Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	23305
Gene name	Acyl-CoA synthetase long chain family member 6
Gene symbol	ACSL6
Synonyms (NCBI Gene)	ACS2FACL6LACS 6LACS2LACS5
Chromosome	5
Chromosome location	5q31.1
Summary	The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes

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Show/Hide all (271)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025504	hsa-miR-34a-5p	Proteomics	21566225
MIRT669636	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT669635	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT669634	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT669633	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT669632	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT669631	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT669630	hsa-miR-1281	HITS-CLIP	23824327
MIRT669629	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT669628	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT669627	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT669626	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT669625	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT669624	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT669623	hsa-miR-4284	HITS-CLIP	23824327
MIRT669622	hsa-miR-1206	HITS-CLIP	23824327
MIRT669621	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT504023	hsa-miR-618	PAR-CLIP	23446348
MIRT504022	hsa-miR-4714-5p	PAR-CLIP	23446348
MIRT504021	hsa-miR-6814-5p	PAR-CLIP	23446348
MIRT504020	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT504019	hsa-miR-532-3p	PAR-CLIP	23446348
MIRT504017	hsa-miR-2116-3p	PAR-CLIP	23446348
MIRT504018	hsa-miR-3921	PAR-CLIP	23446348
MIRT504016	hsa-miR-4653-5p	PAR-CLIP	23446348
MIRT504015	hsa-miR-4682	PAR-CLIP	23446348
MIRT504014	hsa-miR-942-5p	PAR-CLIP	23446348
MIRT504013	hsa-miR-4713-5p	PAR-CLIP	23446348
MIRT504012	hsa-miR-6867-3p	PAR-CLIP	23446348
MIRT504010	hsa-miR-629-3p	PAR-CLIP	23446348
MIRT504009	hsa-miR-6875-3p	PAR-CLIP	23446348
MIRT504008	hsa-miR-4659a-3p	PAR-CLIP	23446348
MIRT504007	hsa-miR-4659b-3p	PAR-CLIP	23446348
MIRT504023	hsa-miR-618	PAR-CLIP	23446348
MIRT504022	hsa-miR-4714-5p	PAR-CLIP	23446348
MIRT504021	hsa-miR-6814-5p	PAR-CLIP	23446348
MIRT504020	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT504019	hsa-miR-532-3p	PAR-CLIP	23446348
MIRT504017	hsa-miR-2116-3p	PAR-CLIP	23446348
MIRT504018	hsa-miR-3921	PAR-CLIP	23446348
MIRT504016	hsa-miR-4653-5p	PAR-CLIP	23446348
MIRT504015	hsa-miR-4682	PAR-CLIP	23446348
MIRT504014	hsa-miR-942-5p	PAR-CLIP	23446348
MIRT504013	hsa-miR-4713-5p	PAR-CLIP	23446348
MIRT504012	hsa-miR-6867-3p	PAR-CLIP	23446348
MIRT504011	hsa-miR-670-3p	PAR-CLIP	23446348
MIRT504010	hsa-miR-629-3p	PAR-CLIP	23446348
MIRT504009	hsa-miR-6875-3p	PAR-CLIP	23446348
MIRT504008	hsa-miR-4659a-3p	PAR-CLIP	23446348
MIRT504007	hsa-miR-4659b-3p	PAR-CLIP	23446348
MIRT445417	hsa-miR-5584-3p	PAR-CLIP	22100165
MIRT445416	hsa-miR-4277	PAR-CLIP	22100165
MIRT445415	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT445414	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT445413	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445412	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT445417	hsa-miR-5584-3p	PAR-CLIP	22100165
MIRT445416	hsa-miR-4277	PAR-CLIP	22100165
MIRT445415	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT445414	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT445413	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445412	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT669636	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT669635	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT669634	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT669633	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT669632	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT669631	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT669630	hsa-miR-1281	HITS-CLIP	23824327
MIRT669629	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT669628	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT669627	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT669626	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT669625	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT669624	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT669623	hsa-miR-4284	HITS-CLIP	23824327
MIRT669622	hsa-miR-1206	HITS-CLIP	23824327
MIRT669621	hsa-miR-4524b-3p	HITS-CLIP	23824327
MIRT504023	hsa-miR-618	PAR-CLIP	23446348
MIRT504022	hsa-miR-4714-5p	PAR-CLIP	23446348
MIRT504021	hsa-miR-6814-5p	PAR-CLIP	23446348
MIRT504020	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT504019	hsa-miR-532-3p	PAR-CLIP	23446348
MIRT504017	hsa-miR-2116-3p	PAR-CLIP	23446348
MIRT504018	hsa-miR-3921	PAR-CLIP	23446348
MIRT504016	hsa-miR-4653-5p	PAR-CLIP	23446348
MIRT504015	hsa-miR-4682	PAR-CLIP	23446348
MIRT504014	hsa-miR-942-5p	PAR-CLIP	23446348
MIRT504013	hsa-miR-4713-5p	PAR-CLIP	23446348
MIRT504012	hsa-miR-6867-3p	PAR-CLIP	23446348
MIRT504010	hsa-miR-629-3p	PAR-CLIP	23446348
MIRT504009	hsa-miR-6875-3p	PAR-CLIP	23446348
MIRT504008	hsa-miR-4659a-3p	PAR-CLIP	23446348
MIRT504007	hsa-miR-4659b-3p	PAR-CLIP	23446348
MIRT504023	hsa-miR-618	PAR-CLIP	23446348
MIRT504022	hsa-miR-4714-5p	PAR-CLIP	23446348
MIRT504021	hsa-miR-6814-5p	PAR-CLIP	23446348
MIRT504020	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT504019	hsa-miR-532-3p	PAR-CLIP	23446348
MIRT504017	hsa-miR-2116-3p	PAR-CLIP	23446348
MIRT504018	hsa-miR-3921	PAR-CLIP	23446348
MIRT504016	hsa-miR-4653-5p	PAR-CLIP	23446348
MIRT504015	hsa-miR-4682	PAR-CLIP	23446348
MIRT504014	hsa-miR-942-5p	PAR-CLIP	23446348
MIRT504013	hsa-miR-4713-5p	PAR-CLIP	23446348
MIRT504012	hsa-miR-6867-3p	PAR-CLIP	23446348
MIRT504011	hsa-miR-670-3p	PAR-CLIP	23446348
MIRT504010	hsa-miR-629-3p	PAR-CLIP	23446348
MIRT504009	hsa-miR-6875-3p	PAR-CLIP	23446348
MIRT504008	hsa-miR-4659a-3p	PAR-CLIP	23446348
MIRT504007	hsa-miR-4659b-3p	PAR-CLIP	23446348
MIRT445417	hsa-miR-5584-3p	PAR-CLIP	22100165
MIRT445416	hsa-miR-4277	PAR-CLIP	22100165
MIRT445415	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT445414	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT445413	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445412	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT445417	hsa-miR-5584-3p	PAR-CLIP	22100165
MIRT445416	hsa-miR-4277	PAR-CLIP	22100165
MIRT445415	hsa-miR-539-5p	PAR-CLIP	22100165
MIRT445414	hsa-miR-431-5p	PAR-CLIP	22100165
MIRT445413	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445412	hsa-miR-580-3p	PAR-CLIP	22100165
MIRT763592	hsa-miR-1321	CLIP-seq
MIRT763593	hsa-miR-1913	CLIP-seq
MIRT763594	hsa-miR-1976	CLIP-seq
MIRT763595	hsa-miR-3162-5p	CLIP-seq
MIRT763596	hsa-miR-3199	CLIP-seq
MIRT763597	hsa-miR-324-3p	CLIP-seq
MIRT763598	hsa-miR-4258	CLIP-seq
MIRT763599	hsa-miR-4279	CLIP-seq
MIRT763600	hsa-miR-4438	CLIP-seq
MIRT763601	hsa-miR-4707-3p	CLIP-seq
MIRT763602	hsa-miR-4722-3p	CLIP-seq
MIRT763603	hsa-miR-4739	CLIP-seq
MIRT763604	hsa-miR-4740-3p	CLIP-seq
MIRT763605	hsa-miR-4756-5p	CLIP-seq
MIRT763606	hsa-miR-500a	CLIP-seq
MIRT763607	hsa-miR-5095	CLIP-seq
MIRT763608	hsa-miR-617	CLIP-seq
MIRT763609	hsa-miR-10a	CLIP-seq
MIRT763610	hsa-miR-10b	CLIP-seq
MIRT763611	hsa-miR-1193	CLIP-seq
MIRT763612	hsa-miR-1208	CLIP-seq
MIRT763613	hsa-miR-1256	CLIP-seq
MIRT763614	hsa-miR-129-5p	CLIP-seq
MIRT763592	hsa-miR-1321	CLIP-seq
MIRT763615	hsa-miR-1323	CLIP-seq
MIRT763593	hsa-miR-1913	CLIP-seq
MIRT763616	hsa-miR-1915	CLIP-seq
MIRT763594	hsa-miR-1976	CLIP-seq
MIRT763617	hsa-miR-2115	CLIP-seq
MIRT763618	hsa-miR-2278	CLIP-seq
MIRT763619	hsa-miR-2392	CLIP-seq
MIRT763620	hsa-miR-3152-3p	CLIP-seq
MIRT763595	hsa-miR-3162-5p	CLIP-seq
MIRT763596	hsa-miR-3199	CLIP-seq
MIRT763597	hsa-miR-324-3p	CLIP-seq
MIRT763621	hsa-miR-339-5p	CLIP-seq
MIRT763622	hsa-miR-371-5p	CLIP-seq
MIRT763623	hsa-miR-371b-5p	CLIP-seq
MIRT763599	hsa-miR-4279	CLIP-seq
MIRT763624	hsa-miR-4282	CLIP-seq
MIRT763625	hsa-miR-4420	CLIP-seq
MIRT763626	hsa-miR-4421	CLIP-seq
MIRT763600	hsa-miR-4438	CLIP-seq
MIRT763627	hsa-miR-4468	CLIP-seq
MIRT763628	hsa-miR-450b-5p	CLIP-seq
MIRT763629	hsa-miR-4642	CLIP-seq
MIRT763630	hsa-miR-4661-3p	CLIP-seq
MIRT763631	hsa-miR-4662a-5p	CLIP-seq
MIRT763632	hsa-miR-4676-5p	CLIP-seq
MIRT763601	hsa-miR-4707-3p	CLIP-seq
MIRT763602	hsa-miR-4722-3p	CLIP-seq
MIRT763633	hsa-miR-4725-5p	CLIP-seq
MIRT763603	hsa-miR-4739	CLIP-seq
MIRT763604	hsa-miR-4740-3p	CLIP-seq
MIRT763605	hsa-miR-4756-5p	CLIP-seq
MIRT763634	hsa-miR-483-5p	CLIP-seq
MIRT763635	hsa-miR-504	CLIP-seq
MIRT763636	hsa-miR-507	CLIP-seq
MIRT763607	hsa-miR-5095	CLIP-seq
MIRT763637	hsa-miR-516a-3p	CLIP-seq
MIRT763638	hsa-miR-518a-5p	CLIP-seq
MIRT763639	hsa-miR-527	CLIP-seq
MIRT763640	hsa-miR-548aa	CLIP-seq
MIRT763641	hsa-miR-548o	CLIP-seq
MIRT763642	hsa-miR-557	CLIP-seq
MIRT763643	hsa-miR-575	CLIP-seq
MIRT763608	hsa-miR-617	CLIP-seq
MIRT763644	hsa-miR-892a	CLIP-seq
MIRT763645	hsa-let-7a	CLIP-seq
MIRT763646	hsa-let-7b	CLIP-seq
MIRT763647	hsa-let-7c	CLIP-seq
MIRT763648	hsa-let-7d	CLIP-seq
MIRT763649	hsa-let-7e	CLIP-seq
MIRT763650	hsa-let-7f	CLIP-seq
MIRT763651	hsa-let-7g	CLIP-seq
MIRT763652	hsa-let-7i	CLIP-seq
MIRT763653	hsa-miR-196a	CLIP-seq
MIRT763654	hsa-miR-196b	CLIP-seq
MIRT763655	hsa-miR-202	CLIP-seq
MIRT763656	hsa-miR-3653	CLIP-seq
MIRT763657	hsa-miR-3658	CLIP-seq
MIRT763658	hsa-miR-3926	CLIP-seq
MIRT763659	hsa-miR-4458	CLIP-seq
MIRT763660	hsa-miR-4500	CLIP-seq
MIRT763661	hsa-miR-4511	CLIP-seq
MIRT763662	hsa-miR-4699-3p	CLIP-seq
MIRT763663	hsa-miR-4724-5p	CLIP-seq
MIRT763664	hsa-miR-4753-5p	CLIP-seq
MIRT763665	hsa-miR-548b-3p	CLIP-seq
MIRT763666	hsa-miR-98	CLIP-seq
MIRT1925058	hsa-miR-3671	CLIP-seq
MIRT1925059	hsa-miR-3689a-3p	CLIP-seq
MIRT1925060	hsa-miR-3689c	CLIP-seq
MIRT1925061	hsa-miR-3689d	CLIP-seq
MIRT1925062	hsa-miR-4459	CLIP-seq
MIRT1925063	hsa-miR-4728-5p	CLIP-seq
MIRT1925064	hsa-miR-579	CLIP-seq
MIRT1925065	hsa-miR-944	CLIP-seq
MIRT2166515	hsa-miR-105	CLIP-seq
MIRT763609	hsa-miR-10a	CLIP-seq
MIRT763610	hsa-miR-10b	CLIP-seq
MIRT2166516	hsa-miR-1307	CLIP-seq
MIRT763616	hsa-miR-1915	CLIP-seq
MIRT763594	hsa-miR-1976	CLIP-seq
MIRT2166517	hsa-miR-2276	CLIP-seq
MIRT763618	hsa-miR-2278	CLIP-seq
MIRT2166518	hsa-miR-3135	CLIP-seq
MIRT763596	hsa-miR-3199	CLIP-seq
MIRT763621	hsa-miR-339-5p	CLIP-seq
MIRT2166519	hsa-miR-3646	CLIP-seq
MIRT763599	hsa-miR-4279	CLIP-seq
MIRT763626	hsa-miR-4421	CLIP-seq
MIRT763600	hsa-miR-4438	CLIP-seq
MIRT1925062	hsa-miR-4459	CLIP-seq
MIRT763627	hsa-miR-4468	CLIP-seq
MIRT763630	hsa-miR-4661-3p	CLIP-seq
MIRT763602	hsa-miR-4722-3p	CLIP-seq
MIRT763663	hsa-miR-4724-5p	CLIP-seq
MIRT763633	hsa-miR-4725-5p	CLIP-seq
MIRT763604	hsa-miR-4740-3p	CLIP-seq
MIRT2166520	hsa-miR-494	CLIP-seq
MIRT2166521	hsa-miR-499-3p	CLIP-seq
MIRT2166522	hsa-miR-499a-3p	CLIP-seq
MIRT763635	hsa-miR-504	CLIP-seq
MIRT763607	hsa-miR-5095	CLIP-seq
MIRT2166523	hsa-miR-542-3p	CLIP-seq
MIRT2166524	hsa-miR-664	CLIP-seq
MIRT2166525	hsa-miR-935	CLIP-seq
MIRT763609	hsa-miR-10a	CLIP-seq
MIRT763610	hsa-miR-10b	CLIP-seq
MIRT2674326	hsa-miR-1267	CLIP-seq
MIRT2166516	hsa-miR-1307	CLIP-seq
MIRT763615	hsa-miR-1323	CLIP-seq
MIRT2674327	hsa-miR-1908	CLIP-seq
MIRT2674328	hsa-miR-3135b	CLIP-seq
MIRT763621	hsa-miR-339-5p	CLIP-seq
MIRT2674329	hsa-miR-3652	CLIP-seq
MIRT763622	hsa-miR-371-5p	CLIP-seq
MIRT763623	hsa-miR-371b-5p	CLIP-seq
MIRT2674330	hsa-miR-4294	CLIP-seq
MIRT763626	hsa-miR-4421	CLIP-seq
MIRT2674331	hsa-miR-4423-5p	CLIP-seq
MIRT2674332	hsa-miR-4430	CLIP-seq
MIRT2674333	hsa-miR-4652-3p	CLIP-seq
MIRT763633	hsa-miR-4725-5p	CLIP-seq
MIRT763635	hsa-miR-504	CLIP-seq
MIRT763641	hsa-miR-548o	CLIP-seq
MIRT2674334	hsa-miR-663	CLIP-seq

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000038	Process	Very long-chain fatty acid metabolic process	IBA
GO:0000166	Function	Nucleotide binding	IEA
GO:0001676	Process	Long-chain fatty acid metabolic process	IBA
GO:0001676	Process	Long-chain fatty acid metabolic process	IDA	20429931, 24269233
GO:0001676	Process	Long-chain fatty acid metabolic process	IMP	22633490
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IDA	20429931, 24269233
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IEA
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IMP	22633490
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	NAS	10548543
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	TAS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005524	Function	ATP binding	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005777	Component	Peroxisome	IEA
GO:0005778	Component	Peroxisomal membrane	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	24269233
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005886	Component	Plasma membrane	NAS	10548543
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006637	Process	Acyl-CoA metabolic process	NAS	10548543
GO:0007405	Process	Neuroblast proliferation	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IDA	16834775, 20429931
GO:0016020	Component	Membrane	IEA
GO:0016874	Function	Ligase activity	IEA
GO:0019899	Function	Enzyme binding	IPI	20429931
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	IBA
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	TAS
GO:0042803	Function	Protein homodimerization activity	IDA	20429931
GO:0047676	Function	Arachidonate-CoA ligase activity	IBA
GO:0047676	Function	Arachidonate-CoA ligase activity	IEA
GO:0047676	Function	Arachidonate-CoA ligase activity	ISS

MIM	HGNC	e!Ensembl
604443	16496	ENSG00000164398

Q9UKU0

Protein name

Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 6) (LACS 6)

Protein function

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490, PubMed:24269233). Plays an important role in fatty acid metabolism in br

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00501	AMP-binding	103 → 563	AMP-binding enzyme	Family
PF13193	AMP-binding_C	572 → 661	AMP-binding enzyme C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain. {ECO:0000269|PubMed:10548543}.

Sequence

MQTQEILRILRLPELGDLGQFFRSLSATTLVSMGALAAILAYWFTHRPKALQPPCNLLMQ
SEEVEDSGGARRSVIGSGPQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPKQPYQW
LSYQEVADRAEFLGSGLLQHNCKACTDQFIGVFAQNRPEWIIVELACYTYSMVVVPLYDT
LGPGAIRYIINTADISTVIVDKPQKAVLLLEHVERKETPGLKLIILMDPFEEALKERGQK
CGVVIKSMQAVEDCGQENHQAPVPPQPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGF
LKVTEKVIFPRQDDVLISFLPLAHMFERVIQSVVYCHGGRVGFFQGDIRLLSDDMKALCP
TIFPVVPRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKI
QASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHV
GAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGD
IGKWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGI
VVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQVKAIHIHS
DMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM

Sequence length

697

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ACSL6-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AMPHETAMINE OR RELATED ACTING SYMPATHOMIMETIC ABUSE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AMPHETAMINE-RELATED DISORDERS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATOPIC ECZEMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (26)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute Coronary Syndrome	Coronary Syndrome	BEFREE	29566413, 30340765		★★★★★ ★☆☆☆☆ Found in Text Mining only
Acute Erythroblastic Leukemia	Erythroblastic Leukemia	BEFREE	10502316		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer`s Disease	Alzheimer disease	GWASCAT_DG	25778476		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	32813933	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	29973580	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	30340765		★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	28805067		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic Neoplasms	BEFREE	10502316		★★★★★ ★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	27341449	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	27171439	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	10502316, 27171439		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	GENOMICS_ENGLAND_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental disorders	Mental Disorders	BEFREE	16827919		★★★★★ ★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	10502316		★★★★★ ★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	GENOMICS_ENGLAND_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	29566413, 30340765		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22436383		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	28805067	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Failure, Premature	Ovarian Failure	BEFREE	18555221		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycythemia Vera	Polycythemia Vera	LHGDN	16572202		★★★★★ ★☆☆☆☆ Found in Text Mining only
Premature Menopause	Premature Menopause	BEFREE	18555221		★★★★★ ★☆☆☆☆ Found in Text Mining only
Refractory anaemia with excess blasts	Myelodysplastic syndrome	BEFREE	10502316		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizoaffective Disorder	Schizoaffective Disorder	BEFREE	16827919		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	16827919, 17030554, 18718982, 22205969		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	16827919, 17030554, 18718982		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	LHGDN	17030554, 18718982		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ACSL6 (acyl-CoA synthetase long chain family member 6)