Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	203102
Gene name	ADAM metallopeptidase domain 32
Gene symbol	ADAM32
Synonyms (NCBI Gene)	-
Chromosome	8
Chromosome location	8p11.22
Summary	This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. This gene is predominantly expressed in the t

miRTarBase ID	miRNA	Experiments	Reference
MIRT017529	hsa-miR-335-5p	Microarray	18185580

12 Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0007155	Process	Cell adhesion	IBA
GO:0007339	Process	Binding of sperm to zona pellucida	IBA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008584	Process	Male gonad development	IBA
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
618602	15479	ENSG00000197140

Q8TC27

Protein name

Disintegrin and metalloproteinase domain-containing protein 32 (ADAM 32)

Protein function

May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00200	Disintegrin	400 → 474	Disintegrin	Domain
PF01421	Reprolysin	186 → 383	Reprolysin (M12B) family zinc metalloprotease	Domain
PF01562	Pep_M12B_propep	23 → 144	Reprolysin family propeptide	Family
PF08516	ADAM_CR	479 → 594	ADAM cysteine-rich	Family

Tissue specificity

TISSUE SPECIFICITY: Testis specific. {ECO:0000269|PubMed:12568724}.

Sequence

MFRLWLLLAGLCGLLASRPGFQNSLLQIVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLY
TVHLKQRYFLADNFMIYLYNQGSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSGLRGI
LQFENVSYGIEPLESAVEFQHVLYKLKNEDNDIAIFIDRSLKEQPMDDNIFISEKSEPAV
PDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWS
DENKISTVGEADELLQKFLEWKQSYLNLRPHDIAYLLIYMDYPRYLGAVFPGTMCITRYS
AGVALYPKEITLEAFAVIVTQMLALSLGISYDDPKKCQCSESTCIMNPEVVQSNGVKTFS
SCSLRSFQNFISNVGVKCLQNKPQMQKKSPKPVCGNGRLEGNEICDCGTEAQCGPASCCD
FRTCVLKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLING
LSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPFACYEEIQSQSDRFGNCGRDRNNKYV
FCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGS
QCDIGRVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGF
SIFPEEDMGSIMERASGKTENTWLLGFLIALPILIVTTAIVLARKQLKKWFAKEEEFPSS
ESKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKSEDSAEAYTSRSKSQDST
QTQSSSN

Sequence length

787

Interactions

View interactions

Related Genes Genes most often co-reported with ADAM32 across shared curated disease and pathway associations. 0 Download as csv Download as pdf
No strongly related genes found yet for ADAM32.

Diseases Linked via Similar Genes Diseases curated for genes most similar to ADAM32 (see Related Genes above), that are NOT already directly curated for ADAM32 itself -- a lead worth checking, not a confirmed association. 0 Download as csv Download as pdf
No additional diseases found yet through genes similar to ADAM32.

ADAM32 (ADAM metallopeptidase domain 32)

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