ANKRD13A (ankyrin repeat domain 13A)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 88455
• Gene name: Ankyrin repeat domain 13A
• Gene symbol: ANKRD13A
• Synonyms (NCBI Gene): ANKRD13, NY-REN-25
• Chromosome: 12
• Chromosome location: 12q24.11

miRNA Show/Hide all (209)

miRTarBase ID	miRNA	Experiments	Reference
MIRT026934	hsa-miR-192-5p	Microarray	19074876
MIRT054350	hsa-miR-204-5p	Flow cytometry, Luciferase reporter assay, qRT-PCR, Western blot	23620728
MIRT705698	hsa-miR-651-3p	HITS-CLIP	23313552
MIRT705696	hsa-miR-6871-3p	HITS-CLIP	23313552
MIRT705697	hsa-miR-4274	HITS-CLIP	23313552
MIRT705695	hsa-miR-556-5p	HITS-CLIP	23313552
MIRT705694	hsa-miR-6865-3p	HITS-CLIP	23313552
MIRT705693	hsa-miR-4521	HITS-CLIP	23313552
MIRT705692	hsa-miR-3663-3p	HITS-CLIP	23313552
MIRT705691	hsa-miR-6828-5p	HITS-CLIP	23313552
MIRT705690	hsa-miR-675-3p	HITS-CLIP	23313552
MIRT705689	hsa-miR-297	HITS-CLIP	23313552
MIRT705688	hsa-miR-3149	HITS-CLIP	23313552
MIRT705698	hsa-miR-651-3p	HITS-CLIP	23313552
MIRT705696	hsa-miR-6871-3p	HITS-CLIP	23313552
MIRT705697	hsa-miR-4274	HITS-CLIP	23313552
MIRT705695	hsa-miR-556-5p	HITS-CLIP	23313552
MIRT705694	hsa-miR-6865-3p	HITS-CLIP	23313552
MIRT705693	hsa-miR-4521	HITS-CLIP	23313552
MIRT705692	hsa-miR-3663-3p	HITS-CLIP	23313552
MIRT705691	hsa-miR-6828-5p	HITS-CLIP	23313552
MIRT705690	hsa-miR-675-3p	HITS-CLIP	23313552
MIRT705689	hsa-miR-297	HITS-CLIP	23313552
MIRT705688	hsa-miR-3149	HITS-CLIP	23313552
MIRT782657	hsa-miR-1	CLIP-seq
MIRT782658	hsa-miR-124	CLIP-seq
MIRT782659	hsa-miR-1321	CLIP-seq
MIRT782660	hsa-miR-1343	CLIP-seq
MIRT782661	hsa-miR-137	CLIP-seq
MIRT782662	hsa-miR-148a	CLIP-seq
MIRT782663	hsa-miR-148b	CLIP-seq
MIRT782664	hsa-miR-152	CLIP-seq
MIRT782665	hsa-miR-154	CLIP-seq
MIRT782666	hsa-miR-206	CLIP-seq
MIRT782667	hsa-miR-2113	CLIP-seq
MIRT782668	hsa-miR-2278	CLIP-seq
MIRT782669	hsa-miR-3128	CLIP-seq
MIRT782670	hsa-miR-3150a-3p	CLIP-seq
MIRT782671	hsa-miR-3161	CLIP-seq
MIRT782672	hsa-miR-3162-5p	CLIP-seq
MIRT782673	hsa-miR-3175	CLIP-seq
MIRT782674	hsa-miR-34c-3p	CLIP-seq
MIRT782675	hsa-miR-3662	CLIP-seq
MIRT782676	hsa-miR-3673	CLIP-seq
MIRT782677	hsa-miR-3714	CLIP-seq
MIRT782678	hsa-miR-3910	CLIP-seq
MIRT782679	hsa-miR-3944-5p	CLIP-seq
MIRT782680	hsa-miR-409-3p	CLIP-seq
MIRT782681	hsa-miR-425	CLIP-seq
MIRT782682	hsa-miR-4276	CLIP-seq
MIRT782683	hsa-miR-4282	CLIP-seq
MIRT782684	hsa-miR-431	CLIP-seq
MIRT782685	hsa-miR-4420	CLIP-seq
MIRT782686	hsa-miR-4462	CLIP-seq
MIRT782687	hsa-miR-4468	CLIP-seq
MIRT782688	hsa-miR-4477b	CLIP-seq
MIRT782689	hsa-miR-4519	CLIP-seq
MIRT782690	hsa-miR-4637	CLIP-seq
MIRT782691	hsa-miR-4667-5p	CLIP-seq
MIRT782692	hsa-miR-4700-5p	CLIP-seq
MIRT782693	hsa-miR-4738-3p	CLIP-seq
MIRT782694	hsa-miR-4739	CLIP-seq
MIRT782695	hsa-miR-4756-5p	CLIP-seq
MIRT782696	hsa-miR-483-3p	CLIP-seq
MIRT782697	hsa-miR-506	CLIP-seq
MIRT782698	hsa-miR-520d-5p	CLIP-seq
MIRT782699	hsa-miR-524-5p	CLIP-seq
MIRT782700	hsa-miR-548c-3p	CLIP-seq
MIRT782701	hsa-miR-568	CLIP-seq
MIRT782702	hsa-miR-613	CLIP-seq
MIRT782703	hsa-miR-643	CLIP-seq
MIRT782704	hsa-miR-758	CLIP-seq
MIRT782705	hsa-miR-939	CLIP-seq
MIRT1930987	hsa-miR-1292	CLIP-seq
MIRT1930988	hsa-miR-1915	CLIP-seq
MIRT782669	hsa-miR-3128	CLIP-seq
MIRT1930989	hsa-miR-376a	CLIP-seq
MIRT1930990	hsa-miR-376b	CLIP-seq
MIRT782679	hsa-miR-3944-5p	CLIP-seq
MIRT782681	hsa-miR-425	CLIP-seq
MIRT782685	hsa-miR-4420	CLIP-seq
MIRT782686	hsa-miR-4462	CLIP-seq
MIRT782690	hsa-miR-4637	CLIP-seq
MIRT1930991	hsa-miR-515-5p	CLIP-seq
MIRT1930992	hsa-miR-9	CLIP-seq
MIRT2171573	hsa-miR-1244	CLIP-seq
MIRT2171574	hsa-miR-199a-3p	CLIP-seq
MIRT2171575	hsa-miR-199b-3p	CLIP-seq
MIRT782667	hsa-miR-2113	CLIP-seq
MIRT2171576	hsa-miR-2276	CLIP-seq
MIRT2171577	hsa-miR-3129-5p	CLIP-seq
MIRT2171578	hsa-miR-323b-3p	CLIP-seq
MIRT2171579	hsa-miR-3688-3p	CLIP-seq
MIRT782679	hsa-miR-3944-5p	CLIP-seq
MIRT2171580	hsa-miR-4307	CLIP-seq
MIRT2171581	hsa-miR-619	CLIP-seq
MIRT2426268	hsa-miR-10a	CLIP-seq
MIRT2426269	hsa-miR-10b	CLIP-seq
MIRT2426270	hsa-miR-1178	CLIP-seq
MIRT2426271	hsa-miR-1236	CLIP-seq
MIRT2426272	hsa-miR-147b	CLIP-seq
MIRT782662	hsa-miR-148a	CLIP-seq
MIRT782663	hsa-miR-148b	CLIP-seq
MIRT782664	hsa-miR-152	CLIP-seq
MIRT782665	hsa-miR-154	CLIP-seq
MIRT2426273	hsa-miR-1910	CLIP-seq
MIRT1930988	hsa-miR-1915	CLIP-seq
MIRT2426274	hsa-miR-204	CLIP-seq
MIRT2426275	hsa-miR-210	CLIP-seq
MIRT2426276	hsa-miR-211	CLIP-seq
MIRT2426277	hsa-miR-2114	CLIP-seq
MIRT2426278	hsa-miR-2355-5p	CLIP-seq
MIRT2426279	hsa-miR-3121-3p	CLIP-seq
MIRT2426280	hsa-miR-337-3p	CLIP-seq
MIRT2426281	hsa-miR-3607-3p	CLIP-seq
MIRT2426282	hsa-miR-3613-3p	CLIP-seq
MIRT2426283	hsa-miR-3686	CLIP-seq
MIRT2426284	hsa-miR-3938	CLIP-seq
MIRT782679	hsa-miR-3944-5p	CLIP-seq
MIRT2426285	hsa-miR-4264	CLIP-seq
MIRT782682	hsa-miR-4276	CLIP-seq
MIRT2171580	hsa-miR-4307	CLIP-seq
MIRT2426286	hsa-miR-4311	CLIP-seq
MIRT2426287	hsa-miR-4423-5p	CLIP-seq
MIRT2426288	hsa-miR-4424	CLIP-seq
MIRT2426289	hsa-miR-4501	CLIP-seq
MIRT2426290	hsa-miR-4509	CLIP-seq
MIRT2426291	hsa-miR-4528	CLIP-seq
MIRT2426292	hsa-miR-455-3p	CLIP-seq
MIRT2426293	hsa-miR-4648	CLIP-seq
MIRT2426294	hsa-miR-4654	CLIP-seq
MIRT2426295	hsa-miR-4687-3p	CLIP-seq
MIRT2426296	hsa-miR-4694-3p	CLIP-seq
MIRT2426297	hsa-miR-4698	CLIP-seq
MIRT2426298	hsa-miR-4742-3p	CLIP-seq
MIRT2426299	hsa-miR-4753-3p	CLIP-seq
MIRT2426300	hsa-miR-4768-5p	CLIP-seq
MIRT2426301	hsa-miR-4769-5p	CLIP-seq
MIRT2426302	hsa-miR-4774-3p	CLIP-seq
MIRT2426303	hsa-miR-4779	CLIP-seq
MIRT2426304	hsa-miR-4781-3p	CLIP-seq
MIRT2426305	hsa-miR-4802-5p	CLIP-seq
MIRT2426306	hsa-miR-494	CLIP-seq
MIRT2426307	hsa-miR-495	CLIP-seq
MIRT2426308	hsa-miR-518a-5p	CLIP-seq
MIRT2426309	hsa-miR-527	CLIP-seq
MIRT2426310	hsa-miR-548m	CLIP-seq
MIRT2426311	hsa-miR-567	CLIP-seq
MIRT2426312	hsa-miR-606	CLIP-seq
MIRT2426313	hsa-miR-609	CLIP-seq
MIRT2426314	hsa-miR-630	CLIP-seq
MIRT2426315	hsa-miR-642b	CLIP-seq
MIRT2426316	hsa-miR-647	CLIP-seq
MIRT2426317	hsa-miR-676	CLIP-seq
MIRT2426318	hsa-miR-765	CLIP-seq
MIRT2426273	hsa-miR-1910	CLIP-seq
MIRT2426274	hsa-miR-204	CLIP-seq
MIRT2426276	hsa-miR-211	CLIP-seq
MIRT2426277	hsa-miR-2114	CLIP-seq
MIRT2426285	hsa-miR-4264	CLIP-seq
MIRT2426292	hsa-miR-455-3p	CLIP-seq
MIRT782658	hsa-miR-124	CLIP-seq
MIRT2474658	hsa-miR-203	CLIP-seq
MIRT2474659	hsa-miR-2277-3p	CLIP-seq
MIRT2474660	hsa-miR-3611	CLIP-seq
MIRT2426282	hsa-miR-3613-3p	CLIP-seq
MIRT782677	hsa-miR-3714	CLIP-seq
MIRT782678	hsa-miR-3910	CLIP-seq
MIRT782680	hsa-miR-409-3p	CLIP-seq
MIRT2474661	hsa-miR-4251	CLIP-seq
MIRT2426286	hsa-miR-4311	CLIP-seq
MIRT2474662	hsa-miR-4324	CLIP-seq
MIRT2426288	hsa-miR-4424	CLIP-seq
MIRT782688	hsa-miR-4477b	CLIP-seq
MIRT2474663	hsa-miR-4504	CLIP-seq
MIRT2426290	hsa-miR-4509	CLIP-seq
MIRT2474664	hsa-miR-4677-3p	CLIP-seq
MIRT2474665	hsa-miR-4679	CLIP-seq
MIRT2474666	hsa-miR-4690-3p	CLIP-seq
MIRT2426296	hsa-miR-4694-3p	CLIP-seq
MIRT782693	hsa-miR-4738-3p	CLIP-seq
MIRT782697	hsa-miR-506	CLIP-seq
MIRT2474667	hsa-miR-542-3p	CLIP-seq
MIRT782700	hsa-miR-548c-3p	CLIP-seq
MIRT2426310	hsa-miR-548m	CLIP-seq
MIRT2426312	hsa-miR-606	CLIP-seq
MIRT2426315	hsa-miR-642b	CLIP-seq
MIRT782658	hsa-miR-124	CLIP-seq
MIRT2675015	hsa-miR-3187-3p	CLIP-seq
MIRT2426282	hsa-miR-3613-3p	CLIP-seq
MIRT782675	hsa-miR-3662	CLIP-seq
MIRT782677	hsa-miR-3714	CLIP-seq
MIRT782678	hsa-miR-3910	CLIP-seq
MIRT782680	hsa-miR-409-3p	CLIP-seq
MIRT2474661	hsa-miR-4251	CLIP-seq
MIRT2426286	hsa-miR-4311	CLIP-seq
MIRT2474662	hsa-miR-4324	CLIP-seq
MIRT2426288	hsa-miR-4424	CLIP-seq
MIRT782688	hsa-miR-4477b	CLIP-seq
MIRT2426290	hsa-miR-4509	CLIP-seq
MIRT2675016	hsa-miR-4529-5p	CLIP-seq
MIRT782693	hsa-miR-4738-3p	CLIP-seq
MIRT2675017	hsa-miR-4775	CLIP-seq
MIRT782697	hsa-miR-506	CLIP-seq
MIRT2675018	hsa-miR-539	CLIP-seq
MIRT2426310	hsa-miR-548m	CLIP-seq
MIRT782701	hsa-miR-568	CLIP-seq
MIRT2675019	hsa-miR-599	CLIP-seq
MIRT2426312	hsa-miR-606	CLIP-seq

Gene ontology (GO) Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002091	Process	Negative regulation of receptor internalization	IEA
GO:0002091	Process	Negative regulation of receptor internalization	IMP	22298428
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	22298428
GO:0005768	Component	Endosome	IEA
GO:0005770	Component	Late endosome	IDA	22298428
GO:0005770	Component	Late endosome	IEA
GO:0005886	Component	Plasma membrane	IDA	22298428
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	22298428
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0140036	Function	Ubiquitin-modified protein reader activity	IDA	22298428
GO:0140036	Function	Ubiquitin-modified protein reader activity	IEA
GO:0140036	Function	Ubiquitin-modified protein reader activity	IPI	22298428
GO:1905667	Process	Negative regulation of protein localization to endosome	IDA	22298428

Other IDs

• MIM: 615123
• HGNC: 21268
• e!Ensembl: ENSG00000076513

Protein

• UniProt ID: Q8IZ07
• Protein name: Ankyrin repeat domain-containing protein 13A (Protein KE03)
• Protein function: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated E
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11904	GPCR_chapero_1	156 → 470	GPCR-chaperone	Domain
  PF13637	Ank_4	41 → 92		Repeat

• Sequence:

  MSSACDAGDHYPLHLLVWKNDYRQLEKELQGQNVEAVDPRGRTLLHLAVSLGHLESARVL
  LRHKADVTKENRQGWTVLHEAVSTGDPEMVYTVLQHRDYHNTSMALEGVPELLQKILEAP
  DFYVQMKWEFTSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSFIFKG
  EDNWAELMEVNHDDKVVTTERFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKN
  IAFERTKSGFWGWRTDKAEVVNGYEAKVYTVNNVNVITKIRTEHLTEEEKKRYKADRNPL
  ESLLGTVEHQFGAQGDLTTECATANNPTAITPDEYFNEEFDLKDRDIGRPKELTIRTQKF
  KAMLWMCEEFPLSLVEQVIPIIDLMARTSAHFARLRDFIKLEFPPGFPVKIEIPLFHVLN
  ARITFGNVNGCSTAEESVSQNVEGTQADSASHITNFEVDQSVFEIPESYYVQDNGRNVHL
  QDEDYEIMQFAIQQSLLESSRSQELSGPASNGGISQTNTYDAQYERAIQESLLTSTEGLC
  PSALSETSRFDNDLQLAMELSAKELEEWELRLQEEEAELQQVLQLSLTDK

• Sequence length: 590

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Familial cancer of breast	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	34694569	Associate	★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	34839354	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for ANKRD13A.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ANKRD13A.