Log in to save this analysis

Save This Analysis

Gene Gene information from NCBI Gene database.
Entrez ID 64343
Gene name 5-azacytidine induced 2
Gene symbol AZI2
Synonyms (NCBI Gene)
AZ2NAP1TILP
Chromosome 3
Chromosome location 3p24.1
Summary AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]
miRNA miRNA information provided by mirtarbase database.
478 Show/Hide all (478)
miRTarBase ID miRNA Experiments Reference
MIRT019757 hsa-miR-375 Microarray 20215506
MIRT609527 hsa-miR-1250-3p HITS-CLIP 19536157
MIRT609526 hsa-miR-153-5p HITS-CLIP 19536157
MIRT609525 hsa-miR-5696 HITS-CLIP 19536157
MIRT609524 hsa-miR-579-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
11 Show/Hide all (11)
GO ID Ontology Definition Evidence Reference
GO:0000278 Process Mitotic cell cycle IEA
GO:0005515 Function Protein binding IPI 14743216, 21903422, 21931555, 22014111, 29251827, 32707033
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
GO:0042110 Process T cell activation IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609916 24002 ENSG00000163512
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H6S1
Protein name 5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (Nap1) (TILP)
Protein function Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (PubMed:14560022, PubMed:21931631). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (PubMed:14560022, PubMed:21931631). Enh
PDB 5EP6 , 5Z7G , 5Z7L , 7EA2 , 7EA7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12845 TBD 213 → 265 TBD domain Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed (PubMed:14560022). Abundant expression seen in the pancreas and testis (PubMed:14560022). {ECO:0000269|PubMed:14560022}.
Sequence
MDALVEDDICILNHEKAHKRDTVTPVSIYSGDESVASHFALVTAYEDIKKRLKDSEKENS
LLKKRIRFLEEKLIARFEEETSSVGREQVNKAYHAYREVCIDRDNLKSKLDKMNKDNSES
LKVLNEQLQSKEVELLQLRTEVETQQVMRNLNPPSSNWEVEKLSCDLKIHGLEQELELMR
KECSDLKIELQKAKQTDPYQEDNLKSRDLQKLSISSDNMQHAYWELKREMSNLHLVTQVQ
AELLRKLKTSTAIKKACAPVGCSED
LGRDSTKLHLMNFTATYTRHPPLLPNGKALCHTTS
SPLPGDVKVLSEKAILQSWTDNERSIPNDGTCFQEHSSYGRNSLEDNSWVFPSPPKSSET
AFGETKTKTLPLPNLPPLHYLDQHNQNCLYKN
Sequence length 392
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway
RIG-I-like receptor signaling pathway