APOF (apolipoprotein F)

Download as csv Download as pdf

Log in to save this analysis

Save This Analysis

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Diseases linked via similar genes

Gene

• Entrez ID: 319
• Gene name: Apolipoprotein F
• Gene symbol: APOF
• Synonyms (NCBI Gene): Apo-F, LTIP
• Chromosome: 12
• Chromosome location: 12q13.3
• Summary: The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol. [provided by RefSeq, Jul 2008]

miRNA Show/Hide all (57)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030053	hsa-miR-26b-5p	Microarray	19088304
MIRT043031	hsa-miR-324-5p	CLASH	23622248
MIRT790054	hsa-miR-1184	CLIP-seq
MIRT790055	hsa-miR-125a-3p	CLIP-seq
MIRT790056	hsa-miR-1307	CLIP-seq
MIRT790057	hsa-miR-3934	CLIP-seq
MIRT790058	hsa-miR-4258	CLIP-seq
MIRT790059	hsa-miR-4634	CLIP-seq
MIRT790060	hsa-miR-4638-5p	CLIP-seq
MIRT790061	hsa-miR-4680-5p	CLIP-seq
MIRT790062	hsa-miR-5095	CLIP-seq
MIRT790063	hsa-miR-513a-3p	CLIP-seq
MIRT790064	hsa-miR-639	CLIP-seq
MIRT790065	hsa-miR-720	CLIP-seq
MIRT790066	hsa-miR-764	CLIP-seq
MIRT1933053	hsa-miR-1	CLIP-seq
MIRT1933054	hsa-miR-1915	CLIP-seq
MIRT1933055	hsa-miR-206	CLIP-seq
MIRT1933056	hsa-miR-3652	CLIP-seq
MIRT1933057	hsa-miR-3673	CLIP-seq
MIRT1933058	hsa-miR-4430	CLIP-seq
MIRT790059	hsa-miR-4634	CLIP-seq
MIRT1933059	hsa-miR-4726-3p	CLIP-seq
MIRT1933060	hsa-miR-613	CLIP-seq
MIRT1933053	hsa-miR-1	CLIP-seq
MIRT790054	hsa-miR-1184	CLIP-seq
MIRT790055	hsa-miR-125a-3p	CLIP-seq
MIRT2173231	hsa-miR-129-5p	CLIP-seq
MIRT790056	hsa-miR-1307	CLIP-seq
MIRT1933054	hsa-miR-1915	CLIP-seq
MIRT1933055	hsa-miR-206	CLIP-seq
MIRT2173232	hsa-miR-24	CLIP-seq
MIRT2173233	hsa-miR-3155	CLIP-seq
MIRT2173234	hsa-miR-3155b	CLIP-seq
MIRT1933056	hsa-miR-3652	CLIP-seq
MIRT2173235	hsa-miR-3672	CLIP-seq
MIRT1933057	hsa-miR-3673	CLIP-seq
MIRT790057	hsa-miR-3934	CLIP-seq
MIRT1933058	hsa-miR-4430	CLIP-seq
MIRT790059	hsa-miR-4634	CLIP-seq
MIRT790060	hsa-miR-4638-5p	CLIP-seq
MIRT2173236	hsa-miR-4713-5p	CLIP-seq
MIRT1933059	hsa-miR-4726-3p	CLIP-seq
MIRT2173237	hsa-miR-484	CLIP-seq
MIRT1933060	hsa-miR-613	CLIP-seq
MIRT790064	hsa-miR-639	CLIP-seq
MIRT790065	hsa-miR-720	CLIP-seq
MIRT790066	hsa-miR-764	CLIP-seq
MIRT1933053	hsa-miR-1	CLIP-seq
MIRT1933055	hsa-miR-206	CLIP-seq
MIRT1933056	hsa-miR-3652	CLIP-seq
MIRT1933057	hsa-miR-3673	CLIP-seq
MIRT1933058	hsa-miR-4430	CLIP-seq
MIRT790059	hsa-miR-4634	CLIP-seq
MIRT2384325	hsa-miR-4794	CLIP-seq
MIRT1933060	hsa-miR-613	CLIP-seq
MIRT790059	hsa-miR-4634	CLIP-seq

Gene ontology (GO) Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	TAS	8093033
GO:0005319	Function	Lipid transporter activity	TAS	6816269
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	28935895
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006629	Process	Lipid metabolic process	TAS	8093033
GO:0006641	Process	Triglyceride metabolic process	IEA
GO:0006869	Process	Lipid transport	IEA
GO:0006869	Process	Lipid transport	TAS	6816269
GO:0008202	Process	Steroid metabolic process	IEA
GO:0008203	Process	Cholesterol metabolic process	IBA
GO:0008203	Process	Cholesterol metabolic process	IEA
GO:0008203	Process	Cholesterol metabolic process	IEA
GO:0008203	Process	Cholesterol metabolic process	TAS	6816269
GO:0015485	Function	Cholesterol binding	TAS	6816269
GO:0033344	Process	Cholesterol efflux	IEA
GO:0034362	Component	Low-density lipoprotein particle	IEA
GO:0034364	Component	High-density lipoprotein particle	IEA

Other IDs

• MIM: 107760
• HGNC: 615
• e!Ensembl: ENSG00000175336

Protein

• UniProt ID: Q13790
• Protein name: Apolipoprotein F (Apo-F) (Lipid transfer inhibitor protein) (LTIP)
• Protein function: Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII. {ECO:
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15148	Apolipo_F	62 → 260	Apolipoprotein F	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma. {ECO:0000269|PubMed:8093033}.
• Sequence:

  MTGLCGYSAPDMRGLRLIMIPVELLLCYLLLHPVDATSYGKQTNVLMHFPLSLESQTPSS
  DPLSCQFLHPKSLPGFSHMAPLPKFLVSLALRNALEEAGCQADVWALQLQLYRQGGVNAT
  QVLIQHLRGLQKGRSTERNVSVEALASALQLLAREQQSTGRVGRSLPTEDCENEKEQAVH
  NVVQLLPGVGTFYNLGTALYYATQNCLGKARERGRDGAIDLGYDLLMTMAGMSGGPMGLA
  ISAALKPALRSGVQQLIQYYQDQKDANISQPETTKEGLRAISDVSDLEETTTLASFISEV
  VSSAPYWGWAIIKSYDLDPGAGSLEI

• Sequence length: 326

Pathways

Reactome Pathway:

LDL remodeling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
CARCINOMA, HEPATOCELLULAR	—	CTD	28284560	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (13)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	38115320	Associate	★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	30729226		★☆☆☆☆ Found in Text Mining only
Fatty Liver	Fatty liver	Pubtator	40250425	Associate	★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	30729226		★☆☆☆☆ Found in Text Mining only
Hypercholesterolemia	Hypercholesterolemia	BEFREE	19008550		★☆☆☆☆ Found in Text Mining only
Hyperlipidemia	Hyperlipidemia	BEFREE	19008550		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	25726912		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	28284560		★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	25726912		★☆☆☆☆ Found in Text Mining only
Non-alcoholic Fatty Liver Disease	Non-Alcoholic Fatty Liver Disease	BEFREE	28935895		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	19265796	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	25977605	Associate	★☆☆☆☆ Found in Text Mining only
Pulmonary edema of mountaineers	Pulmonary edema	Pubtator	40640242	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for APOF.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to APOF.