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Gene Gene information from NCBI Gene database.
Entrez ID 10513
Gene name Amyloid beta precursor protein binding protein 2
Gene symbol APPBP2
Synonyms (NCBI Gene)
APP-BP2HS.84084PAT1
Chromosome 17
Chromosome location 17q23.2
Summary The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, a
miRNA miRNA information provided by mirtarbase database.
1304 Show/Hide all (1304)
miRTarBase ID miRNA Experiments Reference
MIRT048025 hsa-miR-148a-3p CLASH 23622248
MIRT481724 hsa-miR-144-3p PAR-CLIP 22012620
MIRT481723 hsa-miR-128-3p PAR-CLIP 22012620
MIRT481722 hsa-miR-27a-3p PAR-CLIP 22012620
MIRT481721 hsa-miR-27b-3p PAR-CLIP 22012620
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
24 Show/Hide all (24)
GO ID Ontology Definition Evidence Reference
GO:0003777 Function Microtubule motor activity TAS 9843960
GO:0005515 Function Protein binding IPI 16189514, 19060904, 25416956, 25852190, 32296183, 32814053
GO:0005634 Component Nucleus IEA
GO:0005634 Component Nucleus NAS 11742091
GO:0005654 Component Nucleoplasm IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605324 622 ENSG00000062725
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92624
Protein name Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) (Protein interacting with APP tail 1)
Protein function Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their
PDB 8JAL , 8JAQ , 8JAR , 8JAS , 8JAU , 8JAV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13374 TPR_10 470 → 509 Repeat
PF13424 TPR_12 397 → 461 Repeat
Sequence
MAAVELEWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEF
CELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAI
QVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYH
LGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGL
PVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLN
VDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERA
IGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKA
FGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQ
LLGQEDYEVALSVGHLASL
YNYDMNQYENAEKLYLRSIAIGKKLFGEG
YSGLEYDYRGLIKLYNSIGNYEKVFEYHNVL
SNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLISQNVEGPSC
Sequence length 585
Interactions View interactions