APEX2 (apurinic/apyrimidinic endodeoxyribonuclease 2)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 27301
• Gene name: Apurinic/apyrimidinic endodeoxyribonuclease 2
• Gene symbol: APEX2
• Synonyms (NCBI Gene): APE2, APEXL2, XTH2, ZGRF2
• Chromosome: X
• Chromosome location: Xp11.21
• Summary: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so

miRNA Show/Hide all (111)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002638	hsa-miR-124-3p	Microarray	15685193
MIRT002638	hsa-miR-124-3p	Microarray	15685193
MIRT002638	hsa-miR-124-3p	Microarray	18668037
MIRT692489	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT692488	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT692487	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT692486	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT692485	hsa-miR-302e	HITS-CLIP	23313552
MIRT692484	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT692483	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT692482	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT692481	hsa-miR-520b	HITS-CLIP	23313552
MIRT692480	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT692479	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT692478	hsa-miR-520e	HITS-CLIP	23313552
MIRT692477	hsa-miR-4438	HITS-CLIP	23313552
MIRT692476	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT692475	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT692474	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT692473	hsa-miR-6787-3p	HITS-CLIP	23313552
MIRT692472	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT692471	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT692470	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT692469	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT692468	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT692467	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT692466	hsa-miR-5095	HITS-CLIP	23313552
MIRT692465	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT692464	hsa-miR-640	HITS-CLIP	23313552
MIRT692463	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT692489	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT692488	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT692487	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT692486	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT692485	hsa-miR-302e	HITS-CLIP	23313552
MIRT692484	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT692483	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT692482	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT692481	hsa-miR-520b	HITS-CLIP	23313552
MIRT692480	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT692479	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT692478	hsa-miR-520e	HITS-CLIP	23313552
MIRT692477	hsa-miR-4438	HITS-CLIP	23313552
MIRT692476	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT692475	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT692474	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT692473	hsa-miR-6787-3p	HITS-CLIP	23313552
MIRT692472	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT692471	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT692470	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT692469	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT692468	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT692467	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT692466	hsa-miR-5095	HITS-CLIP	23313552
MIRT692465	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT692464	hsa-miR-640	HITS-CLIP	23313552
MIRT692463	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT789107	hsa-miR-1252	CLIP-seq
MIRT789108	hsa-miR-1304	CLIP-seq
MIRT789109	hsa-miR-1343	CLIP-seq
MIRT789110	hsa-miR-196a	CLIP-seq
MIRT789111	hsa-miR-196b	CLIP-seq
MIRT789112	hsa-miR-2355-5p	CLIP-seq
MIRT789113	hsa-miR-28-5p	CLIP-seq
MIRT789114	hsa-miR-2964a-5p	CLIP-seq
MIRT789115	hsa-miR-3126-5p	CLIP-seq
MIRT789116	hsa-miR-3139	CLIP-seq
MIRT789117	hsa-miR-3154	CLIP-seq
MIRT789118	hsa-miR-377	CLIP-seq
MIRT789119	hsa-miR-3927	CLIP-seq
MIRT789120	hsa-miR-4419a	CLIP-seq
MIRT789121	hsa-miR-4476	CLIP-seq
MIRT789122	hsa-miR-4510	CLIP-seq
MIRT789123	hsa-miR-4533	CLIP-seq
MIRT789124	hsa-miR-4633-3p	CLIP-seq
MIRT789125	hsa-miR-4668-3p	CLIP-seq
MIRT789126	hsa-miR-486-3p	CLIP-seq
MIRT789127	hsa-miR-591	CLIP-seq
MIRT789128	hsa-miR-708	CLIP-seq
MIRT1932778	hsa-miR-124	CLIP-seq
MIRT789109	hsa-miR-1343	CLIP-seq
MIRT1932779	hsa-miR-3159	CLIP-seq
MIRT1932780	hsa-miR-3714	CLIP-seq
MIRT789118	hsa-miR-377	CLIP-seq
MIRT1932781	hsa-miR-3910	CLIP-seq
MIRT1932782	hsa-miR-3936	CLIP-seq
MIRT1932783	hsa-miR-3978	CLIP-seq
MIRT1932784	hsa-miR-4492	CLIP-seq
MIRT1932785	hsa-miR-4498	CLIP-seq
MIRT1932786	hsa-miR-4505	CLIP-seq
MIRT789125	hsa-miR-4668-3p	CLIP-seq
MIRT1932787	hsa-miR-4669	CLIP-seq
MIRT1932788	hsa-miR-4796-3p	CLIP-seq
MIRT789126	hsa-miR-486-3p	CLIP-seq
MIRT1932789	hsa-miR-506	CLIP-seq
MIRT1932790	hsa-miR-513a-5p	CLIP-seq
MIRT1932791	hsa-miR-762	CLIP-seq
MIRT1932778	hsa-miR-124	CLIP-seq
MIRT789109	hsa-miR-1343	CLIP-seq
MIRT1932779	hsa-miR-3159	CLIP-seq
MIRT1932780	hsa-miR-3714	CLIP-seq
MIRT789118	hsa-miR-377	CLIP-seq
MIRT1932781	hsa-miR-3910	CLIP-seq
MIRT1932783	hsa-miR-3978	CLIP-seq
MIRT789121	hsa-miR-4476	CLIP-seq
MIRT789125	hsa-miR-4668-3p	CLIP-seq
MIRT1932787	hsa-miR-4669	CLIP-seq
MIRT1932788	hsa-miR-4796-3p	CLIP-seq
MIRT789126	hsa-miR-486-3p	CLIP-seq
MIRT1932789	hsa-miR-506	CLIP-seq
MIRT1932790	hsa-miR-513a-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001650	Component	Fibrillar center	IDA
GO:0003677	Function	DNA binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0003906	Function	DNA-(apurinic or apyrimidinic site) endonuclease activity	IBA
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IEA
GO:0004527	Function	Exonuclease activity	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 31413325, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006284	Process	Base-excision repair	IBA
GO:0006310	Process	DNA recombination	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0008081	Function	Phosphoric diester hydrolase activity	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008311	Function	Double-stranded DNA 3'-5' DNA exonuclease activity	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 300773
• HGNC: 17889
• e!Ensembl: ENSG00000169188

Protein

• UniProt ID: Q9UBZ4
• Protein name: DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.11.2) (AP endonuclease XTH2) (APEX nuclease 2) (APEX nuclease-like 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2)
• Protein function: Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (PubMed:16687656). Initiates repair of AP sites in DNA by catalyzing hyd
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03372	Exo_endo_phos	5 → 304	Endonuclease/Exonuclease/phosphatase family	Domain
  PF06839	zf-GRF	467 → 517	GRF zinc finger	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in brain and kidney. Weakly expressed in the fetal brain. {ECO:0000269|PubMed:11376153}.
• Sequence:

  MLRVVSWNINGIRRPLQGVANQEPSNCAAVAVGRILDELDADIVCLQETKVTRDALTEPL
  AIVEGYNSYFSFSRNRSGYSGVATFCKDNATPVAAEEGLSGLFATQNGDVGCYGNMDEFT
  QEELRALDSEGRALLTQHKIRTWEGKEKTLTLINVYCPHADPGRPERLVFKMRFYRLLQI
  RAEALLAAGSHVIILGDLNTAHRPIDHWDAVNLECFEEDPGRKWMDSLLSNLGCQSASHV
  GPFIDSYRCFQPKQEGAFTCWSAVTGARHLNYGSRLDYVLGDRTLVIDTFQASFLLPEVM
  GSDHCPVGAVLSVSSVPAKQCPPLCTRFLPEFAGTQLKILRFLVPLEQSPVLEQSTLQHN
  NQTRVQTCQNKAQVRSTRPQPSQVGSSRGQKNLKSYFQPSPSCPQASPDIELPSLPLMSA
  LMTPKTPEEKAVAKVVKGQAKTSEAKDEKELRTSFWKSVLAGPLRTPLCGGHREPCVMRT
  VKKPGPNLGRRFYMCARPRGPPTDPSSRCNFFLWSRPS

• Sequence length: 518

Related Genes

No strongly related genes found yet for APEX2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to APEX2.