BTNL3 (butyrophilin like 3)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Diseases linked via similar genes

Gene

• Entrez ID: 10917
• Gene name: Butyrophilin like 3
• Gene symbol: BTNL3
• Synonyms (NCBI Gene): BTN9.1, BTNLR
• Chromosome: 5
• Chromosome location: 5q35.3

miRNA Show/Hide all (117)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019277	hsa-miR-148b-3p	Microarray	17612493
MIRT710451	hsa-miR-3192-5p	HITS-CLIP	19536157
MIRT710450	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT710449	hsa-miR-6086	HITS-CLIP	19536157
MIRT710448	hsa-miR-661	HITS-CLIP	19536157
MIRT710447	hsa-miR-7106-5p	HITS-CLIP	19536157
MIRT710446	hsa-miR-149-3p	HITS-CLIP	19536157
MIRT710445	hsa-miR-4728-5p	HITS-CLIP	19536157
MIRT710444	hsa-miR-6785-5p	HITS-CLIP	19536157
MIRT710443	hsa-miR-6883-5p	HITS-CLIP	19536157
MIRT710442	hsa-miR-6799-5p	HITS-CLIP	19536157
MIRT710441	hsa-miR-134-5p	HITS-CLIP	19536157
MIRT710440	hsa-miR-3118	HITS-CLIP	19536157
MIRT710439	hsa-miR-3164	HITS-CLIP	19536157
MIRT710438	hsa-miR-6820-3p	HITS-CLIP	19536157
MIRT710437	hsa-miR-1273h-5p	HITS-CLIP	19536157
MIRT710436	hsa-miR-30b-3p	HITS-CLIP	19536157
MIRT710435	hsa-miR-3689a-3p	HITS-CLIP	19536157
MIRT710434	hsa-miR-3689b-3p	HITS-CLIP	19536157
MIRT710433	hsa-miR-3689c	HITS-CLIP	19536157
MIRT710432	hsa-miR-6779-5p	HITS-CLIP	19536157
MIRT710431	hsa-miR-6780a-5p	HITS-CLIP	19536157
MIRT710430	hsa-miR-6808-3p	HITS-CLIP	19536157
MIRT710429	hsa-miR-758-3p	HITS-CLIP	19536157
MIRT710451	hsa-miR-3192-5p	HITS-CLIP	19536157
MIRT710450	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT710449	hsa-miR-6086	HITS-CLIP	19536157
MIRT710448	hsa-miR-661	HITS-CLIP	19536157
MIRT710447	hsa-miR-7106-5p	HITS-CLIP	19536157
MIRT710446	hsa-miR-149-3p	HITS-CLIP	19536157
MIRT710445	hsa-miR-4728-5p	HITS-CLIP	19536157
MIRT710444	hsa-miR-6785-5p	HITS-CLIP	19536157
MIRT710443	hsa-miR-6883-5p	HITS-CLIP	19536157
MIRT710442	hsa-miR-6799-5p	HITS-CLIP	19536157
MIRT710441	hsa-miR-134-5p	HITS-CLIP	19536157
MIRT710440	hsa-miR-3118	HITS-CLIP	19536157
MIRT710439	hsa-miR-3164	HITS-CLIP	19536157
MIRT710438	hsa-miR-6820-3p	HITS-CLIP	19536157
MIRT710437	hsa-miR-1273h-5p	HITS-CLIP	19536157
MIRT710436	hsa-miR-30b-3p	HITS-CLIP	19536157
MIRT710435	hsa-miR-3689a-3p	HITS-CLIP	19536157
MIRT710434	hsa-miR-3689b-3p	HITS-CLIP	19536157
MIRT710433	hsa-miR-3689c	HITS-CLIP	19536157
MIRT710432	hsa-miR-6779-5p	HITS-CLIP	19536157
MIRT710431	hsa-miR-6780a-5p	HITS-CLIP	19536157
MIRT710430	hsa-miR-6808-3p	HITS-CLIP	19536157
MIRT710429	hsa-miR-758-3p	HITS-CLIP	19536157
MIRT710451	hsa-miR-3192-5p	HITS-CLIP	19536157
MIRT710450	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT710449	hsa-miR-6086	HITS-CLIP	19536157
MIRT710448	hsa-miR-661	HITS-CLIP	19536157
MIRT710447	hsa-miR-7106-5p	HITS-CLIP	19536157
MIRT710446	hsa-miR-149-3p	HITS-CLIP	19536157
MIRT710445	hsa-miR-4728-5p	HITS-CLIP	19536157
MIRT710444	hsa-miR-6785-5p	HITS-CLIP	19536157
MIRT710443	hsa-miR-6883-5p	HITS-CLIP	19536157
MIRT710442	hsa-miR-6799-5p	HITS-CLIP	19536157
MIRT710441	hsa-miR-134-5p	HITS-CLIP	19536157
MIRT710440	hsa-miR-3118	HITS-CLIP	19536157
MIRT710439	hsa-miR-3164	HITS-CLIP	19536157
MIRT710438	hsa-miR-6820-3p	HITS-CLIP	19536157
MIRT710437	hsa-miR-1273h-5p	HITS-CLIP	19536157
MIRT710436	hsa-miR-30b-3p	HITS-CLIP	19536157
MIRT710435	hsa-miR-3689a-3p	HITS-CLIP	19536157
MIRT710434	hsa-miR-3689b-3p	HITS-CLIP	19536157
MIRT710433	hsa-miR-3689c	HITS-CLIP	19536157
MIRT710432	hsa-miR-6779-5p	HITS-CLIP	19536157
MIRT710431	hsa-miR-6780a-5p	HITS-CLIP	19536157
MIRT710430	hsa-miR-6808-3p	HITS-CLIP	19536157
MIRT710429	hsa-miR-758-3p	HITS-CLIP	19536157
MIRT710451	hsa-miR-3192-5p	HITS-CLIP	19536157
MIRT710450	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT710449	hsa-miR-6086	HITS-CLIP	19536157
MIRT710448	hsa-miR-661	HITS-CLIP	19536157
MIRT710447	hsa-miR-7106-5p	HITS-CLIP	19536157
MIRT710446	hsa-miR-149-3p	HITS-CLIP	19536157
MIRT710445	hsa-miR-4728-5p	HITS-CLIP	19536157
MIRT710444	hsa-miR-6785-5p	HITS-CLIP	19536157
MIRT710443	hsa-miR-6883-5p	HITS-CLIP	19536157
MIRT710442	hsa-miR-6799-5p	HITS-CLIP	19536157
MIRT710441	hsa-miR-134-5p	HITS-CLIP	19536157
MIRT710440	hsa-miR-3118	HITS-CLIP	19536157
MIRT710439	hsa-miR-3164	HITS-CLIP	19536157
MIRT710438	hsa-miR-6820-3p	HITS-CLIP	19536157
MIRT710437	hsa-miR-1273h-5p	HITS-CLIP	19536157
MIRT710436	hsa-miR-30b-3p	HITS-CLIP	19536157
MIRT710435	hsa-miR-3689a-3p	HITS-CLIP	19536157
MIRT710434	hsa-miR-3689b-3p	HITS-CLIP	19536157
MIRT710433	hsa-miR-3689c	HITS-CLIP	19536157
MIRT710432	hsa-miR-6779-5p	HITS-CLIP	19536157
MIRT710431	hsa-miR-6780a-5p	HITS-CLIP	19536157
MIRT710430	hsa-miR-6808-3p	HITS-CLIP	19536157
MIRT710429	hsa-miR-758-3p	HITS-CLIP	19536157
MIRT827486	hsa-miR-4477a	CLIP-seq
MIRT827487	hsa-miR-4680-3p	CLIP-seq
MIRT1944845	hsa-miR-1231	CLIP-seq
MIRT1944846	hsa-miR-4287	CLIP-seq
MIRT1944847	hsa-miR-4469	CLIP-seq
MIRT1944848	hsa-miR-4639-3p	CLIP-seq
MIRT1944849	hsa-miR-4685-3p	CLIP-seq
MIRT1944850	hsa-miR-4687-3p	CLIP-seq
MIRT1944851	hsa-miR-4711-3p	CLIP-seq
MIRT1944852	hsa-miR-4780	CLIP-seq
MIRT1944853	hsa-miR-623	CLIP-seq
MIRT1944854	hsa-miR-647	CLIP-seq
MIRT2183346	hsa-miR-1205	CLIP-seq
MIRT2183347	hsa-miR-1266	CLIP-seq
MIRT2183348	hsa-miR-1909	CLIP-seq
MIRT2183349	hsa-miR-24	CLIP-seq
MIRT2183350	hsa-miR-298	CLIP-seq
MIRT2183351	hsa-miR-3127-5p	CLIP-seq
MIRT2183352	hsa-miR-3918	CLIP-seq
MIRT2183353	hsa-miR-4436b-3p	CLIP-seq
MIRT2183354	hsa-miR-4437	CLIP-seq
MIRT2183355	hsa-miR-4518	CLIP-seq
MIRT2183356	hsa-miR-548b-3p	CLIP-seq
MIRT2384909	hsa-miR-2276	CLIP-seq

Gene ontology (GO) Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001817	Process	Regulation of cytokine production	IBA
GO:0003674	Function	Molecular_function	ND
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005515	Function	Protein binding	IPI	29339503
GO:0005575	Component	Cellular_component	ND
GO:0008150	Process	Biological_process	ND
GO:0009897	Component	External side of plasma membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0050852	Process	T cell receptor signaling pathway	IBA

Other IDs

• MIM: 606192
• HGNC: 1143
• e!Ensembl: ENSG00000168903

Protein

• UniProt ID: Q6UXE8
• Protein name: Butyrophilin-like protein 3 (Butyrophilin-like receptor)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00622	SPRY	340 → 458	SPRY domain	Family
  PF07686	V-set	22 → 132	Immunoglobulin V-set domain	Domain
  PF13765	PRY	290 → 336	SPRY-associated domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in small intestine, colon, testis, spleen, and leukocyte. {ECO:0000269|PubMed:10429365}.
• Sequence:

  MAFVLILVLSFYELVSGQWQVTGPGKFVQALVGEDAVFSCSLFPETSAEAMEVRFFRNQF
  HAVVHLYRDGEDWESKQMPQYRGRTEFVKDSIAGGRVSLRLKNITPSDIGLYGCWFSSQI
  YDEEATWELRVAALGSLPLISIVGYVDGGIQLLCLSSGWFPQPTAKWKGPQGQDLSSDSR
  ANADGYSLYDVEISIIVQENAGSILCSIHLAEQSHEVESKVLIGETFFQPSPWRLASILL
  GLLCGALCGVVMGMIIVFFKSKGKIQAELDWRRKHGQAELRDARKHAVEVTLDPETAHPK
  LCVSDLKTVTHRKAPQEVPHSEKRFTRKSVVASQGFQAGKHYWEVDVGQNVGWYVGVCRD
  DVDRGKNNVTLSPNNGYWVLRLTTEHLYFTFNPHFISLPPSTPPTRVGVFLDYEGGTISF
  FNTNDQSLIYTLLTCQFEGLLRPYIQHAMYDEEKGTPIFICPVSWG

• Sequence length: 466

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Adrenocortical carcinoma, hereditary	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Celiac Disease	Celiac disease	BEFREE	30739797		★☆☆☆☆ Found in Text Mining only
Celiac Disease	Celiac disease	Pubtator	30739797	Associate	★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	30137272	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for BTNL3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to BTNL3.