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Gene Gene information from NCBI Gene database.
Entrez ID 139322
Gene name Apolipoprotein O like
Gene symbol APOOL
Synonyms (NCBI Gene)
CXorf33FAM121AMICOS27Mic27UNQ8193
Chromosome X
Chromosome location Xq21.1
Summary This gene encodes a protein which contains an apolipoprotein O superfamily domain. This domain is found on proteins in circulating lipoprotein complexes. [provided by RefSeq, Sep 2011]
miRNA miRNA information provided by mirtarbase database.
1010 Show/Hide all (1010)
miRTarBase ID miRNA Experiments Reference
MIRT634843 hsa-miR-141-3p HITS-CLIP 23824327
MIRT634842 hsa-miR-200a-3p HITS-CLIP 23824327
MIRT634841 hsa-miR-4318 HITS-CLIP 23824327
MIRT634840 hsa-miR-4733-5p HITS-CLIP 23824327
MIRT669523 hsa-miR-4746-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21 Show/Hide all (21)
GO ID Ontology Definition Evidence Reference
GO:0001401 Component SAM complex HDA 26477565
GO:0005515 Function Protein binding IPI 25764979
GO:0005576 Component Extracellular region TAS
GO:0005739 Component Mitochondrion HTP 34800366
GO:0005739 Component Mitochondrion IDA 25781180, 25997101
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
300955 24009 ENSG00000155008
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6UXV4
Protein name MICOS complex subunit MIC27 (Apolipoprotein O-like) (Protein FAM121A)
Protein function Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Speci
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09769 ApoO 36 → 179 Apolipoprotein O Family
Sequence
MAAIRMGKLTTMPAGLIYASVSVHAAKQEESKKQLVKPEQLPIYTAPPLQSKYVEEQPGH
LQMGFASIRTATGCYIGWCKGVYVFVKNGIMDTVQFGKDAYVYLKNPPRDFLPKMGVITV
SGLAGLVSARKGSKFKKITYPLGLATLGATVCYPVQSVIIAKVTAKKVYATSQQIFGAV
K
SLWTKSSKEESLPKPKEKTKLGSSSEIEVPAKTTHVLKHSVPLPTELSSEAKTKSESTSG
ATQFMPDPKLMDHGQSHPEDIDMYSTRS
Sequence length 268
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Platelet degranulation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Lung cancer Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Neoplasms Breast neoplasm Pubtator 37728703 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Glioblastoma Glioblastoma Pubtator 21649900 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only