ANKRD53 (ankyrin repeat domain 53)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 79998
• Gene name: Ankyrin repeat domain 53
• Gene symbol: ANKRD53
• Synonyms (NCBI Gene): -
• Chromosome: 2
• Chromosome location: 2p13.3

miRNA Show/Hide all (17)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018580	hsa-miR-335-5p	Microarray	18185580
MIRT490570	hsa-miR-548an	PAR-CLIP	23592263
MIRT490569	hsa-miR-3714	PAR-CLIP	23592263
MIRT490568	hsa-miR-6499-5p	PAR-CLIP	23592263
MIRT490567	hsa-miR-3648	PAR-CLIP	23592263
MIRT490566	hsa-miR-564	PAR-CLIP	23592263
MIRT490570	hsa-miR-548an	PAR-CLIP	23592263
MIRT490569	hsa-miR-3714	PAR-CLIP	23592263
MIRT490568	hsa-miR-6499-5p	PAR-CLIP	23592263
MIRT490567	hsa-miR-3648	PAR-CLIP	23592263
MIRT490566	hsa-miR-564	PAR-CLIP	23592263
MIRT785043	hsa-miR-1321	CLIP-seq
MIRT785044	hsa-miR-2467-3p	CLIP-seq
MIRT785045	hsa-miR-3678-3p	CLIP-seq
MIRT785046	hsa-miR-3919	CLIP-seq
MIRT785047	hsa-miR-4739	CLIP-seq
MIRT785048	hsa-miR-4756-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000922	Component	Spindle pole	IBA
GO:0000922	Component	Spindle pole	IDA	26820536
GO:0000922	Component	Spindle pole	IEA
GO:0005515	Function	Protein binding	IPI	26820536, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005819	Component	Spindle	IDA	26820536
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0007080	Process	Mitotic metaphase chromosome alignment	IBA
GO:0007080	Process	Mitotic metaphase chromosome alignment	IMP	26820536
GO:0031116	Process	Positive regulation of microtubule polymerization	IBA
GO:0031116	Process	Positive regulation of microtubule polymerization	IMP	26820536
GO:0051301	Process	Cell division	IEA
GO:0060236	Process	Regulation of mitotic spindle organization	IBA
GO:0060236	Process	Regulation of mitotic spindle organization	IMP	26820536
GO:1902412	Process	Regulation of mitotic cytokinesis	IBA
GO:1902412	Process	Regulation of mitotic cytokinesis	IEA
GO:1902412	Process	Regulation of mitotic cytokinesis	IMP	26820536

Other IDs

• MIM: 617009
• HGNC: 25691
• e!Ensembl: ENSG00000144031

Protein

• UniProt ID: Q8N9V6
• Protein name: Ankyrin repeat domain-containing protein 53
• Protein function: Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12796	Ank_2	164 → 241	Ankyrin repeats (3 copies)	Repeat
  PF12796	Ank_2	189 → 275	Ankyrin repeats (3 copies)	Repeat

• Sequence:

  MASAGSTARRAGSGSWHSERGEGRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPL
  PDLADHLSAQATALARPRRPASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNV
  EWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHL
  VIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQ
  DAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEY
  QKEHKILREAAIRKWLHGKLHPGHSLVSNTKQARATALSKTPEQRESQRSRSFHPSVDAR
  LQCIPQPTEMPKPIYRKPTVKRPTMWNVSNNPARPPTTQISHSQGIRLGVHPDPTPEHDF
  SSFLEVRPDGHGGARLHTVDGHWVAPVPRLPFEVLLRMLYPRVWPYRMKVPQGFYPISMR
  EVPRKRHLGDNTFWTDTLAMNLRDTFDEAFLAAVRSHQGLPTLPSPQTNP

• Sequence length: 530

Related Genes

No strongly related genes found yet for ANKRD53.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ANKRD53.