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Gene Gene information from NCBI Gene database.
Entrez ID 23536
Gene name Adenosine deaminase tRNA specific 1
Gene symbol ADAT1
Synonyms (NCBI Gene)
HADAT1
Chromosome 16
Chromosome location 16q23.1
Summary This gene is a member of the ADAR (adenosine deaminase acting on RNA) family. Using site-specific adenosine modification, proteins encoded by these genes participate in the pre-mRNA editing of nuclear transcripts. The protein encoded by this gene, tRNA-sp
miRNA miRNA information provided by mirtarbase database.
541 Show/Hide all (541)
miRTarBase ID miRNA Experiments Reference
MIRT040601 hsa-miR-92b-3p CLASH 23622248
MIRT685126 hsa-miR-5690 HITS-CLIP 23313552
MIRT685125 hsa-miR-4768-3p HITS-CLIP 23313552
MIRT685124 hsa-miR-6746-5p HITS-CLIP 23313552
MIRT685123 hsa-miR-4722-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12 Show/Hide all (12)
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding IEA
GO:0003723 Function RNA binding IMP 10430867
GO:0004000 Function Adenosine deaminase activity IEA
GO:0006396 Process RNA processing IEA
GO:0008033 Process TRNA processing IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604230 228 ENSG00000065457
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BUB4
Protein name tRNA-specific adenosine deaminase 1 (hADAT1) (EC 3.5.4.34) (tRNA-specific adenosine-37 deaminase)
Protein function Specifically deaminates adenosine-37 to inosine in tRNA-Ala.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02137 A_deamin 63 → 495 Adenosine-deaminase (editase) domain Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:10430867}.
Sequence
Sequence length 502
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Prostate cancer Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations