ADAMTSL5 (ADAMTS like 5)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 339366
• Gene name: ADAMTS like 5
• Gene symbol: ADAMTSL5
• Synonyms (NCBI Gene): THSD6
• Chromosome: 19
• Chromosome location: 19p13.3

miRNA Show/Hide all (209)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022758	hsa-miR-124-3p	Microarray	18668037
MIRT766877	hsa-miR-106a	CLIP-seq
MIRT766878	hsa-miR-106b	CLIP-seq
MIRT766879	hsa-miR-1225-3p	CLIP-seq
MIRT766880	hsa-miR-1225-5p	CLIP-seq
MIRT766881	hsa-miR-1226	CLIP-seq
MIRT766882	hsa-miR-1231	CLIP-seq
MIRT766883	hsa-miR-1233	CLIP-seq
MIRT766884	hsa-miR-1244	CLIP-seq
MIRT766885	hsa-miR-1245b-3p	CLIP-seq
MIRT766886	hsa-miR-1254	CLIP-seq
MIRT766887	hsa-miR-1270	CLIP-seq
MIRT766888	hsa-miR-1276	CLIP-seq
MIRT766889	hsa-miR-128	CLIP-seq
MIRT766890	hsa-miR-1283	CLIP-seq
MIRT766891	hsa-miR-1293	CLIP-seq
MIRT766892	hsa-miR-1304	CLIP-seq
MIRT766893	hsa-miR-1343	CLIP-seq
MIRT766894	hsa-miR-147	CLIP-seq
MIRT766895	hsa-miR-17	CLIP-seq
MIRT766896	hsa-miR-1825	CLIP-seq
MIRT766897	hsa-miR-1827	CLIP-seq
MIRT766898	hsa-miR-185	CLIP-seq
MIRT766899	hsa-miR-1912	CLIP-seq
MIRT766900	hsa-miR-1915	CLIP-seq
MIRT766901	hsa-miR-199a-3p	CLIP-seq
MIRT766902	hsa-miR-199a-5p	CLIP-seq
MIRT766903	hsa-miR-199b-3p	CLIP-seq
MIRT766904	hsa-miR-199b-5p	CLIP-seq
MIRT766905	hsa-miR-20a	CLIP-seq
MIRT766906	hsa-miR-20b	CLIP-seq
MIRT766907	hsa-miR-22	CLIP-seq
MIRT766908	hsa-miR-2278	CLIP-seq
MIRT766909	hsa-miR-2467-5p	CLIP-seq
MIRT766910	hsa-miR-302a	CLIP-seq
MIRT766911	hsa-miR-302b	CLIP-seq
MIRT766912	hsa-miR-302c	CLIP-seq
MIRT766913	hsa-miR-302d	CLIP-seq
MIRT766914	hsa-miR-302e	CLIP-seq
MIRT766915	hsa-miR-30a	CLIP-seq
MIRT766916	hsa-miR-30b	CLIP-seq
MIRT766917	hsa-miR-30c	CLIP-seq
MIRT766918	hsa-miR-30d	CLIP-seq
MIRT766919	hsa-miR-30e	CLIP-seq
MIRT766920	hsa-miR-3116	CLIP-seq
MIRT766921	hsa-miR-3122	CLIP-seq
MIRT766922	hsa-miR-3129-5p	CLIP-seq
MIRT766923	hsa-miR-3130-5p	CLIP-seq
MIRT766924	hsa-miR-3171	CLIP-seq
MIRT766925	hsa-miR-3182	CLIP-seq
MIRT766926	hsa-miR-3188	CLIP-seq
MIRT766927	hsa-miR-3192	CLIP-seq
MIRT766928	hsa-miR-3612	CLIP-seq
MIRT766929	hsa-miR-3613-3p	CLIP-seq
MIRT766930	hsa-miR-3650	CLIP-seq
MIRT766931	hsa-miR-3667-5p	CLIP-seq
MIRT766932	hsa-miR-3675-3p	CLIP-seq
MIRT766933	hsa-miR-3689a-3p	CLIP-seq
MIRT766934	hsa-miR-3689c	CLIP-seq
MIRT766935	hsa-miR-372	CLIP-seq
MIRT766936	hsa-miR-373	CLIP-seq
MIRT766937	hsa-miR-3911	CLIP-seq
MIRT766938	hsa-miR-3913-5p	CLIP-seq
MIRT766939	hsa-miR-3929	CLIP-seq
MIRT766940	hsa-miR-3942-3p	CLIP-seq
MIRT766941	hsa-miR-3975	CLIP-seq
MIRT766942	hsa-miR-4259	CLIP-seq
MIRT766943	hsa-miR-4265	CLIP-seq
MIRT766944	hsa-miR-4296	CLIP-seq
MIRT766945	hsa-miR-4302	CLIP-seq
MIRT766946	hsa-miR-4306	CLIP-seq
MIRT766947	hsa-miR-4311	CLIP-seq
MIRT766948	hsa-miR-4314	CLIP-seq
MIRT766949	hsa-miR-4322	CLIP-seq
MIRT766950	hsa-miR-4417	CLIP-seq
MIRT766951	hsa-miR-4419a	CLIP-seq
MIRT766952	hsa-miR-4419b	CLIP-seq
MIRT766953	hsa-miR-4443	CLIP-seq
MIRT766954	hsa-miR-4455	CLIP-seq
MIRT766955	hsa-miR-4459	CLIP-seq
MIRT766956	hsa-miR-4468	CLIP-seq
MIRT766957	hsa-miR-4478	CLIP-seq
MIRT766958	hsa-miR-4482	CLIP-seq
MIRT766959	hsa-miR-4483	CLIP-seq
MIRT766960	hsa-miR-4510	CLIP-seq
MIRT766961	hsa-miR-4519	CLIP-seq
MIRT766962	hsa-miR-451b	CLIP-seq
MIRT766963	hsa-miR-4531	CLIP-seq
MIRT766964	hsa-miR-4644	CLIP-seq
MIRT766965	hsa-miR-4646-5p	CLIP-seq
MIRT766966	hsa-miR-4648	CLIP-seq
MIRT766967	hsa-miR-4654	CLIP-seq
MIRT766968	hsa-miR-4684-5p	CLIP-seq
MIRT766969	hsa-miR-4696	CLIP-seq
MIRT766970	hsa-miR-4703-3p	CLIP-seq
MIRT766971	hsa-miR-4711-3p	CLIP-seq
MIRT766972	hsa-miR-4715-5p	CLIP-seq
MIRT766973	hsa-miR-4722-5p	CLIP-seq
MIRT766974	hsa-miR-4728-5p	CLIP-seq
MIRT766975	hsa-miR-4733-3p	CLIP-seq
MIRT766976	hsa-miR-4743	CLIP-seq
MIRT766977	hsa-miR-4747-5p	CLIP-seq
MIRT766978	hsa-miR-4763-5p	CLIP-seq
MIRT766979	hsa-miR-4769-5p	CLIP-seq
MIRT766980	hsa-miR-4786-3p	CLIP-seq
MIRT766981	hsa-miR-485-5p	CLIP-seq
MIRT766982	hsa-miR-515-3p	CLIP-seq
MIRT766983	hsa-miR-516a-3p	CLIP-seq
MIRT766984	hsa-miR-519d	CLIP-seq
MIRT766985	hsa-miR-519e	CLIP-seq
MIRT766986	hsa-miR-520a-3p	CLIP-seq
MIRT766987	hsa-miR-520b	CLIP-seq
MIRT766988	hsa-miR-520c-3p	CLIP-seq
MIRT766989	hsa-miR-520d-3p	CLIP-seq
MIRT766990	hsa-miR-520e	CLIP-seq
MIRT766991	hsa-miR-520f	CLIP-seq
MIRT766992	hsa-miR-548c-3p	CLIP-seq
MIRT766993	hsa-miR-548t	CLIP-seq
MIRT766994	hsa-miR-550a	CLIP-seq
MIRT766995	hsa-miR-552	CLIP-seq
MIRT766996	hsa-miR-556-5p	CLIP-seq
MIRT766997	hsa-miR-558	CLIP-seq
MIRT766998	hsa-miR-578	CLIP-seq
MIRT766999	hsa-miR-583	CLIP-seq
MIRT767000	hsa-miR-620	CLIP-seq
MIRT767001	hsa-miR-636	CLIP-seq
MIRT767002	hsa-miR-644	CLIP-seq
MIRT767003	hsa-miR-650	CLIP-seq
MIRT767004	hsa-miR-661	CLIP-seq
MIRT767005	hsa-miR-663b	CLIP-seq
MIRT767006	hsa-miR-671-5p	CLIP-seq
MIRT767007	hsa-miR-885-3p	CLIP-seq
MIRT767008	hsa-miR-93	CLIP-seq
MIRT767009	hsa-miR-940	CLIP-seq
MIRT766879	hsa-miR-1225-3p	CLIP-seq
MIRT766883	hsa-miR-1233	CLIP-seq
MIRT766928	hsa-miR-3612	CLIP-seq
MIRT766933	hsa-miR-3689a-3p	CLIP-seq
MIRT766934	hsa-miR-3689c	CLIP-seq
MIRT766939	hsa-miR-3929	CLIP-seq
MIRT766952	hsa-miR-4419b	CLIP-seq
MIRT766953	hsa-miR-4443	CLIP-seq
MIRT766957	hsa-miR-4478	CLIP-seq
MIRT766974	hsa-miR-4728-5p	CLIP-seq
MIRT766981	hsa-miR-485-5p	CLIP-seq
MIRT767003	hsa-miR-650	CLIP-seq
MIRT766877	hsa-miR-106a	CLIP-seq
MIRT766878	hsa-miR-106b	CLIP-seq
MIRT766892	hsa-miR-1304	CLIP-seq
MIRT766893	hsa-miR-1343	CLIP-seq
MIRT766895	hsa-miR-17	CLIP-seq
MIRT766898	hsa-miR-185	CLIP-seq
MIRT766905	hsa-miR-20a	CLIP-seq
MIRT766906	hsa-miR-20b	CLIP-seq
MIRT766909	hsa-miR-2467-5p	CLIP-seq
MIRT766910	hsa-miR-302a	CLIP-seq
MIRT766911	hsa-miR-302b	CLIP-seq
MIRT766912	hsa-miR-302c	CLIP-seq
MIRT766913	hsa-miR-302d	CLIP-seq
MIRT766914	hsa-miR-302e	CLIP-seq
MIRT766926	hsa-miR-3188	CLIP-seq
MIRT766935	hsa-miR-372	CLIP-seq
MIRT766936	hsa-miR-373	CLIP-seq
MIRT766941	hsa-miR-3975	CLIP-seq
MIRT766946	hsa-miR-4306	CLIP-seq
MIRT2167279	hsa-miR-4428	CLIP-seq
MIRT766964	hsa-miR-4644	CLIP-seq
MIRT766981	hsa-miR-485-5p	CLIP-seq
MIRT766983	hsa-miR-516a-3p	CLIP-seq
MIRT766984	hsa-miR-519d	CLIP-seq
MIRT766986	hsa-miR-520a-3p	CLIP-seq
MIRT766987	hsa-miR-520b	CLIP-seq
MIRT766988	hsa-miR-520c-3p	CLIP-seq
MIRT766989	hsa-miR-520d-3p	CLIP-seq
MIRT766990	hsa-miR-520e	CLIP-seq
MIRT766991	hsa-miR-520f	CLIP-seq
MIRT766993	hsa-miR-548t	CLIP-seq
MIRT767001	hsa-miR-636	CLIP-seq
MIRT767007	hsa-miR-885-3p	CLIP-seq
MIRT767008	hsa-miR-93	CLIP-seq
MIRT766879	hsa-miR-1225-3p	CLIP-seq
MIRT766883	hsa-miR-1233	CLIP-seq
MIRT766892	hsa-miR-1304	CLIP-seq
MIRT766909	hsa-miR-2467-5p	CLIP-seq
MIRT766926	hsa-miR-3188	CLIP-seq
MIRT766933	hsa-miR-3689a-3p	CLIP-seq
MIRT766934	hsa-miR-3689c	CLIP-seq
MIRT766939	hsa-miR-3929	CLIP-seq
MIRT766941	hsa-miR-3975	CLIP-seq
MIRT766952	hsa-miR-4419b	CLIP-seq
MIRT766957	hsa-miR-4478	CLIP-seq
MIRT766974	hsa-miR-4728-5p	CLIP-seq
MIRT766981	hsa-miR-485-5p	CLIP-seq
MIRT766890	hsa-miR-1283	CLIP-seq
MIRT766929	hsa-miR-3613-3p	CLIP-seq
MIRT766931	hsa-miR-3667-5p	CLIP-seq
MIRT766932	hsa-miR-3675-3p	CLIP-seq
MIRT2469937	hsa-miR-4282	CLIP-seq
MIRT766968	hsa-miR-4684-5p	CLIP-seq
MIRT2469938	hsa-miR-548n	CLIP-seq
MIRT766993	hsa-miR-548t	CLIP-seq
MIRT766890	hsa-miR-1283	CLIP-seq
MIRT766929	hsa-miR-3613-3p	CLIP-seq
MIRT766931	hsa-miR-3667-5p	CLIP-seq
MIRT766932	hsa-miR-3675-3p	CLIP-seq
MIRT2469937	hsa-miR-4282	CLIP-seq
MIRT766968	hsa-miR-4684-5p	CLIP-seq
MIRT2469938	hsa-miR-548n	CLIP-seq
MIRT766993	hsa-miR-548t	CLIP-seq

Gene ontology (GO) Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001527	Component	Microfibril	IDA	23010571
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005576	Component	Extracellular region	IDA	23010571
GO:0005576	Component	Extracellular region	IEA
GO:0008201	Function	Heparin binding	IDA	23010571
GO:0008201	Function	Heparin binding	IEA
GO:0030198	Process	Extracellular matrix organization	IEA
GO:0031012	Component	Extracellular matrix	IDA	23010571
GO:0050436	Function	Microfibril binding	IDA	23010571

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q6ZMM2
• Protein name: ADAMTS-like protein 5 (ADAMTSL-5) (Thrombospondin type-1 domain-containing protein 6)
• Protein function: May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01759	NTR	374 → 477	UNC-6/NTR/C345C module	Domain
  PF05986	ADAM_spacer1	202 → 311	ADAM-TS Spacer 1	Family
  PF00090	TSP_1	49 → 96	Thrombospondin type 1 domain	Domain

• Sequence:

  MGKLRPGRVEWLASGHTERPHLFQNLLLFLWALLNCGLGVSAQGPGEWTPWVSWTRCSSS
  CGRGVSVRSRRCLRLPGEEPCWGDSHEYRLCQLPDCPPGAVPFRDLQCALYNGRPVLGTQ
  KTYQWVPFHGAPNQCDLNCLAEGHAFYHSFGRVLDGTACSPGAQGVCVAGRCLSAGCDGL
  LGSGALEDRCGRCGGANDSCLFVQRVFRDAGAFAGYWNVTLIPEGARHIRVEHRSRNHLA
  LMGGDGRYVLNGHWVVSPPGTYEAAGTHVVYTRDTGPQETLQAAGPTSHDLLLQVLLQEP
  NPGIEFEFWLPRERYSPFQARVQALGWPLRQPQPRGVEPQPPAAPAVTPAQTPTLAPDPC
  PPCPDTRGRAHRLLHYCGSDFVFQARVLGHHHQAQETRYEVRIQLVYKNRSPLRAREYVW
  APGHCPCPMLAPHRDYLMAVQRLVSPDGTQDQLLLPHAGYARPWSPAEDSRIRLTARRCP
  G

• Sequence length: 481

Pathways

Reactome Pathway

Defective B3GALTL causes Peters-plus syndrome (PpS)

O-glycosylation of TSR domain-containing proteins

Related Genes

Sort by: Blended Diseases Pathways Evidence source

SPON2 2 shared pathwaysDefective B3GALTL causes Peters-plus syndrome (PpS), O-glycosylation of TSR domain-containing proteins Related via 2 shared pathways including Defective B3GALTL causes Peters-plus syndrome (PpS), O-glycosylation of TSR domain-containing proteins. SPON1 2 shared pathwaysDefective B3GALTL causes Peters-plus syndrome (PpS), O-glycosylation of TSR domain-containing proteins Related via 2 shared pathways including Defective B3GALTL causes Peters-plus syndrome (PpS), O-glycosylation of TSR domain-containing proteins. ADAMTS8 2 shared pathwaysDefective B3GALTL causes Peters-plus syndrome (PpS), O-glycosylation of TSR domain-containing proteins Related via 2 shared pathways including Defective B3GALTL causes Peters-plus syndrome (PpS), O-glycosylation of TSR domain-containing proteins. ADAMTS7 2 shared pathwaysDefective B3GALTL causes Peters-plus syndrome (PpS), O-glycosylation of TSR domain-containing proteins Related via 2 shared pathways including Defective B3GALTL causes Peters-plus syndrome (PpS), O-glycosylation of TSR domain-containing proteins. ADAMTS6 2 shared pathwaysDefective B3GALTL causes Peters-plus syndrome (PpS), O-glycosylation of TSR domain-containing proteins Related via 2 shared pathways including Defective B3GALTL causes Peters-plus syndrome (PpS), O-glycosylation of TSR domain-containing proteins.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
SPON2	0	[]	2	["Defective B3GALTL causes Peters-plus syndrome (PpS)","O-glycosylation of TSR domain-containing proteins"]	0	[]
SPON1	0	[]	2	["Defective B3GALTL causes Peters-plus syndrome (PpS)","O-glycosylation of TSR domain-containing proteins"]	0	[]
ADAMTS8	0	[]	2	["Defective B3GALTL causes Peters-plus syndrome (PpS)","O-glycosylation of TSR domain-containing proteins"]	0	[]
ADAMTS7	0	[]	2	["Defective B3GALTL causes Peters-plus syndrome (PpS)","O-glycosylation of TSR domain-containing proteins"]	0	[]
ADAMTS6	0	[]	2	["Defective B3GALTL causes Peters-plus syndrome (PpS)","O-glycosylation of TSR domain-containing proteins"]	0	[]

Diseases Linked via Similar Genes

Prostatic neoplasms Linked via 2 of 5 related genesSPON2, ADAMTS8 Breast cancer Linked via 2 of 5 related genesSPON1, ADAMTS8 Scoliosis Linked via 2 of 5 related genesSPON1, ADAMTS6 Open angle glaucoma Linked via 2 of 5 related genesADAMTS8, ADAMTS6 Basal cell carcinoma Linked via 1 of 5 related genesSPON2

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Prostatic neoplasms	2	["SPON2","ADAMTS8"]
Breast cancer	2	["SPON1","ADAMTS8"]
Scoliosis	2	["SPON1","ADAMTS6"]
Open angle glaucoma	2	["ADAMTS8","ADAMTS6"]
Basal cell carcinoma	1	["SPON2"]