Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	115201
Gene name	Autophagy related 4A cysteine peptidase
Gene symbol	ATG4A
Synonyms (NCBI Gene)	APG4AAUTL2HsAPG4A
Chromosome	X
Chromosome location	Xq22.3
Summary	Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, a

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022814	hsa-miR-124-3p	Microarray	18668037
MIRT024785	hsa-miR-215-5p	Microarray	19074876
MIRT024785	hsa-miR-215-5p	Microarray	19074876
MIRT026607	hsa-miR-192-5p	Microarray	19074876
MIRT036957	hsa-miR-877-3p	CLASH	23622248
MIRT036957	hsa-miR-877-3p	CLASH	23622248
MIRT805444	hsa-miR-182	CLIP-seq
MIRT805445	hsa-miR-224	CLIP-seq
MIRT805446	hsa-miR-24	CLIP-seq
MIRT805447	hsa-miR-31	CLIP-seq
MIRT805448	hsa-miR-4251	CLIP-seq
MIRT805449	hsa-miR-4284	CLIP-seq
MIRT805450	hsa-miR-4303	CLIP-seq
MIRT805451	hsa-miR-4329	CLIP-seq
MIRT805452	hsa-miR-4420	CLIP-seq
MIRT805453	hsa-miR-4762-3p	CLIP-seq
MIRT805454	hsa-miR-509-3p	CLIP-seq
MIRT805455	hsa-miR-539	CLIP-seq
MIRT805456	hsa-miR-548v	CLIP-seq
MIRT805457	hsa-miR-103a	CLIP-seq
MIRT805458	hsa-miR-107	CLIP-seq
MIRT805459	hsa-miR-1205	CLIP-seq
MIRT805460	hsa-miR-1301	CLIP-seq
MIRT805444	hsa-miR-182	CLIP-seq
MIRT805461	hsa-miR-1972	CLIP-seq
MIRT805462	hsa-miR-2052	CLIP-seq
MIRT805463	hsa-miR-219-1-3p	CLIP-seq
MIRT805447	hsa-miR-31	CLIP-seq
MIRT805464	hsa-miR-3140-3p	CLIP-seq
MIRT805465	hsa-miR-3200-5p	CLIP-seq
MIRT805466	hsa-miR-3660	CLIP-seq
MIRT805467	hsa-miR-3689a-5p	CLIP-seq
MIRT805468	hsa-miR-3689b	CLIP-seq
MIRT805469	hsa-miR-3689e	CLIP-seq
MIRT805470	hsa-miR-3689f	CLIP-seq
MIRT805471	hsa-miR-3926	CLIP-seq
MIRT805472	hsa-miR-4290	CLIP-seq
MIRT805473	hsa-miR-4317	CLIP-seq
MIRT805474	hsa-miR-4501	CLIP-seq
MIRT805475	hsa-miR-4504	CLIP-seq
MIRT805476	hsa-miR-4526	CLIP-seq
MIRT805477	hsa-miR-4687-5p	CLIP-seq
MIRT805478	hsa-miR-5047	CLIP-seq
MIRT805454	hsa-miR-509-3p	CLIP-seq
MIRT805479	hsa-miR-542-3p	CLIP-seq
MIRT805480	hsa-miR-548l	CLIP-seq
MIRT805481	hsa-miR-548n	CLIP-seq
MIRT805456	hsa-miR-548v	CLIP-seq
MIRT805482	hsa-miR-576-3p	CLIP-seq
MIRT805483	hsa-miR-579	CLIP-seq
MIRT805484	hsa-miR-596	CLIP-seq
MIRT805485	hsa-miR-616	CLIP-seq
MIRT805486	hsa-miR-646	CLIP-seq
MIRT805487	hsa-miR-922	CLIP-seq
MIRT1937865	hsa-miR-561	CLIP-seq
MIRT805457	hsa-miR-103a	CLIP-seq
MIRT805458	hsa-miR-107	CLIP-seq
MIRT2444170	hsa-miR-1238	CLIP-seq
MIRT805460	hsa-miR-1301	CLIP-seq
MIRT805473	hsa-miR-4317	CLIP-seq
MIRT805478	hsa-miR-5047	CLIP-seq
MIRT805486	hsa-miR-646	CLIP-seq
MIRT805457	hsa-miR-103a	CLIP-seq
MIRT805458	hsa-miR-107	CLIP-seq
MIRT2480784	hsa-miR-1206	CLIP-seq
MIRT2444170	hsa-miR-1238	CLIP-seq
MIRT805460	hsa-miR-1301	CLIP-seq
MIRT2480785	hsa-miR-142-5p	CLIP-seq
MIRT805446	hsa-miR-24	CLIP-seq
MIRT2480786	hsa-miR-297	CLIP-seq
MIRT2480787	hsa-miR-3074-3p	CLIP-seq
MIRT805464	hsa-miR-3140-3p	CLIP-seq
MIRT2480788	hsa-miR-3146	CLIP-seq
MIRT2480789	hsa-miR-3149	CLIP-seq
MIRT2480790	hsa-miR-4264	CLIP-seq
MIRT2480791	hsa-miR-4269	CLIP-seq
MIRT805449	hsa-miR-4284	CLIP-seq
MIRT805473	hsa-miR-4317	CLIP-seq
MIRT2480792	hsa-miR-433	CLIP-seq
MIRT2480793	hsa-miR-4461	CLIP-seq
MIRT2480794	hsa-miR-4514	CLIP-seq
MIRT2480795	hsa-miR-4642	CLIP-seq
MIRT2480796	hsa-miR-4692	CLIP-seq
MIRT2480797	hsa-miR-4704-3p	CLIP-seq
MIRT2480798	hsa-miR-4742-5p	CLIP-seq
MIRT2480799	hsa-miR-491-3p	CLIP-seq
MIRT805478	hsa-miR-5047	CLIP-seq
MIRT1937865	hsa-miR-561	CLIP-seq
MIRT2480800	hsa-miR-628-5p	CLIP-seq
MIRT805486	hsa-miR-646	CLIP-seq
MIRT2480785	hsa-miR-142-5p	CLIP-seq
MIRT805446	hsa-miR-24	CLIP-seq
MIRT2480786	hsa-miR-297	CLIP-seq
MIRT2480787	hsa-miR-3074-3p	CLIP-seq
MIRT805464	hsa-miR-3140-3p	CLIP-seq
MIRT2480788	hsa-miR-3146	CLIP-seq
MIRT2480789	hsa-miR-3149	CLIP-seq
MIRT2480790	hsa-miR-4264	CLIP-seq
MIRT2480791	hsa-miR-4269	CLIP-seq
MIRT805449	hsa-miR-4284	CLIP-seq
MIRT2480792	hsa-miR-433	CLIP-seq
MIRT2480793	hsa-miR-4461	CLIP-seq
MIRT2480794	hsa-miR-4514	CLIP-seq
MIRT2480795	hsa-miR-4642	CLIP-seq
MIRT2480796	hsa-miR-4692	CLIP-seq
MIRT2480797	hsa-miR-4704-3p	CLIP-seq
MIRT2480798	hsa-miR-4742-5p	CLIP-seq
MIRT1937865	hsa-miR-561	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000045	Process	Autophagosome assembly	IBA
GO:0000045	Process	Autophagosome assembly	IDA	21177865
GO:0000423	Process	Mitophagy	IBA
GO:0004197	Function	Cysteine-type endopeptidase activity	IBA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0006508	Process	Proteolysis	IDA	12473658, 15169837, 21177865
GO:0006508	Process	Proteolysis	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006914	Process	Autophagy	IDA	30661429
GO:0006914	Process	Autophagy	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IDA	12473658, 15169837, 21177865, 30661429, 32732290
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016485	Process	Protein processing	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019786	Function	Protein-phosphatidylethanolamide deconjugating activity	IBA
GO:0019786	Function	Protein-phosphatidylethanolamide deconjugating activity	IDA	31315929
GO:0019786	Function	Protein-phosphatidylethanolamide deconjugating activity	IEA
GO:0034727	Process	Piecemeal microautophagy of the nucleus	IBA
GO:0035973	Process	Aggrephagy	IBA
GO:0051697	Process	Protein delipidation	IDA	29458288, 32732290

MIM	HGNC	e!Ensembl
300663	16489	ENSG00000101844

Q8WYN0

Protein name

Cysteine protease ATG4A (EC 3.4.22.-) (AUT-like 2 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 2) (Autophagin-2) (Autophagy-related protein 4 homolog A) (HsAPG4A) (hAPG4A)

Protein function

Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:12473658, PubMed:15169837, PubMed:17347651, PubMed:21177865, PubMed:21245471, PubMed:22302004, PubMed:

PDB

2P82

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03416	Peptidase_C54	42 → 336	Peptidase family C54	Family

Sequence

MESVLSKYEDQITIFTDYLEEYPDTDELVWILGKQHLLKTEKSKLLSDISARLWFTYRRK
FSPIGGTGPSSDAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEYQRILQCFLD
RKDCCYSIHQMAQMGVGEGKSIGEWFGPNTVAQVLKKLALFDEWNSLAVYVSMDNTVVIE
DIKKMCRVLPLSADTAGDRPPDSLTASNQSKGTSAYCSAWKPLLLIVPLRLGINQINPVY
VDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTEENGTVNDQTF
HCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQKEILKENLRMFELVQKHPSHWP
PFVPPAKPEVTTTGAEFIDSTEQLEEFDLEEDFEILSV

Sequence length

398

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Autophagy - other	Macroautophagy
Autophagy - animal

ATG4A (autophagy related 4A cysteine peptidase)

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