AHSA1 (activator of HSP90 ATPase activity 1)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 10598
• Gene name: Activator of HSP90 ATPase activity 1
• Gene symbol: AHSA1
• Synonyms (NCBI Gene): AHA1, C14orf3, hAha1, p38
• Chromosome: 14
• Chromosome location: 14q24.3

miRNA Show/Hide all (90)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024961	hsa-miR-214-3p	Microarray;Other	19859982
MIRT048262	hsa-miR-196a-5p	CLASH	23622248
MIRT046705	hsa-miR-222-3p	CLASH	23622248
MIRT044204	hsa-miR-99b-5p	CLASH	23622248
MIRT041598	hsa-miR-193b-3p	CLASH	23622248
MIRT041101	hsa-miR-503-5p	CLASH	23622248
MIRT774000	hsa-miR-1321	CLIP-seq
MIRT774001	hsa-miR-296-5p	CLIP-seq
MIRT774002	hsa-miR-299-3p	CLIP-seq
MIRT774003	hsa-miR-3157-3p	CLIP-seq
MIRT774004	hsa-miR-3184	CLIP-seq
MIRT774005	hsa-miR-3190	CLIP-seq
MIRT774006	hsa-miR-3202	CLIP-seq
MIRT774007	hsa-miR-423-5p	CLIP-seq
MIRT774008	hsa-miR-4290	CLIP-seq
MIRT774009	hsa-miR-4307	CLIP-seq
MIRT774010	hsa-miR-4491	CLIP-seq
MIRT774011	hsa-miR-4530	CLIP-seq
MIRT774012	hsa-miR-4533	CLIP-seq
MIRT774013	hsa-miR-4539	CLIP-seq
MIRT774014	hsa-miR-4643	CLIP-seq
MIRT774015	hsa-miR-4657	CLIP-seq
MIRT774016	hsa-miR-466	CLIP-seq
MIRT774017	hsa-miR-4707-5p	CLIP-seq
MIRT774018	hsa-miR-4728-5p	CLIP-seq
MIRT774019	hsa-miR-4739	CLIP-seq
MIRT774020	hsa-miR-4756-5p	CLIP-seq
MIRT774021	hsa-miR-4789-3p	CLIP-seq
MIRT774022	hsa-miR-539	CLIP-seq
MIRT774023	hsa-miR-570	CLIP-seq
MIRT774024	hsa-miR-874	CLIP-seq
MIRT774025	hsa-miR-922	CLIP-seq
MIRT1928425	hsa-miR-1269	CLIP-seq
MIRT1928426	hsa-miR-1269b	CLIP-seq
MIRT1928427	hsa-miR-1288	CLIP-seq
MIRT774000	hsa-miR-1321	CLIP-seq
MIRT1928428	hsa-miR-185	CLIP-seq
MIRT774002	hsa-miR-299-3p	CLIP-seq
MIRT774004	hsa-miR-3184	CLIP-seq
MIRT774005	hsa-miR-3190	CLIP-seq
MIRT774006	hsa-miR-3202	CLIP-seq
MIRT1928429	hsa-miR-378	CLIP-seq
MIRT1928430	hsa-miR-378b	CLIP-seq
MIRT1928431	hsa-miR-378c	CLIP-seq
MIRT1928432	hsa-miR-378d	CLIP-seq
MIRT1928433	hsa-miR-378e	CLIP-seq
MIRT1928434	hsa-miR-378f	CLIP-seq
MIRT1928435	hsa-miR-378h	CLIP-seq
MIRT1928436	hsa-miR-378i	CLIP-seq
MIRT1928437	hsa-miR-422a	CLIP-seq
MIRT774007	hsa-miR-423-5p	CLIP-seq
MIRT1928438	hsa-miR-4306	CLIP-seq
MIRT1928439	hsa-miR-4323	CLIP-seq
MIRT1928440	hsa-miR-4433	CLIP-seq
MIRT1928441	hsa-miR-4459	CLIP-seq
MIRT1928442	hsa-miR-4487	CLIP-seq
MIRT774010	hsa-miR-4491	CLIP-seq
MIRT1928443	hsa-miR-4515	CLIP-seq
MIRT774011	hsa-miR-4530	CLIP-seq
MIRT774012	hsa-miR-4533	CLIP-seq
MIRT1928444	hsa-miR-4644	CLIP-seq
MIRT774015	hsa-miR-4657	CLIP-seq
MIRT774018	hsa-miR-4728-5p	CLIP-seq
MIRT774019	hsa-miR-4739	CLIP-seq
MIRT1928445	hsa-miR-4740-5p	CLIP-seq
MIRT774020	hsa-miR-4756-5p	CLIP-seq
MIRT1928446	hsa-miR-4768-3p	CLIP-seq
MIRT774023	hsa-miR-570	CLIP-seq
MIRT774025	hsa-miR-922	CLIP-seq
MIRT2169197	hsa-miR-1289	CLIP-seq
MIRT2169198	hsa-miR-198	CLIP-seq
MIRT2169199	hsa-miR-214	CLIP-seq
MIRT2169200	hsa-miR-3135b	CLIP-seq
MIRT2169201	hsa-miR-3198	CLIP-seq
MIRT2169202	hsa-miR-331-3p	CLIP-seq
MIRT2169203	hsa-miR-338-3p	CLIP-seq
MIRT2169204	hsa-miR-3616-5p	CLIP-seq
MIRT2169205	hsa-miR-3619-5p	CLIP-seq
MIRT2169206	hsa-miR-3647-5p	CLIP-seq
MIRT2169207	hsa-miR-3652	CLIP-seq
MIRT2169208	hsa-miR-4294	CLIP-seq
MIRT2169209	hsa-miR-4309	CLIP-seq
MIRT2169210	hsa-miR-4430	CLIP-seq
MIRT774011	hsa-miR-4530	CLIP-seq
MIRT2169211	hsa-miR-4690-5p	CLIP-seq
MIRT2169212	hsa-miR-4795-5p	CLIP-seq
MIRT774023	hsa-miR-570	CLIP-seq
MIRT2169213	hsa-miR-573	CLIP-seq
MIRT2169214	hsa-miR-761	CLIP-seq
MIRT774025	hsa-miR-922	CLIP-seq

Gene ontology (GO) Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001671	Function	ATPase activator activity	IBA
GO:0001671	Function	ATPase activator activity	IDA	12504007, 27353360, 29127155
GO:0001671	Function	ATPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	12604615, 16696853, 19875381, 20618441, 25036637, 25486457, 27353360, 30382094, 35271311
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0006457	Process	Protein folding	IBA
GO:0032781	Process	Positive regulation of ATP-dependent activity	IDA	29127155
GO:0036506	Process	Maintenance of unfolded protein	EXP	37486705
GO:0036506	Process	Maintenance of unfolded protein	IDA	37486705
GO:0044183	Function	Protein folding chaperone	EXP	33808352
GO:0044183	Function	Protein folding chaperone	IDA	33808352
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0051082	Function	Unfolded protein binding	EXP	33808352
GO:0051087	Function	Protein-folding chaperone binding	IDA	12504007, 27353360
GO:0051087	Function	Protein-folding chaperone binding	IEA
GO:0051879	Function	Hsp90 protein binding	IEA
GO:0051879	Function	Hsp90 protein binding	IPI	29127155
GO:0070062	Component	Extracellular exosome	HDA	19056867

Other IDs

• MIM: 608466
• HGNC: 1189
• e!Ensembl: ENSG00000100591

Protein

• UniProt ID: O95433
• Protein name: Activator of 90 kDa heat shock protein ATPase homolog 1 (AHA1) (p38)
• Protein function: Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby pro
• PDB: 1X53 , 7DMD , 7DME
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08327	AHSA1	216 → 332	Activator of Hsp90 ATPase homolog 1-like protein	Family
  PF09229	Aha1_N	29 → 159	Activator of Hsp90 ATPase, N-terminal	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta. {ECO:0000269|PubMed:11554768}.
• Sequence:

  MAKWGEGDPRWIVEERADATNVNNWHWTERDASNWSTDKLKTLFLAVQVQNEEGKCEVTE
  VSKLDGEASINNRKGKLIFFYEWSVKLNWTGTSKSGVQYKGHVEIPNLSDENSVDEVEIS
  VSLAKDEPDTNLVALMKEEGVKLLREAMGIYISTLKTEFTQGMILPTMNGESVDPVGQPA
  LKTEERKAKPAPSKTQARPVGVKIPTCKITLKETFLTSPEELYRVFTTQELVQAFTHAPA
  TLEADRGGKFHMVDGNVSGEFTDLVPEKHIVMKWRFKSWPEGHFATITLTFIDKNGETEL
  CMEGRGIPAPEEERTRQGWQRYYFEGIKQTFGYGARLF

• Sequence length: 338

Related Genes

No strongly related genes found yet for AHSA1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to AHSA1.