ACSF2 (acyl-CoA synthetase family member 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 80221
• Gene name: Acyl-CoA synthetase family member 2
• Gene symbol: ACSF2
• Synonyms (NCBI Gene): ACSMW, AVYV493
• Chromosome: 17
• Chromosome location: 17q21.33

miRNA Show/Hide all (88)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017740	hsa-miR-335-5p	Microarray	18185580
MIRT029317	hsa-miR-26b-5p	Microarray	19088304
MIRT453193	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT453192	hsa-miR-4459	PAR-CLIP	23592263
MIRT453191	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT453190	hsa-miR-5004-5p	PAR-CLIP	23592263
MIRT453189	hsa-miR-4751	PAR-CLIP	23592263
MIRT453188	hsa-miR-3915	PAR-CLIP	23592263
MIRT453187	hsa-miR-1224-5p	PAR-CLIP	23592263
MIRT453186	hsa-miR-4689	PAR-CLIP	23592263
MIRT453185	hsa-miR-6858-5p	PAR-CLIP	23592263
MIRT453184	hsa-miR-1273e	PAR-CLIP	23592263
MIRT453183	hsa-miR-1304-5p	PAR-CLIP	23592263
MIRT453193	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT453192	hsa-miR-4459	PAR-CLIP	23592263
MIRT453191	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT453190	hsa-miR-5004-5p	PAR-CLIP	23592263
MIRT453189	hsa-miR-4751	PAR-CLIP	23592263
MIRT453188	hsa-miR-3915	PAR-CLIP	23592263
MIRT453187	hsa-miR-1224-5p	PAR-CLIP	23592263
MIRT453186	hsa-miR-4689	PAR-CLIP	23592263
MIRT453185	hsa-miR-6858-5p	PAR-CLIP	23592263
MIRT453184	hsa-miR-1273e	PAR-CLIP	23592263
MIRT453183	hsa-miR-1304-5p	PAR-CLIP	23592263
MIRT1924988	hsa-miR-1324	CLIP-seq
MIRT1924989	hsa-miR-4457	CLIP-seq
MIRT1924990	hsa-miR-513b	CLIP-seq
MIRT2166324	hsa-miR-1	CLIP-seq
MIRT2166325	hsa-miR-1254	CLIP-seq
MIRT1924988	hsa-miR-1324	CLIP-seq
MIRT2166326	hsa-miR-149	CLIP-seq
MIRT2166327	hsa-miR-185	CLIP-seq
MIRT2166328	hsa-miR-206	CLIP-seq
MIRT2166329	hsa-miR-24	CLIP-seq
MIRT2166330	hsa-miR-299-3p	CLIP-seq
MIRT2166331	hsa-miR-3116	CLIP-seq
MIRT2166332	hsa-miR-3144-5p	CLIP-seq
MIRT2166333	hsa-miR-3191	CLIP-seq
MIRT2166334	hsa-miR-4284	CLIP-seq
MIRT2166335	hsa-miR-4306	CLIP-seq
MIRT1924989	hsa-miR-4457	CLIP-seq
MIRT2166336	hsa-miR-455-5p	CLIP-seq
MIRT2166337	hsa-miR-4644	CLIP-seq
MIRT2166338	hsa-miR-4652-5p	CLIP-seq
MIRT2166339	hsa-miR-4667-5p	CLIP-seq
MIRT2166340	hsa-miR-4700-5p	CLIP-seq
MIRT2166341	hsa-miR-4731-5p	CLIP-seq
MIRT1924990	hsa-miR-513b	CLIP-seq
MIRT2166342	hsa-miR-550a	CLIP-seq
MIRT2166343	hsa-miR-613	CLIP-seq
MIRT2166344	hsa-miR-661	CLIP-seq
MIRT2166327	hsa-miR-185	CLIP-seq
MIRT2383827	hsa-miR-3660	CLIP-seq
MIRT2383828	hsa-miR-4256	CLIP-seq
MIRT2166335	hsa-miR-4306	CLIP-seq
MIRT2383829	hsa-miR-4526	CLIP-seq
MIRT2166337	hsa-miR-4644	CLIP-seq
MIRT2166324	hsa-miR-1	CLIP-seq
MIRT2468863	hsa-miR-1271	CLIP-seq
MIRT2468864	hsa-miR-1275	CLIP-seq
MIRT2468865	hsa-miR-1285	CLIP-seq
MIRT2468866	hsa-miR-1321	CLIP-seq
MIRT2468867	hsa-miR-182	CLIP-seq
MIRT2166328	hsa-miR-206	CLIP-seq
MIRT2468868	hsa-miR-2861	CLIP-seq
MIRT2166330	hsa-miR-299-3p	CLIP-seq
MIRT2468869	hsa-miR-3151	CLIP-seq
MIRT2468870	hsa-miR-3187-5p	CLIP-seq
MIRT2468871	hsa-miR-4419a	CLIP-seq
MIRT2468872	hsa-miR-4447	CLIP-seq
MIRT2468873	hsa-miR-4472	CLIP-seq
MIRT2468874	hsa-miR-4510	CLIP-seq
MIRT2468875	hsa-miR-4512	CLIP-seq
MIRT2468876	hsa-miR-4520a-3p	CLIP-seq
MIRT2468877	hsa-miR-4525	CLIP-seq
MIRT2468878	hsa-miR-4665-5p	CLIP-seq
MIRT2468879	hsa-miR-4723-5p	CLIP-seq
MIRT2468880	hsa-miR-4728-5p	CLIP-seq
MIRT2468881	hsa-miR-4739	CLIP-seq
MIRT2468882	hsa-miR-4756-5p	CLIP-seq
MIRT2468883	hsa-miR-4763-5p	CLIP-seq
MIRT2468884	hsa-miR-4779	CLIP-seq
MIRT2468885	hsa-miR-491-5p	CLIP-seq
MIRT2468886	hsa-miR-612	CLIP-seq
MIRT2166343	hsa-miR-613	CLIP-seq
MIRT2468887	hsa-miR-625	CLIP-seq
MIRT2166344	hsa-miR-661	CLIP-seq
MIRT2468888	hsa-miR-96	CLIP-seq

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001676	Process	Long-chain fatty acid metabolic process	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	TAS
GO:0005515	Function	Protein binding	IPI	21516116, 25416956, 27499296, 31515488, 32296183, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IBA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006637	Process	Acyl-CoA metabolic process	TAS
GO:0016874	Function	Ligase activity	IEA
GO:0031956	Function	Medium-chain fatty acid-CoA ligase activity	IBA
GO:0031956	Function	Medium-chain fatty acid-CoA ligase activity	IDA	17762044
GO:0031956	Function	Medium-chain fatty acid-CoA ligase activity	IEA

Other IDs

• MIM: 610465
• HGNC: 26101
• e!Ensembl: ENSG00000167107

Protein

• UniProt ID: Q96CM8
• Protein name: Medium-chain acyl-CoA ligase ACSF2, mitochondrial (EC 6.2.1.2)
• Protein function: Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA (PubMed:17762044). Has some preference toward medium-chain substrates (PubMed:17762044). Plays a role in adipocyte differentiation (PubMed
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00501	AMP-binding	78 → 516	AMP-binding enzyme	Family
  PF13193	AMP-binding_C	524 → 599	AMP-binding enzyme C-terminal domain	Domain

• Sequence:

  MAVYVGMLRLGRLCAGSSGVLGARAALSRSWQEARLQGVRFLSSREVDRMVSTPIGGLSY
  VQGCTKKHLNSKTVGQCLETTAQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIG
  LCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVFPKQ
  FKTQQYYNVLKQICPEVENAQPGALKSQRLPDLTTVISVDAPLPGTLLLDEVVAAGSTRQ
  HLDQLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQ
  LRMILPNPLYHCLGSVAGTMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMF
  VDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAH
  FPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTE
  EAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQV
  VGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI
  QKFKLREQMERHLNL

• Sequence length: 615

Pathways

Reactome Pathway:

Mitochondrial Fatty Acid Beta-Oxidation

Related Genes

No strongly related genes found yet for ACSF2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ACSF2.