ASPHD2 (aspartate beta-hydroxylase domain containing 2)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Diseases linked via similar genes

Gene

• Entrez ID: 57168
• Gene name: Aspartate beta-hydroxylase domain containing 2
• Gene symbol: ASPHD2
• Synonyms (NCBI Gene): -
• Chromosome: 22
• Chromosome location: 22q12.1

miRNA Show/Hide all (125)

miRTarBase ID	miRNA	Experiments	Reference
MIRT803163	hsa-miR-1226	CLIP-seq
MIRT803164	hsa-miR-1227	CLIP-seq
MIRT803165	hsa-miR-1286	CLIP-seq
MIRT803166	hsa-miR-2116	CLIP-seq
MIRT803167	hsa-miR-27a	CLIP-seq
MIRT803168	hsa-miR-27b	CLIP-seq
MIRT803169	hsa-miR-323-3p	CLIP-seq
MIRT803170	hsa-miR-3918	CLIP-seq
MIRT803171	hsa-miR-412	CLIP-seq
MIRT803172	hsa-miR-4276	CLIP-seq
MIRT803173	hsa-miR-4659a-5p	CLIP-seq
MIRT803174	hsa-miR-4659b-5p	CLIP-seq
MIRT803175	hsa-miR-4677-5p	CLIP-seq
MIRT803176	hsa-miR-4722-5p	CLIP-seq
MIRT803177	hsa-miR-4768-3p	CLIP-seq
MIRT803178	hsa-miR-499a-5p	CLIP-seq
MIRT803179	hsa-miR-501-3p	CLIP-seq
MIRT803180	hsa-miR-502-3p	CLIP-seq
MIRT803181	hsa-miR-513a-5p	CLIP-seq
MIRT803182	hsa-miR-624	CLIP-seq
MIRT803163	hsa-miR-1226	CLIP-seq
MIRT803165	hsa-miR-1286	CLIP-seq
MIRT803176	hsa-miR-4722-5p	CLIP-seq
MIRT803163	hsa-miR-1226	CLIP-seq
MIRT803165	hsa-miR-1286	CLIP-seq
MIRT1937198	hsa-miR-3649	CLIP-seq
MIRT803176	hsa-miR-4722-5p	CLIP-seq
MIRT1937199	hsa-miR-501-5p	CLIP-seq
MIRT803163	hsa-miR-1226	CLIP-seq
MIRT2176859	hsa-miR-1258	CLIP-seq
MIRT803165	hsa-miR-1286	CLIP-seq
MIRT2176860	hsa-miR-1295	CLIP-seq
MIRT2176861	hsa-miR-346	CLIP-seq
MIRT2176862	hsa-miR-4717-5p	CLIP-seq
MIRT803176	hsa-miR-4722-5p	CLIP-seq
MIRT2384525	hsa-miR-1271	CLIP-seq
MIRT2384526	hsa-miR-182	CLIP-seq
MIRT2384527	hsa-miR-34a	CLIP-seq
MIRT2384528	hsa-miR-34c-5p	CLIP-seq
MIRT2384529	hsa-miR-449a	CLIP-seq
MIRT2384530	hsa-miR-449b	CLIP-seq
MIRT2384531	hsa-miR-96	CLIP-seq
MIRT2480238	hsa-miR-105	CLIP-seq
MIRT2480239	hsa-miR-1202	CLIP-seq
MIRT2480240	hsa-miR-1251	CLIP-seq
MIRT2480241	hsa-miR-1254	CLIP-seq
MIRT2176859	hsa-miR-1258	CLIP-seq
MIRT2480242	hsa-miR-1264	CLIP-seq
MIRT2176860	hsa-miR-1295	CLIP-seq
MIRT2480243	hsa-miR-1305	CLIP-seq
MIRT2480244	hsa-miR-1343	CLIP-seq
MIRT2480245	hsa-miR-1976	CLIP-seq
MIRT803166	hsa-miR-2116	CLIP-seq
MIRT2480246	hsa-miR-2355-5p	CLIP-seq
MIRT803167	hsa-miR-27a	CLIP-seq
MIRT803168	hsa-miR-27b	CLIP-seq
MIRT2480247	hsa-miR-3116	CLIP-seq
MIRT2480248	hsa-miR-3117-5p	CLIP-seq
MIRT803169	hsa-miR-323-3p	CLIP-seq
MIRT2480249	hsa-miR-326	CLIP-seq
MIRT2480250	hsa-miR-330-5p	CLIP-seq
MIRT1937198	hsa-miR-3649	CLIP-seq
MIRT2480251	hsa-miR-3652	CLIP-seq
MIRT2480252	hsa-miR-3663-5p	CLIP-seq
MIRT2480253	hsa-miR-3668	CLIP-seq
MIRT2480254	hsa-miR-3675-3p	CLIP-seq
MIRT2480255	hsa-miR-369-3p	CLIP-seq
MIRT2480256	hsa-miR-374c	CLIP-seq
MIRT2480257	hsa-miR-377	CLIP-seq
MIRT2480258	hsa-miR-3910	CLIP-seq
MIRT2480259	hsa-miR-3921	CLIP-seq
MIRT2480260	hsa-miR-3972	CLIP-seq
MIRT803171	hsa-miR-412	CLIP-seq
MIRT2480261	hsa-miR-4294	CLIP-seq
MIRT2480262	hsa-miR-4315	CLIP-seq
MIRT2480263	hsa-miR-4430	CLIP-seq
MIRT2480264	hsa-miR-4474-3p	CLIP-seq
MIRT2480265	hsa-miR-4485	CLIP-seq
MIRT2480266	hsa-miR-4505	CLIP-seq
MIRT2480267	hsa-miR-4653-5p	CLIP-seq
MIRT2480268	hsa-miR-4659a-3p	CLIP-seq
MIRT2480269	hsa-miR-4659b-3p	CLIP-seq
MIRT803175	hsa-miR-4677-5p	CLIP-seq
MIRT2176862	hsa-miR-4717-5p	CLIP-seq
MIRT2480270	hsa-miR-4743	CLIP-seq
MIRT803177	hsa-miR-4768-3p	CLIP-seq
MIRT2480271	hsa-miR-4786-5p	CLIP-seq
MIRT2480272	hsa-miR-507	CLIP-seq
MIRT2480273	hsa-miR-509-3p	CLIP-seq
MIRT803181	hsa-miR-513a-5p	CLIP-seq
MIRT2480274	hsa-miR-548aa	CLIP-seq
MIRT2480275	hsa-miR-548an	CLIP-seq
MIRT2480276	hsa-miR-548q	CLIP-seq
MIRT2480277	hsa-miR-557	CLIP-seq
MIRT2480278	hsa-miR-582-3p	CLIP-seq
MIRT2480279	hsa-miR-593	CLIP-seq
MIRT803182	hsa-miR-624	CLIP-seq
MIRT2480280	hsa-miR-634	CLIP-seq
MIRT2480281	hsa-miR-644	CLIP-seq
MIRT2480282	hsa-miR-648	CLIP-seq
MIRT2480283	hsa-miR-655	CLIP-seq
MIRT2480284	hsa-miR-661	CLIP-seq
MIRT2480285	hsa-miR-668	CLIP-seq
MIRT2480286	hsa-miR-767-3p	CLIP-seq
MIRT2480287	hsa-miR-888	CLIP-seq
MIRT2480288	hsa-miR-892a	CLIP-seq
MIRT2176859	hsa-miR-1258	CLIP-seq
MIRT2480242	hsa-miR-1264	CLIP-seq
MIRT2176860	hsa-miR-1295	CLIP-seq
MIRT2480244	hsa-miR-1343	CLIP-seq
MIRT2480245	hsa-miR-1976	CLIP-seq
MIRT803166	hsa-miR-2116	CLIP-seq
MIRT2480249	hsa-miR-326	CLIP-seq
MIRT2480250	hsa-miR-330-5p	CLIP-seq
MIRT1937198	hsa-miR-3649	CLIP-seq
MIRT2480252	hsa-miR-3663-5p	CLIP-seq
MIRT2480259	hsa-miR-3921	CLIP-seq
MIRT2480261	hsa-miR-4294	CLIP-seq
MIRT2480267	hsa-miR-4653-5p	CLIP-seq
MIRT803175	hsa-miR-4677-5p	CLIP-seq
MIRT2176862	hsa-miR-4717-5p	CLIP-seq
MIRT2480278	hsa-miR-582-3p	CLIP-seq
MIRT2480279	hsa-miR-593	CLIP-seq
MIRT803182	hsa-miR-624	CLIP-seq
MIRT2480285	hsa-miR-668	CLIP-seq

Gene ontology (GO) Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051213	Function	Dioxygenase activity	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q6ICH7
• Protein name: Aspartate beta-hydroxylase domain-containing protein 2 (EC 1.14.11.-)
• Protein function: May function as 2-oxoglutarate-dependent dioxygenase.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05118	Asp_Arg_Hydrox	192 → 351	Aspartyl/Asparaginyl beta-hydroxylase	Domain

• Sequence:

  MVWAPLGPPRTDCLTLLHTPSKDSPKMSLEWLVAWSWSLDGLRDCIATGIQSVRDCDTTA
  VITVACLLVLFVWYCYHVGREQPRPYVSVNSLMQAADANGLQNGYVYCQSPECVRCTHNE
  GLNQKLYHNLQEYAKRYSWSGMGRIHKGIREQGRYLNSRPSIQKPEVFFLPDLPTTPYFS
  RDAQKHDVEVLERNFQTILCEFETLYKAFSNCSLPQGWKMNSTPSGEWFTFYLVNQGVCV
  PRNCRKCPRTYRLLGSLRTCIGNNVFGNACISVLSPGTVITEHYGPTNIRIRCHLGLKTP
  NGCELVVGGEPQCWAEGRCLLFDDSFLHAAFHEGSAEDGPRVVFMVDLWHPNVAAAERQA
  LDFIFAPGR

• Sequence length: 369

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Cervical cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

No strongly related genes found yet for ASPHD2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ASPHD2.