BTF3 (basic transcription factor 3)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 689
• Gene name: Basic transcription factor 3
• Gene symbol: BTF3
• Synonyms (NCBI Gene): BETA-NAC, BTF3a, BTF3b, NACB
• Chromosome: 5
• Chromosome location: 5q13.2
• Summary: This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This

miRNA Show/Hide all (60)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021187	hsa-miR-186-5p	Sequencing	20371350
MIRT030634	hsa-miR-22-3p	Sequencing	20371350
MIRT031986	hsa-miR-16-5p	Proteomics	18668040
MIRT049443	hsa-miR-92a-3p	CLASH	23622248
MIRT039540	hsa-miR-652-3p	CLASH	23622248
MIRT039000	hsa-let-7a-3p	CLASH	23622248
MIRT037856	hsa-miR-455-3p	CLASH	23622248
MIRT826869	hsa-miR-219-2-3p	CLIP-seq
MIRT826870	hsa-miR-2964a-3p	CLIP-seq
MIRT826871	hsa-miR-548a-3p	CLIP-seq
MIRT826872	hsa-miR-548ae	CLIP-seq
MIRT826873	hsa-miR-548aj	CLIP-seq
MIRT826874	hsa-miR-548am	CLIP-seq
MIRT826875	hsa-miR-548e	CLIP-seq
MIRT826876	hsa-miR-548f	CLIP-seq
MIRT826877	hsa-miR-548p	CLIP-seq
MIRT826878	hsa-miR-548x	CLIP-seq
MIRT826879	hsa-miR-568	CLIP-seq
MIRT826880	hsa-miR-4778-3p	CLIP-seq
MIRT2183111	hsa-miR-1587	CLIP-seq
MIRT2183112	hsa-miR-3163	CLIP-seq
MIRT2183113	hsa-miR-361-5p	CLIP-seq
MIRT2183114	hsa-miR-4274	CLIP-seq
MIRT2183115	hsa-miR-4282	CLIP-seq
MIRT2183116	hsa-miR-4674	CLIP-seq
MIRT2183117	hsa-miR-513a-3p	CLIP-seq
MIRT2183118	hsa-miR-635	CLIP-seq
MIRT2486675	hsa-miR-1276	CLIP-seq
MIRT2486676	hsa-miR-1303	CLIP-seq
MIRT2183111	hsa-miR-1587	CLIP-seq
MIRT2183113	hsa-miR-361-5p	CLIP-seq
MIRT2183115	hsa-miR-4282	CLIP-seq
MIRT2183116	hsa-miR-4674	CLIP-seq
MIRT2486677	hsa-miR-4777-5p	CLIP-seq
MIRT2183117	hsa-miR-513a-3p	CLIP-seq
MIRT2486678	hsa-miR-548c-3p	CLIP-seq
MIRT2486679	hsa-miR-558	CLIP-seq
MIRT2183118	hsa-miR-635	CLIP-seq
MIRT2486675	hsa-miR-1276	CLIP-seq
MIRT2486676	hsa-miR-1303	CLIP-seq
MIRT2183111	hsa-miR-1587	CLIP-seq
MIRT2676100	hsa-miR-15a	CLIP-seq
MIRT2676101	hsa-miR-15b	CLIP-seq
MIRT2676102	hsa-miR-16	CLIP-seq
MIRT2676103	hsa-miR-195	CLIP-seq
MIRT2183112	hsa-miR-3163	CLIP-seq
MIRT2183113	hsa-miR-361-5p	CLIP-seq
MIRT2676104	hsa-miR-424	CLIP-seq
MIRT2183114	hsa-miR-4274	CLIP-seq
MIRT2183115	hsa-miR-4282	CLIP-seq
MIRT2676105	hsa-miR-4524	CLIP-seq
MIRT2183116	hsa-miR-4674	CLIP-seq
MIRT2486677	hsa-miR-4777-5p	CLIP-seq
MIRT2676106	hsa-miR-497	CLIP-seq
MIRT2676107	hsa-miR-503	CLIP-seq
MIRT2183117	hsa-miR-513a-3p	CLIP-seq
MIRT2486678	hsa-miR-548c-3p	CLIP-seq
MIRT2486679	hsa-miR-558	CLIP-seq
MIRT2183118	hsa-miR-635	CLIP-seq
MIRT2676108	hsa-miR-646	CLIP-seq

Gene ontology (GO) Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001701	Process	In utero embryonic development	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	18025262, 18433331, 25416956, 30242148, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IDA	10982809
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005854	Component	Nascent polypeptide-associated complex	IBA
GO:0005854	Component	Nascent polypeptide-associated complex	IPI	20214399
GO:0015031	Process	Protein transport	IEA
GO:1905551	Process	Negative regulation of protein localization to endoplasmic reticulum	IDA	10982809

Other IDs

• MIM: 602542
• HGNC: 1125
• e!Ensembl: ENSG00000145741

Protein

• UniProt ID: P20290
• Protein name: Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3)
• Protein function: When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recogn
• PDB: 3LKX , 3MCB , 7QWQ , 7QWR , 9F1B , 9F1C , 9F1D , 9FQ0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01849	NAC	85 → 141	NAC domain	Family

• Sequence:

  MRRTGAPAQADSRGRGRARGGCPGGEATLSQPPPRGGTRGQEPQMKETIMNQEKLAKLQA
  QVRIGGKGTARRKKKVVHRTATADDKKLQFSLKKLGVNNISGIEEVNMFTNQGTVIHFNN
  PKVQASLAANTFTITGHAETKQLTEMLPSILNQLGADSLTSLRRLAEALPKQSVDGKAPL
  ATGEDDDDEVPDLVENFDEASKNEAN

• Sequence length: 206

Related Genes

No strongly related genes found yet for BTF3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to BTF3.