Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	378
Gene name	ARF GTPase 4
Gene symbol	ARF4
Synonyms (NCBI Gene)	ARF2
Chromosome	3
Chromosome location	3p14.3
Summary	This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipa

263 Show/Hide all (263)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002823	hsa-miR-1-3p	pSILAC	18668040
MIRT004061	hsa-miR-7-5p	Microarray	19073608
MIRT002823	hsa-miR-1-3p	Microarray	15685193
MIRT020084	hsa-miR-361-5p	Sequencing	20371350
MIRT021610	hsa-miR-142-3p	Microarray	17612493
MIRT002823	hsa-miR-1-3p	Proteomics	18668040
MIRT002823	hsa-miR-1-3p	Microarray	15685193
MIRT004061	hsa-miR-7-5p	Microarray;Other	19073608
MIRT731951	hsa-miR-221-3p	Luciferase reporter assay	28057486
MIRT731951	hsa-miR-221-3p	Luciferase reporter assay	28057486
MIRT731951	hsa-miR-221-3p	Luciferase reporter assayqRT-PCRWestern blot	28025995
MIRT731951	hsa-miR-221-3p	Luciferase reporter assayqRT-PCRWestern blot	28025995
MIRT792435	hsa-miR-1238	CLIP-seq
MIRT792436	hsa-miR-130a	CLIP-seq
MIRT792437	hsa-miR-130b	CLIP-seq
MIRT792438	hsa-miR-148a	CLIP-seq
MIRT792439	hsa-miR-148b	CLIP-seq
MIRT792440	hsa-miR-149	CLIP-seq
MIRT792441	hsa-miR-152	CLIP-seq
MIRT792442	hsa-miR-194	CLIP-seq
MIRT792443	hsa-miR-198	CLIP-seq
MIRT792444	hsa-miR-2052	CLIP-seq
MIRT792445	hsa-miR-301a	CLIP-seq
MIRT792446	hsa-miR-301b	CLIP-seq
MIRT792447	hsa-miR-3064-5p	CLIP-seq
MIRT792448	hsa-miR-3115	CLIP-seq
MIRT792449	hsa-miR-3129-3p	CLIP-seq
MIRT792450	hsa-miR-3148	CLIP-seq
MIRT792451	hsa-miR-3160-3p	CLIP-seq
MIRT792452	hsa-miR-326	CLIP-seq
MIRT792453	hsa-miR-330-5p	CLIP-seq
MIRT792454	hsa-miR-335	CLIP-seq
MIRT792455	hsa-miR-3613-5p	CLIP-seq
MIRT792456	hsa-miR-3652	CLIP-seq
MIRT792457	hsa-miR-3666	CLIP-seq
MIRT792458	hsa-miR-4255	CLIP-seq
MIRT792459	hsa-miR-4278	CLIP-seq
MIRT792460	hsa-miR-4282	CLIP-seq
MIRT792461	hsa-miR-4295	CLIP-seq
MIRT792462	hsa-miR-4430	CLIP-seq
MIRT792463	hsa-miR-4505	CLIP-seq
MIRT792464	hsa-miR-452	CLIP-seq
MIRT792465	hsa-miR-454	CLIP-seq
MIRT792466	hsa-miR-4645-5p	CLIP-seq
MIRT792467	hsa-miR-4668-5p	CLIP-seq
MIRT792468	hsa-miR-4673	CLIP-seq
MIRT792469	hsa-miR-4676-3p	CLIP-seq
MIRT792470	hsa-miR-4696	CLIP-seq
MIRT792471	hsa-miR-4716-3p	CLIP-seq
MIRT792472	hsa-miR-4735-5p	CLIP-seq
MIRT792473	hsa-miR-4747-5p	CLIP-seq
MIRT792474	hsa-miR-4768-5p	CLIP-seq
MIRT792475	hsa-miR-4775	CLIP-seq
MIRT792476	hsa-miR-4794	CLIP-seq
MIRT792477	hsa-miR-513a-3p	CLIP-seq
MIRT792478	hsa-miR-548m	CLIP-seq
MIRT792479	hsa-miR-590-3p	CLIP-seq
MIRT792480	hsa-miR-625	CLIP-seq
MIRT1545467	hsa-miR-3613-3p	CLIP-seq
MIRT1933841	hsa-miR-190	CLIP-seq
MIRT1933842	hsa-miR-190b	CLIP-seq
MIRT792442	hsa-miR-194	CLIP-seq
MIRT1933843	hsa-miR-30a	CLIP-seq
MIRT1933844	hsa-miR-30b	CLIP-seq
MIRT1933845	hsa-miR-30c	CLIP-seq
MIRT1933846	hsa-miR-30d	CLIP-seq
MIRT1933847	hsa-miR-30e	CLIP-seq
MIRT792449	hsa-miR-3129-3p	CLIP-seq
MIRT792455	hsa-miR-3613-5p	CLIP-seq
MIRT792472	hsa-miR-4735-5p	CLIP-seq
MIRT1933848	hsa-miR-4762-5p	CLIP-seq
MIRT792475	hsa-miR-4775	CLIP-seq
MIRT792479	hsa-miR-590-3p	CLIP-seq
MIRT1933849	hsa-miR-630	CLIP-seq
MIRT1933850	hsa-miR-654-3p	CLIP-seq
MIRT1933851	hsa-miR-664	CLIP-seq
MIRT792436	hsa-miR-130a	CLIP-seq
MIRT792437	hsa-miR-130b	CLIP-seq
MIRT792438	hsa-miR-148a	CLIP-seq
MIRT792439	hsa-miR-148b	CLIP-seq
MIRT792441	hsa-miR-152	CLIP-seq
MIRT2173731	hsa-miR-221	CLIP-seq
MIRT2173732	hsa-miR-222	CLIP-seq
MIRT792445	hsa-miR-301a	CLIP-seq
MIRT792446	hsa-miR-301b	CLIP-seq
MIRT792451	hsa-miR-3160-3p	CLIP-seq
MIRT2173733	hsa-miR-3171	CLIP-seq
MIRT2173734	hsa-miR-3189-3p	CLIP-seq
MIRT1545467	hsa-miR-3613-3p	CLIP-seq
MIRT792457	hsa-miR-3666	CLIP-seq
MIRT792458	hsa-miR-4255	CLIP-seq
MIRT792461	hsa-miR-4295	CLIP-seq
MIRT2173735	hsa-miR-4433	CLIP-seq
MIRT2173736	hsa-miR-451b	CLIP-seq
MIRT792465	hsa-miR-454	CLIP-seq
MIRT792470	hsa-miR-4696	CLIP-seq
MIRT2173737	hsa-miR-4717-5p	CLIP-seq
MIRT2173738	hsa-miR-548a-5p	CLIP-seq
MIRT2173739	hsa-miR-548ab	CLIP-seq
MIRT2173740	hsa-miR-548ak	CLIP-seq
MIRT2173741	hsa-miR-548b-5p	CLIP-seq
MIRT2173742	hsa-miR-548c-5p	CLIP-seq
MIRT2173743	hsa-miR-548d-5p	CLIP-seq
MIRT2173744	hsa-miR-548h	CLIP-seq
MIRT2173745	hsa-miR-548i	CLIP-seq
MIRT2173746	hsa-miR-548j	CLIP-seq
MIRT2173747	hsa-miR-548k	CLIP-seq
MIRT2173748	hsa-miR-548l	CLIP-seq
MIRT792478	hsa-miR-548m	CLIP-seq
MIRT2173749	hsa-miR-548w	CLIP-seq
MIRT2173750	hsa-miR-548y	CLIP-seq
MIRT2173751	hsa-miR-559	CLIP-seq
MIRT2173752	hsa-miR-562	CLIP-seq
MIRT792479	hsa-miR-590-3p	CLIP-seq
MIRT2173753	hsa-miR-647	CLIP-seq
MIRT2173754	hsa-miR-665	CLIP-seq
MIRT2477342	hsa-miR-1231	CLIP-seq
MIRT2477343	hsa-miR-1266	CLIP-seq
MIRT792443	hsa-miR-198	CLIP-seq
MIRT792448	hsa-miR-3115	CLIP-seq
MIRT2477344	hsa-miR-3121-3p	CLIP-seq
MIRT792449	hsa-miR-3129-3p	CLIP-seq
MIRT792450	hsa-miR-3148	CLIP-seq
MIRT2173733	hsa-miR-3171	CLIP-seq
MIRT792454	hsa-miR-335	CLIP-seq
MIRT1545467	hsa-miR-3613-3p	CLIP-seq
MIRT2477345	hsa-miR-3664-3p	CLIP-seq
MIRT2477346	hsa-miR-371b-5p	CLIP-seq
MIRT792459	hsa-miR-4278	CLIP-seq
MIRT792460	hsa-miR-4282	CLIP-seq
MIRT2477347	hsa-miR-4283	CLIP-seq
MIRT2477348	hsa-miR-4288	CLIP-seq
MIRT2477349	hsa-miR-4428	CLIP-seq
MIRT2173735	hsa-miR-4433	CLIP-seq
MIRT2477350	hsa-miR-4437	CLIP-seq
MIRT2477351	hsa-miR-4446-5p	CLIP-seq
MIRT2477352	hsa-miR-4489	CLIP-seq
MIRT2477353	hsa-miR-450b-5p	CLIP-seq
MIRT2477354	hsa-miR-4518	CLIP-seq
MIRT2173736	hsa-miR-451b	CLIP-seq
MIRT2477355	hsa-miR-4639-5p	CLIP-seq
MIRT792466	hsa-miR-4645-5p	CLIP-seq
MIRT2477356	hsa-miR-4663	CLIP-seq
MIRT2477357	hsa-miR-4667-5p	CLIP-seq
MIRT792467	hsa-miR-4668-5p	CLIP-seq
MIRT792468	hsa-miR-4673	CLIP-seq
MIRT2477358	hsa-miR-4686	CLIP-seq
MIRT2477359	hsa-miR-4700-5p	CLIP-seq
MIRT792471	hsa-miR-4716-3p	CLIP-seq
MIRT2173737	hsa-miR-4717-5p	CLIP-seq
MIRT792473	hsa-miR-4747-5p	CLIP-seq
MIRT1933848	hsa-miR-4762-5p	CLIP-seq
MIRT2477360	hsa-miR-4799-5p	CLIP-seq
MIRT2477361	hsa-miR-496	CLIP-seq
MIRT2173738	hsa-miR-548a-5p	CLIP-seq
MIRT2477362	hsa-miR-548aa	CLIP-seq
MIRT2173739	hsa-miR-548ab	CLIP-seq
MIRT2477363	hsa-miR-548ac	CLIP-seq
MIRT2477364	hsa-miR-548ae	CLIP-seq
MIRT2477365	hsa-miR-548aj	CLIP-seq
MIRT2173740	hsa-miR-548ak	CLIP-seq
MIRT2477366	hsa-miR-548am	CLIP-seq
MIRT2173741	hsa-miR-548b-5p	CLIP-seq
MIRT2173742	hsa-miR-548c-5p	CLIP-seq
MIRT2477367	hsa-miR-548d-3p	CLIP-seq
MIRT2173743	hsa-miR-548d-5p	CLIP-seq
MIRT2173744	hsa-miR-548h	CLIP-seq
MIRT2173745	hsa-miR-548i	CLIP-seq
MIRT2173746	hsa-miR-548j	CLIP-seq
MIRT2173747	hsa-miR-548k	CLIP-seq
MIRT2173748	hsa-miR-548l	CLIP-seq
MIRT792478	hsa-miR-548m	CLIP-seq
MIRT2173749	hsa-miR-548w	CLIP-seq
MIRT2477368	hsa-miR-548x	CLIP-seq
MIRT2173750	hsa-miR-548y	CLIP-seq
MIRT2477369	hsa-miR-548z	CLIP-seq
MIRT2173751	hsa-miR-559	CLIP-seq
MIRT2173752	hsa-miR-562	CLIP-seq
MIRT792480	hsa-miR-625	CLIP-seq
MIRT2477370	hsa-miR-632	CLIP-seq
MIRT2477371	hsa-miR-634	CLIP-seq
MIRT2477372	hsa-miR-637	CLIP-seq
MIRT2173753	hsa-miR-647	CLIP-seq
MIRT2173754	hsa-miR-665	CLIP-seq
MIRT2477373	hsa-miR-873	CLIP-seq
MIRT2675216	hsa-miR-1185	CLIP-seq
MIRT2477342	hsa-miR-1231	CLIP-seq
MIRT2477343	hsa-miR-1266	CLIP-seq
MIRT792443	hsa-miR-198	CLIP-seq
MIRT1933843	hsa-miR-30a	CLIP-seq
MIRT1933844	hsa-miR-30b	CLIP-seq
MIRT1933845	hsa-miR-30c	CLIP-seq
MIRT1933846	hsa-miR-30d	CLIP-seq
MIRT1933847	hsa-miR-30e	CLIP-seq
MIRT792448	hsa-miR-3115	CLIP-seq
MIRT2477344	hsa-miR-3121-3p	CLIP-seq
MIRT792449	hsa-miR-3129-3p	CLIP-seq
MIRT792450	hsa-miR-3148	CLIP-seq
MIRT2173733	hsa-miR-3171	CLIP-seq
MIRT792454	hsa-miR-335	CLIP-seq
MIRT1545467	hsa-miR-3613-3p	CLIP-seq
MIRT2477345	hsa-miR-3664-3p	CLIP-seq
MIRT2675217	hsa-miR-3679-5p	CLIP-seq
MIRT2477346	hsa-miR-371b-5p	CLIP-seq
MIRT792459	hsa-miR-4278	CLIP-seq
MIRT792460	hsa-miR-4282	CLIP-seq
MIRT2477347	hsa-miR-4283	CLIP-seq
MIRT2477348	hsa-miR-4288	CLIP-seq
MIRT2477349	hsa-miR-4428	CLIP-seq
MIRT2173735	hsa-miR-4433	CLIP-seq
MIRT2477350	hsa-miR-4437	CLIP-seq
MIRT2477351	hsa-miR-4446-5p	CLIP-seq
MIRT2477352	hsa-miR-4489	CLIP-seq
MIRT2477353	hsa-miR-450b-5p	CLIP-seq
MIRT2477354	hsa-miR-4518	CLIP-seq
MIRT2173736	hsa-miR-451b	CLIP-seq
MIRT2675218	hsa-miR-4528	CLIP-seq
MIRT2477355	hsa-miR-4639-5p	CLIP-seq
MIRT792466	hsa-miR-4645-5p	CLIP-seq
MIRT2477356	hsa-miR-4663	CLIP-seq
MIRT2477357	hsa-miR-4667-5p	CLIP-seq
MIRT792467	hsa-miR-4668-5p	CLIP-seq
MIRT792468	hsa-miR-4673	CLIP-seq
MIRT2477358	hsa-miR-4686	CLIP-seq
MIRT2477359	hsa-miR-4700-5p	CLIP-seq
MIRT792471	hsa-miR-4716-3p	CLIP-seq
MIRT2173737	hsa-miR-4717-5p	CLIP-seq
MIRT792473	hsa-miR-4747-5p	CLIP-seq
MIRT1933848	hsa-miR-4762-5p	CLIP-seq
MIRT2477360	hsa-miR-4799-5p	CLIP-seq
MIRT2477361	hsa-miR-496	CLIP-seq
MIRT2173738	hsa-miR-548a-5p	CLIP-seq
MIRT2477362	hsa-miR-548aa	CLIP-seq
MIRT2173739	hsa-miR-548ab	CLIP-seq
MIRT2477363	hsa-miR-548ac	CLIP-seq
MIRT2477364	hsa-miR-548ae	CLIP-seq
MIRT2477365	hsa-miR-548aj	CLIP-seq
MIRT2173740	hsa-miR-548ak	CLIP-seq
MIRT2477366	hsa-miR-548am	CLIP-seq
MIRT2173741	hsa-miR-548b-5p	CLIP-seq
MIRT2173742	hsa-miR-548c-5p	CLIP-seq
MIRT2477367	hsa-miR-548d-3p	CLIP-seq
MIRT2173743	hsa-miR-548d-5p	CLIP-seq
MIRT2173744	hsa-miR-548h	CLIP-seq
MIRT2173745	hsa-miR-548i	CLIP-seq
MIRT2173746	hsa-miR-548j	CLIP-seq
MIRT2173747	hsa-miR-548k	CLIP-seq
MIRT2173748	hsa-miR-548l	CLIP-seq
MIRT792478	hsa-miR-548m	CLIP-seq
MIRT2173749	hsa-miR-548w	CLIP-seq
MIRT2477368	hsa-miR-548x	CLIP-seq
MIRT2173750	hsa-miR-548y	CLIP-seq
MIRT2477369	hsa-miR-548z	CLIP-seq
MIRT2173751	hsa-miR-559	CLIP-seq
MIRT2173752	hsa-miR-562	CLIP-seq
MIRT2675219	hsa-miR-583	CLIP-seq
MIRT792480	hsa-miR-625	CLIP-seq
MIRT2477370	hsa-miR-632	CLIP-seq
MIRT2477371	hsa-miR-634	CLIP-seq
MIRT2477372	hsa-miR-637	CLIP-seq
MIRT2173753	hsa-miR-647	CLIP-seq
MIRT2173754	hsa-miR-665	CLIP-seq
MIRT2477373	hsa-miR-873	CLIP-seq

49 Show/Hide all (49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	25673879
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IEA
GO:0003924	Function	GTPase activity	TAS
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005154	Function	Epidermal growth factor receptor binding	IDA	12446727
GO:0005515	Function	Protein binding	IPI	17956946, 21988832, 25416956, 26258637, 32296183
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IDA	12446727
GO:0005525	Function	GTP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	IDA	12446727
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0006886	Process	Intracellular protein transport	IBA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	TAS
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IEA
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IGI	24768165
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	TAS
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IEA
GO:0007612	Process	Learning	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IBA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0016477	Process	Cell migration	IDA	22004728
GO:0032587	Component	Ruffle membrane	IDA	12446727
GO:0043066	Process	Negative regulation of apoptotic process	IDA	19041174
GO:0043197	Component	Dendritic spine	IDA	23050017
GO:0045176	Process	Apical protein localization	IEA
GO:0045197	Process	Establishment or maintenance of epithelial cell apical/basal polarity	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	12446727
GO:0048678	Process	Response to axon injury	IEA
GO:0050807	Process	Regulation of synapse organization	IEA
GO:0060271	Process	Cilium assembly	TAS
GO:0060996	Process	Dendritic spine development	IDA	23050017
GO:0060996	Process	Dendritic spine development	IEA
GO:0061512	Process	Protein localization to cilium	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099175	Process	Regulation of postsynapse organization	IEA
GO:0106274	Function	NAD+-protein-arginine ADP-ribosyltransferase activity	IDA	1899243
GO:1902017	Process	Regulation of cilium assembly	IDA	25673879, 26258637
GO:1990583	Function	Phospholipase D activator activity	IDA	12446727
GO:2000377	Process	Regulation of reactive oxygen species metabolic process	IDA	19041174

MIM	HGNC	e!Ensembl
601177	655	ENSG00000168374

P18085

Protein name

ADP-ribosylation factor 4

Protein function

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Part of the

PDB

1Z6X

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00025	Arf	5 → 177	ADP-ribosylation factor family	Domain

Sequence

MGLTISSLFSRLFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN
ICFTVWDVGGQDRIRPLWKHYFQNTQGLIFVVDSNDRERIQEVADELQKMLLVDELRDAV
LLLFANKQDLPNAMAISEMTDKLGLQSLRNRTWYVQATCATQGTGLYEGLDWLSNELSKR

Sequence length

180

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Endocytosis	VxPx cargo-targeting to cilium
	COPI-mediated anterograde transport
	COPI-dependent Golgi-to-ER retrograde traffic

ARF4 (ARF GTPase 4)

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