CALHM1 (calcium homeostasis modulator 1)

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Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 255022
• Gene name: Calcium homeostasis modulator 1
• Gene symbol: CALHM1
• Synonyms (NCBI Gene): FAM26C
• Chromosome: 10
• Chromosome location: 10q24.33
• Summary: This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer`s disease in some populations, but the patho

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs371900329	C>T	Likely-pathogenic	Coding sequence variant, missense variant

miRNA Show/Hide all (200)

miRTarBase ID	miRNA	Experiments	Reference
MIRT859025	hsa-miR-1236	CLIP-seq
MIRT859026	hsa-miR-1260	CLIP-seq
MIRT859027	hsa-miR-1260b	CLIP-seq
MIRT859028	hsa-miR-1262	CLIP-seq
MIRT859029	hsa-miR-138	CLIP-seq
MIRT859030	hsa-miR-150	CLIP-seq
MIRT859031	hsa-miR-185	CLIP-seq
MIRT859032	hsa-miR-188-3p	CLIP-seq
MIRT859033	hsa-miR-2467-5p	CLIP-seq
MIRT859034	hsa-miR-302a	CLIP-seq
MIRT859035	hsa-miR-302b	CLIP-seq
MIRT859036	hsa-miR-302c	CLIP-seq
MIRT859037	hsa-miR-302d	CLIP-seq
MIRT859038	hsa-miR-302e	CLIP-seq
MIRT859039	hsa-miR-3065-5p	CLIP-seq
MIRT859040	hsa-miR-3150b-3p	CLIP-seq
MIRT859041	hsa-miR-3156-3p	CLIP-seq
MIRT859042	hsa-miR-3182	CLIP-seq
MIRT859043	hsa-miR-3188	CLIP-seq
MIRT859044	hsa-miR-3189-3p	CLIP-seq
MIRT859045	hsa-miR-3192	CLIP-seq
MIRT859046	hsa-miR-323-3p	CLIP-seq
MIRT859047	hsa-miR-3545-3p	CLIP-seq
MIRT859048	hsa-miR-3652	CLIP-seq
MIRT859049	hsa-miR-3689a-3p	CLIP-seq
MIRT859050	hsa-miR-3689c	CLIP-seq
MIRT859051	hsa-miR-372	CLIP-seq
MIRT859052	hsa-miR-373	CLIP-seq
MIRT859053	hsa-miR-3926	CLIP-seq
MIRT859054	hsa-miR-3975	CLIP-seq
MIRT859055	hsa-miR-4301	CLIP-seq
MIRT859056	hsa-miR-4306	CLIP-seq
MIRT859057	hsa-miR-4430	CLIP-seq
MIRT859058	hsa-miR-4438	CLIP-seq
MIRT859059	hsa-miR-4505	CLIP-seq
MIRT859060	hsa-miR-4644	CLIP-seq
MIRT859061	hsa-miR-4646-5p	CLIP-seq
MIRT859062	hsa-miR-4649-3p	CLIP-seq
MIRT859063	hsa-miR-4662a-5p	CLIP-seq
MIRT859064	hsa-miR-4691-3p	CLIP-seq
MIRT859065	hsa-miR-4701-3p	CLIP-seq
MIRT859066	hsa-miR-4711-3p	CLIP-seq
MIRT859067	hsa-miR-4715-3p	CLIP-seq
MIRT859068	hsa-miR-4725-5p	CLIP-seq
MIRT859069	hsa-miR-4728-5p	CLIP-seq
MIRT859070	hsa-miR-4731-5p	CLIP-seq
MIRT859071	hsa-miR-4747-5p	CLIP-seq
MIRT859072	hsa-miR-4757-5p	CLIP-seq
MIRT859073	hsa-miR-4774-5p	CLIP-seq
MIRT859074	hsa-miR-4784	CLIP-seq
MIRT859075	hsa-miR-4800-5p	CLIP-seq
MIRT859076	hsa-miR-485-5p	CLIP-seq
MIRT859077	hsa-miR-490-3p	CLIP-seq
MIRT859078	hsa-miR-504	CLIP-seq
MIRT859079	hsa-miR-5095	CLIP-seq
MIRT859080	hsa-miR-512-3p	CLIP-seq
MIRT859081	hsa-miR-520a-3p	CLIP-seq
MIRT859082	hsa-miR-520b	CLIP-seq
MIRT859083	hsa-miR-520c-3p	CLIP-seq
MIRT859084	hsa-miR-520d-3p	CLIP-seq
MIRT859085	hsa-miR-520e	CLIP-seq
MIRT859086	hsa-miR-548s	CLIP-seq
MIRT859087	hsa-miR-576-5p	CLIP-seq
MIRT859088	hsa-miR-661	CLIP-seq
MIRT859089	hsa-miR-711	CLIP-seq
MIRT859090	hsa-miR-765	CLIP-seq
MIRT859091	hsa-miR-889	CLIP-seq
MIRT859026	hsa-miR-1260	CLIP-seq
MIRT859027	hsa-miR-1260b	CLIP-seq
MIRT859032	hsa-miR-188-3p	CLIP-seq
MIRT859034	hsa-miR-302a	CLIP-seq
MIRT859035	hsa-miR-302b	CLIP-seq
MIRT859036	hsa-miR-302c	CLIP-seq
MIRT859037	hsa-miR-302d	CLIP-seq
MIRT859038	hsa-miR-302e	CLIP-seq
MIRT859041	hsa-miR-3156-3p	CLIP-seq
MIRT859051	hsa-miR-372	CLIP-seq
MIRT859052	hsa-miR-373	CLIP-seq
MIRT859055	hsa-miR-4301	CLIP-seq
MIRT859067	hsa-miR-4715-3p	CLIP-seq
MIRT859080	hsa-miR-512-3p	CLIP-seq
MIRT859081	hsa-miR-520a-3p	CLIP-seq
MIRT859082	hsa-miR-520b	CLIP-seq
MIRT859083	hsa-miR-520c-3p	CLIP-seq
MIRT859084	hsa-miR-520d-3p	CLIP-seq
MIRT859085	hsa-miR-520e	CLIP-seq
MIRT859026	hsa-miR-1260	CLIP-seq
MIRT859027	hsa-miR-1260b	CLIP-seq
MIRT859032	hsa-miR-188-3p	CLIP-seq
MIRT859034	hsa-miR-302a	CLIP-seq
MIRT859035	hsa-miR-302b	CLIP-seq
MIRT859036	hsa-miR-302c	CLIP-seq
MIRT859037	hsa-miR-302d	CLIP-seq
MIRT859038	hsa-miR-302e	CLIP-seq
MIRT859041	hsa-miR-3156-3p	CLIP-seq
MIRT859051	hsa-miR-372	CLIP-seq
MIRT859052	hsa-miR-373	CLIP-seq
MIRT859055	hsa-miR-4301	CLIP-seq
MIRT859067	hsa-miR-4715-3p	CLIP-seq
MIRT859080	hsa-miR-512-3p	CLIP-seq
MIRT859081	hsa-miR-520a-3p	CLIP-seq
MIRT859082	hsa-miR-520b	CLIP-seq
MIRT859083	hsa-miR-520c-3p	CLIP-seq
MIRT859084	hsa-miR-520d-3p	CLIP-seq
MIRT859085	hsa-miR-520e	CLIP-seq
MIRT1954994	hsa-miR-1238	CLIP-seq
MIRT859026	hsa-miR-1260	CLIP-seq
MIRT859027	hsa-miR-1260b	CLIP-seq
MIRT859030	hsa-miR-150	CLIP-seq
MIRT859032	hsa-miR-188-3p	CLIP-seq
MIRT1954995	hsa-miR-1915	CLIP-seq
MIRT859034	hsa-miR-302a	CLIP-seq
MIRT859035	hsa-miR-302b	CLIP-seq
MIRT859036	hsa-miR-302c	CLIP-seq
MIRT859037	hsa-miR-302d	CLIP-seq
MIRT859038	hsa-miR-302e	CLIP-seq
MIRT1954996	hsa-miR-3155	CLIP-seq
MIRT1954997	hsa-miR-3155b	CLIP-seq
MIRT859041	hsa-miR-3156-3p	CLIP-seq
MIRT859044	hsa-miR-3189-3p	CLIP-seq
MIRT1954998	hsa-miR-3663-5p	CLIP-seq
MIRT859051	hsa-miR-372	CLIP-seq
MIRT859052	hsa-miR-373	CLIP-seq
MIRT859055	hsa-miR-4301	CLIP-seq
MIRT859058	hsa-miR-4438	CLIP-seq
MIRT859061	hsa-miR-4646-5p	CLIP-seq
MIRT1954999	hsa-miR-4691-5p	CLIP-seq
MIRT859067	hsa-miR-4715-3p	CLIP-seq
MIRT1955000	hsa-miR-4726-3p	CLIP-seq
MIRT859070	hsa-miR-4731-5p	CLIP-seq
MIRT859071	hsa-miR-4747-5p	CLIP-seq
MIRT859072	hsa-miR-4757-5p	CLIP-seq
MIRT1955001	hsa-miR-484	CLIP-seq
MIRT859079	hsa-miR-5095	CLIP-seq
MIRT859080	hsa-miR-512-3p	CLIP-seq
MIRT1955002	hsa-miR-515-5p	CLIP-seq
MIRT859081	hsa-miR-520a-3p	CLIP-seq
MIRT859082	hsa-miR-520b	CLIP-seq
MIRT859083	hsa-miR-520c-3p	CLIP-seq
MIRT859084	hsa-miR-520d-3p	CLIP-seq
MIRT859085	hsa-miR-520e	CLIP-seq
MIRT859088	hsa-miR-661	CLIP-seq
MIRT859090	hsa-miR-765	CLIP-seq
MIRT2192721	hsa-miR-1245	CLIP-seq
MIRT859026	hsa-miR-1260	CLIP-seq
MIRT859027	hsa-miR-1260b	CLIP-seq
MIRT2192722	hsa-miR-1470	CLIP-seq
MIRT859030	hsa-miR-150	CLIP-seq
MIRT859032	hsa-miR-188-3p	CLIP-seq
MIRT1954995	hsa-miR-1915	CLIP-seq
MIRT859034	hsa-miR-302a	CLIP-seq
MIRT859035	hsa-miR-302b	CLIP-seq
MIRT859036	hsa-miR-302c	CLIP-seq
MIRT859037	hsa-miR-302d	CLIP-seq
MIRT859038	hsa-miR-302e	CLIP-seq
MIRT2192723	hsa-miR-3127-5p	CLIP-seq
MIRT1954996	hsa-miR-3155	CLIP-seq
MIRT1954997	hsa-miR-3155b	CLIP-seq
MIRT859041	hsa-miR-3156-3p	CLIP-seq
MIRT859044	hsa-miR-3189-3p	CLIP-seq
MIRT1954998	hsa-miR-3663-5p	CLIP-seq
MIRT859051	hsa-miR-372	CLIP-seq
MIRT859052	hsa-miR-373	CLIP-seq
MIRT2192724	hsa-miR-3918	CLIP-seq
MIRT859055	hsa-miR-4301	CLIP-seq
MIRT2192725	hsa-miR-4423-5p	CLIP-seq
MIRT859058	hsa-miR-4438	CLIP-seq
MIRT2192726	hsa-miR-4469	CLIP-seq
MIRT859061	hsa-miR-4646-5p	CLIP-seq
MIRT2192727	hsa-miR-4667-3p	CLIP-seq
MIRT859067	hsa-miR-4715-3p	CLIP-seq
MIRT1955000	hsa-miR-4726-3p	CLIP-seq
MIRT859070	hsa-miR-4731-5p	CLIP-seq
MIRT859071	hsa-miR-4747-5p	CLIP-seq
MIRT859072	hsa-miR-4757-5p	CLIP-seq
MIRT2192728	hsa-miR-4781-3p	CLIP-seq
MIRT1955001	hsa-miR-484	CLIP-seq
MIRT859079	hsa-miR-5095	CLIP-seq
MIRT859080	hsa-miR-512-3p	CLIP-seq
MIRT1955002	hsa-miR-515-5p	CLIP-seq
MIRT859081	hsa-miR-520a-3p	CLIP-seq
MIRT859082	hsa-miR-520b	CLIP-seq
MIRT859083	hsa-miR-520c-3p	CLIP-seq
MIRT859084	hsa-miR-520d-3p	CLIP-seq
MIRT859085	hsa-miR-520e	CLIP-seq
MIRT2192729	hsa-miR-617	CLIP-seq
MIRT859088	hsa-miR-661	CLIP-seq
MIRT2192721	hsa-miR-1245	CLIP-seq
MIRT2192722	hsa-miR-1470	CLIP-seq
MIRT1954995	hsa-miR-1915	CLIP-seq
MIRT1954996	hsa-miR-3155	CLIP-seq
MIRT1954997	hsa-miR-3155b	CLIP-seq
MIRT859044	hsa-miR-3189-3p	CLIP-seq
MIRT2192726	hsa-miR-4469	CLIP-seq
MIRT859061	hsa-miR-4646-5p	CLIP-seq
MIRT2192727	hsa-miR-4667-3p	CLIP-seq
MIRT1955000	hsa-miR-4726-3p	CLIP-seq
MIRT859071	hsa-miR-4747-5p	CLIP-seq
MIRT1955001	hsa-miR-484	CLIP-seq
MIRT859088	hsa-miR-661	CLIP-seq

Gene ontology (GO) Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005227	Function	Calcium-activated cation channel activity	IDA	22711817
GO:0005244	Function	Voltage-gated monoatomic ion channel activity	IDA	22711817, 23300080
GO:0005244	Function	Voltage-gated monoatomic ion channel activity	IEA
GO:0005245	Function	Voltage-gated calcium channel activity	IEA
GO:0005261	Function	Monoatomic cation channel activity	IBA
GO:0005262	Function	Calcium channel activity	IEA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	22711817, 23300080
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006812	Process	Monoatomic cation transport	IDA	22711817
GO:0006816	Process	Calcium ion transport	IEA
GO:0015867	Process	ATP transport	IEA
GO:0015867	Process	ATP transport	ISS
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	ISS
GO:0022832	Function	Voltage-gated channel activity	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034765	Process	Regulation of monoatomic ion transmembrane transport	IDA	23300080
GO:0042802	Function	Identical protein binding	IPI	18585350
GO:0044853	Component	Plasma membrane raft	IEA
GO:0050909	Process	Sensory perception of taste	IEA
GO:0050913	Process	Sensory perception of bitter taste	IEA
GO:0050913	Process	Sensory perception of bitter taste	ISS
GO:0050916	Process	Sensory perception of sweet taste	IEA
GO:0050916	Process	Sensory perception of sweet taste	ISS
GO:0050917	Process	Sensory perception of umami taste	IEA
GO:0050917	Process	Sensory perception of umami taste	ISS
GO:0051260	Process	Protein homooligomerization	IDA	23300080
GO:0051291	Process	Protein heterooligomerization	IEA
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:1904669	Process	ATP export	IDA	32832629
GO:1904669	Process	ATP export	IEA

Other IDs

• MIM: 612234
• HGNC: 23494
• e!Ensembl: ENSG00000185933

Protein

• UniProt ID: Q8IU99
• Protein name: Calcium homeostasis modulator protein 1 (Protein FAM26C)
• Protein function: Pore-forming subunit of gustatory voltage-gated ion channels required for sensory perception of sweet, bitter and umami tastes (By similarity). With CALHM3 forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells, ATP
• PDB: 8GMP , 8GMR , 8S8Z , 8S90
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14798	Ca_hom_mod	2 → 256	Calcium homeostasis modulator	Family

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells. {ECO:0000269|PubMed:18585350, ECO:0000269|PubMed:19997627}.
• Sequence:

  MMDKFRMIFQFLQSNQESFMNGICGIMALASAQMYSAFDFNCPCLPGYNAAYSAGILLAP
  PLVLFLLGLVMNNNVSMLAEEWKRPLGRRAKDPAVLRYMFCSMAQRALIAPVVWVAVTLL
  DGKCFLCAFCTAVPVSALGNGSLAPGLPAPELARLLARVPCPEIYDGDWLLAREVAVRYL
  RCISQALGWSFVLLTTLLAFVVRSVRPCFTQAAFLKSKYWSHYIDIERKLFDETCTEHAK
  AFAKVCIQQFFEAMNHDLELGHTHGTLATAPASAAAPTTPDGAEEEREKLRGITDQGTMN
  RLLTSWHKCKPPLRLGQEEPPLMGNGWAGGGPRPPRKEVATYFSKV

• Sequence length: 346

Pathways

KEGG Pathway:

Taste transduction

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
URINARY BLADDER NEOPLASMS	—	CTD	26039340	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (14)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	18585350, 19191331, 19472444, 20005921, 20634593, 21574960, 21629967, 22874670, 24069280, 26416646, 31745181	Associate	★☆☆☆☆ Found in Text Mining only
Alzheimer Disease, Early Onset	Alzheimer disease	BEFREE	24069280		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease, Late Onset	Alzheimer disease	BEFREE	19191331, 19472444, 20164573, 20164592, 20164602, 20634593, 23884934		★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	CTD_human_DG	26039340		★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	21378601		★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognitive disorder	BEFREE	20005921		★☆☆☆☆ Found in Text Mining only
Creutzfeldt-Jakob Disease, Sporadic	Creutzfeldt-Jakob disease	BEFREE	22874670		★☆☆☆☆ Found in Text Mining only
Diabetic Neuralgia	Diabetic Neuralgia	BEFREE	26781424		★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down syndrome	Pubtator	26166206	Associate	★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	21439911		★☆☆☆☆ Found in Text Mining only
Epilepsy, Temporal Lobe	Epilepsy	BEFREE	21439911, 24326043		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	CTD_human_DG	26039340		★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	21574960, 26416646	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	25424713, 27401531		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for CALHM1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CALHM1.