CACHD1 (cache domain containing 1)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 57685
• Gene name: Cache domain containing 1
• Gene symbol: CACHD1
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1p31.3

miRNA Show/Hide all (63)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051781	hsa-let-7c-5p	CLASH	23622248
MIRT045356	hsa-miR-185-5p	CLASH	23622248
MIRT043233	hsa-miR-324-5p	CLASH	23622248
MIRT040828	hsa-miR-18a-3p	CLASH	23622248
MIRT659936	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT659935	hsa-miR-623	HITS-CLIP	23824327
MIRT659934	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT659933	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT659932	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT659931	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT659930	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT659936	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT659935	hsa-miR-623	HITS-CLIP	23824327
MIRT659934	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT659933	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT659932	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT659931	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT659930	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT857378	hsa-miR-140-3p	CLIP-seq
MIRT857379	hsa-miR-144	CLIP-seq
MIRT857380	hsa-miR-3121-3p	CLIP-seq
MIRT857381	hsa-miR-3179	CLIP-seq
MIRT857382	hsa-miR-371-5p	CLIP-seq
MIRT857383	hsa-miR-3936	CLIP-seq
MIRT857384	hsa-miR-411	CLIP-seq
MIRT857385	hsa-miR-4514	CLIP-seq
MIRT857386	hsa-miR-4672	CLIP-seq
MIRT857387	hsa-miR-4692	CLIP-seq
MIRT857388	hsa-miR-4789-5p	CLIP-seq
MIRT857389	hsa-miR-553	CLIP-seq
MIRT857390	hsa-miR-590-3p	CLIP-seq
MIRT857391	hsa-miR-888	CLIP-seq
MIRT857392	hsa-miR-940	CLIP-seq
MIRT1954662	hsa-miR-145	CLIP-seq
MIRT1954663	hsa-miR-1913	CLIP-seq
MIRT1954664	hsa-miR-324-3p	CLIP-seq
MIRT1954665	hsa-miR-4749-3p	CLIP-seq
MIRT2192256	hsa-miR-1237	CLIP-seq
MIRT2192257	hsa-miR-3064-5p	CLIP-seq
MIRT857380	hsa-miR-3121-3p	CLIP-seq
MIRT2192258	hsa-miR-3182	CLIP-seq
MIRT2192259	hsa-miR-4652-3p	CLIP-seq
MIRT2192260	hsa-miR-4724-3p	CLIP-seq
MIRT2192261	hsa-miR-4794	CLIP-seq
MIRT2192262	hsa-miR-885-5p	CLIP-seq
MIRT2495647	hsa-miR-1321	CLIP-seq
MIRT2495648	hsa-miR-3130-3p	CLIP-seq
MIRT2495649	hsa-miR-330-3p	CLIP-seq
MIRT2495650	hsa-miR-4457	CLIP-seq
MIRT2495651	hsa-miR-4731-3p	CLIP-seq
MIRT2495652	hsa-miR-4739	CLIP-seq
MIRT2495653	hsa-miR-4756-5p	CLIP-seq
MIRT2495654	hsa-miR-4793-3p	CLIP-seq
MIRT2495655	hsa-miR-4801	CLIP-seq
MIRT2495647	hsa-miR-1321	CLIP-seq
MIRT2495648	hsa-miR-3130-3p	CLIP-seq
MIRT2495649	hsa-miR-330-3p	CLIP-seq
MIRT2495650	hsa-miR-4457	CLIP-seq
MIRT2495651	hsa-miR-4731-3p	CLIP-seq
MIRT2495652	hsa-miR-4739	CLIP-seq
MIRT2495653	hsa-miR-4756-5p	CLIP-seq
MIRT2495654	hsa-miR-4793-3p	CLIP-seq
MIRT2495655	hsa-miR-4801	CLIP-seq

Gene ontology (GO) Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005245	Function	Voltage-gated calcium channel activity	IBA
GO:0005891	Component	Voltage-gated calcium channel complex	IBA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0070588	Process	Calcium ion transmembrane transport	IEA

Other IDs

• MIM: 620144
• HGNC: 29314
• e!Ensembl: ENSG00000158966

Protein

• UniProt ID: Q5VU97
• Protein name: VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1)
• Protein function: May regulate voltage-dependent calcium channels.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00092	VWA	228 → 413	von Willebrand factor type A domain	Domain
  PF08399	VWA_N	89 → 204	VWA N-terminal	Family

• Sequence:

  MARQPEEEETAVARARRPPLWLLCLVACWLLGAGAEADFSILDEAQVLASQMRRLAAEEL
  GVVTMQRIFNSFVYTEKISNGESEVQQLAKKIREKFNRYLDVVNRNKQVVEASYTAHLTS
  PLTAIQDCCTIPPSMMEFDGNFNTNVSRTISCDRLSTTVNSRAFNPGRDLNSVLADNLKS
  NPGIKWQYFSSEEGIFTVFPAHKFRCKGSYEHRSRPIYVSTVRPQSKHIVVILDHGASVT
  DTQLQIAKDAAQVILSAIDEHDKISVLTVADTVRTCSLDQCYKTFLSPATSETKRKMSTF
  VSSVKSSDSPTQHAVGFQKAFQLIRSTNNNTKFQANTDMVIIYLSAGITSKDSSEEDKKA
  TLQVINEENSFLNNSVMILTYALMNDGVTGLKELAFLRDLAEQNSGKYGVPDRMALPVIK
  GSMMVLNQLSNLETTVGRFYTNLPNRMIDEAVFSLPFSDEMGDGLIMTVSKPCYFGNLLL
  GIVGVDVNLAYILEDVTYYQDSLASYTFLIDDKGYTLMHPSLTRPYLLSEPPLHTDIIHY
  ENIPKFELVRQNILSLPLGSQIIAVPVNSSLSWHINKLRETGKEAYNVSYAWKMVQDTSF
  ILCIVVIQPEIPVKQLKNLNTVPSSKLLYHRLDLLGQPSACLHFKQLATLESPTIMLSAG
  SFSSPYEHLSQPETKRMVEHYTAYLSDNTRLIANPGLKFSVRNEVMATSHVTDEWMTQME
  MSSLNTYIVRRYIATPNGVLRIYPGSLMDKAFDPTRRQWYLHAVANPGLISLTGPYLDVG
  GAGYVVTISHTIHSSSTQLSSGHTVAVMGIDFTLRYFYKVLMDLLPVCNQDGGNKIRCFI
  MEDRGYLVAHPTLIDPKGHAPVEQQHITHKEPLVANDILNHPNFVKKNLCNSFSDRTVQR
  FYKFNTSLAGDLTNLVHGSHCSKYRLARIPGTNAFVGIVNETCDSLAFCACSMVDRLCLN
  CHRMEQNECECPCECPLEVNECTGNLTNAENRNPSCEVHQEPVTYTAIDPGLQDALHQCV
  NSRCSQRLESGDCFGVLDCEWCMVDSDGKTHLDKPYCAPQKECFGGIVGAKSPYVDDMGA
  IGDEVITLNMIKSAPVGPVAGGIMGCIMVLVLAVYAYRHQIHRRSHQHMSPLAAQEMSVR
  MSNLENDRDERDDDSHEDRGIISNTRFIAAVIERHAHSPERRRRYWGRSGTESDHGYSTM
  SPQEDSENPPCNNDPLSAGVDVGNHDEDLDLDTPPQTAALLSHKFHHYRSHHPTLHHSHH
  LQAAVTVHTVDAEC

• Sequence length: 1274

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Familial prostate cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell lung carcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Anxiety	Anxiety Disorder	GWASCAT_DG	29942085		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	30181139		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASDB_DG	21926974		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for CACHD1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to CACHD1.