 → 341	Calpain family cysteine protease	Family
  PF01067	Calpain_III	358 → 487	Calpain large subunit, domain III	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed only in placenta.
• Sequence:

  MGPPLKLFKNQKYQELKQECIKDSRLFCDPTFLPENDSLFYNRLLPGKVVWKRPQDICDD
  PHLIVGNISNHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGI
  FHFRFWHFGEWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGL
  TITDIIVDFTGTLAETVDMQKGRYTELVEEKYKLFGELYKTFTKGGLICCSIESPNQEEQ
  EVETDWGLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISE
  EWQQLTASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCRNVNNPIFGRKELESVLGCW
  TVDDDPLMNRSGGCYNNRDTFLQNPQYIFTVPEDGHKVIMSLQQKDLRTYRRMGRPDNYI
  IGFELFKVEMNRKFRLHHLYIQERAGTSTYIDTRTVFLSKYLKKGNYVLVPTMFQHGRTS
  EFLLRIFSEVPVQLRELTLDMPKMSCWNLARGYPKVVTQITVHSAEDLEKKYANETVNPY
  LVIKCGKEEVRSPVQKNTVHAIFDTQAIFYRRTTDIPIIVQVWNSRKFCDQFLGQVTLDA
  DPSDCRDLKSLYLRKKGGPTAKVKQGHISFKVISSDDLTEL

• Sequence length: 641

Pathways

Reactome Pathway:

Degradation of the extracellular matrix

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Prostate cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (11)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Neoplasms	Breast neoplasm	Pubtator	33176622	Associate	★☆☆☆☆ Found in Text Mining only
Carcinosarcoma	Carcinoma	Pubtator	17291261	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Leiomyosarcoma	Leiomyosarcoma	Pubtator	17291261	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	26375440		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26375440, 28454386, 30185659		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	26375440, 28454386, 30185659		★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	17291261	Associate	★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	BEFREE	30185659		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	28454386		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	36930113	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for CAPN6.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CAPN6.