ARL4D (ARF like GTPase 4D)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 379
• Gene name: ARF like GTPase 4D
• Gene symbol: ARL4D
• Synonyms (NCBI Gene): ARF4L
• Chromosome: 17
• Chromosome location: 17q21.31
• Summary: ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This prote

miRNA Show/Hide all (234)

miRTarBase ID	miRNA	Experiments	Reference
MIRT718586	hsa-miR-224-5p	HITS-CLIP	19536157
MIRT718585	hsa-miR-4733-5p	HITS-CLIP	19536157
MIRT718584	hsa-miR-6729-3p	HITS-CLIP	19536157
MIRT718583	hsa-miR-3691-3p	HITS-CLIP	19536157
MIRT718582	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT718581	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT718580	hsa-miR-5695	HITS-CLIP	19536157
MIRT718579	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT718578	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT450047	hsa-miR-5680	PAR-CLIP	22100165
MIRT450046	hsa-miR-4635	PAR-CLIP	22100165
MIRT450045	hsa-miR-219b-3p	PAR-CLIP	22100165
MIRT450044	hsa-miR-219a-2-3p	PAR-CLIP	22100165
MIRT450043	hsa-miR-183-3p	PAR-CLIP	22100165
MIRT450042	hsa-miR-4452	PAR-CLIP	22100165
MIRT718586	hsa-miR-224-5p	HITS-CLIP	19536157
MIRT718585	hsa-miR-4733-5p	HITS-CLIP	19536157
MIRT718584	hsa-miR-6729-3p	HITS-CLIP	19536157
MIRT718583	hsa-miR-3691-3p	HITS-CLIP	19536157
MIRT718582	hsa-miR-186-3p	HITS-CLIP	19536157
MIRT718581	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT718580	hsa-miR-5695	HITS-CLIP	19536157
MIRT718579	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT718578	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT450047	hsa-miR-5680	PAR-CLIP	22100165
MIRT450046	hsa-miR-4635	PAR-CLIP	22100165
MIRT450045	hsa-miR-219b-3p	PAR-CLIP	22100165
MIRT450044	hsa-miR-219a-2-3p	PAR-CLIP	22100165
MIRT450043	hsa-miR-183-3p	PAR-CLIP	22100165
MIRT450042	hsa-miR-4452	PAR-CLIP	22100165
MIRT798084	hsa-let-7a	CLIP-seq
MIRT798085	hsa-let-7b	CLIP-seq
MIRT798086	hsa-let-7c	CLIP-seq
MIRT798087	hsa-let-7d	CLIP-seq
MIRT798088	hsa-let-7e	CLIP-seq
MIRT798089	hsa-let-7f	CLIP-seq
MIRT798090	hsa-let-7g	CLIP-seq
MIRT798091	hsa-let-7i	CLIP-seq
MIRT798092	hsa-miR-1197	CLIP-seq
MIRT798093	hsa-miR-1253	CLIP-seq
MIRT798094	hsa-miR-1255a	CLIP-seq
MIRT798095	hsa-miR-1255b	CLIP-seq
MIRT798096	hsa-miR-1271	CLIP-seq
MIRT798097	hsa-miR-128	CLIP-seq
MIRT798098	hsa-miR-27a	CLIP-seq
MIRT798099	hsa-miR-27b	CLIP-seq
MIRT798100	hsa-miR-3130-3p	CLIP-seq
MIRT798101	hsa-miR-3136-5p	CLIP-seq
MIRT798102	hsa-miR-3138	CLIP-seq
MIRT798103	hsa-miR-3150a-3p	CLIP-seq
MIRT798104	hsa-miR-3151	CLIP-seq
MIRT798105	hsa-miR-3175	CLIP-seq
MIRT798106	hsa-miR-345	CLIP-seq
MIRT798107	hsa-miR-3605-5p	CLIP-seq
MIRT798108	hsa-miR-3617	CLIP-seq
MIRT798109	hsa-miR-369-3p	CLIP-seq
MIRT798110	hsa-miR-374c	CLIP-seq
MIRT798111	hsa-miR-3919	CLIP-seq
MIRT798112	hsa-miR-3927	CLIP-seq
MIRT798113	hsa-miR-4438	CLIP-seq
MIRT798114	hsa-miR-4439	CLIP-seq
MIRT798115	hsa-miR-4447	CLIP-seq
MIRT798116	hsa-miR-4451	CLIP-seq
MIRT798117	hsa-miR-4458	CLIP-seq
MIRT798118	hsa-miR-4472	CLIP-seq
MIRT798119	hsa-miR-4500	CLIP-seq
MIRT798120	hsa-miR-4513	CLIP-seq
MIRT798121	hsa-miR-4520a-3p	CLIP-seq
MIRT798122	hsa-miR-4662a-5p	CLIP-seq
MIRT798123	hsa-miR-4676-5p	CLIP-seq
MIRT798124	hsa-miR-4712-3p	CLIP-seq
MIRT798125	hsa-miR-4728-5p	CLIP-seq
MIRT798126	hsa-miR-4797-5p	CLIP-seq
MIRT798127	hsa-miR-491-5p	CLIP-seq
MIRT798128	hsa-miR-513a-5p	CLIP-seq
MIRT798129	hsa-miR-518a-5p	CLIP-seq
MIRT798130	hsa-miR-527	CLIP-seq
MIRT798131	hsa-miR-575	CLIP-seq
MIRT798132	hsa-miR-622	CLIP-seq
MIRT798133	hsa-miR-641	CLIP-seq
MIRT798134	hsa-miR-655	CLIP-seq
MIRT798135	hsa-miR-939	CLIP-seq
MIRT798136	hsa-miR-96	CLIP-seq
MIRT798137	hsa-miR-98	CLIP-seq
MIRT1935727	hsa-miR-199a-5p	CLIP-seq
MIRT1935728	hsa-miR-199b-5p	CLIP-seq
MIRT798098	hsa-miR-27a	CLIP-seq
MIRT798099	hsa-miR-27b	CLIP-seq
MIRT1935729	hsa-miR-4286	CLIP-seq
MIRT1935730	hsa-miR-4302	CLIP-seq
MIRT798084	hsa-let-7a	CLIP-seq
MIRT798085	hsa-let-7b	CLIP-seq
MIRT798086	hsa-let-7c	CLIP-seq
MIRT798087	hsa-let-7d	CLIP-seq
MIRT798088	hsa-let-7e	CLIP-seq
MIRT798089	hsa-let-7f	CLIP-seq
MIRT798090	hsa-let-7g	CLIP-seq
MIRT798091	hsa-let-7i	CLIP-seq
MIRT798092	hsa-miR-1197	CLIP-seq
MIRT2175831	hsa-miR-1224-3p	CLIP-seq
MIRT2175832	hsa-miR-1260	CLIP-seq
MIRT2175833	hsa-miR-1260b	CLIP-seq
MIRT798097	hsa-miR-128	CLIP-seq
MIRT2175834	hsa-miR-1280	CLIP-seq
MIRT2175835	hsa-miR-21	CLIP-seq
MIRT798098	hsa-miR-27a	CLIP-seq
MIRT798099	hsa-miR-27b	CLIP-seq
MIRT2175836	hsa-miR-3125	CLIP-seq
MIRT798103	hsa-miR-3150a-3p	CLIP-seq
MIRT2175837	hsa-miR-3163	CLIP-seq
MIRT798105	hsa-miR-3175	CLIP-seq
MIRT2175838	hsa-miR-3179	CLIP-seq
MIRT2175839	hsa-miR-3202	CLIP-seq
MIRT2175840	hsa-miR-340	CLIP-seq
MIRT2175841	hsa-miR-3620	CLIP-seq
MIRT2175842	hsa-miR-370	CLIP-seq
MIRT2175843	hsa-miR-3916	CLIP-seq
MIRT798112	hsa-miR-3927	CLIP-seq
MIRT2175844	hsa-miR-3944-5p	CLIP-seq
MIRT2175845	hsa-miR-4281	CLIP-seq
MIRT798113	hsa-miR-4438	CLIP-seq
MIRT798116	hsa-miR-4451	CLIP-seq
MIRT798117	hsa-miR-4458	CLIP-seq
MIRT2175846	hsa-miR-4476	CLIP-seq
MIRT798119	hsa-miR-4500	CLIP-seq
MIRT2175847	hsa-miR-4667-5p	CLIP-seq
MIRT2175848	hsa-miR-4700-5p	CLIP-seq
MIRT798125	hsa-miR-4728-5p	CLIP-seq
MIRT798128	hsa-miR-513a-5p	CLIP-seq
MIRT2175849	hsa-miR-590-5p	CLIP-seq
MIRT2175850	hsa-miR-595	CLIP-seq
MIRT2175851	hsa-miR-626	CLIP-seq
MIRT2175852	hsa-miR-648	CLIP-seq
MIRT2175853	hsa-miR-661	CLIP-seq
MIRT798135	hsa-miR-939	CLIP-seq
MIRT798137	hsa-miR-98	CLIP-seq
MIRT2426470	hsa-miR-105	CLIP-seq
MIRT798113	hsa-miR-4438	CLIP-seq
MIRT2426471	hsa-miR-4742-5p	CLIP-seq
MIRT2426472	hsa-miR-5095	CLIP-seq
MIRT2175831	hsa-miR-1224-3p	CLIP-seq
MIRT2175832	hsa-miR-1260	CLIP-seq
MIRT2175833	hsa-miR-1260b	CLIP-seq
MIRT2479128	hsa-miR-1275	CLIP-seq
MIRT2175834	hsa-miR-1280	CLIP-seq
MIRT2479129	hsa-miR-1321	CLIP-seq
MIRT2479130	hsa-miR-134	CLIP-seq
MIRT2479131	hsa-miR-2355-5p	CLIP-seq
MIRT2479132	hsa-miR-3118	CLIP-seq
MIRT2175836	hsa-miR-3125	CLIP-seq
MIRT798103	hsa-miR-3150a-3p	CLIP-seq
MIRT2479133	hsa-miR-3164	CLIP-seq
MIRT2479134	hsa-miR-3166	CLIP-seq
MIRT798105	hsa-miR-3175	CLIP-seq
MIRT2175838	hsa-miR-3179	CLIP-seq
MIRT2175839	hsa-miR-3202	CLIP-seq
MIRT2175841	hsa-miR-3620	CLIP-seq
MIRT2479135	hsa-miR-3689a-3p	CLIP-seq
MIRT2479136	hsa-miR-3689c	CLIP-seq
MIRT2175842	hsa-miR-370	CLIP-seq
MIRT2479137	hsa-miR-384	CLIP-seq
MIRT2175843	hsa-miR-3916	CLIP-seq
MIRT2175844	hsa-miR-3944-5p	CLIP-seq
MIRT2479138	hsa-miR-4259	CLIP-seq
MIRT2175845	hsa-miR-4281	CLIP-seq
MIRT798113	hsa-miR-4438	CLIP-seq
MIRT2175846	hsa-miR-4476	CLIP-seq
MIRT2479139	hsa-miR-4501	CLIP-seq
MIRT2479140	hsa-miR-4525	CLIP-seq
MIRT2479141	hsa-miR-4665-5p	CLIP-seq
MIRT2175847	hsa-miR-4667-5p	CLIP-seq
MIRT2175848	hsa-miR-4700-5p	CLIP-seq
MIRT2479142	hsa-miR-4723-5p	CLIP-seq
MIRT798125	hsa-miR-4728-5p	CLIP-seq
MIRT2479143	hsa-miR-4739	CLIP-seq
MIRT2479144	hsa-miR-4756-5p	CLIP-seq
MIRT2479145	hsa-miR-4771	CLIP-seq
MIRT2479146	hsa-miR-4774-5p	CLIP-seq
MIRT798128	hsa-miR-513a-5p	CLIP-seq
MIRT2479147	hsa-miR-548ac	CLIP-seq
MIRT2479148	hsa-miR-548ae	CLIP-seq
MIRT2479149	hsa-miR-548aj	CLIP-seq
MIRT2479150	hsa-miR-548am	CLIP-seq
MIRT2479151	hsa-miR-548d-3p	CLIP-seq
MIRT2479152	hsa-miR-548x	CLIP-seq
MIRT2479153	hsa-miR-548z	CLIP-seq
MIRT2175850	hsa-miR-595	CLIP-seq
MIRT2479154	hsa-miR-625	CLIP-seq
MIRT2175851	hsa-miR-626	CLIP-seq
MIRT2175852	hsa-miR-648	CLIP-seq
MIRT2175853	hsa-miR-661	CLIP-seq
MIRT798135	hsa-miR-939	CLIP-seq
MIRT2175831	hsa-miR-1224-3p	CLIP-seq
MIRT2175832	hsa-miR-1260	CLIP-seq
MIRT2175833	hsa-miR-1260b	CLIP-seq
MIRT2175834	hsa-miR-1280	CLIP-seq
MIRT2479129	hsa-miR-1321	CLIP-seq
MIRT2479130	hsa-miR-134	CLIP-seq
MIRT2479131	hsa-miR-2355-5p	CLIP-seq
MIRT2479132	hsa-miR-3118	CLIP-seq
MIRT798103	hsa-miR-3150a-3p	CLIP-seq
MIRT2479133	hsa-miR-3164	CLIP-seq
MIRT2479134	hsa-miR-3166	CLIP-seq
MIRT798105	hsa-miR-3175	CLIP-seq
MIRT2175841	hsa-miR-3620	CLIP-seq
MIRT2479135	hsa-miR-3689a-3p	CLIP-seq
MIRT2479136	hsa-miR-3689c	CLIP-seq
MIRT2175842	hsa-miR-370	CLIP-seq
MIRT2479137	hsa-miR-384	CLIP-seq
MIRT2175844	hsa-miR-3944-5p	CLIP-seq
MIRT2479138	hsa-miR-4259	CLIP-seq
MIRT2175845	hsa-miR-4281	CLIP-seq
MIRT798113	hsa-miR-4438	CLIP-seq
MIRT2479139	hsa-miR-4501	CLIP-seq
MIRT2175847	hsa-miR-4667-5p	CLIP-seq
MIRT2175848	hsa-miR-4700-5p	CLIP-seq
MIRT798125	hsa-miR-4728-5p	CLIP-seq
MIRT2479143	hsa-miR-4739	CLIP-seq
MIRT2479144	hsa-miR-4756-5p	CLIP-seq
MIRT2479145	hsa-miR-4771	CLIP-seq
MIRT2479146	hsa-miR-4774-5p	CLIP-seq
MIRT798128	hsa-miR-513a-5p	CLIP-seq
MIRT2479147	hsa-miR-548ac	CLIP-seq
MIRT2479148	hsa-miR-548ae	CLIP-seq
MIRT2479149	hsa-miR-548aj	CLIP-seq
MIRT2479150	hsa-miR-548am	CLIP-seq
MIRT2479151	hsa-miR-548d-3p	CLIP-seq
MIRT2479152	hsa-miR-548x	CLIP-seq
MIRT2479153	hsa-miR-548z	CLIP-seq
MIRT2175850	hsa-miR-595	CLIP-seq
MIRT2175851	hsa-miR-626	CLIP-seq
MIRT2175852	hsa-miR-648	CLIP-seq
MIRT2175853	hsa-miR-661	CLIP-seq
MIRT798135	hsa-miR-939	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IEA
GO:0003924	Function	GTPase activity	TAS	7590735
GO:0005515	Function	Protein binding	IPI	17398095, 25416956
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	17398095
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	17398095
GO:0005886	Component	Plasma membrane	IEA
GO:0006886	Process	Intracellular protein transport	IBA
GO:0009306	Process	Protein secretion	TAS	7590735
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IBA

Other IDs

• MIM: 600732
• HGNC: 656
• e!Ensembl: ENSG00000175906

Protein

• UniProt ID: P49703
• Protein name: ADP-ribosylation factor-like protein 4D (ADP-ribosylation factor-like protein 4L)
• Protein function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that d
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00025	Arf	10 → 187	ADP-ribosylation factor family	Domain

• Sequence:

  MGNHLTEMAPTASSFLPHFQALHVVVIGLDSAGKTSLLYRLKFKEFVQSVPTKGFNTEKI
  RVPLGGSRGITFQVWDVGGQEKLRPLWRSYTRRTDGLVFVVDAAEAERLEEAKVELHRIS
  RASDNQGVPVLVLANKQDQPGALSAAEVEKRLAVRELAAATLTHVQGCSAVDGLGLQQGL
  ERLYEMILKRKKAARGGKKRR

• Sequence length: 201

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (8)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Brain Neoplasms	Brain Neoplasms	BEFREE	12472661		★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	LHGDN	12472661		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	18240926		★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Medulloblastoma	Pubtator	36273157	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	18240926		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	34585646	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	31959204	Associate	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	38172584	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for ARL4D.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ARL4D.