ASCL5 (achaete-scute family bHLH transcription factor 5)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 647219
• Gene name: Achaete-scute family bHLH transcription factor 5
• Gene symbol: ASCL5
• Synonyms (NCBI Gene): ASH-5, AmeloD, bHLHa47
• Chromosome: 1
• Chromosome location: 1q32.1

miRNA Show/Hide all (64)

miRTarBase ID	miRNA	Experiments	Reference
MIRT708906	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT708905	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT708904	hsa-miR-5695	HITS-CLIP	19536157
MIRT708903	hsa-miR-6781-5p	HITS-CLIP	19536157
MIRT708902	hsa-miR-128-1-5p	HITS-CLIP	19536157
MIRT708901	hsa-miR-128-2-5p	HITS-CLIP	19536157
MIRT708899	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT708900	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT708906	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT708905	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT708904	hsa-miR-5695	HITS-CLIP	19536157
MIRT708903	hsa-miR-6781-5p	HITS-CLIP	19536157
MIRT708902	hsa-miR-128-1-5p	HITS-CLIP	19536157
MIRT708901	hsa-miR-128-2-5p	HITS-CLIP	19536157
MIRT708899	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT708900	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT708906	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT708905	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT708904	hsa-miR-5695	HITS-CLIP	19536157
MIRT708903	hsa-miR-6781-5p	HITS-CLIP	19536157
MIRT708902	hsa-miR-128-1-5p	HITS-CLIP	19536157
MIRT708901	hsa-miR-128-2-5p	HITS-CLIP	19536157
MIRT708899	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT708900	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT708906	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT708905	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT708904	hsa-miR-5695	HITS-CLIP	19536157
MIRT708903	hsa-miR-6781-5p	HITS-CLIP	19536157
MIRT708902	hsa-miR-128-1-5p	HITS-CLIP	19536157
MIRT708901	hsa-miR-128-2-5p	HITS-CLIP	19536157
MIRT708899	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT708900	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT708906	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT708905	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT708904	hsa-miR-5695	HITS-CLIP	19536157
MIRT708903	hsa-miR-6781-5p	HITS-CLIP	19536157
MIRT708902	hsa-miR-128-1-5p	HITS-CLIP	19536157
MIRT708901	hsa-miR-128-2-5p	HITS-CLIP	19536157
MIRT708899	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT708900	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT708906	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT708905	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT708904	hsa-miR-5695	HITS-CLIP	19536157
MIRT708903	hsa-miR-6781-5p	HITS-CLIP	19536157
MIRT708902	hsa-miR-128-1-5p	HITS-CLIP	19536157
MIRT708901	hsa-miR-128-2-5p	HITS-CLIP	19536157
MIRT708899	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT708900	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT708906	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT708905	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT708904	hsa-miR-5695	HITS-CLIP	19536157
MIRT708903	hsa-miR-6781-5p	HITS-CLIP	19536157
MIRT708902	hsa-miR-128-1-5p	HITS-CLIP	19536157
MIRT708901	hsa-miR-128-2-5p	HITS-CLIP	19536157
MIRT708899	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT708900	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT708906	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT708905	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT708904	hsa-miR-5695	HITS-CLIP	19536157
MIRT708903	hsa-miR-6781-5p	HITS-CLIP	19536157
MIRT708902	hsa-miR-128-1-5p	HITS-CLIP	19536157
MIRT708901	hsa-miR-128-2-5p	HITS-CLIP	19536157
MIRT708899	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT708900	hsa-miR-6792-3p	HITS-CLIP	19536157

Gene ontology (GO) Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005667	Component	Transcription regulator complex	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0046983	Function	Protein dimerization activity	IEA
GO:0048513	Process	Animal organ development	IEA
GO:0060429	Process	Epithelium development	IEA
GO:0090575	Component	RNA polymerase II transcription regulator complex	IBA

Other IDs

• MIM: 620809
• HGNC: 33169
• e!Ensembl: ENSG00000232237

Protein

• UniProt ID: Q7RTU5
• Protein name: Achaete-scute homolog 5 (ASH-5) (hASH5) (Class A basic helix-loop-helix protein 47) (bHLHa47)
• Protein function: Transcription factor. Probably binds E-box motifs 5'-CANNTG-3' in complex with transcription factor TCF3/E12. Negatively modulates transcription of target genes such as CDH1/E-cadherin, perhaps by recruiting the PRC2 repressive complex to regula
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00010	HLH	157 → 208	Helix-loop-helix DNA-binding domain	Domain

• Sequence:

  MPMGAAERGAGPQSSAAPWAGSEKAAKRGPSKSWYPRAAASDVTCPTGGDGADPKPGPFG
  GGLALGPAPRGTMNNNFCRALVDRRPLGPPSCMQLGVMPPPRQAPLPPAEPLGNVPFLLY
  PGPAEPPYYDAYAGVFPYVPFPGAFGVYEYPFEPAFIQKRNERERQRVKCVNEGYARLRG
  HLPGALAEKRLSKVETLRAAIRYIKYLQELLSSAPDGSTPPASRGLPGTGPCPAPPATPR
  PDRPGDGEARAPSSLVPESSESSCFSPSPFLESEESWH

• Sequence length: 278

Related Genes

No strongly related genes found yet for ASCL5.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ASCL5.