ADIRF (adipogenesis regulatory factor)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 10974 |
| Gene name | Adipogenesis regulatory factor |
| Gene symbol | ADIRF |
| Synonyms (NCBI Gene) |
AFROAPM2C10orf116apM-2
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| Chromosome | 10 |
| Chromosome location | 10q23.2 |
| Summary | APM2 gene is exclusively expressed in adipose tissue. Its function is currently unknown. [provided by RefSeq, Jul 2008] |
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q15847 |
| Protein name | Adipogenesis regulatory factor (Adipogenesis factor rich in obesity) (Adipose most abundant gene transcript 2 protein) (Adipose-specific protein 2) (apM-2) |
| Protein function | Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers res |
| Family and domains | |
| Tissue specificity | TISSUE SPECIFICITY: Expressed in adipose tissue (at protein level). Highly expressed in omental and subcutaneous adipose tissues. Expressed in heart, cornea, liver, kidney and spleen. {ECO:0000269|PubMed:23239344, ECO:0000269|Ref.4}. |
| Sequence |
MASKGLQDLKQQVEGTAQEAVSAAGAAAQQVVDQATEAGQKAMDQLAKTTQETIDKTANQ |
| Sequence length | 76 |
| Interactions | View interactions |
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with ADIRF across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to ADIRF (see Related Genes above), that are NOT already directly curated for ADIRF itself -- a lead worth checking, not a confirmed association.
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