AUP1 (AUP1 lipid droplet regulating VLDL assembly factor)

Download as csv Download as pdf

Log in to save this analysis

Save This Analysis

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 550
• Gene name: AUP1 lipid droplet regulating VLDL assembly factor
• Gene symbol: AUP1
• Synonyms (NCBI Gene): -
• Chromosome: 2
• Chromosome location: 2p13.1
• Summary: The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cho

miRNA Show/Hide all (76)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025826	hsa-miR-7-5p	Microarray	19073608
MIRT028820	hsa-miR-26b-5p	Microarray	19088304
MIRT031413	hsa-miR-16-5p	Proteomics	18668040
MIRT051897	hsa-let-7b-5p	CLASH	23622248
MIRT051897	hsa-let-7b-5p	CLASH	23622248
MIRT031413	hsa-miR-16-5p	CLASH	23622248
MIRT049386	hsa-miR-92a-3p	CLASH	23622248
MIRT044801	hsa-miR-320a	CLASH	23622248
MIRT042060	hsa-miR-484	CLASH	23622248
MIRT037175	hsa-miR-877-3p	CLASH	23622248
MIRT1940197	hsa-miR-1539	CLIP-seq
MIRT1940198	hsa-miR-3193	CLIP-seq
MIRT1940199	hsa-miR-326	CLIP-seq
MIRT1940200	hsa-miR-330-5p	CLIP-seq
MIRT1940201	hsa-miR-3605-3p	CLIP-seq
MIRT1940202	hsa-miR-4793-5p	CLIP-seq
MIRT1940203	hsa-miR-760	CLIP-seq
MIRT2482556	hsa-miR-1262	CLIP-seq
MIRT2482557	hsa-miR-1275	CLIP-seq
MIRT1940197	hsa-miR-1539	CLIP-seq
MIRT2482558	hsa-miR-1913	CLIP-seq
MIRT2482559	hsa-miR-204	CLIP-seq
MIRT2482560	hsa-miR-211	CLIP-seq
MIRT2482561	hsa-miR-219-1-3p	CLIP-seq
MIRT1940198	hsa-miR-3193	CLIP-seq
MIRT2482562	hsa-miR-324-3p	CLIP-seq
MIRT1940199	hsa-miR-326	CLIP-seq
MIRT1940200	hsa-miR-330-5p	CLIP-seq
MIRT1940201	hsa-miR-3605-3p	CLIP-seq
MIRT2482563	hsa-miR-361-3p	CLIP-seq
MIRT2482564	hsa-miR-3616-3p	CLIP-seq
MIRT2482565	hsa-miR-3667-3p	CLIP-seq
MIRT2482566	hsa-miR-4259	CLIP-seq
MIRT2482567	hsa-miR-4313	CLIP-seq
MIRT2482568	hsa-miR-4446-3p	CLIP-seq
MIRT2482569	hsa-miR-4525	CLIP-seq
MIRT2482570	hsa-miR-4665-5p	CLIP-seq
MIRT2482571	hsa-miR-4701-3p	CLIP-seq
MIRT2482572	hsa-miR-4710	CLIP-seq
MIRT2482573	hsa-miR-4721	CLIP-seq
MIRT2482574	hsa-miR-4723-5p	CLIP-seq
MIRT2482575	hsa-miR-4755-5p	CLIP-seq
MIRT1940202	hsa-miR-4793-5p	CLIP-seq
MIRT2482576	hsa-miR-571	CLIP-seq
MIRT2482577	hsa-miR-623	CLIP-seq
MIRT2482578	hsa-miR-625	CLIP-seq
MIRT1940203	hsa-miR-760	CLIP-seq
MIRT2482579	hsa-miR-939	CLIP-seq
MIRT2482556	hsa-miR-1262	CLIP-seq
MIRT2482557	hsa-miR-1275	CLIP-seq
MIRT1940197	hsa-miR-1539	CLIP-seq
MIRT2482558	hsa-miR-1913	CLIP-seq
MIRT2482559	hsa-miR-204	CLIP-seq
MIRT2482560	hsa-miR-211	CLIP-seq
MIRT2482561	hsa-miR-219-1-3p	CLIP-seq
MIRT1940198	hsa-miR-3193	CLIP-seq
MIRT2482562	hsa-miR-324-3p	CLIP-seq
MIRT1940201	hsa-miR-3605-3p	CLIP-seq
MIRT2482563	hsa-miR-361-3p	CLIP-seq
MIRT2482564	hsa-miR-3616-3p	CLIP-seq
MIRT2482565	hsa-miR-3667-3p	CLIP-seq
MIRT2482566	hsa-miR-4259	CLIP-seq
MIRT2482567	hsa-miR-4313	CLIP-seq
MIRT2482568	hsa-miR-4446-3p	CLIP-seq
MIRT2482569	hsa-miR-4525	CLIP-seq
MIRT2482570	hsa-miR-4665-5p	CLIP-seq
MIRT2482571	hsa-miR-4701-3p	CLIP-seq
MIRT2482572	hsa-miR-4710	CLIP-seq
MIRT2482573	hsa-miR-4721	CLIP-seq
MIRT2482574	hsa-miR-4723-5p	CLIP-seq
MIRT2482575	hsa-miR-4755-5p	CLIP-seq
MIRT1940202	hsa-miR-4793-5p	CLIP-seq
MIRT2482576	hsa-miR-571	CLIP-seq
MIRT2482577	hsa-miR-623	CLIP-seq
MIRT2482578	hsa-miR-625	CLIP-seq
MIRT2482579	hsa-miR-939	CLIP-seq

Gene ontology (GO) Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	22119785, 23840749, 29902443, 32296183
GO:0005776	Component	Autophagosome	IDA	29902443
GO:0005776	Component	Autophagosome	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	21857022
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	21127063, 23197321, 23223569
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005811	Component	Lipid droplet	IDA	21127063, 21857022, 23197321, 23223569, 29902443
GO:0005811	Component	Lipid droplet	IEA
GO:0009615	Process	Response to virus	IMP	29902443
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0030970	Process	Retrograde protein transport, ER to cytosol	IMP	25660456
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031624	Function	Ubiquitin conjugating enzyme binding	IPI	21127063, 21857022, 23223569
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	23223569
GO:0034389	Process	Lipid droplet organization	IDA	24039768
GO:0036503	Process	ERAD pathway	IBA
GO:0036503	Process	ERAD pathway	IEA
GO:0036503	Process	ERAD pathway	IMP	21857022, 23223569
GO:0043130	Function	Ubiquitin binding	IEA
GO:0061724	Process	Lipophagy	IMP	29902443
GO:0070062	Component	Extracellular exosome	HDA	18570454
GO:0140042	Process	Lipid droplet formation	IMP	21857022
GO:1990044	Process	Protein localization to lipid droplet	IDA	21127063
GO:1990044	Process	Protein localization to lipid droplet	IMP	23223569

Other IDs

• MIM: 602434
• HGNC: 891
• e!Ensembl: ENSG00000115307

Protein

• UniProt ID: Q9Y679
• Protein name: Lipid droplet-regulating VLDL assembly factor AUP1 (Ancient ubiquitous protein 1)
• Protein function: Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome (PubMed:18711132, PubMed:21857022). Plays a role in lipid droplet formation (PubMed:
• PDB: 2EKF , 7LEW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02845	CUE	298 → 337	CUE domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain. {ECO:0000269|PubMed:12042322}.
• Sequence:

  MELPSGPGPERLFDSHRLPGDCFLLLVLLLYAPVGFCLLVLRLFLGIHVFLVSCALPDSV
  LRRFVVRTMCAVLGLVARQEDSGLRDHSVRVLISNHVTPFDHNIVNLLTTCSTPLLNSPP
  SFVCWSRGFMEMNGRGELVESLKRFCASTRLPPTPLLLFPEEEATNGREGLLRFSSWPFS
  IQDVVQPLTLQVQRPLVSVTVSDASWVSELLWSLFVPFTVYQVRWLRPVHRQLGEANEEF
  ALRVQQLVAKELGQTGTRLTPADKAEHMKRQRHPRLRPQSAQSSFPPSPGPSPDVQLATL
  AQRVKEVLPHVPLGVIQRDLAKTGCVDLTITNLLEGAVAFMPEDITKGTQSLPTASASKF
  PSSGPVTPQPTALTFAKSSWARQESLQERKQALYEYARRRFTERRAQEAD

• Sequence length: 410

Related Genes

No strongly related genes found yet for AUP1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to AUP1.