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Gene Gene information from NCBI Gene database.
Entrez ID 494470
Gene name Arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C
Gene symbol ARK2C
Synonyms (NCBI Gene)
ARKL2RNF111L2RNF165lncAMPC
Chromosome 18
Chromosome location 18q21.1
miRNA miRNA information provided by mirtarbase database.
305 Show/Hide all (305)
miRTarBase ID miRNA Experiments Reference
MIRT724359 hsa-miR-4682 HITS-CLIP 19536157
MIRT724358 hsa-miR-6857-3p HITS-CLIP 19536157
MIRT724357 hsa-miR-4740-5p HITS-CLIP 19536157
MIRT724356 hsa-miR-1288-3p HITS-CLIP 19536157
MIRT724355 hsa-miR-4515 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20 Show/Hide all (20)
GO ID Ontology Definition Evidence Reference
GO:0000209 Process Protein polyubiquitination IEA
GO:0005515 Function Protein binding IPI 23610558
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
GO:0007409 Process Axonogenesis IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6ZSG1
Protein name E3 ubiquitin-protein ligase ARK2C (EC 2.3.2.27) (RING finger protein 165) (RNF165)
Protein function E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated
PDB 5D0I , 5D0K , 5D0M , 5ULH , 5ULK , 7R70 , 7R71
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13639 zf-RING_2 292 → 335 Ring finger domain Domain
Sequence
MVLVHVGYLVLPVFGSVRNRGAPFQRSQHPHATSCRHFHLGPPQPQQLAPDFPLAHPVQS
QPGLSAHMAPAHQHSGALHQSLTPLPTLQFQDVTGPSFLPQALHQQYLLQQQLLEAQHRR
LVSHPRRSQERVSVHPHRLHPSFDFGQLQTPQPRYLAEGTDWDLSVDAGLSPAQFQVRPI
PQHYQHYLATPRMHHFPRNSSSTQMVVHEIRNYPYPQLHFLALQGLNPSRHTSAVRESYE
ELLQLEDRLGNVTRGAVQNTIERFTFPHKYKKRRPQDGKGKKDEGEESDTDEKCTICLSM
LEDGEDVRRLPCMHLFHQLCVDQWLAMSKKCPICR
VDIETQLGADS
Sequence length 346
Interactions View interactions