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Gene Gene information from NCBI Gene database.
Entrez ID 151888
Gene name B and T lymphocyte associated
Gene symbol BTLA
Synonyms (NCBI Gene)
BTLA1CD272
Chromosome 3
Chromosome location 3q13.2
Summary This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple trans
miRNA miRNA information provided by mirtarbase database.
633 Show/Hide all (633)
miRTarBase ID miRNA Experiments Reference
MIRT017901 hsa-miR-335-5p Microarray 18185580
MIRT054107 hsa-miR-630 Microarray 22995316
MIRT723244 hsa-miR-1264 HITS-CLIP 19536157
MIRT723243 hsa-miR-6882-5p HITS-CLIP 19536157
MIRT723242 hsa-miR-323b-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15 Show/Hide all (15)
GO ID Ontology Definition Evidence Reference
GO:0002250 Process Adaptive immune response IEA
GO:0002376 Process Immune system process IEA
GO:0002768 Process Immune response-regulating cell surface receptor signaling pathway IBA
GO:0002768 Process Immune response-regulating cell surface receptor signaling pathway IEA
GO:0005515 Function Protein binding IPI 27152329
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607925 21087 ENSG00000186265
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q7Z6A9
Protein name B- and T-lymphocyte attenuator (B- and T-lymphocyte-associated protein) (CD antigen CD272)
Protein function Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). May interact in cis (on the same cell) or in trans (on
PDB 2AW2 , 6NYP , 8F60 , 8F6L , 8F6O
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00047 ig 41 → 130 Immunoglobulin domain Domain
Sequence
MKTLPAMLGTGKLFWVFFLIPYLDIWNIHGKESCDVQLYIKRQSEHSILAGDPFELECPV
KYCANRPHVTWCKLNGTTCVKLEDRQTSWKEEKNISFFILHFEPVLPNDNGSYRCSANFQ
SNLIESHSTT
LYVTDVKSASERPSKDEMASRPWLLYRLLPLGGLPLLITTCFCLFCCLRR
HQGKQNELSDTAGREINLVDAHLKSEQTEASTRQNSQVLLSETGIYDNDPDLCFRMQEGS
EVYSNPCLEENKPGIVYASLNHSVIGPNSRLARNVKEAPTEYASICVRS
Sequence length 289
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Costimulation by the CD28 family