APBB3 (amyloid beta precursor protein binding family B member 3)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 10307
• Gene name: Amyloid beta precursor protein binding family B member 3
• Gene symbol: APBB3
• Synonyms (NCBI Gene): FE65L2, SRA
• Chromosome: 5
• Chromosome location: 5q31.3
• Summary: The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer`s disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is though

miRNA Show/Hide all (35)

miRTarBase ID	miRNA	Experiments	Reference
MIRT646493	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT646492	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT646491	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT646490	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT646489	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT646488	hsa-miR-3130-3p	HITS-CLIP	23824327
MIRT646487	hsa-miR-4468	HITS-CLIP	23824327
MIRT646486	hsa-miR-5189-3p	HITS-CLIP	23824327
MIRT646485	hsa-miR-210-5p	HITS-CLIP	23824327
MIRT646484	hsa-miR-8055	HITS-CLIP	23824327
MIRT646493	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT646492	hsa-miR-6801-3p	HITS-CLIP	23824327
MIRT646491	hsa-miR-6810-3p	HITS-CLIP	23824327
MIRT646490	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT646489	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT646488	hsa-miR-3130-3p	HITS-CLIP	23824327
MIRT646487	hsa-miR-4468	HITS-CLIP	23824327
MIRT646486	hsa-miR-5189-3p	HITS-CLIP	23824327
MIRT646485	hsa-miR-210-5p	HITS-CLIP	23824327
MIRT646484	hsa-miR-8055	HITS-CLIP	23824327
MIRT788905	hsa-miR-198	CLIP-seq
MIRT788906	hsa-miR-296-3p	CLIP-seq
MIRT788907	hsa-miR-4457	CLIP-seq
MIRT788908	hsa-miR-4520a-3p	CLIP-seq
MIRT788909	hsa-miR-4520b-3p	CLIP-seq
MIRT788910	hsa-miR-4685-5p	CLIP-seq
MIRT788911	hsa-miR-4688	CLIP-seq
MIRT788912	hsa-miR-4731-3p	CLIP-seq
MIRT788913	hsa-miR-4801	CLIP-seq
MIRT788914	hsa-miR-711	CLIP-seq
MIRT788915	hsa-miR-939	CLIP-seq
MIRT788916	hsa-miR-3622b-5p	CLIP-seq
MIRT788917	hsa-miR-4423-3p	CLIP-seq
MIRT788918	hsa-miR-4797-5p	CLIP-seq
MIRT788914	hsa-miR-711	CLIP-seq

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	IBA
GO:0001540	Function	Amyloid-beta binding	IEA
GO:0005515	Function	Protein binding	IPI	9461550, 10081969, 16273093, 25814554, 31413325, 32814053, 33961781, 35914814
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	12153398
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	10081969
GO:0005829	Component	Cytosol	IDA	12153398
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0016020	Component	Membrane	IDA	12153398
GO:0016604	Component	Nuclear body	IDA
GO:0050714	Process	Positive regulation of protein secretion	IDA	12153398
GO:0050750	Function	Low-density lipoprotein particle receptor binding	IPI	12153398
GO:0060090	Function	Molecular adaptor activity	IBA

Other IDs

• MIM: 602711
• HGNC: 20708
• e!Ensembl: ENSG00000113108

Protein

• UniProt ID: O95704
• Protein name: Amyloid-beta A4 precursor protein-binding family B member 3 (Protein Fe65-like 2) (Fe65L2)
• Protein function: May modulate the internalization of amyloid-beta precursor protein.
• PDB: 2DYQ , 2YSC
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00640	PID	119 → 257	Phosphotyrosine interaction domain (PTB/PID)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in various tissues, highest expression in brain. {ECO:0000269|PubMed:12153398}.
• Sequence:

  MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPT
  WELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFA
  VRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMS
  LVNPLDHSLIHCQPLVHIRVWGVGSSKGRDRDFAFVASDKDSCMLKCHVFCCDVPAKAIA
  SALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEALYMGTLP
  VTKAMGMDVLNEAIGTLTARGDRNAWVPTMLSVSDSLMTAHPIQAEASTEEEPLWQCPVR
  LVTFIGVGRDPHTFGLIADLGRQSFQCAAFWCQPHAGGLSEAVQAACMVQYQKCLVASAA
  RGKAWGAQARARLRLKRTSSMDSPGGPLPLPLLKGGVGGAGATPRKRGVFSFLDAFRLKP
  SLLHMP

• Sequence length: 486

Related Genes

No strongly related genes found yet for APBB3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to APBB3.