ALDOA (aldolase, fructose-bisphosphate A)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 226 |
| Gene name | Aldolase, fructose-bisphosphate A |
| Gene symbol | ALDOA |
| Synonyms (NCBI Gene) |
ALDAGSD12HEL-S-87p
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| Chromosome | 16 |
| Chromosome location | 16p11.2 |
| Summary | This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone ph |
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miRNA
miRNA information provided by mirtarbase database.
557
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Transcription factors
Transcription factors information provided by TRRUST V2 database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
46
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P04075 | ||||||||||
| Protein name | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | ||||||||||
| Protein function | Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarit | ||||||||||
| PDB | 1ALD , 2ALD , 4ALD , 5KY6 , 6XMH , 6XML , 6XMM , 6XMO | ||||||||||
| Family and domains |
Pfam
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| Sequence | |||||||||||
| Sequence length | 364 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with ALDOA across shared curated disease and pathway associations.
5
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to ALDOA (see Related Genes above), that are NOT already directly curated for ALDOA itself -- a lead worth checking, not a confirmed association.
5
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