AZI2 (5-azacytidine induced 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 64343 |
| Gene name | 5-azacytidine induced 2 |
| Gene symbol | AZI2 |
| Synonyms (NCBI Gene) |
AZ2NAP1TILP
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| Chromosome | 3 |
| Chromosome location | 3p24.1 |
| Summary | AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008] |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9H6S1 | ||||||||||
| Protein name | 5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (Nap1) (TILP) | ||||||||||
| Protein function | Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (PubMed:14560022, PubMed:21931631). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (PubMed:14560022, PubMed:21931631). Enh | ||||||||||
| PDB | 5EP6 , 5Z7G , 5Z7L , 7EA2 , 7EA7 | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Widely expressed (PubMed:14560022). Abundant expression seen in the pancreas and testis (PubMed:14560022). {ECO:0000269|PubMed:14560022}. | ||||||||||
| Sequence |
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| Sequence length | 392 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Related Genes
Genes most often co-reported with AZI2 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to AZI2 (see Related Genes above), that are NOT already directly curated for AZI2 itself -- a lead worth checking, not a confirmed association.
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