Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	63827
Gene name	Brevican
Gene symbol	BCAN
Synonyms (NCBI Gene)	BEHABCSPG7
Chromosome	1
Chromosome location	1q23.1
Summary	This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular mat

173 Show/Hide all (173)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021697	hsa-miR-133a-3p	Microarray	21396852
MIRT489342	hsa-miR-3938	PAR-CLIP	20371350
MIRT489341	hsa-miR-4780	PAR-CLIP	20371350
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	20371350
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	20371350
MIRT489338	hsa-miR-3148	PAR-CLIP	20371350
MIRT489336	hsa-miR-6124	PAR-CLIP	20371350
MIRT489337	hsa-miR-623	PAR-CLIP	20371350
MIRT489335	hsa-miR-204-5p	PAR-CLIP	20371350
MIRT489334	hsa-miR-211-5p	PAR-CLIP	20371350
MIRT489333	hsa-miR-3978	PAR-CLIP	20371350
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	20371350
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	20371350
MIRT489342	hsa-miR-3938	PAR-CLIP	20371350
MIRT529928	hsa-miR-4793-5p	PAR-CLIP	20371350
MIRT489341	hsa-miR-4780	PAR-CLIP	20371350
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	20371350
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	20371350
MIRT489338	hsa-miR-3148	PAR-CLIP	20371350
MIRT489336	hsa-miR-6124	PAR-CLIP	20371350
MIRT489337	hsa-miR-623	PAR-CLIP	20371350
MIRT489335	hsa-miR-204-5p	PAR-CLIP	20371350
MIRT489334	hsa-miR-211-5p	PAR-CLIP	20371350
MIRT489333	hsa-miR-3978	PAR-CLIP	20371350
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	20371350
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	20371350
MIRT489342	hsa-miR-3938	PAR-CLIP	21572407
MIRT529928	hsa-miR-4793-5p	PAR-CLIP	21572407
MIRT489341	hsa-miR-4780	PAR-CLIP	21572407
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	21572407
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	21572407
MIRT489338	hsa-miR-3148	PAR-CLIP	21572407
MIRT489336	hsa-miR-6124	PAR-CLIP	21572407
MIRT489337	hsa-miR-623	PAR-CLIP	21572407
MIRT489335	hsa-miR-204-5p	PAR-CLIP	21572407
MIRT489334	hsa-miR-211-5p	PAR-CLIP	21572407
MIRT489333	hsa-miR-3978	PAR-CLIP	21572407
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	21572407
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	21572407
MIRT489344	hsa-miR-548as-3p	PAR-CLIP	22012620
MIRT489342	hsa-miR-3938	PAR-CLIP	22012620
MIRT529928	hsa-miR-4793-5p	PAR-CLIP	22012620
MIRT489341	hsa-miR-4780	PAR-CLIP	22012620
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	22012620
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	22012620
MIRT489338	hsa-miR-3148	PAR-CLIP	22012620
MIRT489336	hsa-miR-6124	PAR-CLIP	22012620
MIRT489337	hsa-miR-623	PAR-CLIP	22012620
MIRT489335	hsa-miR-204-5p	PAR-CLIP	22012620
MIRT489334	hsa-miR-211-5p	PAR-CLIP	22012620
MIRT489333	hsa-miR-3978	PAR-CLIP	22012620
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	22012620
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	22012620
MIRT489344	hsa-miR-548as-3p	PAR-CLIP	23592263
MIRT489342	hsa-miR-3938	PAR-CLIP	23592263
MIRT489341	hsa-miR-4780	PAR-CLIP	23592263
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	23592263
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	23592263
MIRT489338	hsa-miR-3148	PAR-CLIP	23592263
MIRT489336	hsa-miR-6124	PAR-CLIP	23592263
MIRT489337	hsa-miR-623	PAR-CLIP	23592263
MIRT489335	hsa-miR-204-5p	PAR-CLIP	23592263
MIRT489334	hsa-miR-211-5p	PAR-CLIP	23592263
MIRT489333	hsa-miR-3978	PAR-CLIP	23592263
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	23592263
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	23592263
MIRT489335	hsa-miR-204-5p	PAR-CLIP	27292025
MIRT489334	hsa-miR-211-5p	PAR-CLIP	27292025
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	27292025
MIRT489338	hsa-miR-3148	PAR-CLIP	27292025
MIRT489342	hsa-miR-3938	PAR-CLIP	27292025
MIRT489333	hsa-miR-3978	PAR-CLIP	27292025
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	27292025
MIRT489341	hsa-miR-4780	PAR-CLIP	27292025
MIRT529928	hsa-miR-4793-5p	PAR-CLIP	27292025
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	27292025
MIRT489336	hsa-miR-6124	PAR-CLIP	27292025
MIRT489337	hsa-miR-623	PAR-CLIP	27292025
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	27292025
MIRT489342	hsa-miR-3938	PAR-CLIP	20371350
MIRT489341	hsa-miR-4780	PAR-CLIP	20371350
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	20371350
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	20371350
MIRT489338	hsa-miR-3148	PAR-CLIP	20371350
MIRT489336	hsa-miR-6124	PAR-CLIP	20371350
MIRT489337	hsa-miR-623	PAR-CLIP	20371350
MIRT489335	hsa-miR-204-5p	PAR-CLIP	20371350
MIRT489334	hsa-miR-211-5p	PAR-CLIP	20371350
MIRT489333	hsa-miR-3978	PAR-CLIP	20371350
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	20371350
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	20371350
MIRT489342	hsa-miR-3938	PAR-CLIP	20371350
MIRT529928	hsa-miR-4793-5p	PAR-CLIP	20371350
MIRT489341	hsa-miR-4780	PAR-CLIP	20371350
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	20371350
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	20371350
MIRT489338	hsa-miR-3148	PAR-CLIP	20371350
MIRT489336	hsa-miR-6124	PAR-CLIP	20371350
MIRT489337	hsa-miR-623	PAR-CLIP	20371350
MIRT489335	hsa-miR-204-5p	PAR-CLIP	20371350
MIRT489334	hsa-miR-211-5p	PAR-CLIP	20371350
MIRT489333	hsa-miR-3978	PAR-CLIP	20371350
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	20371350
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	20371350
MIRT489342	hsa-miR-3938	PAR-CLIP	21572407
MIRT529928	hsa-miR-4793-5p	PAR-CLIP	21572407
MIRT489341	hsa-miR-4780	PAR-CLIP	21572407
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	21572407
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	21572407
MIRT489338	hsa-miR-3148	PAR-CLIP	21572407
MIRT489336	hsa-miR-6124	PAR-CLIP	21572407
MIRT489337	hsa-miR-623	PAR-CLIP	21572407
MIRT489335	hsa-miR-204-5p	PAR-CLIP	21572407
MIRT489334	hsa-miR-211-5p	PAR-CLIP	21572407
MIRT489333	hsa-miR-3978	PAR-CLIP	21572407
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	21572407
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	21572407
MIRT489344	hsa-miR-548as-3p	PAR-CLIP	22012620
MIRT489342	hsa-miR-3938	PAR-CLIP	22012620
MIRT529928	hsa-miR-4793-5p	PAR-CLIP	22012620
MIRT489341	hsa-miR-4780	PAR-CLIP	22012620
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	22012620
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	22012620
MIRT489338	hsa-miR-3148	PAR-CLIP	22012620
MIRT489336	hsa-miR-6124	PAR-CLIP	22012620
MIRT489337	hsa-miR-623	PAR-CLIP	22012620
MIRT489335	hsa-miR-204-5p	PAR-CLIP	22012620
MIRT489334	hsa-miR-211-5p	PAR-CLIP	22012620
MIRT489333	hsa-miR-3978	PAR-CLIP	22012620
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	22012620
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	22012620
MIRT489344	hsa-miR-548as-3p	PAR-CLIP	23592263
MIRT489342	hsa-miR-3938	PAR-CLIP	23592263
MIRT489341	hsa-miR-4780	PAR-CLIP	23592263
MIRT489340	hsa-miR-6780b-3p	PAR-CLIP	23592263
MIRT489339	hsa-miR-2276-3p	PAR-CLIP	23592263
MIRT489338	hsa-miR-3148	PAR-CLIP	23592263
MIRT489336	hsa-miR-6124	PAR-CLIP	23592263
MIRT489337	hsa-miR-623	PAR-CLIP	23592263
MIRT489335	hsa-miR-204-5p	PAR-CLIP	23592263
MIRT489334	hsa-miR-211-5p	PAR-CLIP	23592263
MIRT489333	hsa-miR-3978	PAR-CLIP	23592263
MIRT489332	hsa-miR-4755-5p	PAR-CLIP	23592263
MIRT489331	hsa-miR-5006-3p	PAR-CLIP	23592263
MIRT817304	hsa-miR-3151	CLIP-seq
MIRT817305	hsa-miR-3194-3p	CLIP-seq
MIRT817306	hsa-miR-4283	CLIP-seq
MIRT817307	hsa-miR-4447	CLIP-seq
MIRT817308	hsa-miR-4472	CLIP-seq
MIRT817309	hsa-miR-4489	CLIP-seq
MIRT817310	hsa-miR-4492	CLIP-seq
MIRT817311	hsa-miR-4498	CLIP-seq
MIRT817312	hsa-miR-491-5p	CLIP-seq
MIRT817313	hsa-miR-576-3p	CLIP-seq
MIRT817314	hsa-miR-762	CLIP-seq
MIRT2384745	hsa-miR-4768-3p	CLIP-seq
MIRT2444664	hsa-miR-3622a-3p	CLIP-seq
MIRT2444665	hsa-miR-3622b-3p	CLIP-seq
MIRT2444666	hsa-miR-3690	CLIP-seq
MIRT2444667	hsa-miR-378	CLIP-seq
MIRT2444668	hsa-miR-378b	CLIP-seq
MIRT2444669	hsa-miR-378c	CLIP-seq
MIRT2444670	hsa-miR-378d	CLIP-seq
MIRT2444671	hsa-miR-378e	CLIP-seq
MIRT2444672	hsa-miR-378f	CLIP-seq
MIRT2444673	hsa-miR-378h	CLIP-seq
MIRT2444674	hsa-miR-378i	CLIP-seq
MIRT2444675	hsa-miR-3925-3p	CLIP-seq
MIRT2444676	hsa-miR-422a	CLIP-seq
MIRT2444677	hsa-miR-4712-5p	CLIP-seq
MIRT2444678	hsa-miR-508-5p	CLIP-seq
MIRT2444679	hsa-miR-619	CLIP-seq
MIRT2444680	hsa-miR-770-5p	CLIP-seq

22 Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001501	Process	Skeletal system development	IBA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005540	Function	Hyaluronic acid binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005796	Component	Golgi lumen	IEA
GO:0005796	Component	Golgi lumen	TAS
GO:0007155	Process	Cell adhesion	IEA
GO:0007417	Process	Central nervous system development	IBA
GO:0016020	Component	Membrane	IEA
GO:0021766	Process	Hippocampus development	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0031012	Component	Extracellular matrix	IEA
GO:0043202	Component	Lysosomal lumen	IEA
GO:0043202	Component	Lysosomal lumen	TAS
GO:0045202	Component	Synapse	IBA
GO:0060074	Process	Synapse maturation	IEA
GO:0072534	Component	Perineuronal net	IBA
GO:0072534	Component	Perineuronal net	IEA
GO:0098552	Component	Side of membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA

MIM	HGNC	e!Ensembl
600347	23059	ENSG00000132692

Q96GW7

Protein name

Brevican core protein (Brain-enriched hyaluronan-binding protein) (BEHAB) (Chondroitin sulfate proteoglycan 7)

Protein function

May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00008	EGF	650 → 680	EGF-like domain	Domain
PF00059	Lectin_C	705 → 810	Lectin C-type domain	Domain
PF00084	Sushi	815 → 871	Sushi repeat (SCR repeat)	Domain
PF00193	Xlink	157 → 251	Extracellular link domain	Domain
PF00193	Xlink	258 → 353	Extracellular link domain	Domain
PF07686	V-set	41 → 155	Immunoglobulin V-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in the retina, specifically in the inner nuclear layer, inner plexiform layer and ganglion cell layer (at protein level) (PubMed:29777959). Detected in cerebrospinal fluid (at protein level) (PubMed:25326458). Detected in uri

Sequence

MAQLFLPLLAALVLAQAPAALADVLEGDSSEDRAFRVRIAGDAPLQGVLGGALTIPCHVH
YLRPPPSRRAVLGSPRVKWTFLSRGREAEVLVARGVRVKVNEAYRFRVALPAYPASLTDV
SLALSELRPNDSGIYRCEVQHGIDDSSDAVEVKVKGVVFLYREGSARYAFSFSGAQEACA
RIGAHIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQTPREACYGDMDGFPGVRNYGVV
DPDDLYDVYCYAEDLNGELFLGDPPEKLTLEEARAYCQERGAEIATTGQLYAAWDGGLDH
CSPGWLADGSVRYPIVTPSQRCGGGLPGVKTLFLFPNQTGFPNKHSRFNVYCFRDSAQPS
AIPEASNPASNPASDGLEAIVTVTETLEELQLPQEATESESRGAIYSIPIMEDGGGGSST
PEDPAEAPRTLLEFETQSMVPPTGFSEEEGKALEEEEKYEDEEEKEEEEEEEEVEDEALW
AWPSELSSPGPEASLPTEPAAQEESLSQAPARAVLQPGASPLPDGESEASRPPRVHGPPT
ETLPTPRERNLASPSPSTLVEAREVGEATGGPELSGVPRGESEETGSSEGAPSLLPATRA
PEGTRELEAPSEDNSGRTAPAGTSVQAQPVLPTDSASRGGVAVVPASGDCVPSPCHNGGT
CLEEEEGVRCLCLPGYGGDLCDVGLRFCNPGWDAFQGACYKHFSTRRSWEEAETQCRMYG
AHLASISTPEEQDFINNRYREYQWIGLNDRTIEGDFLWSDGVPLLYENWNPGQPDSYFLS
GENCVVMVWHDQGQWSDVPCNYHLSYTCKMGLVSCGPPPELPLAQVFGRPRLRYEVDTVL
RYRCREGLAQRNLPLIRCQENGRWEAPQISCVPRRPARALHPEEDPEGRQGRLLGRWKAL
LIPPSSPMPGP

Sequence length

911

Interactions

View interactions

Reactome Pathway
Degradation of the extracellular matrix
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate biosynthesis
Dermatan sulfate biosynthesis
CS/DS degradation
ECM proteoglycans
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective CHST3 causes SEDCJD
Defective CHST14 causes EDS, musculocontractural type
Defective CHSY1 causes TPBS
Defective B3GALT6 causes EDSP2 and SEMDJL1

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
High myopia	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE MYOPIA	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (30)
Adult Oligodendroglioma	Oligodendroglioma	BEFREE	29308320		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	36982604	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	Pubtator	21997179	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	38355786	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	20439033		★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Injuries	Brain injuries	Pubtator	30980710	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Injuries Traumatic	Brain injuries	Pubtator	30980710	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Tumor, Primary	Brain Neoplasms	BEFREE	18611854		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	20439033		★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Oligodendroglioma	Oligodendroglioma	BEFREE	29308320		★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
NCAN	[]	11	["A tetrasaccharide linker sequence is required for GAG synthesis","Defective B4GALT7 causes EDS, progeroid type","Defective B3GAT3 causes JDSSDHD","Defective B3GALT6 causes EDSP2 and SEMDJL1","Dermatan sulfate biosynthesis","Chondroitin sulfate biosynthesis","CS\/DS degradation","Defective CHST3 causes SEDCJD","Defective CHST14 causes EDS, musculocontractural type","Defective CHSY1 causes TPBS","ECM proteoglycans"]	[]
BGN	[]	11	["A tetrasaccharide linker sequence is required for GAG synthesis","Defective B4GALT7 causes EDS, progeroid type","Defective B3GAT3 causes JDSSDHD","Defective B3GALT6 causes EDSP2 and SEMDJL1","Dermatan sulfate biosynthesis","Chondroitin sulfate biosynthesis","CS\/DS degradation","Defective CHST3 causes SEDCJD","Defective CHST14 causes EDS, musculocontractural type","Defective CHSY1 causes TPBS","ECM proteoglycans"]	[]
CSPG5	[]	10	["A tetrasaccharide linker sequence is required for GAG synthesis","Defective B4GALT7 causes EDS, progeroid type","Defective B3GAT3 causes JDSSDHD","Defective B3GALT6 causes EDSP2 and SEMDJL1","Dermatan sulfate biosynthesis","Chondroitin sulfate biosynthesis","CS\/DS degradation","Defective CHST3 causes SEDCJD","Defective CHST14 causes EDS, musculocontractural type","Defective CHSY1 causes TPBS"]	[]
CSPG4	[]	10	["A tetrasaccharide linker sequence is required for GAG synthesis","Defective B4GALT7 causes EDS, progeroid type","Defective B3GAT3 causes JDSSDHD","Defective B3GALT6 causes EDSP2 and SEMDJL1","Dermatan sulfate biosynthesis","Chondroitin sulfate biosynthesis","CS\/DS degradation","Defective CHST3 causes SEDCJD","Defective CHST14 causes EDS, musculocontractural type","Defective CHSY1 causes TPBS"]	[]
DCN	[]	12	["A tetrasaccharide linker sequence is required for GAG synthesis","Defective B4GALT7 causes EDS, progeroid type","Defective B3GAT3 causes JDSSDHD","Defective B3GALT6 causes EDSP2 and SEMDJL1","Dermatan sulfate biosynthesis","Degradation of the extracellular matrix","Chondroitin sulfate biosynthesis","CS\/DS degradation","Defective CHST3 causes SEDCJD","Defective CHST14 causes EDS, musculocontractural type","Defective CHSY1 causes TPBS","ECM proteoglycans"]	[]

BCAN (brevican)

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