ACSBG1 (acyl-CoA synthetase bubblegum family member 1)

Gene

• Entrez ID: 23205
• Gene name: Acyl-CoA synthetase bubblegum family member 1
• Gene symbol: ACSBG1
• Synonyms (NCBI Gene): BG, BG1, BGM, GR-LACS, LPD
• Chromosome: 15
• Chromosome location: 15q25.1
• Summary: The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT724566	hsa-miR-4457	HITS-CLIP	19536157
MIRT724565	hsa-miR-125b-2-3p	HITS-CLIP	19536157
MIRT616864	hsa-miR-1290	HITS-CLIP	19536157
MIRT724564	hsa-miR-4450	HITS-CLIP	19536157
MIRT616863	hsa-miR-4766-3p	HITS-CLIP	19536157
MIRT724563	hsa-miR-513b-5p	HITS-CLIP	19536157
MIRT616862	hsa-miR-374b-3p	HITS-CLIP	19536157
MIRT669654	hsa-miR-3183	HITS-CLIP	23824327
MIRT669653	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT669652	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT669651	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT669650	hsa-miR-4421	HITS-CLIP	23824327
MIRT669649	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT669648	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT669647	hsa-miR-4469	HITS-CLIP	23824327
MIRT669646	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT669645	hsa-miR-623	HITS-CLIP	23824327
MIRT669644	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT669643	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT669642	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT669641	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT669640	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT669639	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT669638	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT669637	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT616868	hsa-miR-3942-5p	HITS-CLIP	23824327
MIRT616867	hsa-miR-4703-5p	HITS-CLIP	23824327
MIRT616866	hsa-miR-3908	HITS-CLIP	23824327
MIRT616865	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT616864	hsa-miR-1290	HITS-CLIP	23824327
MIRT616863	hsa-miR-4766-3p	HITS-CLIP	23824327
MIRT616862	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT461448	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT461447	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT461446	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT461444	hsa-miR-4257	PAR-CLIP	23592263
MIRT461445	hsa-miR-4459	PAR-CLIP	23592263
MIRT461443	hsa-miR-665	PAR-CLIP	23592263
MIRT461442	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT461441	hsa-miR-619-5p	PAR-CLIP	23592263
MIRT461440	hsa-miR-6506-5p	PAR-CLIP	23592263
MIRT461439	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT461438	hsa-miR-558	PAR-CLIP	23592263
MIRT461437	hsa-miR-4487	PAR-CLIP	23592263
MIRT461436	hsa-miR-1827	PAR-CLIP	23592263
MIRT461435	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT461434	hsa-miR-6086	PAR-CLIP	23592263
MIRT461433	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT461432	hsa-miR-3612	PAR-CLIP	23592263
MIRT461431	hsa-miR-650	PAR-CLIP	23592263
MIRT461430	hsa-miR-4792	PAR-CLIP	23592263
MIRT461429	hsa-miR-4710	PAR-CLIP	23592263
MIRT461428	hsa-miR-7855-5p	PAR-CLIP	23592263
MIRT461427	hsa-miR-1273e	PAR-CLIP	23592263
MIRT724566	hsa-miR-4457	HITS-CLIP	19536157
MIRT724565	hsa-miR-125b-2-3p	HITS-CLIP	19536157
MIRT616864	hsa-miR-1290	HITS-CLIP	19536157
MIRT724564	hsa-miR-4450	HITS-CLIP	19536157
MIRT616863	hsa-miR-4766-3p	HITS-CLIP	19536157
MIRT724563	hsa-miR-513b-5p	HITS-CLIP	19536157
MIRT616862	hsa-miR-374b-3p	HITS-CLIP	19536157
MIRT669654	hsa-miR-3183	HITS-CLIP	23824327
MIRT669653	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT669652	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT669651	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT669650	hsa-miR-4421	HITS-CLIP	23824327
MIRT669649	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT669648	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT669647	hsa-miR-4469	HITS-CLIP	23824327
MIRT669646	hsa-miR-6740-3p	HITS-CLIP	23824327
MIRT669645	hsa-miR-623	HITS-CLIP	23824327
MIRT669644	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT669643	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT669642	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT669641	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT669640	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT669639	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT669638	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT669637	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT616868	hsa-miR-3942-5p	HITS-CLIP	23824327
MIRT616867	hsa-miR-4703-5p	HITS-CLIP	23824327
MIRT616866	hsa-miR-3908	HITS-CLIP	23824327
MIRT616865	hsa-miR-144-5p	HITS-CLIP	23824327
MIRT616864	hsa-miR-1290	HITS-CLIP	23824327
MIRT616863	hsa-miR-4766-3p	HITS-CLIP	23824327
MIRT616862	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT461448	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT461447	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT461446	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT461444	hsa-miR-4257	PAR-CLIP	23592263
MIRT461445	hsa-miR-4459	PAR-CLIP	23592263
MIRT461443	hsa-miR-665	PAR-CLIP	23592263
MIRT461442	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT461441	hsa-miR-619-5p	PAR-CLIP	23592263
MIRT461440	hsa-miR-6506-5p	PAR-CLIP	23592263
MIRT461439	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT461438	hsa-miR-558	PAR-CLIP	23592263
MIRT461437	hsa-miR-4487	PAR-CLIP	23592263
MIRT461436	hsa-miR-1827	PAR-CLIP	23592263
MIRT461435	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT461434	hsa-miR-6086	PAR-CLIP	23592263
MIRT461433	hsa-miR-2467-3p	PAR-CLIP	23592263
MIRT461432	hsa-miR-3612	PAR-CLIP	23592263
MIRT461431	hsa-miR-650	PAR-CLIP	23592263
MIRT461430	hsa-miR-4792	PAR-CLIP	23592263
MIRT461429	hsa-miR-4710	PAR-CLIP	23592263
MIRT461428	hsa-miR-7855-5p	PAR-CLIP	23592263
MIRT461427	hsa-miR-1273e	PAR-CLIP	23592263

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000038	Process	Very long-chain fatty acid metabolic process	IDA	10954726
GO:0000166	Function	Nucleotide binding	IEA
GO:0001676	Process	Long-chain fatty acid metabolic process	IDA	10954726, 24269233
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IBA
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IDA	10954726, 24269233
GO:0004467	Function	Long-chain fatty acid-CoA ligase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	10954726
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	24269233
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	24269233
GO:0005886	Component	Plasma membrane	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016874	Function	Ligase activity	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031957	Function	Very long-chain fatty acid-CoA ligase activity	IDA	10954726
GO:0031957	Function	Very long-chain fatty acid-CoA ligase activity	TAS
GO:0035338	Process	Long-chain fatty-acyl-CoA biosynthetic process	TAS
GO:0042552	Process	Myelination	NAS	10954726
GO:0042759	Process	Long-chain fatty acid biosynthetic process	IBA
GO:0051384	Process	Response to glucocorticoid	IEA

Other IDs

• MIM: 614362
• HGNC: 29567
• e!Ensembl: ENSG00000103740

Protein

• UniProt ID: Q96GR2
• Protein name: Long-chain-fatty-acid--CoA ligase ACSBG1 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 1) (hBG1) (hsBG) (hsBGM) (Lipidosin)
• Protein function: Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:10954726, PubMed:12975357, PubMed:2426923
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00501	AMP-binding	109 → 573	AMP-binding enzyme	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed primarily in brain. Expressed at lower level in testis and adrenal gland. Present in all regions of brain except pituitary. {ECO:0000269|PubMed:10954726, ECO:0000269|PubMed:12975357, ECO:0000269|PubMed:24269233}.
• Sequence:

  MPRNSGAGYGCPHGDPSMLDSRETPQESRQDMIVRTTQEKLKTSSLTDRQPLSKESLNHA
  LELSVPEKVNNAQWDAPEEALWTTRADGRVRLRIDPSCPQLPYTVHRMFYEALDKYGDLI
  ALGFKRQDKWEHISYSQYYLLARRAAKGFLKLGLKQAHSVAILGFNSPEWFFSAVGTVFA
  GGIVTGIYTTSSPEACQYIAYDCCANVIMVDTQKQLEKILKIWKQLPHLKAVVIYKEPPP
  NKMANVYTMEEFMELGNEVPEEALDAIIDTQQPNQCCVLVYTSGTTGNPKGVMLSQDNIT
  WTARYGSQAGDIRPAEVQQEVVVSYLPLSHIAAQIYDLWTGIQWGAQVCFAEPDALKGSL
  VNTLREVEPTSHMGVPRVWEKIMERIQEVAAQSGFIRRKMLLWAMSVTLEQNLTCPGSDL
  KPFTTRLADYLVLAKVRQALGFAKCQKNFYGAAPMMAETQHFFLGLNIRLYAGYGLSETS
  GPHFMSSPYNYRLYSSGKLVPGCRVKLVNQDAEGIGEICLWGRTIFMGYLNMEDKTCEAI
  DEEGWLHTGDAGRLDADGFLYITGRLKELIITAGGENVPPVPIEEAVKMELPIISNAMLI
  GDQRKFLSMLLTLKCTLDPDTSDQTDNLTEQAMEFCQRVGSRATTVSEIIEKKDEAVYQA
  IEEGIRRVNMNAAARPYHIQKWAILERDFSISGGELGPTMKLKRLTVLEKYKGIIDSFYQ
  EQKM

• Sequence length: 724

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Cervical cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adrenoleukodystrophy	Adrenoleukodystrophy	BEFREE	11112418, 12719378, 15464426, 15800013, 16371355, 19167491, 26893370		★☆☆☆☆ Found in Text Mining only
Adrenoleukodystrophy	Adrenoleukodystrophy	LHGDN	15800013		★☆☆☆☆ Found in Text Mining only
Adult Hodgkin Lymphoma	Hodgkin Lymphoma	BEFREE	28877615		★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	17351108		★☆☆☆☆ Found in Text Mining only
Breast adenocarcinoma	Breast Adenocarcinoma	BEFREE	14671672		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	14671672		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	27857161	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	23936004		★☆☆☆☆ Found in Text Mining only
Chronic Kidney Diseases	Kidney Disease	BEFREE	29855350		★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	17351108, 21715317		★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	29028807		★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	20543584		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	29028807		★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Diabetic retinopathy	Pubtator	10688808	Associate	★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	17117491, 31027102		★☆☆☆☆ Found in Text Mining only
Gallstones	Gallstones	Pubtator	24083370	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	30596429		★☆☆☆☆ Found in Text Mining only
Hairy Cell Leukemia	Hairy Cell Leukemia	BEFREE	21715317		★☆☆☆☆ Found in Text Mining only
High Grade Lymphoma (neoplasm)	High Grade Lymphoma	BEFREE	30342536		★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin Disease	BEFREE	28877615		★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington Disease	BEFREE	2893260		★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune System Diseases	BEFREE	31840311		★☆☆☆☆ Found in Text Mining only
Immune thrombocytopenic purpura	Immune Thrombocytopenic Purpura	BEFREE	28573819, 31840311		★☆☆☆☆ Found in Text Mining only
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	BEFREE	14671672		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	29028807, 29635312		★☆☆☆☆ Found in Text Mining only
Intestinal Obstruction	Intestinal Obstruction	BEFREE	31027102		★☆☆☆☆ Found in Text Mining only
Irritable Bowel Syndrome	Irritable Bowel Syndrome	BEFREE	29028807		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	21963149, 28551662		★☆☆☆☆ Found in Text Mining only
Long QT Syndrome	Long QT Syndrome	BEFREE	29887480		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	34970420	Associate	★☆☆☆☆ Found in Text Mining only
Lymphohistiocytosis, Hemophagocytic	Lymphohistiocytosis	BEFREE	25337215		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	27993440, 8704180		★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin	Non-Hodgkin lymphoma	BEFREE	9746767		★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin, Familial	Lymphoma	BEFREE	9746767		★☆☆☆☆ Found in Text Mining only
Lymphomatoid Papulosis	Lymphomatoid Papulosis	BEFREE	27993440, 29146059, 29719017		★☆☆☆☆ Found in Text Mining only
Lymphoproliferative Disorders	Lymphoproliferative Disorder	BEFREE	21248177, 23279883, 24228130, 29635312, 30356785, 31840311, 3934321		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	14671672, 21963149		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	23936004		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29510805		★☆☆☆☆ Found in Text Mining only
Malnutrition	Malnutrition	BEFREE	21670064		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	14671672		★☆☆☆☆ Found in Text Mining only
Mantle cell lymphoma	Mantle Cell Lymphoma	BEFREE	21715317		★☆☆☆☆ Found in Text Mining only
Mucopolysaccharidosis VII	Mucopolysaccharidosis	Pubtator	1702266	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	7437515	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	9746767		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	10793069, 17117491, 19595666, 30548331		★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	19167491, 26893370		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	25321415	Associate	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	29447582		★☆☆☆☆ Found in Text Mining only
PARKINSON DISEASE, LATE-ONSET	Parkinson disease	BEFREE	29447582		★☆☆☆☆ Found in Text Mining only
Primary Cutaneous Anaplastic Large Cell Lymphoma	Anaplastic Lymphoma	BEFREE	27993440, 31640798		★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	36924977	Associate	★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	16988840, 17117491, 27846761		★☆☆☆☆ Found in Text Mining only
Systemic Scleroderma	Scleroderma	BEFREE	30457356		★☆☆☆☆ Found in Text Mining only
T-Cell Lymphoma	T-Cell Lymphoma	BEFREE	22367293		★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	29028807		★☆☆☆☆ Found in Text Mining only
Waldenstrom Macroglobulinemia	Waldenstrom`s Macroglobulinemia	BEFREE	30198568		★☆☆☆☆ Found in Text Mining only