ASB5 (ankyrin repeat and SOCS box containing 5)

Download as csv Download as pdf

Log in to save this analysis

Save This Analysis

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 140458
• Gene name: Ankyrin repeat and SOCS box containing 5
• Gene symbol: ASB5
• Synonyms (NCBI Gene): ASB-5
• Chromosome: 4
• Chromosome location: 4q34.2
• Summary: The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins

miRNA Show/Hide all (51)

miRTarBase ID	miRNA	Experiments	Reference
MIRT802328	hsa-miR-1200	CLIP-seq
MIRT802329	hsa-miR-1290	CLIP-seq
MIRT802330	hsa-miR-1297	CLIP-seq
MIRT802331	hsa-miR-137	CLIP-seq
MIRT802332	hsa-miR-25	CLIP-seq
MIRT802333	hsa-miR-26a	CLIP-seq
MIRT802334	hsa-miR-26b	CLIP-seq
MIRT802335	hsa-miR-3074-5p	CLIP-seq
MIRT802336	hsa-miR-3124-3p	CLIP-seq
MIRT802337	hsa-miR-3140-5p	CLIP-seq
MIRT802338	hsa-miR-3167	CLIP-seq
MIRT802339	hsa-miR-32	CLIP-seq
MIRT802340	hsa-miR-363	CLIP-seq
MIRT802341	hsa-miR-3646	CLIP-seq
MIRT802342	hsa-miR-3647-3p	CLIP-seq
MIRT802343	hsa-miR-3662	CLIP-seq
MIRT802344	hsa-miR-367	CLIP-seq
MIRT802345	hsa-miR-3681	CLIP-seq
MIRT802346	hsa-miR-374c	CLIP-seq
MIRT802347	hsa-miR-4325	CLIP-seq
MIRT802348	hsa-miR-4446-5p	CLIP-seq
MIRT802349	hsa-miR-4465	CLIP-seq
MIRT802350	hsa-miR-4666-3p	CLIP-seq
MIRT802351	hsa-miR-518a-5p	CLIP-seq
MIRT802352	hsa-miR-527	CLIP-seq
MIRT802353	hsa-miR-570	CLIP-seq
MIRT802354	hsa-miR-655	CLIP-seq
MIRT802355	hsa-miR-876-5p	CLIP-seq
MIRT802356	hsa-miR-92a	CLIP-seq
MIRT802357	hsa-miR-92b	CLIP-seq
MIRT802348	hsa-miR-4446-5p	CLIP-seq
MIRT802350	hsa-miR-4666-3p	CLIP-seq
MIRT802348	hsa-miR-4446-5p	CLIP-seq
MIRT802350	hsa-miR-4666-3p	CLIP-seq
MIRT802348	hsa-miR-4446-5p	CLIP-seq
MIRT802350	hsa-miR-4666-3p	CLIP-seq
MIRT802348	hsa-miR-4446-5p	CLIP-seq
MIRT802350	hsa-miR-4666-3p	CLIP-seq
MIRT1936872	hsa-miR-216a	CLIP-seq
MIRT1936873	hsa-miR-3065-5p	CLIP-seq
MIRT802337	hsa-miR-3140-5p	CLIP-seq
MIRT1936874	hsa-miR-3163	CLIP-seq
MIRT802342	hsa-miR-3647-3p	CLIP-seq
MIRT1936875	hsa-miR-4282	CLIP-seq
MIRT1936876	hsa-miR-4307	CLIP-seq
MIRT1936877	hsa-miR-4680-3p	CLIP-seq
MIRT1936878	hsa-miR-495	CLIP-seq
MIRT1936879	hsa-miR-520d-5p	CLIP-seq
MIRT1936880	hsa-miR-524-5p	CLIP-seq
MIRT2444083	hsa-miR-3121-3p	CLIP-seq
MIRT2444084	hsa-miR-548p	CLIP-seq

Gene ontology (GO) Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0016567	Process	Protein ubiquitination	IBA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0045732	Process	Positive regulation of protein catabolic process	IBA

Other IDs

• MIM: 615050
• HGNC: 17180
• e!Ensembl: ENSG00000164122

Protein

• UniProt ID: Q8WWX0
• Protein name: Ankyrin repeat and SOCS box protein 5 (ASB-5)
• Protein function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07525	SOCS_box	290 → 328	SOCS box	Domain
  PF12796	Ank_2	74 → 166	Ankyrin repeats (3 copies)	Repeat
  PF12796	Ank_2	172 → 263	Ankyrin repeats (3 copies)	Repeat

• Sequence:

  MSVLEENRPFAQQLSNVYFTILSLFCFKLFVKISLAILSHFYIVKGNRKEAARIAAEFYG
  VTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACAR
  TLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGH
  HECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGKYWDTPLHAA
  AQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPSSLYQLCRLC
  IRSYIGKPRLHLIPQLQLPTLLKNFLQYR

• Sequence length: 329

Pathways

Reactome Pathway

Neddylation

Antigen processing: Ubiquitination & Proteasome degradation

Related Genes

No strongly related genes found yet for ASB5.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ASB5.