ATAD2 (ATPase family AAA domain containing 2)

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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases Diseases linked via similar genes

Gene

• Entrez ID: 29028
• Gene name: ATPase family AAA domain containing 2
• Gene symbol: ATAD2
• Synonyms (NCBI Gene): ANCCA, CT137, PRO2000
• Chromosome: 8
• Chromosome location: 8q24.13
• Summary: A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated wit

miRNA Show/Hide all (345)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020472	hsa-miR-106b-5p	Microarray	17242205
MIRT024263	hsa-miR-215-5p	Microarray	19074876
MIRT026860	hsa-miR-192-5p	Microarray	19074876
MIRT050753	hsa-miR-17-3p	CLASH	23622248
MIRT041465	hsa-miR-193b-3p	CLASH	23622248
MIRT036581	hsa-miR-941	CLASH	23622248
MIRT054430	hsa-miR-372-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	24552534
MIRT054430	hsa-miR-372-3p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	24552534
MIRT450964	hsa-miR-302c-3p	PAR-CLIP	22100165
MIRT450969	hsa-miR-520f-3p	PAR-CLIP	22100165
MIRT450968	hsa-miR-520b	PAR-CLIP	22100165
MIRT450967	hsa-miR-373-3p	PAR-CLIP	22100165
MIRT450966	hsa-miR-520a-3p	PAR-CLIP	22100165
MIRT450965	hsa-miR-302d-3p	PAR-CLIP	22100165
MIRT450964	hsa-miR-302c-3p	PAR-CLIP	22100165
MIRT450963	hsa-miR-520e	PAR-CLIP	22100165
MIRT054430	hsa-miR-372-3p	PAR-CLIP	22100165
MIRT450962	hsa-miR-302e	PAR-CLIP	22100165
MIRT450961	hsa-miR-520d-3p	PAR-CLIP	22100165
MIRT450960	hsa-miR-302a-3p	PAR-CLIP	22100165
MIRT450959	hsa-miR-302b-3p	PAR-CLIP	22100165
MIRT450958	hsa-miR-520c-3p	PAR-CLIP	22100165
MIRT450957	hsa-miR-20b-5p	PAR-CLIP	22100165
MIRT450956	hsa-miR-526b-3p	PAR-CLIP	22100165
MIRT450955	hsa-miR-519d-3p	PAR-CLIP	22100165
MIRT450954	hsa-miR-20a-5p	PAR-CLIP	22100165
MIRT450953	hsa-miR-93-5p	PAR-CLIP	22100165
MIRT450952	hsa-miR-17-5p	PAR-CLIP	22100165
MIRT020472	hsa-miR-106b-5p	PAR-CLIP	22100165
MIRT450951	hsa-miR-106a-5p	PAR-CLIP	22100165
MIRT450950	hsa-miR-548n	PAR-CLIP	22100165
MIRT450949	hsa-miR-548az-5p	PAR-CLIP	22100165
MIRT450948	hsa-miR-548t-5p	PAR-CLIP	22100165
MIRT450947	hsa-miR-4282	PAR-CLIP	22100165
MIRT450946	hsa-miR-3163	PAR-CLIP	22100165
MIRT450945	hsa-miR-4804-3p	PAR-CLIP	22100165
MIRT450944	hsa-miR-4720-3p	PAR-CLIP	22100165
MIRT450943	hsa-miR-374c-5p	PAR-CLIP	22100165
MIRT450942	hsa-miR-655-3p	PAR-CLIP	22100165
MIRT450964	hsa-miR-302c-3p	PAR-CLIP	22100165
MIRT450969	hsa-miR-520f-3p	PAR-CLIP	22100165
MIRT450968	hsa-miR-520b	PAR-CLIP	22100165
MIRT450967	hsa-miR-373-3p	PAR-CLIP	22100165
MIRT450966	hsa-miR-520a-3p	PAR-CLIP	22100165
MIRT450965	hsa-miR-302d-3p	PAR-CLIP	22100165
MIRT450964	hsa-miR-302c-3p	PAR-CLIP	22100165
MIRT450963	hsa-miR-520e	PAR-CLIP	22100165
MIRT054430	hsa-miR-372-3p	PAR-CLIP	22100165
MIRT450962	hsa-miR-302e	PAR-CLIP	22100165
MIRT450961	hsa-miR-520d-3p	PAR-CLIP	22100165
MIRT450960	hsa-miR-302a-3p	PAR-CLIP	22100165
MIRT450959	hsa-miR-302b-3p	PAR-CLIP	22100165
MIRT450958	hsa-miR-520c-3p	PAR-CLIP	22100165
MIRT450957	hsa-miR-20b-5p	PAR-CLIP	22100165
MIRT450956	hsa-miR-526b-3p	PAR-CLIP	22100165
MIRT450955	hsa-miR-519d-3p	PAR-CLIP	22100165
MIRT450954	hsa-miR-20a-5p	PAR-CLIP	22100165
MIRT450953	hsa-miR-93-5p	PAR-CLIP	22100165
MIRT450952	hsa-miR-17-5p	PAR-CLIP	22100165
MIRT020472	hsa-miR-106b-5p	PAR-CLIP	22100165
MIRT450951	hsa-miR-106a-5p	PAR-CLIP	22100165
MIRT450950	hsa-miR-548n	PAR-CLIP	22100165
MIRT450949	hsa-miR-548az-5p	PAR-CLIP	22100165
MIRT450948	hsa-miR-548t-5p	PAR-CLIP	22100165
MIRT450947	hsa-miR-4282	PAR-CLIP	22100165
MIRT450946	hsa-miR-3163	PAR-CLIP	22100165
MIRT450945	hsa-miR-4804-3p	PAR-CLIP	22100165
MIRT450944	hsa-miR-4720-3p	PAR-CLIP	22100165
MIRT450943	hsa-miR-374c-5p	PAR-CLIP	22100165
MIRT450942	hsa-miR-655-3p	PAR-CLIP	22100165
MIRT803682	hsa-miR-1182	CLIP-seq
MIRT803683	hsa-miR-1256	CLIP-seq
MIRT803684	hsa-miR-1297	CLIP-seq
MIRT803685	hsa-miR-134	CLIP-seq
MIRT803686	hsa-miR-140-5p	CLIP-seq
MIRT803687	hsa-miR-149	CLIP-seq
MIRT803688	hsa-miR-193a-5p	CLIP-seq
MIRT803689	hsa-miR-2117	CLIP-seq
MIRT803690	hsa-miR-218	CLIP-seq
MIRT803691	hsa-miR-219-2-3p	CLIP-seq
MIRT803692	hsa-miR-26a	CLIP-seq
MIRT803693	hsa-miR-26b	CLIP-seq
MIRT803694	hsa-miR-3064-5p	CLIP-seq
MIRT803695	hsa-miR-3065-5p	CLIP-seq
MIRT803696	hsa-miR-3074-3p	CLIP-seq
MIRT803697	hsa-miR-3118	CLIP-seq
MIRT803698	hsa-miR-3119	CLIP-seq
MIRT803699	hsa-miR-3154	CLIP-seq
MIRT803700	hsa-miR-3187-3p	CLIP-seq
MIRT803701	hsa-miR-323b-3p	CLIP-seq
MIRT803702	hsa-miR-335	CLIP-seq
MIRT803703	hsa-miR-338-5p	CLIP-seq
MIRT803704	hsa-miR-361-5p	CLIP-seq
MIRT803705	hsa-miR-3655	CLIP-seq
MIRT803706	hsa-miR-3662	CLIP-seq
MIRT803707	hsa-miR-3689a-5p	CLIP-seq
MIRT803708	hsa-miR-3689b	CLIP-seq
MIRT803709	hsa-miR-3689e	CLIP-seq
MIRT803710	hsa-miR-3689f	CLIP-seq
MIRT803711	hsa-miR-3925-3p	CLIP-seq
MIRT803712	hsa-miR-3926	CLIP-seq
MIRT803713	hsa-miR-3941	CLIP-seq
MIRT803714	hsa-miR-3944-5p	CLIP-seq
MIRT803715	hsa-miR-421	CLIP-seq
MIRT803716	hsa-miR-4264	CLIP-seq
MIRT803717	hsa-miR-4273	CLIP-seq
MIRT803718	hsa-miR-4276	CLIP-seq
MIRT803719	hsa-miR-4325	CLIP-seq
MIRT803720	hsa-miR-4327	CLIP-seq
MIRT803721	hsa-miR-4420	CLIP-seq
MIRT803722	hsa-miR-4435	CLIP-seq
MIRT803723	hsa-miR-4452	CLIP-seq
MIRT803724	hsa-miR-4465	CLIP-seq
MIRT803725	hsa-miR-4517	CLIP-seq
MIRT803726	hsa-miR-4643	CLIP-seq
MIRT803727	hsa-miR-466	CLIP-seq
MIRT803728	hsa-miR-4662a-3p	CLIP-seq
MIRT803729	hsa-miR-4666-3p	CLIP-seq
MIRT803730	hsa-miR-4672	CLIP-seq
MIRT803731	hsa-miR-4677-5p	CLIP-seq
MIRT803732	hsa-miR-4678	CLIP-seq
MIRT803733	hsa-miR-4679	CLIP-seq
MIRT803734	hsa-miR-4701-5p	CLIP-seq
MIRT803735	hsa-miR-4709-5p	CLIP-seq
MIRT803736	hsa-miR-4715-5p	CLIP-seq
MIRT803737	hsa-miR-4720-5p	CLIP-seq
MIRT803738	hsa-miR-4729	CLIP-seq
MIRT803739	hsa-miR-4789-3p	CLIP-seq
MIRT803740	hsa-miR-4794	CLIP-seq
MIRT803741	hsa-miR-4795-3p	CLIP-seq
MIRT803742	hsa-miR-4795-5p	CLIP-seq
MIRT803743	hsa-miR-4797-3p	CLIP-seq
MIRT803744	hsa-miR-4799-3p	CLIP-seq
MIRT803745	hsa-miR-491-3p	CLIP-seq
MIRT803746	hsa-miR-518a-5p	CLIP-seq
MIRT803747	hsa-miR-527	CLIP-seq
MIRT803748	hsa-miR-548ac	CLIP-seq
MIRT803749	hsa-miR-548ae	CLIP-seq
MIRT803750	hsa-miR-548ag	CLIP-seq
MIRT803751	hsa-miR-548ai	CLIP-seq
MIRT803752	hsa-miR-548aj	CLIP-seq
MIRT803753	hsa-miR-548am	CLIP-seq
MIRT803754	hsa-miR-548d-3p	CLIP-seq
MIRT803755	hsa-miR-548p	CLIP-seq
MIRT803756	hsa-miR-548s	CLIP-seq
MIRT803757	hsa-miR-548x	CLIP-seq
MIRT803758	hsa-miR-548z	CLIP-seq
MIRT803759	hsa-miR-556-3p	CLIP-seq
MIRT803760	hsa-miR-561	CLIP-seq
MIRT803761	hsa-miR-571	CLIP-seq
MIRT803762	hsa-miR-578	CLIP-seq
MIRT803763	hsa-miR-580	CLIP-seq
MIRT803764	hsa-miR-586	CLIP-seq
MIRT803765	hsa-miR-588	CLIP-seq
MIRT803766	hsa-miR-600	CLIP-seq
MIRT803767	hsa-miR-624	CLIP-seq
MIRT803768	hsa-miR-629	CLIP-seq
MIRT803769	hsa-miR-766	CLIP-seq
MIRT803770	hsa-miR-873	CLIP-seq
MIRT803771	hsa-miR-888	CLIP-seq
MIRT803772	hsa-miR-889	CLIP-seq
MIRT803773	hsa-miR-935	CLIP-seq
MIRT803774	hsa-miR-943	CLIP-seq
MIRT803682	hsa-miR-1182	CLIP-seq
MIRT803683	hsa-miR-1256	CLIP-seq
MIRT1937382	hsa-miR-1284	CLIP-seq
MIRT803684	hsa-miR-1297	CLIP-seq
MIRT803687	hsa-miR-149	CLIP-seq
MIRT803688	hsa-miR-193a-5p	CLIP-seq
MIRT1937383	hsa-miR-216a	CLIP-seq
MIRT803692	hsa-miR-26a	CLIP-seq
MIRT803693	hsa-miR-26b	CLIP-seq
MIRT803694	hsa-miR-3064-5p	CLIP-seq
MIRT803698	hsa-miR-3119	CLIP-seq
MIRT803699	hsa-miR-3154	CLIP-seq
MIRT803700	hsa-miR-3187-3p	CLIP-seq
MIRT1937384	hsa-miR-329	CLIP-seq
MIRT803703	hsa-miR-338-5p	CLIP-seq
MIRT803704	hsa-miR-361-5p	CLIP-seq
MIRT1937385	hsa-miR-362-3p	CLIP-seq
MIRT1937386	hsa-miR-3646	CLIP-seq
MIRT803705	hsa-miR-3655	CLIP-seq
MIRT803706	hsa-miR-3662	CLIP-seq
MIRT803707	hsa-miR-3689a-5p	CLIP-seq
MIRT803708	hsa-miR-3689b	CLIP-seq
MIRT803709	hsa-miR-3689e	CLIP-seq
MIRT803710	hsa-miR-3689f	CLIP-seq
MIRT1937387	hsa-miR-3714	CLIP-seq
MIRT1937388	hsa-miR-3922-5p	CLIP-seq
MIRT803712	hsa-miR-3926	CLIP-seq
MIRT803713	hsa-miR-3941	CLIP-seq
MIRT803717	hsa-miR-4273	CLIP-seq
MIRT1937389	hsa-miR-4275	CLIP-seq
MIRT803719	hsa-miR-4325	CLIP-seq
MIRT803721	hsa-miR-4420	CLIP-seq
MIRT803722	hsa-miR-4435	CLIP-seq
MIRT803723	hsa-miR-4452	CLIP-seq
MIRT803724	hsa-miR-4465	CLIP-seq
MIRT1937390	hsa-miR-4477a	CLIP-seq
MIRT803725	hsa-miR-4517	CLIP-seq
MIRT1937391	hsa-miR-4533	CLIP-seq
MIRT803726	hsa-miR-4643	CLIP-seq
MIRT803727	hsa-miR-466	CLIP-seq
MIRT803728	hsa-miR-4662a-3p	CLIP-seq
MIRT803729	hsa-miR-4666-3p	CLIP-seq
MIRT803730	hsa-miR-4672	CLIP-seq
MIRT803731	hsa-miR-4677-5p	CLIP-seq
MIRT803732	hsa-miR-4678	CLIP-seq
MIRT803733	hsa-miR-4679	CLIP-seq
MIRT1937392	hsa-miR-4698	CLIP-seq
MIRT803734	hsa-miR-4701-5p	CLIP-seq
MIRT803736	hsa-miR-4715-5p	CLIP-seq
MIRT803738	hsa-miR-4729	CLIP-seq
MIRT803739	hsa-miR-4789-3p	CLIP-seq
MIRT1937393	hsa-miR-4789-5p	CLIP-seq
MIRT803740	hsa-miR-4794	CLIP-seq
MIRT803741	hsa-miR-4795-3p	CLIP-seq
MIRT803745	hsa-miR-491-3p	CLIP-seq
MIRT1937394	hsa-miR-499-3p	CLIP-seq
MIRT1937395	hsa-miR-499a-3p	CLIP-seq
MIRT1937396	hsa-miR-513c	CLIP-seq
MIRT1937397	hsa-miR-514b-5p	CLIP-seq
MIRT803750	hsa-miR-548ag	CLIP-seq
MIRT803751	hsa-miR-548ai	CLIP-seq
MIRT1937398	hsa-miR-548c-3p	CLIP-seq
MIRT803755	hsa-miR-548p	CLIP-seq
MIRT803756	hsa-miR-548s	CLIP-seq
MIRT803759	hsa-miR-556-3p	CLIP-seq
MIRT803761	hsa-miR-571	CLIP-seq
MIRT803762	hsa-miR-578	CLIP-seq
MIRT803764	hsa-miR-586	CLIP-seq
MIRT803765	hsa-miR-588	CLIP-seq
MIRT803766	hsa-miR-600	CLIP-seq
MIRT1937399	hsa-miR-603	CLIP-seq
MIRT803768	hsa-miR-629	CLIP-seq
MIRT803771	hsa-miR-888	CLIP-seq
MIRT803772	hsa-miR-889	CLIP-seq
MIRT803773	hsa-miR-935	CLIP-seq
MIRT803774	hsa-miR-943	CLIP-seq
MIRT803682	hsa-miR-1182	CLIP-seq
MIRT2177004	hsa-miR-1233	CLIP-seq
MIRT803683	hsa-miR-1256	CLIP-seq
MIRT803684	hsa-miR-1297	CLIP-seq
MIRT803686	hsa-miR-140-5p	CLIP-seq
MIRT2177005	hsa-miR-142-5p	CLIP-seq
MIRT803687	hsa-miR-149	CLIP-seq
MIRT2177006	hsa-miR-186	CLIP-seq
MIRT803688	hsa-miR-193a-5p	CLIP-seq
MIRT1937383	hsa-miR-216a	CLIP-seq
MIRT803691	hsa-miR-219-2-3p	CLIP-seq
MIRT803692	hsa-miR-26a	CLIP-seq
MIRT803693	hsa-miR-26b	CLIP-seq
MIRT2177007	hsa-miR-302a	CLIP-seq
MIRT2177008	hsa-miR-302b	CLIP-seq
MIRT2177009	hsa-miR-302c	CLIP-seq
MIRT2177010	hsa-miR-302d	CLIP-seq
MIRT803694	hsa-miR-3064-5p	CLIP-seq
MIRT803698	hsa-miR-3119	CLIP-seq
MIRT2177011	hsa-miR-3121-3p	CLIP-seq
MIRT2177012	hsa-miR-3133	CLIP-seq
MIRT803700	hsa-miR-3187-3p	CLIP-seq
MIRT803701	hsa-miR-323b-3p	CLIP-seq
MIRT803702	hsa-miR-335	CLIP-seq
MIRT2177013	hsa-miR-340	CLIP-seq
MIRT803704	hsa-miR-361-5p	CLIP-seq
MIRT803706	hsa-miR-3662	CLIP-seq
MIRT2177014	hsa-miR-372	CLIP-seq
MIRT2177015	hsa-miR-373	CLIP-seq
MIRT2177016	hsa-miR-3914	CLIP-seq
MIRT2177017	hsa-miR-3920	CLIP-seq
MIRT803712	hsa-miR-3926	CLIP-seq
MIRT803713	hsa-miR-3941	CLIP-seq
MIRT803714	hsa-miR-3944-5p	CLIP-seq
MIRT1937389	hsa-miR-4275	CLIP-seq
MIRT2177018	hsa-miR-4290	CLIP-seq
MIRT803719	hsa-miR-4325	CLIP-seq
MIRT2177019	hsa-miR-4427	CLIP-seq
MIRT803722	hsa-miR-4435	CLIP-seq
MIRT803724	hsa-miR-4465	CLIP-seq
MIRT803725	hsa-miR-4517	CLIP-seq
MIRT1937391	hsa-miR-4533	CLIP-seq
MIRT803726	hsa-miR-4643	CLIP-seq
MIRT803727	hsa-miR-466	CLIP-seq
MIRT803728	hsa-miR-4662a-3p	CLIP-seq
MIRT803730	hsa-miR-4672	CLIP-seq
MIRT2177020	hsa-miR-4687-5p	CLIP-seq
MIRT803734	hsa-miR-4701-5p	CLIP-seq
MIRT803736	hsa-miR-4715-5p	CLIP-seq
MIRT2177021	hsa-miR-4719	CLIP-seq
MIRT803738	hsa-miR-4729	CLIP-seq
MIRT803739	hsa-miR-4789-3p	CLIP-seq
MIRT803740	hsa-miR-4794	CLIP-seq
MIRT803741	hsa-miR-4795-3p	CLIP-seq
MIRT803742	hsa-miR-4795-5p	CLIP-seq
MIRT2177022	hsa-miR-485-3p	CLIP-seq
MIRT803745	hsa-miR-491-3p	CLIP-seq
MIRT1937394	hsa-miR-499-3p	CLIP-seq
MIRT1937395	hsa-miR-499a-3p	CLIP-seq
MIRT2177023	hsa-miR-513b	CLIP-seq
MIRT2177024	hsa-miR-519a	CLIP-seq
MIRT2177025	hsa-miR-519b-3p	CLIP-seq
MIRT2177026	hsa-miR-519c-3p	CLIP-seq
MIRT803750	hsa-miR-548ag	CLIP-seq
MIRT803751	hsa-miR-548ai	CLIP-seq
MIRT803756	hsa-miR-548s	CLIP-seq
MIRT803759	hsa-miR-556-3p	CLIP-seq
MIRT803761	hsa-miR-571	CLIP-seq
MIRT803764	hsa-miR-586	CLIP-seq
MIRT803765	hsa-miR-588	CLIP-seq
MIRT803766	hsa-miR-600	CLIP-seq
MIRT803771	hsa-miR-888	CLIP-seq
MIRT803772	hsa-miR-889	CLIP-seq
MIRT803773	hsa-miR-935	CLIP-seq
MIRT2177027	hsa-miR-944	CLIP-seq
MIRT803682	hsa-miR-1182	CLIP-seq
MIRT803683	hsa-miR-1256	CLIP-seq
MIRT803688	hsa-miR-193a-5p	CLIP-seq
MIRT803713	hsa-miR-3941	CLIP-seq
MIRT803717	hsa-miR-4273	CLIP-seq
MIRT803721	hsa-miR-4420	CLIP-seq
MIRT803723	hsa-miR-4452	CLIP-seq
MIRT803725	hsa-miR-4517	CLIP-seq
MIRT803726	hsa-miR-4643	CLIP-seq
MIRT803727	hsa-miR-466	CLIP-seq
MIRT803728	hsa-miR-4662a-3p	CLIP-seq
MIRT803730	hsa-miR-4672	CLIP-seq
MIRT803731	hsa-miR-4677-5p	CLIP-seq
MIRT803732	hsa-miR-4678	CLIP-seq
MIRT803738	hsa-miR-4729	CLIP-seq
MIRT803739	hsa-miR-4789-3p	CLIP-seq
MIRT803741	hsa-miR-4795-3p	CLIP-seq
MIRT803745	hsa-miR-491-3p	CLIP-seq
MIRT803750	hsa-miR-548ag	CLIP-seq
MIRT803751	hsa-miR-548ai	CLIP-seq
MIRT803755	hsa-miR-548p	CLIP-seq
MIRT803759	hsa-miR-556-3p	CLIP-seq
MIRT803764	hsa-miR-586	CLIP-seq
MIRT803766	hsa-miR-600	CLIP-seq
MIRT803772	hsa-miR-889	CLIP-seq
MIRT803773	hsa-miR-935	CLIP-seq
MIRT803687	hsa-miR-149	CLIP-seq
MIRT803694	hsa-miR-3064-5p	CLIP-seq
MIRT803698	hsa-miR-3119	CLIP-seq
MIRT803719	hsa-miR-4325	CLIP-seq
MIRT803740	hsa-miR-4794	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
AR	Unknown	22771493
E2F1	Unknown	22771493

Gene ontology (GO) Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003682	Function	Chromatin binding	IBA
GO:0005515	Function	Protein binding	IPI	17998543, 25640309, 31527615
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	25593309
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006334	Process	Nucleosome assembly	IBA
GO:0006337	Process	Nucleosome disassembly	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0016887	Function	ATP hydrolysis activity	IDA	17998543
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0042393	Function	Histone binding	IBA
GO:0045815	Process	Transcription initiation-coupled chromatin remodeling	IBA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	17998543
GO:0070062	Component	Extracellular exosome	HDA	19056867

Other IDs

• MIM: 611941
• HGNC: 30123
• e!Ensembl: ENSG00000156802

Protein

• UniProt ID: Q6PL18
• Protein name: ATPase family AAA domain-containing protein 2 (EC 3.6.1.-) (AAA nuclear coregulator cancer-associated protein) (ANCCA)
• Protein function: May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target
• PDB: 3DAI , 4QSP , 4QSQ , 4QSR , 4QSS , 4QST , 4QSU , 4QSV , 4QSW , 4QSX , 4QUT , 4QUU , 4TT2 , 4TT4 , 4TT6 , 4TTE , 4TU4 , 4TU6 , 4TYL , 4TZ2 , 4TZ8 , 5A5N , 5A5O , 5A5P , 5A5Q , 5A5R , 5A81 , 5A82 , 5A83 , 5EPB , 5F36 , 5F3A , 5LJ0 , 5QXI , 5QXJ , 5QXK , 5QXL , 5QXM , 5QXN , 5QXO , 5QXP , 5QXQ , 5QXR , 5QXS , 5QXT , 5QXU , 5QXV , 5QXW , 5QXX , 5QXY , 5QXZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00004	AAA	463 → 598	ATPase family associated with various cellular activities (AAA)	Domain
  PF00439	Bromodomain	993 → 1074	Bromodomain	Domain
  PF17862	AAA_lid_3	621 → 680	AAA+ lid domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors. {ECO:0000269|PubMed:15721472, ECO:0000269|PubMed:17076897, ECO:0000269|PubMed:17660802}.
• Sequence:

  MVVLRSSLELHNHSAASATGSLDLSSDFLSLEHIGRRRLRSAGAAQKKPAATTAKAGDGS
  SVKEVETYHRTRALRSLRKDAQNSSDSSFEKNVEITEQLANGRHFTRQLARQQADKKKEE
  HREDKVIPVTRSLRARNIVQSTEHLHEDNGDVEVRRSCRIRSRYSGVNQSMLFDKLITNT
  AEAVLQKMDDMKKMRRQRMRELEDLGVFNETEESNLNMYTRGKQKDIQRTDEETTDNQEG
  SVESSEEGEDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEENQKRYYLRQRK
  ATVYYQAPLEKPRHQRKPNIFYSGPASPARPRYRLSSAGPRSPYCKRMNRRRHAIHSSDS
  TSSSSSEDEQHFERRRKRSRNRAINRCLPLNFRKDELKGIYKDRMKIGASLADVDPMQLD
  SSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARAL
  ANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR
  SSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPD
  KEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIYT
  TSEKLQLDLSSINISAKDFEVAMQKMIPASQRAVTSPGQALSTVVKPLLQNTVDKILEAL
  QRVFPHAEFRTNKTLDSDISCPLLESDLAYSDDDVPSVYENGLSQKSSHKAKDNFNFLHL
  NRNACYQPMSFRPRILIVGEPGFGQGSHLAPAVIHALEKFTVYTLDIPVLFGVSTTSPEE
  TCAQVIREAKRTAPSIVYVPHIHVWWEIVGPTLKATFTTLLQNIPSFAPVLLLATSDKPH
  SALPEEVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLP
  VAPPPEPRSLTAEEVKRLEEQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPD
  YVTVIKQPMDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACA
  LRDTAYAIIKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSD
  PEQNEKLKTPSTPVACSTPAQLKRKIRKKSNWYLGTIKKRRKISQAKDDSQNAIDHKIES
  DTEETQDTSVDHNETGNTGESSVEENEKQQNASESKLELRNNSNTCNIENELEDSRKTTA
  CTELRDKIACNGDASSSQIIHISDENEGKEMCVLRMTRARRSQVEQQQLITVEKALAILS
  QPTPSLVVDHERLKNLLKTVVKKSQNYNIFQLENLYAVISQCIYRHRKDHDKTSLIQKME
  QEVENFSCSR

• Sequence length: 1390

Pathways

Reactome Pathway:

TFAP2 (AP-2) family regulates transcription of growth factors and their receptors

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Colorectal cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (51)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	22914773, 23775406, 31186081		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	19843847, 20864510, 21158754, 31721721		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	17998543, 20124470, 20864510, 23393560, 24391143, 24489661, 32174193, 37922300	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	24552534, 32462022	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	22043308, 24552534, 25687855, 32462022	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	24761900, 31746426		★☆☆☆☆ Found in Text Mining only
Cerebellar Ataxia and Hypogonadotropic Hypogonadism	Cerebellar ataxia and hypogonadotropic hypogonadism	Pubtator	20864510	Associate	★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	25813398		★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	25813398		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	29958090		★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	28069330		★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	BEFREE	23393560, 25934333, 26308378		★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	23393560, 26308378, 36479043	Associate	★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	25934333	Stimulate	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	36046597	Associate	★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	35672694	Stimulate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	22043308, 24552534, 24805933, 25687855, 26497681, 31733289		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	23033341, 35672694	Associate	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	25934333, 36046597	Stimulate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	19843847, 20581866, 20864510, 31721721		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of endometrium	Endometrial Cancer	BEFREE	26308378		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	24552534, 25687855		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	20581866		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	24761900, 31746426		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	30867788		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	19318566, 23038103		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	31452712		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	19318566, 19843847, 20374707, 20855524, 23831842, 24761900, 24805933, 25934333, 26308378, 28798233, 29148850, 29958090, 31574824, 31746426, 31747529, 31789405		★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	25813398		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	17998543		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	20864510		★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	31516577		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19318566, 19843847, 20855524, 20864510, 23038103, 24761900, 25687855, 25813398, 26308378, 26497681, 31186081, 31746426, 31747529		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	32044716, 34922489	Associate	★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	24761900, 31746426		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	22174824, 24761900, 33090389, 37479754	Associate	★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	31746426	Stimulate	★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	30867788		★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	29515109		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	19318566, 23038103		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	22771493, 30009471	Associate	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	23038103		★☆☆☆☆ Found in Text Mining only
Retinoblastoma	Retinoblastoma	BEFREE	30993715		★☆☆☆☆ Found in Text Mining only
Small cell carcinoma of lung	Lung carcinoma	BEFREE	27131099		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	31747529		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	32669963	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	31452712		★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	39333272	Associate	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	20864510	Associate	★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	31789405		★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	30816541	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for ATAD2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ATAD2.