BTBD2 (BTB domain containing 2)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55643
• Gene name: BTB domain containing 2
• Gene symbol: BTBD2
• Synonyms (NCBI Gene): -
• Chromosome: 19
• Chromosome location: 19p13.3
• Summary: The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in prot

miRNA Show/Hide all (132)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017784	hsa-miR-335-5p	Microarray	18185580
MIRT028236	hsa-miR-33a-5p	Sequencing	20371350
MIRT028296	hsa-miR-32-5p	Sequencing	20371350
MIRT051204	hsa-miR-16-5p	CLASH	23622248
MIRT050544	hsa-miR-20a-5p	CLASH	23622248
MIRT043194	hsa-miR-324-5p	CLASH	23622248
MIRT441100	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT441100	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT826372	hsa-miR-144	CLIP-seq
MIRT826373	hsa-miR-146b-3p	CLIP-seq
MIRT826374	hsa-miR-149	CLIP-seq
MIRT826375	hsa-miR-3150a-3p	CLIP-seq
MIRT826376	hsa-miR-3173-5p	CLIP-seq
MIRT826377	hsa-miR-3175	CLIP-seq
MIRT826378	hsa-miR-3184	CLIP-seq
MIRT826379	hsa-miR-3192	CLIP-seq
MIRT826380	hsa-miR-3649	CLIP-seq
MIRT826381	hsa-miR-3665	CLIP-seq
MIRT826382	hsa-miR-3690	CLIP-seq
MIRT826383	hsa-miR-3919	CLIP-seq
MIRT826384	hsa-miR-423-5p	CLIP-seq
MIRT826385	hsa-miR-4254	CLIP-seq
MIRT826386	hsa-miR-4268	CLIP-seq
MIRT826387	hsa-miR-4300	CLIP-seq
MIRT826388	hsa-miR-4314	CLIP-seq
MIRT826389	hsa-miR-4417	CLIP-seq
MIRT826390	hsa-miR-4433	CLIP-seq
MIRT826391	hsa-miR-4436b-3p	CLIP-seq
MIRT826392	hsa-miR-4438	CLIP-seq
MIRT826393	hsa-miR-4448	CLIP-seq
MIRT826394	hsa-miR-4481	CLIP-seq
MIRT826395	hsa-miR-4519	CLIP-seq
MIRT826396	hsa-miR-4646-5p	CLIP-seq
MIRT826397	hsa-miR-4675	CLIP-seq
MIRT826398	hsa-miR-4707-5p	CLIP-seq
MIRT826399	hsa-miR-4709-5p	CLIP-seq
MIRT826400	hsa-miR-4728-5p	CLIP-seq
MIRT826401	hsa-miR-4733-3p	CLIP-seq
MIRT826402	hsa-miR-4741	CLIP-seq
MIRT826403	hsa-miR-4743	CLIP-seq
MIRT826404	hsa-miR-4745-5p	CLIP-seq
MIRT826405	hsa-miR-4761-3p	CLIP-seq
MIRT826406	hsa-miR-491-5p	CLIP-seq
MIRT826407	hsa-miR-503	CLIP-seq
MIRT826408	hsa-miR-5095	CLIP-seq
MIRT826409	hsa-miR-513a-5p	CLIP-seq
MIRT826410	hsa-miR-539	CLIP-seq
MIRT826411	hsa-miR-541	CLIP-seq
MIRT826412	hsa-miR-553	CLIP-seq
MIRT826413	hsa-miR-640	CLIP-seq
MIRT826414	hsa-miR-654-5p	CLIP-seq
MIRT826415	hsa-miR-665	CLIP-seq
MIRT826416	hsa-miR-711	CLIP-seq
MIRT826417	hsa-miR-764	CLIP-seq
MIRT826418	hsa-miR-873	CLIP-seq
MIRT826419	hsa-miR-874	CLIP-seq
MIRT826420	hsa-miR-920	CLIP-seq
MIRT826421	hsa-miR-939	CLIP-seq
MIRT1944376	hsa-miR-1182	CLIP-seq
MIRT1944377	hsa-miR-1207-5p	CLIP-seq
MIRT1944378	hsa-miR-1245b-3p	CLIP-seq
MIRT1944379	hsa-miR-15a	CLIP-seq
MIRT1944380	hsa-miR-15b	CLIP-seq
MIRT1944381	hsa-miR-16	CLIP-seq
MIRT1944382	hsa-miR-1909	CLIP-seq
MIRT1944383	hsa-miR-195	CLIP-seq
MIRT1944384	hsa-miR-296-5p	CLIP-seq
MIRT1944385	hsa-miR-3065-3p	CLIP-seq
MIRT1944386	hsa-miR-3189-5p	CLIP-seq
MIRT1944387	hsa-miR-326	CLIP-seq
MIRT1944388	hsa-miR-330-5p	CLIP-seq
MIRT1944389	hsa-miR-361-3p	CLIP-seq
MIRT1944390	hsa-miR-424	CLIP-seq
MIRT826387	hsa-miR-4300	CLIP-seq
MIRT1944391	hsa-miR-4313	CLIP-seq
MIRT826389	hsa-miR-4417	CLIP-seq
MIRT826391	hsa-miR-4436b-3p	CLIP-seq
MIRT1944392	hsa-miR-4447	CLIP-seq
MIRT1944393	hsa-miR-4472	CLIP-seq
MIRT1944394	hsa-miR-4505	CLIP-seq
MIRT1944395	hsa-miR-4508	CLIP-seq
MIRT1944396	hsa-miR-4530	CLIP-seq
MIRT1944397	hsa-miR-4651	CLIP-seq
MIRT1944398	hsa-miR-4667-5p	CLIP-seq
MIRT1944399	hsa-miR-4700-5p	CLIP-seq
MIRT826399	hsa-miR-4709-5p	CLIP-seq
MIRT1944400	hsa-miR-4731-5p	CLIP-seq
MIRT826401	hsa-miR-4733-3p	CLIP-seq
MIRT1944401	hsa-miR-4734	CLIP-seq
MIRT826405	hsa-miR-4761-3p	CLIP-seq
MIRT1944402	hsa-miR-4763-3p	CLIP-seq
MIRT1944403	hsa-miR-486-3p	CLIP-seq
MIRT1944404	hsa-miR-497	CLIP-seq
MIRT826411	hsa-miR-541	CLIP-seq
MIRT1944405	hsa-miR-608	CLIP-seq
MIRT1944406	hsa-miR-637	CLIP-seq
MIRT826414	hsa-miR-654-5p	CLIP-seq
MIRT826420	hsa-miR-920	CLIP-seq
MIRT1944407	hsa-miR-922	CLIP-seq
MIRT826421	hsa-miR-939	CLIP-seq
MIRT1944376	hsa-miR-1182	CLIP-seq
MIRT1944377	hsa-miR-1207-5p	CLIP-seq
MIRT826373	hsa-miR-146b-3p	CLIP-seq
MIRT1944382	hsa-miR-1909	CLIP-seq
MIRT1944384	hsa-miR-296-5p	CLIP-seq
MIRT826376	hsa-miR-3173-5p	CLIP-seq
MIRT1944386	hsa-miR-3189-5p	CLIP-seq
MIRT1944387	hsa-miR-326	CLIP-seq
MIRT1944388	hsa-miR-330-5p	CLIP-seq
MIRT2182942	hsa-miR-338-3p	CLIP-seq
MIRT2182943	hsa-miR-378g	CLIP-seq
MIRT826387	hsa-miR-4300	CLIP-seq
MIRT1944392	hsa-miR-4447	CLIP-seq
MIRT1944393	hsa-miR-4472	CLIP-seq
MIRT1944396	hsa-miR-4530	CLIP-seq
MIRT1944397	hsa-miR-4651	CLIP-seq
MIRT1944398	hsa-miR-4667-5p	CLIP-seq
MIRT2182944	hsa-miR-4682	CLIP-seq
MIRT2182945	hsa-miR-4685-5p	CLIP-seq
MIRT2182946	hsa-miR-4691-3p	CLIP-seq
MIRT1944399	hsa-miR-4700-5p	CLIP-seq
MIRT1944401	hsa-miR-4734	CLIP-seq
MIRT1944402	hsa-miR-4763-3p	CLIP-seq
MIRT1944403	hsa-miR-486-3p	CLIP-seq
MIRT826411	hsa-miR-541	CLIP-seq
MIRT1944405	hsa-miR-608	CLIP-seq
MIRT1944406	hsa-miR-637	CLIP-seq
MIRT826413	hsa-miR-640	CLIP-seq
MIRT826414	hsa-miR-654-5p	CLIP-seq
MIRT826419	hsa-miR-874	CLIP-seq
MIRT826420	hsa-miR-920	CLIP-seq
MIRT826421	hsa-miR-939	CLIP-seq

Gene ontology (GO) Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000932	Component	P-body	IBA
GO:0000932	Component	P-body	IDA	12878161
GO:0000932	Component	P-body	IEA
GO:0005515	Function	Protein binding	IPI	12878161, 16169070, 17543862, 19615732, 21145461, 28514442, 32296183, 33961781, 34591642
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0022008	Process	Neurogenesis	IBA

Other IDs

• MIM: 608531
• HGNC: 15504
• e!Ensembl: ENSG00000133243

Protein

• UniProt ID: Q9BX70
• Protein name: BTB/POZ domain-containing protein 2
• PDB: 3NO8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00651	BTB	107 → 217	BTB/POZ domain	Domain
  PF07707	BACK	222 → 329	BTB And C-terminal Kelch	Domain
  PF08005	PHR	375 → 524	PHR domain	Domain

• Sequence:

  MAAGGSGGRASCPPGVGVGPGTGGSPGPSANAAATPAPGNAAAAAAAAAAAAAAPGPTPP
  APPGPGTDAQAAGAERAEEAAGPGAAALQREAAYNWQASKPTVQERFAFLFNNEVLCDVH
  FLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVEPAAFLALLKFLYS
  DEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADNAFMLLTQARLFDEPQLASL
  CLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWSEAECQRQQLQ
  VTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQSGILVDREVVSLFLHFTVNPKPRVEFI
  DRPRCCLRGKECSINRFQQVESRWGYSGTSDRIRFSVNKRIFVVGFGLYGSIHGPTDYQV
  NIQIIHTDSNTVLGQNDTGFSCDGSASTFRVMFKEPVEVLPNVNYTACATLKGPDSHYGT
  KGLRKVTHESPTTGAKTCFTFCYAAGNNNGTSVEDGQIPEVIFYT

• Sequence length: 525

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
BTBD2-related disorder	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Glioblastoma	Glioblastoma	BEFREE	20368557		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	20368557	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	20368557		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for BTBD2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to BTBD2.