CALHM2 (calcium homeostasis modulator family member 2)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 51063
• Gene name: Calcium homeostasis modulator family member 2
• Gene symbol: CALHM2
• Synonyms (NCBI Gene): FAM26B
• Chromosome: 10
• Chromosome location: 10q24.33

miRNA Show/Hide all (69)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1955003	hsa-miR-1291	CLIP-seq
MIRT1955004	hsa-miR-3064-5p	CLIP-seq
MIRT1955005	hsa-miR-3173-5p	CLIP-seq
MIRT1955006	hsa-miR-328	CLIP-seq
MIRT1955007	hsa-miR-3622a-3p	CLIP-seq
MIRT1955008	hsa-miR-3622b-3p	CLIP-seq
MIRT1955009	hsa-miR-3652	CLIP-seq
MIRT1955010	hsa-miR-370	CLIP-seq
MIRT1955011	hsa-miR-4283	CLIP-seq
MIRT1955012	hsa-miR-4430	CLIP-seq
MIRT1955013	hsa-miR-4489	CLIP-seq
MIRT1955014	hsa-miR-4505	CLIP-seq
MIRT1955015	hsa-miR-4731-5p	CLIP-seq
MIRT1955003	hsa-miR-1291	CLIP-seq
MIRT2495933	hsa-miR-193a-5p	CLIP-seq
MIRT2495934	hsa-miR-2115	CLIP-seq
MIRT1955004	hsa-miR-3064-5p	CLIP-seq
MIRT1955005	hsa-miR-3173-5p	CLIP-seq
MIRT1955006	hsa-miR-328	CLIP-seq
MIRT2495935	hsa-miR-331-3p	CLIP-seq
MIRT2495936	hsa-miR-3612	CLIP-seq
MIRT2495937	hsa-miR-3618	CLIP-seq
MIRT1955007	hsa-miR-3622a-3p	CLIP-seq
MIRT1955008	hsa-miR-3622b-3p	CLIP-seq
MIRT1955009	hsa-miR-3652	CLIP-seq
MIRT2495938	hsa-miR-3679-3p	CLIP-seq
MIRT1955010	hsa-miR-370	CLIP-seq
MIRT1955011	hsa-miR-4283	CLIP-seq
MIRT2495939	hsa-miR-4312	CLIP-seq
MIRT1955012	hsa-miR-4430	CLIP-seq
MIRT2495940	hsa-miR-4443	CLIP-seq
MIRT1955013	hsa-miR-4489	CLIP-seq
MIRT1955014	hsa-miR-4505	CLIP-seq
MIRT2495941	hsa-miR-4717-5p	CLIP-seq
MIRT1955015	hsa-miR-4731-5p	CLIP-seq
MIRT2495942	hsa-miR-4793-3p	CLIP-seq
MIRT2495943	hsa-miR-485-5p	CLIP-seq
MIRT2495944	hsa-miR-650	CLIP-seq
MIRT2495945	hsa-miR-934	CLIP-seq
MIRT1955003	hsa-miR-1291	CLIP-seq
MIRT2677245	hsa-miR-132	CLIP-seq
MIRT2495933	hsa-miR-193a-5p	CLIP-seq
MIRT2495934	hsa-miR-2115	CLIP-seq
MIRT2677246	hsa-miR-212	CLIP-seq
MIRT1955004	hsa-miR-3064-5p	CLIP-seq
MIRT1955005	hsa-miR-3173-5p	CLIP-seq
MIRT1955006	hsa-miR-328	CLIP-seq
MIRT2495935	hsa-miR-331-3p	CLIP-seq
MIRT2495936	hsa-miR-3612	CLIP-seq
MIRT2495937	hsa-miR-3618	CLIP-seq
MIRT1955007	hsa-miR-3622a-3p	CLIP-seq
MIRT1955008	hsa-miR-3622b-3p	CLIP-seq
MIRT1955009	hsa-miR-3652	CLIP-seq
MIRT2495938	hsa-miR-3679-3p	CLIP-seq
MIRT1955010	hsa-miR-370	CLIP-seq
MIRT2677247	hsa-miR-3926	CLIP-seq
MIRT1955011	hsa-miR-4283	CLIP-seq
MIRT2495939	hsa-miR-4312	CLIP-seq
MIRT1955012	hsa-miR-4430	CLIP-seq
MIRT2495940	hsa-miR-4443	CLIP-seq
MIRT1955013	hsa-miR-4489	CLIP-seq
MIRT1955014	hsa-miR-4505	CLIP-seq
MIRT2495941	hsa-miR-4717-5p	CLIP-seq
MIRT1955015	hsa-miR-4731-5p	CLIP-seq
MIRT2495942	hsa-miR-4793-3p	CLIP-seq
MIRT2495943	hsa-miR-485-5p	CLIP-seq
MIRT2677248	hsa-miR-548s	CLIP-seq
MIRT2495944	hsa-miR-650	CLIP-seq
MIRT2495945	hsa-miR-934	CLIP-seq

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005261	Function	Monoatomic cation channel activity	IBA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IDA	16751333
GO:0048167	Process	Regulation of synaptic plasticity	IEA
GO:0048167	Process	Regulation of synaptic plasticity	ISS
GO:0070509	Process	Calcium ion import	IEA
GO:0070509	Process	Calcium ion import	ISS
GO:0098655	Process	Monoatomic cation transmembrane transport	IEA
GO:1903978	Process	Regulation of microglial cell activation	IEA
GO:1903978	Process	Regulation of microglial cell activation	ISS
GO:1904669	Process	ATP export	IDA	32832629
GO:1904669	Process	ATP export	IEA

Other IDs

• MIM: 612235
• HGNC: 23493
• e!Ensembl: ENSG00000138172

Protein

• UniProt ID: Q9HA72
• Protein name: Calcium homeostasis modulator protein 2 (Protein FAM26B)
• Protein function: Pore-forming subunit of Ca(2+) homeostasis modulator channels. Mediates ATP release from astrocytes and ATP-induced Ca(2+) influx in microglia thus regulating neuronal ATP and Ca(2+) homeostasis, synaptic transmission and neuroinflammatory respo
• PDB: 6LMU , 6LMW , 6LMX , 6UIV , 6UIW , 6UIX , 6VAI , 6VAK , 6VAL , 8RMK , 8RML , 8RMM
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14798	Ca_hom_mod	6 → 256	Calcium homeostasis modulator	Family

• Tissue specificity: TISSUE SPECIFICITY: Placenta. {ECO:0000269|PubMed:32374262}.
• Sequence:

  MAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAA
  IGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVI
  SLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPCKENPDNLSDFREEVSRRL
  RYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSR
  VLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLH
  KWAQGLAGNGAAPDNVEMALLPS

• Sequence length: 323

Related Genes

No strongly related genes found yet for CALHM2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CALHM2.