ADAT1 (adenosine deaminase tRNA specific 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 23536 |
| Gene name | Adenosine deaminase tRNA specific 1 |
| Gene symbol | ADAT1 |
| Synonyms (NCBI Gene) |
HADAT1
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| Chromosome | 16 |
| Chromosome location | 16q23.1 |
| Summary | This gene is a member of the ADAR (adenosine deaminase acting on RNA) family. Using site-specific adenosine modification, proteins encoded by these genes participate in the pre-mRNA editing of nuclear transcripts. The protein encoded by this gene, tRNA-sp |
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miRNA
miRNA information provided by mirtarbase database.
541
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9BUB4 | ||||||||||
| Protein name | tRNA-specific adenosine deaminase 1 (hADAT1) (EC 3.5.4.34) (tRNA-specific adenosine-37 deaminase) | ||||||||||
| Protein function | Specifically deaminates adenosine-37 to inosine in tRNA-Ala. | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:10430867}. | ||||||||||
| Sequence |
MWTADEIAQLCYEHYGIRLPKKGKPEPNHEWTLLAAVVKIQSPADKACDTPDKPVQVTKE |
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| Sequence length | 502 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with ADAT1 across shared curated disease and pathway associations.
0
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to ADAT1 (see Related Genes above), that are NOT already directly curated for ADAT1 itself -- a lead worth checking, not a confirmed association.
0
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