Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	63827
Gene name	Brevican
Gene symbol	BCAN
Synonyms (NCBI Gene)	BEHABCSPG7
Chromosome	1
Chromosome location	1q23.1
Summary	This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular mat

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Show/Hide all (173)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021697	hsa-miR-133a-3p	Microarray	21396852
MIRT489342	hsa-miR-3938	PAR-CLIP	20371350
MIRT489341	hsa-miR-4780	PAR-CLIP	20371350
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	20371350
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	20371350
MIRT489338	hsa-miR-3148	PAR-CLIP	20371350
MIRT489336	hsa-miR-6124	PAR-CLIP	20371350
MIRT489337	hsa-miR-623	PAR-CLIP	20371350
MIRT489335	hsa-miR-204-5p	PAR-CLIP	20371350
MIRT489334	hsa-miR-211-5p	PAR-CLIP	20371350
MIRT489333	hsa-miR-3978	PAR-CLIP	20371350
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	20371350
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	20371350
MIRT489342	hsa-miR-3938	PAR-CLIP	20371350
MIRT529928	hsa-miR-4793-5p	PAR-CLIP	20371350
MIRT489341	hsa-miR-4780	PAR-CLIP	20371350
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	20371350
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	20371350
MIRT489338	hsa-miR-3148	PAR-CLIP	20371350
MIRT489336	hsa-miR-6124	PAR-CLIP	20371350
MIRT489337	hsa-miR-623	PAR-CLIP	20371350
MIRT489335	hsa-miR-204-5p	PAR-CLIP	20371350
MIRT489334	hsa-miR-211-5p	PAR-CLIP	20371350
MIRT489333	hsa-miR-3978	PAR-CLIP	20371350
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	20371350
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	20371350
MIRT489342	hsa-miR-3938	PAR-CLIP	21572407
MIRT529928	hsa-miR-4793-5p	PAR-CLIP	21572407
MIRT489341	hsa-miR-4780	PAR-CLIP	21572407
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	21572407
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	21572407
MIRT489338	hsa-miR-3148	PAR-CLIP	21572407
MIRT489336	hsa-miR-6124	PAR-CLIP	21572407
MIRT489337	hsa-miR-623	PAR-CLIP	21572407
MIRT489335	hsa-miR-204-5p	PAR-CLIP	21572407
MIRT489334	hsa-miR-211-5p	PAR-CLIP	21572407
MIRT489333	hsa-miR-3978	PAR-CLIP	21572407
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	21572407
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	21572407
MIRT489344	hsa-miR-548as-3p	PAR-CLIP	22012620
MIRT489342	hsa-miR-3938	PAR-CLIP	22012620
MIRT529928	hsa-miR-4793-5p	PAR-CLIP	22012620
MIRT489341	hsa-miR-4780	PAR-CLIP	22012620
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	22012620
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	22012620
MIRT489338	hsa-miR-3148	PAR-CLIP	22012620
MIRT489336	hsa-miR-6124	PAR-CLIP	22012620
MIRT489337	hsa-miR-623	PAR-CLIP	22012620
MIRT489335	hsa-miR-204-5p	PAR-CLIP	22012620
MIRT489334	hsa-miR-211-5p	PAR-CLIP	22012620
MIRT489333	hsa-miR-3978	PAR-CLIP	22012620
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	22012620
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	22012620
MIRT489344	hsa-miR-548as-3p	PAR-CLIP	23592263
MIRT489342	hsa-miR-3938	PAR-CLIP	23592263
MIRT489341	hsa-miR-4780	PAR-CLIP	23592263
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	23592263
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	23592263
MIRT489338	hsa-miR-3148	PAR-CLIP	23592263
MIRT489336	hsa-miR-6124	PAR-CLIP	23592263
MIRT489337	hsa-miR-623	PAR-CLIP	23592263
MIRT489335	hsa-miR-204-5p	PAR-CLIP	23592263
MIRT489334	hsa-miR-211-5p	PAR-CLIP	23592263
MIRT489333	hsa-miR-3978	PAR-CLIP	23592263
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	23592263
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	23592263
MIRT489335	hsa-miR-204-5p	PAR-CLIP	27292025
MIRT489334	hsa-miR-211-5p	PAR-CLIP	27292025
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	27292025
MIRT489338	hsa-miR-3148	PAR-CLIP	27292025
MIRT489342	hsa-miR-3938	PAR-CLIP	27292025
MIRT489333	hsa-miR-3978	PAR-CLIP	27292025
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	27292025
MIRT489341	hsa-miR-4780	PAR-CLIP	27292025
MIRT529928	hsa-miR-4793-5p	PAR-CLIP	27292025
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	27292025
MIRT489336	hsa-miR-6124	PAR-CLIP	27292025
MIRT489337	hsa-miR-623	PAR-CLIP	27292025
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	27292025
MIRT489342	hsa-miR-3938	PAR-CLIP	20371350
MIRT489341	hsa-miR-4780	PAR-CLIP	20371350
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	20371350
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	20371350
MIRT489338	hsa-miR-3148	PAR-CLIP	20371350
MIRT489336	hsa-miR-6124	PAR-CLIP	20371350
MIRT489337	hsa-miR-623	PAR-CLIP	20371350
MIRT489335	hsa-miR-204-5p	PAR-CLIP	20371350
MIRT489334	hsa-miR-211-5p	PAR-CLIP	20371350
MIRT489333	hsa-miR-3978	PAR-CLIP	20371350
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	20371350
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	20371350
MIRT489342	hsa-miR-3938	PAR-CLIP	20371350
MIRT529928	hsa-miR-4793-5p	PAR-CLIP	20371350
MIRT489341	hsa-miR-4780	PAR-CLIP	20371350
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	20371350
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	20371350
MIRT489338	hsa-miR-3148	PAR-CLIP	20371350
MIRT489336	hsa-miR-6124	PAR-CLIP	20371350
MIRT489337	hsa-miR-623	PAR-CLIP	20371350
MIRT489335	hsa-miR-204-5p	PAR-CLIP	20371350
MIRT489334	hsa-miR-211-5p	PAR-CLIP	20371350
MIRT489333	hsa-miR-3978	PAR-CLIP	20371350
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	20371350
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	20371350
MIRT489342	hsa-miR-3938	PAR-CLIP	21572407
MIRT529928	hsa-miR-4793-5p	PAR-CLIP	21572407
MIRT489341	hsa-miR-4780	PAR-CLIP	21572407
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	21572407
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	21572407
MIRT489338	hsa-miR-3148	PAR-CLIP	21572407
MIRT489336	hsa-miR-6124	PAR-CLIP	21572407
MIRT489337	hsa-miR-623	PAR-CLIP	21572407
MIRT489335	hsa-miR-204-5p	PAR-CLIP	21572407
MIRT489334	hsa-miR-211-5p	PAR-CLIP	21572407
MIRT489333	hsa-miR-3978	PAR-CLIP	21572407
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	21572407
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	21572407
MIRT489344	hsa-miR-548as-3p	PAR-CLIP	22012620
MIRT489342	hsa-miR-3938	PAR-CLIP	22012620
MIRT529928	hsa-miR-4793-5p	PAR-CLIP	22012620
MIRT489341	hsa-miR-4780	PAR-CLIP	22012620
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	22012620
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	22012620
MIRT489338	hsa-miR-3148	PAR-CLIP	22012620
MIRT489336	hsa-miR-6124	PAR-CLIP	22012620
MIRT489337	hsa-miR-623	PAR-CLIP	22012620
MIRT489335	hsa-miR-204-5p	PAR-CLIP	22012620
MIRT489334	hsa-miR-211-5p	PAR-CLIP	22012620
MIRT489333	hsa-miR-3978	PAR-CLIP	22012620
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	22012620
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	22012620
MIRT489344	hsa-miR-548as-3p	PAR-CLIP	23592263
MIRT489342	hsa-miR-3938	PAR-CLIP	23592263
MIRT489341	hsa-miR-4780	PAR-CLIP	23592263
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	23592263
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	23592263
MIRT489338	hsa-miR-3148	PAR-CLIP	23592263
MIRT489336	hsa-miR-6124	PAR-CLIP	23592263
MIRT489337	hsa-miR-623	PAR-CLIP	23592263
MIRT489335	hsa-miR-204-5p	PAR-CLIP	23592263
MIRT489334	hsa-miR-211-5p	PAR-CLIP	23592263
MIRT489333	hsa-miR-3978	PAR-CLIP	23592263
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	23592263
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	23592263
MIRT817304	hsa-miR-3151	CLIP-seq
MIRT817305	hsa-miR-3194-3p	CLIP-seq
MIRT817306	hsa-miR-4283	CLIP-seq
MIRT817307	hsa-miR-4447	CLIP-seq
MIRT817308	hsa-miR-4472	CLIP-seq
MIRT817309	hsa-miR-4489	CLIP-seq
MIRT817310	hsa-miR-4492	CLIP-seq
MIRT817311	hsa-miR-4498	CLIP-seq
MIRT817312	hsa-miR-491-5p	CLIP-seq
MIRT817313	hsa-miR-576-3p	CLIP-seq
MIRT817314	hsa-miR-762	CLIP-seq
MIRT2384745	hsa-miR-4768-3p	CLIP-seq
MIRT2444664	hsa-miR-3622a-3p	CLIP-seq
MIRT2444665	hsa-miR-3622b-3p	CLIP-seq
MIRT2444666	hsa-miR-3690	CLIP-seq
MIRT2444667	hsa-miR-378	CLIP-seq
MIRT2444668	hsa-miR-378b	CLIP-seq
MIRT2444669	hsa-miR-378c	CLIP-seq
MIRT2444670	hsa-miR-378d	CLIP-seq
MIRT2444671	hsa-miR-378e	CLIP-seq
MIRT2444672	hsa-miR-378f	CLIP-seq
MIRT2444673	hsa-miR-378h	CLIP-seq
MIRT2444674	hsa-miR-378i	CLIP-seq
MIRT2444675	hsa-miR-3925-3p	CLIP-seq
MIRT2444676	hsa-miR-422a	CLIP-seq
MIRT2444677	hsa-miR-4712-5p	CLIP-seq
MIRT2444678	hsa-miR-508-5p	CLIP-seq
MIRT2444679	hsa-miR-619	CLIP-seq
MIRT2444680	hsa-miR-770-5p	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001501	Process	Skeletal system development	IBA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005540	Function	Hyaluronic acid binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005796	Component	Golgi lumen	IEA
GO:0005796	Component	Golgi lumen	TAS
GO:0007155	Process	Cell adhesion	IEA
GO:0007417	Process	Central nervous system development	IBA
GO:0016020	Component	Membrane	IEA
GO:0021766	Process	Hippocampus development	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0031012	Component	Extracellular matrix	IEA
GO:0043202	Component	Lysosomal lumen	IEA
GO:0043202	Component	Lysosomal lumen	TAS
GO:0045202	Component	Synapse	IBA
GO:0060074	Process	Synapse maturation	IEA
GO:0072534	Component	Perineuronal net	IBA
GO:0072534	Component	Perineuronal net	IEA
GO:0098552	Component	Side of membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA

MIM	HGNC	e!Ensembl
600347	23059	ENSG00000132692

Q96GW7

Protein name

Brevican core protein (Brain-enriched hyaluronan-binding protein) (BEHAB) (Chondroitin sulfate proteoglycan 7)

Protein function

May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	41 → 155	Immunoglobulin V-set domain	Domain
PF00193	Xlink	157 → 251	Extracellular link domain	Domain
PF00193	Xlink	258 → 353	Extracellular link domain	Domain
PF00008	EGF	650 → 680	EGF-like domain	Domain
PF00059	Lectin_C	705 → 810	Lectin C-type domain	Domain
PF00084	Sushi	815 → 871	Sushi repeat (SCR repeat)	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in the retina, specifically in the inner nuclear layer, inner plexiform layer and ganglion cell layer (at protein level) (PubMed:29777959). Detected in cerebrospinal fluid (at protein level) (PubMed:25326458). Detected in uri

Sequence

MAQLFLPLLAALVLAQAPAALADVLEGDSSEDRAFRVRIAGDAPLQGVLGGALTIPCHVH
YLRPPPSRRAVLGSPRVKWTFLSRGREAEVLVARGVRVKVNEAYRFRVALPAYPASLTDV
SLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFSGAQEACA
RIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGVV
DPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLDH
CSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKHSRFNVYCFRDSAQPS
AIPEASNPASNPASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSST
PEDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALW
AWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGPPT
ETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRA
PEGTRELEAPSEDNSGRTAPAGTSVQAQPVLPTDSASRGGVAVVPASGDCVPSPCHNGGT
CLEEEEGVRCLCLPGYGGDLCDVGLRFCNPGWDAFQGACYKHFSTRRSWEEAETQCRMYG
AHLASISTPEEQDFINNRYREYQWIGLNDRTIEGDFLWSDGVPLLYENWNPGQPDSYFLS
GENCVVMVWHDQGQWSDVPCNYHLSYTCKMGLVSCGPPPELPLAQVFGRPRLRYEVDTVL
RYRCREGLAQRNLPLIRCQENGRWEAPQISCVPRRPARALHPEEDPEGRQGRLLGRWKAL
LIPPSSPMPGP

Sequence length

911

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
High myopia	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE MYOPIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (30)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adult Oligodendroglioma	Oligodendroglioma	BEFREE	29308320		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	36982604	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	Pubtator	21997179	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	38355786	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	20439033		★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Injuries	Brain injuries	Pubtator	30980710	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Injuries Traumatic	Brain injuries	Pubtator	30980710	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Tumor, Primary	Brain Neoplasms	BEFREE	18611854		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	20439033		★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Oligodendroglioma	Oligodendroglioma	BEFREE	29308320		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dementia Vascular	Vascular dementia	Pubtator	39909351	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	16003758, 16133547		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	LHGDN	16133547		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	33694259	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	16133547		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	10364444, 11054543, 16133547, 18611854, 19633295, 25052349, 28695888, 9502798		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	11054543, 23253190, 25748242, 28161812	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	LHGDN	16133547, 18611854		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hydrocephalus	Hydrocephalus	Pubtator	22186713	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	34637697	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leiomyoma	Leiomyoma	Pubtator	30567472	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Glioma	Glioma	BEFREE	16061654		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	20439033		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28695888		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mild cognitive disorder	Cognitive disorder	BEFREE	26337292		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25052349		★★★★★ ★☆☆☆☆ Found in Text Mining only
oligodendroglioma	Oligodendroglioma	BEFREE	16061654, 29308320		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	20950796		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	Pubtator	33070392	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Well Differentiated Oligodendroglioma	Oligodendroglioma	BEFREE	16061654, 29308320		★★★★★ ★☆☆☆☆ Found in Text Mining only

BCAN (brevican)