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Gene Gene information from NCBI Gene database.
Entrez ID 140456
Gene name Ankyrin repeat and SOCS box containing 11
Gene symbol ASB11
Synonyms (NCBI Gene)
-
Chromosome X
Chromosome location Xp22.2
Summary The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins
miRNA miRNA information provided by mirtarbase database.
400 Show/Hide all (400)
miRTarBase ID miRNA Experiments Reference
MIRT017058 hsa-miR-335-5p Microarray 18185580
MIRT716013 hsa-miR-4803 HITS-CLIP 19536157
MIRT716012 hsa-miR-6889-3p HITS-CLIP 19536157
MIRT716011 hsa-miR-5008-3p HITS-CLIP 19536157
MIRT716010 hsa-miR-6737-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14 Show/Hide all (14)
GO ID Ontology Definition Evidence Reference
GO:0005783 Component Endoplasmic reticulum IDA 24337577
GO:0005783 Component Endoplasmic reticulum IEA
GO:0005829 Component Cytosol IEA
GO:0005829 Component Cytosol TAS
GO:0016567 Process Protein ubiquitination IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
300626 17186 ENSG00000165192
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8WXH4
Protein name Ankyrin repeat and SOCS box protein 11 (ASB-11)
Protein function Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as BIK, DIRAS2 and R
PDB 4UUC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07525 SOCS_box 284 → 322 SOCS box Domain
PF12796 Ank_2 69 → 162 Ankyrin repeats (3 copies) Repeat
PF12796 Ank_2 156 → 226 Ankyrin repeats (3 copies) Repeat
PF12796 Ank_2 33 → 125 Ankyrin repeats (3 copies) Repeat
PF13637 Ank_4 228 → 281 Repeat
Sequence
MEDGPVFYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGIS
DCWADRSP
LHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLEN
GAHVN
GVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECME
ILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQ
WLDTPLHAAARQSN
VEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLR
EGPPALSQLCRLCVRKCLG
RACHQAIHKLHLPEPLERFLLY
Q
Sequence length 323
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Melanoma Benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1 Benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Melanoma Melanoma Pubtator 37848033 Associate
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations