BLZF1 (basic leucine zipper nuclear factor 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 8548
• Gene name: Basic leucine zipper nuclear factor 1
• Gene symbol: BLZF1
• Synonyms (NCBI Gene): GOLGIN-45, JEM-1, JEM-1s, JEM1
• Chromosome: 1
• Chromosome location: 1q24.2

miRNA Show/Hide all (116)

miRTarBase ID	miRNA	Experiments	Reference
MIRT822204	hsa-miR-122	CLIP-seq
MIRT822205	hsa-miR-1228	CLIP-seq
MIRT822206	hsa-miR-1297	CLIP-seq
MIRT822207	hsa-miR-140-3p	CLIP-seq
MIRT822208	hsa-miR-150	CLIP-seq
MIRT822209	hsa-miR-1915	CLIP-seq
MIRT822210	hsa-miR-26a	CLIP-seq
MIRT822211	hsa-miR-26b	CLIP-seq
MIRT822212	hsa-miR-3135b	CLIP-seq
MIRT822213	hsa-miR-3620	CLIP-seq
MIRT822214	hsa-miR-3622b-5p	CLIP-seq
MIRT822215	hsa-miR-3649	CLIP-seq
MIRT822216	hsa-miR-3652	CLIP-seq
MIRT822217	hsa-miR-3934	CLIP-seq
MIRT822218	hsa-miR-4430	CLIP-seq
MIRT822219	hsa-miR-4465	CLIP-seq
MIRT822220	hsa-miR-4695-3p	CLIP-seq
MIRT822221	hsa-miR-4726-3p	CLIP-seq
MIRT822222	hsa-miR-4735-5p	CLIP-seq
MIRT822223	hsa-miR-4772-3p	CLIP-seq
MIRT822224	hsa-miR-4775	CLIP-seq
MIRT822225	hsa-miR-4794	CLIP-seq
MIRT822226	hsa-miR-552	CLIP-seq
MIRT822227	hsa-miR-562	CLIP-seq
MIRT822228	hsa-miR-590-3p	CLIP-seq
MIRT822229	hsa-miR-767-5p	CLIP-seq
MIRT822204	hsa-miR-122	CLIP-seq
MIRT822207	hsa-miR-140-3p	CLIP-seq
MIRT822208	hsa-miR-150	CLIP-seq
MIRT822212	hsa-miR-3135b	CLIP-seq
MIRT822214	hsa-miR-3622b-5p	CLIP-seq
MIRT822215	hsa-miR-3649	CLIP-seq
MIRT822216	hsa-miR-3652	CLIP-seq
MIRT822217	hsa-miR-3934	CLIP-seq
MIRT1942998	hsa-miR-4421	CLIP-seq
MIRT822218	hsa-miR-4430	CLIP-seq
MIRT822220	hsa-miR-4695-3p	CLIP-seq
MIRT822226	hsa-miR-552	CLIP-seq
MIRT822227	hsa-miR-562	CLIP-seq
MIRT822229	hsa-miR-767-5p	CLIP-seq
MIRT822204	hsa-miR-122	CLIP-seq
MIRT2181758	hsa-miR-1224-3p	CLIP-seq
MIRT2181759	hsa-miR-1260	CLIP-seq
MIRT2181760	hsa-miR-1260b	CLIP-seq
MIRT2181761	hsa-miR-1280	CLIP-seq
MIRT822206	hsa-miR-1297	CLIP-seq
MIRT822207	hsa-miR-140-3p	CLIP-seq
MIRT822208	hsa-miR-150	CLIP-seq
MIRT2181762	hsa-miR-188-3p	CLIP-seq
MIRT822209	hsa-miR-1915	CLIP-seq
MIRT822210	hsa-miR-26a	CLIP-seq
MIRT822211	hsa-miR-26b	CLIP-seq
MIRT822212	hsa-miR-3135b	CLIP-seq
MIRT2181763	hsa-miR-3156-3p	CLIP-seq
MIRT822213	hsa-miR-3620	CLIP-seq
MIRT822214	hsa-miR-3622b-5p	CLIP-seq
MIRT822215	hsa-miR-3649	CLIP-seq
MIRT822216	hsa-miR-3652	CLIP-seq
MIRT822217	hsa-miR-3934	CLIP-seq
MIRT1942998	hsa-miR-4421	CLIP-seq
MIRT822218	hsa-miR-4430	CLIP-seq
MIRT2181764	hsa-miR-4446-5p	CLIP-seq
MIRT822219	hsa-miR-4465	CLIP-seq
MIRT822220	hsa-miR-4695-3p	CLIP-seq
MIRT822221	hsa-miR-4726-3p	CLIP-seq
MIRT822223	hsa-miR-4772-3p	CLIP-seq
MIRT822226	hsa-miR-552	CLIP-seq
MIRT822227	hsa-miR-562	CLIP-seq
MIRT822229	hsa-miR-767-5p	CLIP-seq
MIRT822204	hsa-miR-122	CLIP-seq
MIRT822205	hsa-miR-1228	CLIP-seq
MIRT2485433	hsa-miR-1245	CLIP-seq
MIRT822207	hsa-miR-140-3p	CLIP-seq
MIRT822212	hsa-miR-3135b	CLIP-seq
MIRT2485434	hsa-miR-325	CLIP-seq
MIRT822213	hsa-miR-3620	CLIP-seq
MIRT822214	hsa-miR-3622b-5p	CLIP-seq
MIRT822215	hsa-miR-3649	CLIP-seq
MIRT822216	hsa-miR-3652	CLIP-seq
MIRT2485435	hsa-miR-3923	CLIP-seq
MIRT822217	hsa-miR-3934	CLIP-seq
MIRT822218	hsa-miR-4430	CLIP-seq
MIRT2485436	hsa-miR-4436a	CLIP-seq
MIRT2485437	hsa-miR-4454	CLIP-seq
MIRT2485438	hsa-miR-4662a-5p	CLIP-seq
MIRT822220	hsa-miR-4695-3p	CLIP-seq
MIRT2485439	hsa-miR-4720-3p	CLIP-seq
MIRT822222	hsa-miR-4735-5p	CLIP-seq
MIRT822223	hsa-miR-4772-3p	CLIP-seq
MIRT822224	hsa-miR-4775	CLIP-seq
MIRT822225	hsa-miR-4794	CLIP-seq
MIRT2485440	hsa-miR-4804-3p	CLIP-seq
MIRT2485441	hsa-miR-508-5p	CLIP-seq
MIRT822226	hsa-miR-552	CLIP-seq
MIRT2485442	hsa-miR-582-5p	CLIP-seq
MIRT822228	hsa-miR-590-3p	CLIP-seq
MIRT822229	hsa-miR-767-5p	CLIP-seq
MIRT822204	hsa-miR-122	CLIP-seq
MIRT822205	hsa-miR-1228	CLIP-seq
MIRT2675996	hsa-miR-129-5p	CLIP-seq
MIRT822207	hsa-miR-140-3p	CLIP-seq
MIRT822212	hsa-miR-3135b	CLIP-seq
MIRT822213	hsa-miR-3620	CLIP-seq
MIRT822214	hsa-miR-3622b-5p	CLIP-seq
MIRT822215	hsa-miR-3649	CLIP-seq
MIRT822216	hsa-miR-3652	CLIP-seq
MIRT822217	hsa-miR-3934	CLIP-seq
MIRT822218	hsa-miR-4430	CLIP-seq
MIRT822220	hsa-miR-4695-3p	CLIP-seq
MIRT822222	hsa-miR-4735-5p	CLIP-seq
MIRT822223	hsa-miR-4772-3p	CLIP-seq
MIRT822224	hsa-miR-4775	CLIP-seq
MIRT822225	hsa-miR-4794	CLIP-seq
MIRT822226	hsa-miR-552	CLIP-seq
MIRT822228	hsa-miR-590-3p	CLIP-seq
MIRT822229	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0005515	Function	Protein binding	IPI	20211142, 21988832, 24722188, 25416956, 25910212, 26871637, 30194290, 31515488, 32296183, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	11739401
GO:0005634	Component	Nucleus	IDA	9129147
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	11056056
GO:0005794	Component	Golgi apparatus	IDA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005801	Component	Cis-Golgi network	NAS	29225785
GO:0007030	Process	Golgi organization	IBA
GO:0007030	Process	Golgi organization	IDA	11739401
GO:0007030	Process	Golgi organization	IEA
GO:0007030	Process	Golgi organization	NAS	29225785
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0019899	Function	Enzyme binding	IPI	21478859
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	21478859
GO:0043001	Process	Golgi to plasma membrane protein transport	IBA
GO:0043001	Process	Golgi to plasma membrane protein transport	IDA	11739401
GO:0043001	Process	Golgi to plasma membrane protein transport	IEA

Other IDs

• MIM: 608692
• HGNC: 1065
• e!Ensembl: ENSG00000117475

Protein

• UniProt ID: Q9H2G9
• Protein name: Golgin-45 (Basic leucine zipper nuclear factor 1) (JEM-1) (p45 basic leucine-zipper nuclear factor)
• Protein function: Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08227	DASH_Hsk3	181 → 226	DASH complex subunit Hsk3 like	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected in adrenal gland (PubMed:9129147). {ECO:0000269|PubMed:11056056, ECO:0000269|PubMed:11739401, ECO:0000269|PubMed:9129147}.
• Sequence:

  MTTKNLETKVTVTSSPIRGAGDGMETEEPPKSVEVTSGVQSRKHHSLQSPWKKAVPSESP
  GVLQLGKMLTEKAMEVKAVRILVPKAAITHDIPNKNTKVKSLGHHKGEFLGQSEGVIEPN
  KELSEVKNVLEKLKNSERRLLQDKEGLSNQLRVQTEVNRELKKLLVASVGDDLQYHFERL
  AREKNQLILENEALGRNTAQLSEQLERMSIQCDVWRSKFLASRVMADELTNSRAALQRQN
  RDAHGAIQDLLSEREQFRQEMIATQKLLEELLVSLQWGREQTYSPSVQPHSTAELALTNH
  KLAKAVNSHLLGNVGINNQKKIPSTVEFCSTPAEKMAETVLRILDPVTCKESSPDNPFFE
  SSPTTLLATKKNIGRFHPYTRYENITFNCCNHCRGELIAL

• Sequence length: 400

Pathways

Reactome Pathway:

Golgi Cisternae Pericentriolar Stack Reorganization

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Malignant tumor of urinary bladder	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (8)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute Promyelocytic Leukemia	Promyelocytic Leukemia	BEFREE	9823948		★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	27226551		★☆☆☆☆ Found in Text Mining only
Frontotemporal Lobar Degeneration	Frontotemporal dementia	BEFREE	27226551		★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington Disease	BEFREE	8751857		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	9129147		★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	2243138, 2400807		★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	27226551, 30406848		★☆☆☆☆ Found in Text Mining only
Venous Thromboembolism	Venous thromboembolism	Pubtator	22672568	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for BLZF1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to BLZF1.