BHLHA15 (basic helix-loop-helix family member a15)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 168620
• Gene name: Basic helix-loop-helix family member a15
• Gene symbol: BHLHA15
• Synonyms (NCBI Gene): BHLHB8, MIST1
• Chromosome: 7
• Chromosome location: 7q21.3

miRNA Show/Hide all (44)

miRTarBase ID	miRNA	Experiments	Reference
MIRT712610	hsa-miR-6732-5p	HITS-CLIP	19536157
MIRT712609	hsa-miR-6841-3p	HITS-CLIP	19536157
MIRT712608	hsa-miR-1915-5p	HITS-CLIP	19536157
MIRT712607	hsa-miR-4731-5p	HITS-CLIP	19536157
MIRT712606	hsa-miR-5589-5p	HITS-CLIP	19536157
MIRT712605	hsa-miR-185-5p	HITS-CLIP	19536157
MIRT712604	hsa-miR-4306	HITS-CLIP	19536157
MIRT712603	hsa-miR-4644	HITS-CLIP	19536157
MIRT712602	hsa-miR-5192	HITS-CLIP	19536157
MIRT712601	hsa-miR-615-5p	HITS-CLIP	19536157
MIRT712600	hsa-miR-502-5p	HITS-CLIP	19536157
MIRT712599	hsa-miR-4531	HITS-CLIP	19536157
MIRT712598	hsa-miR-1270	HITS-CLIP	19536157
MIRT712597	hsa-miR-620	HITS-CLIP	19536157
MIRT712610	hsa-miR-6732-5p	HITS-CLIP	19536157
MIRT712609	hsa-miR-6841-3p	HITS-CLIP	19536157
MIRT712608	hsa-miR-1915-5p	HITS-CLIP	19536157
MIRT712607	hsa-miR-4731-5p	HITS-CLIP	19536157
MIRT712606	hsa-miR-5589-5p	HITS-CLIP	19536157
MIRT712605	hsa-miR-185-5p	HITS-CLIP	19536157
MIRT712604	hsa-miR-4306	HITS-CLIP	19536157
MIRT712603	hsa-miR-4644	HITS-CLIP	19536157
MIRT712602	hsa-miR-5192	HITS-CLIP	19536157
MIRT712601	hsa-miR-615-5p	HITS-CLIP	19536157
MIRT712600	hsa-miR-502-5p	HITS-CLIP	19536157
MIRT712599	hsa-miR-4531	HITS-CLIP	19536157
MIRT712598	hsa-miR-1270	HITS-CLIP	19536157
MIRT712597	hsa-miR-620	HITS-CLIP	19536157
MIRT821181	hsa-miR-3169	CLIP-seq
MIRT1942731	hsa-miR-3126-5p	CLIP-seq
MIRT1942732	hsa-miR-3192	CLIP-seq
MIRT1942733	hsa-miR-3199	CLIP-seq
MIRT1942734	hsa-miR-3689a-3p	CLIP-seq
MIRT1942735	hsa-miR-3689c	CLIP-seq
MIRT1942736	hsa-miR-4283	CLIP-seq
MIRT1942737	hsa-miR-432	CLIP-seq
MIRT1942738	hsa-miR-4443	CLIP-seq
MIRT1942739	hsa-miR-4489	CLIP-seq
MIRT1942740	hsa-miR-4492	CLIP-seq
MIRT1942741	hsa-miR-4498	CLIP-seq
MIRT1942742	hsa-miR-4505	CLIP-seq
MIRT1942743	hsa-miR-4515	CLIP-seq
MIRT1942744	hsa-miR-4728-5p	CLIP-seq
MIRT1942745	hsa-miR-762	CLIP-seq

Gene ontology (GO) Show/Hide all (38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0002071	Process	Glandular epithelial cell maturation	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006851	Process	Mitochondrial calcium ion transmembrane transport	IEA
GO:0007030	Process	Golgi organization	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007267	Process	Cell-cell signaling	IEA
GO:0007423	Process	Sensory organ development	IBA
GO:0010832	Process	Negative regulation of myotube differentiation	IEA
GO:0010832	Process	Negative regulation of myotube differentiation	ISS
GO:0019722	Process	Calcium-mediated signaling	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	IEA
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	ISS
GO:0042149	Process	Cellular response to glucose starvation	IEA
GO:0042149	Process	Cellular response to glucose starvation	ISS
GO:0042593	Process	Glucose homeostasis	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0044331	Process	Cell-cell adhesion mediated by cadherin	IEA
GO:0045216	Process	Cell-cell junction organization	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046983	Function	Protein dimerization activity	IEA
GO:0048312	Process	Intracellular distribution of mitochondria	IEA
GO:0051649	Process	Establishment of localization in cell	IEA
GO:0051674	Process	Localization of cell	IEA
GO:0061564	Process	Axon development	IBA
GO:0070888	Function	E-box binding	IBA
GO:0072560	Process	Type B pancreatic cell maturation	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IEA

Other IDs

• MIM: 608606
• HGNC: 22265
• e!Ensembl: ENSG00000180535

Protein

• UniProt ID: Q7RTS1
• Protein name: Class A basic helix-loop-helix protein 15 (bHLHa15) (Class B basic helix-loop-helix protein 8) (bHLHb8) (Muscle, intestine and stomach expression 1) (MIST-1)
• Protein function: Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHL
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00010	HLH	76 → 128	Helix-loop-helix DNA-binding domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in brain, liver, spleen and skeletal muscle. {ECO:0000269|PubMed:14516699}.
• Sequence:

  MKTKNRPPRRRAPVQDTEATPGEGTPDGSLPNPGPEPAKGLRSRPARAAARAPGEGRRRR
  PGPSGPGGRRDSSIQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLA
  KNYIKSLTATILTMSSSRLPGLEGPGPKLYQHYQQQQQVAGGALGATEAQPQGHLQRYST
  QIHSFREGT

• Sequence length: 189

Pathways

KEGG Pathway:

Maturity onset diabetes of the young

Related Genes

No strongly related genes found yet for BHLHA15.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to BHLHA15.