Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	533
Gene name	ATPase H+ transporting V0 subunit b
Gene symbol	ATP6V0B
Synonyms (NCBI Gene)	ATP6FHATPLVMA16
Chromosome	1
Chromosome location	1p34.1
Summary	This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymoge

229 Show/Hide all (229)

miRTarBase ID	miRNA	Experiments	Reference
MIRT341458	hsa-miR-548aa	PAR-CLIP	23592263
MIRT341461	hsa-miR-548ap-3p	PAR-CLIP	23592263
MIRT341455	hsa-miR-548t-3p	PAR-CLIP	23592263
MIRT452083	hsa-miR-548n	PAR-CLIP	23592263
MIRT341462	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT341454	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT341456	hsa-miR-3609	PAR-CLIP	23592263
MIRT341459	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT452082	hsa-miR-5692a	PAR-CLIP	23592263
MIRT341453	hsa-miR-634	PAR-CLIP	23592263
MIRT341457	hsa-miR-3942-5p	PAR-CLIP	23592263
MIRT341460	hsa-miR-4703-5p	PAR-CLIP	23592263
MIRT452081	hsa-miR-3622a-5p	PAR-CLIP	23592263
MIRT341451	hsa-miR-95-5p	PAR-CLIP	23592263
MIRT452080	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT452079	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT452078	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT452077	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT452076	hsa-miR-1827	PAR-CLIP	23592263
MIRT452075	hsa-miR-3177-3p	PAR-CLIP	23592263
MIRT452074	hsa-miR-564	PAR-CLIP	23592263
MIRT452073	hsa-miR-4433a-5p	PAR-CLIP	23592263
MIRT452072	hsa-miR-4316	PAR-CLIP	23592263
MIRT452071	hsa-miR-4433b-5p	PAR-CLIP	23592263
MIRT341458	hsa-miR-548aa	PAR-CLIP	23592263
MIRT341461	hsa-miR-548ap-3p	PAR-CLIP	23592263
MIRT341455	hsa-miR-548t-3p	PAR-CLIP	23592263
MIRT452083	hsa-miR-548n	PAR-CLIP	23592263
MIRT341462	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT341454	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT341456	hsa-miR-3609	PAR-CLIP	23592263
MIRT341459	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT452082	hsa-miR-5692a	PAR-CLIP	23592263
MIRT341453	hsa-miR-634	PAR-CLIP	23592263
MIRT341457	hsa-miR-3942-5p	PAR-CLIP	23592263
MIRT341460	hsa-miR-4703-5p	PAR-CLIP	23592263
MIRT452081	hsa-miR-3622a-5p	PAR-CLIP	23592263
MIRT341451	hsa-miR-95-5p	PAR-CLIP	23592263
MIRT452080	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT452079	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT452078	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT452077	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT452076	hsa-miR-1827	PAR-CLIP	23592263
MIRT452075	hsa-miR-3177-3p	PAR-CLIP	23592263
MIRT452074	hsa-miR-564	PAR-CLIP	23592263
MIRT452073	hsa-miR-4433a-5p	PAR-CLIP	23592263
MIRT452072	hsa-miR-4316	PAR-CLIP	23592263
MIRT452071	hsa-miR-4433b-5p	PAR-CLIP	23592263
MIRT808610	hsa-miR-1224-5p	CLIP-seq
MIRT808611	hsa-miR-1234	CLIP-seq
MIRT808612	hsa-miR-1254	CLIP-seq
MIRT808613	hsa-miR-1269	CLIP-seq
MIRT808614	hsa-miR-1269b	CLIP-seq
MIRT808615	hsa-miR-1275	CLIP-seq
MIRT808616	hsa-miR-1288	CLIP-seq
MIRT808617	hsa-miR-15a	CLIP-seq
MIRT808618	hsa-miR-15b	CLIP-seq
MIRT808619	hsa-miR-16	CLIP-seq
MIRT808620	hsa-miR-1912	CLIP-seq
MIRT808621	hsa-miR-195	CLIP-seq
MIRT808622	hsa-miR-214	CLIP-seq
MIRT808623	hsa-miR-3116	CLIP-seq
MIRT808624	hsa-miR-3619-5p	CLIP-seq
MIRT808625	hsa-miR-3689d	CLIP-seq
MIRT808626	hsa-miR-3690	CLIP-seq
MIRT808627	hsa-miR-378	CLIP-seq
MIRT808628	hsa-miR-378b	CLIP-seq
MIRT808629	hsa-miR-378c	CLIP-seq
MIRT808630	hsa-miR-378d	CLIP-seq
MIRT808631	hsa-miR-378e	CLIP-seq
MIRT808632	hsa-miR-378f	CLIP-seq
MIRT808633	hsa-miR-378h	CLIP-seq
MIRT808634	hsa-miR-378i	CLIP-seq
MIRT808635	hsa-miR-3940-5p	CLIP-seq
MIRT808636	hsa-miR-422a	CLIP-seq
MIRT808637	hsa-miR-424	CLIP-seq
MIRT808638	hsa-miR-4291	CLIP-seq
MIRT808639	hsa-miR-4418	CLIP-seq
MIRT808640	hsa-miR-4426	CLIP-seq
MIRT808641	hsa-miR-4447	CLIP-seq
MIRT808642	hsa-miR-4472	CLIP-seq
MIRT808643	hsa-miR-4476	CLIP-seq
MIRT808644	hsa-miR-4507	CLIP-seq
MIRT808645	hsa-miR-4515	CLIP-seq
MIRT808646	hsa-miR-4525	CLIP-seq
MIRT808647	hsa-miR-4647	CLIP-seq
MIRT808648	hsa-miR-4662b	CLIP-seq
MIRT808649	hsa-miR-4665-5p	CLIP-seq
MIRT808650	hsa-miR-4704-5p	CLIP-seq
MIRT808651	hsa-miR-4719	CLIP-seq
MIRT808652	hsa-miR-4723-5p	CLIP-seq
MIRT808653	hsa-miR-4740-5p	CLIP-seq
MIRT808654	hsa-miR-4751	CLIP-seq
MIRT808655	hsa-miR-4797-5p	CLIP-seq
MIRT808656	hsa-miR-497	CLIP-seq
MIRT808657	hsa-miR-509-3-5p	CLIP-seq
MIRT808658	hsa-miR-509-5p	CLIP-seq
MIRT808659	hsa-miR-513b	CLIP-seq
MIRT808660	hsa-miR-515-3p	CLIP-seq
MIRT808661	hsa-miR-519e	CLIP-seq
MIRT808662	hsa-miR-552	CLIP-seq
MIRT808663	hsa-miR-596	CLIP-seq
MIRT808664	hsa-miR-625	CLIP-seq
MIRT808665	hsa-miR-761	CLIP-seq
MIRT808666	hsa-miR-764	CLIP-seq
MIRT808667	hsa-miR-922	CLIP-seq
MIRT808668	hsa-miR-1291	CLIP-seq
MIRT808669	hsa-miR-1321	CLIP-seq
MIRT808670	hsa-miR-145	CLIP-seq
MIRT808671	hsa-miR-1909	CLIP-seq
MIRT808672	hsa-miR-1915	CLIP-seq
MIRT808673	hsa-miR-3591-3p	CLIP-seq
MIRT808674	hsa-miR-4267	CLIP-seq
MIRT808675	hsa-miR-4270	CLIP-seq
MIRT808676	hsa-miR-4441	CLIP-seq
MIRT808677	hsa-miR-4475	CLIP-seq
MIRT808678	hsa-miR-451b	CLIP-seq
MIRT808679	hsa-miR-4728-5p	CLIP-seq
MIRT808680	hsa-miR-4739	CLIP-seq
MIRT808681	hsa-miR-4756-5p	CLIP-seq
MIRT808682	hsa-miR-4766-5p	CLIP-seq
MIRT808683	hsa-miR-488	CLIP-seq
MIRT808684	hsa-miR-766	CLIP-seq
MIRT808610	hsa-miR-1224-5p	CLIP-seq
MIRT808611	hsa-miR-1234	CLIP-seq
MIRT808612	hsa-miR-1254	CLIP-seq
MIRT808613	hsa-miR-1269	CLIP-seq
MIRT808614	hsa-miR-1269b	CLIP-seq
MIRT808616	hsa-miR-1288	CLIP-seq
MIRT808668	hsa-miR-1291	CLIP-seq
MIRT808669	hsa-miR-1321	CLIP-seq
MIRT808617	hsa-miR-15a	CLIP-seq
MIRT808618	hsa-miR-15b	CLIP-seq
MIRT808619	hsa-miR-16	CLIP-seq
MIRT808671	hsa-miR-1909	CLIP-seq
MIRT808621	hsa-miR-195	CLIP-seq
MIRT808622	hsa-miR-214	CLIP-seq
MIRT808623	hsa-miR-3116	CLIP-seq
MIRT808673	hsa-miR-3591-3p	CLIP-seq
MIRT808624	hsa-miR-3619-5p	CLIP-seq
MIRT808626	hsa-miR-3690	CLIP-seq
MIRT808627	hsa-miR-378	CLIP-seq
MIRT808628	hsa-miR-378b	CLIP-seq
MIRT808629	hsa-miR-378c	CLIP-seq
MIRT808630	hsa-miR-378d	CLIP-seq
MIRT808631	hsa-miR-378e	CLIP-seq
MIRT808632	hsa-miR-378f	CLIP-seq
MIRT808633	hsa-miR-378h	CLIP-seq
MIRT808634	hsa-miR-378i	CLIP-seq
MIRT808636	hsa-miR-422a	CLIP-seq
MIRT808637	hsa-miR-424	CLIP-seq
MIRT808675	hsa-miR-4270	CLIP-seq
MIRT808638	hsa-miR-4291	CLIP-seq
MIRT808639	hsa-miR-4418	CLIP-seq
MIRT808676	hsa-miR-4441	CLIP-seq
MIRT808645	hsa-miR-4515	CLIP-seq
MIRT808678	hsa-miR-451b	CLIP-seq
MIRT808679	hsa-miR-4728-5p	CLIP-seq
MIRT808680	hsa-miR-4739	CLIP-seq
MIRT808653	hsa-miR-4740-5p	CLIP-seq
MIRT808654	hsa-miR-4751	CLIP-seq
MIRT808681	hsa-miR-4756-5p	CLIP-seq
MIRT808682	hsa-miR-4766-5p	CLIP-seq
MIRT808655	hsa-miR-4797-5p	CLIP-seq
MIRT808683	hsa-miR-488	CLIP-seq
MIRT808656	hsa-miR-497	CLIP-seq
MIRT808657	hsa-miR-509-3-5p	CLIP-seq
MIRT808658	hsa-miR-509-5p	CLIP-seq
MIRT808660	hsa-miR-515-3p	CLIP-seq
MIRT808661	hsa-miR-519e	CLIP-seq
MIRT808662	hsa-miR-552	CLIP-seq
MIRT808663	hsa-miR-596	CLIP-seq
MIRT808665	hsa-miR-761	CLIP-seq
MIRT808666	hsa-miR-764	CLIP-seq
MIRT808667	hsa-miR-922	CLIP-seq
MIRT2481627	hsa-miR-933	CLIP-seq
MIRT808610	hsa-miR-1224-5p	CLIP-seq
MIRT808611	hsa-miR-1234	CLIP-seq
MIRT808612	hsa-miR-1254	CLIP-seq
MIRT808613	hsa-miR-1269	CLIP-seq
MIRT808614	hsa-miR-1269b	CLIP-seq
MIRT808616	hsa-miR-1288	CLIP-seq
MIRT808668	hsa-miR-1291	CLIP-seq
MIRT808669	hsa-miR-1321	CLIP-seq
MIRT808617	hsa-miR-15a	CLIP-seq
MIRT808618	hsa-miR-15b	CLIP-seq
MIRT808619	hsa-miR-16	CLIP-seq
MIRT808671	hsa-miR-1909	CLIP-seq
MIRT808621	hsa-miR-195	CLIP-seq
MIRT808622	hsa-miR-214	CLIP-seq
MIRT808623	hsa-miR-3116	CLIP-seq
MIRT808673	hsa-miR-3591-3p	CLIP-seq
MIRT808624	hsa-miR-3619-5p	CLIP-seq
MIRT808626	hsa-miR-3690	CLIP-seq
MIRT808627	hsa-miR-378	CLIP-seq
MIRT808628	hsa-miR-378b	CLIP-seq
MIRT808629	hsa-miR-378c	CLIP-seq
MIRT808630	hsa-miR-378d	CLIP-seq
MIRT808631	hsa-miR-378e	CLIP-seq
MIRT808632	hsa-miR-378f	CLIP-seq
MIRT808633	hsa-miR-378h	CLIP-seq
MIRT808634	hsa-miR-378i	CLIP-seq
MIRT808636	hsa-miR-422a	CLIP-seq
MIRT808637	hsa-miR-424	CLIP-seq
MIRT808675	hsa-miR-4270	CLIP-seq
MIRT808638	hsa-miR-4291	CLIP-seq
MIRT808639	hsa-miR-4418	CLIP-seq
MIRT808676	hsa-miR-4441	CLIP-seq
MIRT808645	hsa-miR-4515	CLIP-seq
MIRT808678	hsa-miR-451b	CLIP-seq
MIRT808679	hsa-miR-4728-5p	CLIP-seq
MIRT808680	hsa-miR-4739	CLIP-seq
MIRT808653	hsa-miR-4740-5p	CLIP-seq
MIRT808654	hsa-miR-4751	CLIP-seq
MIRT808681	hsa-miR-4756-5p	CLIP-seq
MIRT808682	hsa-miR-4766-5p	CLIP-seq
MIRT808655	hsa-miR-4797-5p	CLIP-seq
MIRT808683	hsa-miR-488	CLIP-seq
MIRT808656	hsa-miR-497	CLIP-seq
MIRT808657	hsa-miR-509-3-5p	CLIP-seq
MIRT808658	hsa-miR-509-5p	CLIP-seq
MIRT808660	hsa-miR-515-3p	CLIP-seq
MIRT808661	hsa-miR-519e	CLIP-seq
MIRT808662	hsa-miR-552	CLIP-seq
MIRT808663	hsa-miR-596	CLIP-seq
MIRT808665	hsa-miR-761	CLIP-seq
MIRT808666	hsa-miR-764	CLIP-seq
MIRT808667	hsa-miR-922	CLIP-seq
MIRT2481627	hsa-miR-933	CLIP-seq

33 Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	NAS	32001091
GO:0000220	Component	Vacuolar proton-transporting V-type ATPase, V0 domain	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005765	Component	Lysosomal membrane	NAS	32001091
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	NAS	32001091
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0007035	Process	Vacuolar acidification	NAS	32001091
GO:0007042	Process	Lysosomal lumen acidification	NAS	32001091, 33065002
GO:0010008	Component	Endosome membrane	NAS	32001091
GO:0010008	Component	Endosome membrane	TAS
GO:0015078	Function	Proton transmembrane transporter activity	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IDA	33065002
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9653649
GO:0016241	Process	Regulation of macroautophagy	NAS	22982048
GO:0030665	Component	Clathrin-coated vesicle membrane	IEA
GO:0030670	Component	Phagocytic vesicle membrane	TAS
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0033176	Component	Proton-transporting V-type ATPase complex	IEA
GO:0033176	Component	Proton-transporting V-type ATPase complex	NAS	33065002
GO:0033177	Component	Proton-transporting two-sector ATPase complex, proton-transporting domain	IEA
GO:0033179	Component	Proton-transporting V-type ATPase, V0 domain	IEA
GO:0046961	Function	Proton-transporting ATPase activity, rotational mechanism	IEA
GO:0046961	Function	Proton-transporting ATPase activity, rotational mechanism	TAS	9653649
GO:0048388	Process	Endosomal lumen acidification	NAS	32001091
GO:0051452	Process	Intracellular pH reduction	NAS	32001091
GO:0061795	Process	Golgi lumen acidification	NAS	32001091
GO:1902600	Process	Proton transmembrane transport	IEA
GO:1902600	Process	Proton transmembrane transport	NAS	33065002
GO:1902600	Process	Proton transmembrane transport	TAS	9653649

MIM	HGNC	e!Ensembl
603717	861	ENSG00000117410

Q99437

Protein name

V-type proton ATPase 21 kDa proteolipid subunit c'' (V-ATPase 21 kDa proteolipid subunit c'') (Vacuolar proton pump 21 kDa proteolipid subunit c'') (hATPL)

Protein function

Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33

PDB

6WLW , 6WM2 , 6WM3 , 6WM4 , 7U4T , 7UNF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00137	ATP-synt_C	138 → 197	ATP synthase subunit C	Family
PF00137	ATP-synt_C	52 → 111	ATP synthase subunit C	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MTGLALLYSGVFVAFWACALAVGVCYTIFDLGFRFDVAWFLTETSPFMWSNLGIGLAISL
SVVGAAWGIYITGSSIIGGGVKAPRIKTKNLVSIIFCEAVAIYGIIMAIVISNMAEPFSA
TDPKAIGHRNYHAGYSMFGAGLTVGLSNLFCGVCVGIVGSGAALADAQNPSLFVKILIVE
IFGSAIGLFGVIVAILQTSRVKMGD

Sequence length

205

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Oxidative phosphorylation	ROS and RNS production in phagocytes
Metabolic pathways	Insulin receptor recycling
Lysosome	Transferrin endocytosis and recycling
Phagosome	Amino acids regulate mTORC1
Synaptic vesicle cycle	Ion channel transport
Vibrio cholerae infection
Epithelial cell signaling in Helicobacter pylori infection
Tuberculosis
Human papillomavirus infection
Rheumatoid arthritis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
SCHIZOPHRENIA	—	GWAS catalog	31740837	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Bronchopulmonary Dysplasia	Bronchopulmonary dysplasia	Pubtator	23295978	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36105252, 36458010	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
TCIRG1	[]	13	["Oxidative phosphorylation","Lysosome","Phagosome","Synaptic vesicle cycle","Vibrio cholerae infection","Epithelial cell signaling in Helicobacter pylori infection","Tuberculosis","Rheumatoid arthritis","ROS and RNS production in phagocytes","Insulin receptor recycling","Transferrin endocytosis and recycling","Amino acids regulate mTORC1"]	[]
ATP6V0C	[]	13	["Oxidative phosphorylation","Lysosome","Phagosome","Synaptic vesicle cycle","Vibrio cholerae infection","Epithelial cell signaling in Helicobacter pylori infection","Tuberculosis","Rheumatoid arthritis","ROS and RNS production in phagocytes","Insulin receptor recycling","Transferrin endocytosis and recycling","Amino acids regulate mTORC1"]	[]
ATP6V0D2	[]	13	["Oxidative phosphorylation","Lysosome","Phagosome","Synaptic vesicle cycle","Vibrio cholerae infection","Epithelial cell signaling in Helicobacter pylori infection","Tuberculosis","Rheumatoid arthritis","ROS and RNS production in phagocytes","Insulin receptor recycling","Transferrin endocytosis and recycling","Amino acids regulate mTORC1"]	[]
ATP6V0A2	[]	12	["Oxidative phosphorylation","Lysosome","Phagosome","Synaptic vesicle cycle","Vibrio cholerae infection","Epithelial cell signaling in Helicobacter pylori infection","Tuberculosis","Rheumatoid arthritis","ROS and RNS production in phagocytes","Insulin receptor recycling","Transferrin endocytosis and recycling","Ion channel transport"]	[]
ATP6V0A4	[]	12	["Oxidative phosphorylation","Lysosome","Phagosome","Synaptic vesicle cycle","Vibrio cholerae infection","Epithelial cell signaling in Helicobacter pylori infection","Tuberculosis","Rheumatoid arthritis","ROS and RNS production in phagocytes","Insulin receptor recycling","Transferrin endocytosis and recycling","Ion channel transport"]	[]

ATP6V0B (ATPase H+ transporting V0 subunit b)

Bookmark This Gene