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Gene Gene information from NCBI Gene database.
Entrez ID 157567
Gene name Ankyrin repeat domain 46
Gene symbol ANKRD46
Synonyms (NCBI Gene)
ANK-SGENX-115279
Chromosome 8
Chromosome location 8q22.3
Summary This gene encodes a protein containing multiple ankyrin repeats. Ankyrin domains function in protein-protein interactions in a variety of cellular processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
miRNA miRNA information provided by mirtarbase database.
743 Show/Hide all (743)
miRTarBase ID miRNA Experiments Reference
MIRT005773 hsa-miR-21-5p ImmunoblotImmunohistochemistryLuciferase reporter assayMicroarrayqRT-PCRWestern blot 21219636
MIRT005773 hsa-miR-21-5p ImmunoblotImmunohistochemistryLuciferase reporter assayMicroarrayqRT-PCRWestern blot 21219636
MIRT019737 hsa-miR-375 Microarray 20215506
MIRT029288 hsa-miR-26b-5p Microarray 19088304
MIRT710601 hsa-miR-6776-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
2
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0016020 Component Membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86W74
Protein name Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12796 Ank_2 16 → 105 Ankyrin repeats (3 copies) Repeat
Sequence
MSYVFVNDSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDI
CQLLHKFGADLLATDYQGNTALHLCGHVDTIQFLVSNGLKIDICN
HQGATPLVLAKRRGV
NKDVIRLLESLEEQEVKGFNRGTHSKLETMQTAESESAMESHSLLNPNLQQGEGVLSSFR
TTWQEFVEDLGFWRVLLLIFVIALLSLGIAYYVSGVLPFVENQPELVH
Sequence length 228
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
ASTHMA — GWAS catalog 27611488
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Malignant neoplasm of breast Breast Cancer BEFREE 21219636
★★★★★
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 21219636
★★★★★
★☆☆☆☆
Found in Text Mining only
Stomach Neoplasms Stomach neoplasms Pubtator 22559327 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only