AGAP4 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 4)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 119016
• Gene name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
• Gene symbol: AGAP4
• Synonyms (NCBI Gene): AGAP-4, AGAP-8, AGAP8, CTGLF1, CTGLF5, MRIP2
• Chromosome: 10
• Chromosome location: 10q11.22

miRNA Show/Hide all (42)

miRTarBase ID	miRNA	Experiments	Reference
MIRT036118	hsa-miR-1296-5p	CLASH	23622248
MIRT771652	hsa-miR-182	CLIP-seq
MIRT771653	hsa-miR-3163	CLIP-seq
MIRT771654	hsa-miR-4470	CLIP-seq
MIRT771655	hsa-miR-548c-3p	CLIP-seq
MIRT771656	hsa-miR-584	CLIP-seq
MIRT771652	hsa-miR-182	CLIP-seq
MIRT2471110	hsa-miR-203	CLIP-seq
MIRT2471111	hsa-miR-2113	CLIP-seq
MIRT771653	hsa-miR-3163	CLIP-seq
MIRT2471112	hsa-miR-362-5p	CLIP-seq
MIRT2471113	hsa-miR-3647-3p	CLIP-seq
MIRT2471114	hsa-miR-4303	CLIP-seq
MIRT2471115	hsa-miR-4424	CLIP-seq
MIRT2471116	hsa-miR-4446-5p	CLIP-seq
MIRT771654	hsa-miR-4470	CLIP-seq
MIRT2471117	hsa-miR-4680-3p	CLIP-seq
MIRT2471118	hsa-miR-4682	CLIP-seq
MIRT2471119	hsa-miR-4699-3p	CLIP-seq
MIRT2471120	hsa-miR-4795-3p	CLIP-seq
MIRT2471121	hsa-miR-495	CLIP-seq
MIRT2471122	hsa-miR-500b	CLIP-seq
MIRT2471123	hsa-miR-501-5p	CLIP-seq
MIRT771655	hsa-miR-548c-3p	CLIP-seq
MIRT771656	hsa-miR-584	CLIP-seq
MIRT2471124	hsa-miR-599	CLIP-seq
MIRT2471125	hsa-miR-758	CLIP-seq
MIRT771652	hsa-miR-182	CLIP-seq
MIRT2471110	hsa-miR-203	CLIP-seq
MIRT771653	hsa-miR-3163	CLIP-seq
MIRT2471113	hsa-miR-3647-3p	CLIP-seq
MIRT2674689	hsa-miR-3672	CLIP-seq
MIRT2471114	hsa-miR-4303	CLIP-seq
MIRT2471115	hsa-miR-4424	CLIP-seq
MIRT771654	hsa-miR-4470	CLIP-seq
MIRT2471117	hsa-miR-4680-3p	CLIP-seq
MIRT2471118	hsa-miR-4682	CLIP-seq
MIRT2471120	hsa-miR-4795-3p	CLIP-seq
MIRT2471121	hsa-miR-495	CLIP-seq
MIRT771655	hsa-miR-548c-3p	CLIP-seq
MIRT771656	hsa-miR-584	CLIP-seq
MIRT2471125	hsa-miR-758	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003924	Function	GTPase activity	IBA
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 621155
• HGNC: 23459
• e!Ensembl: ENSG00000188234

Protein

• UniProt ID: Q96P64
• Protein name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4 (AGAP-4) (Centaurin-gamma-like family member 1) (Centaurin-gamma-like family member 5)
• Protein function: Putative GTPase-activating protein.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01412	ArfGap	441 → 557	Putative GTPase activating protein for Arf	Domain
  PF12796	Ank_2	568 → 662	Ankyrin repeats (3 copies)	Repeat

• Sequence:

  MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE
  DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYS
  LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMK
  KRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD
  KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM
  KNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKSNGLSKDMDTGLGDSICFSPSISS
  TTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL
  ASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS
  GIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEK
  ERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGD
  GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD
  KCV

• Sequence length: 663

Pathways

KEGG Pathway:

Endocytosis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Familial cancer of breast	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Liver carcinoma	Liver carcinoma	BEFREE	18400762		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for AGAP4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to AGAP4.